Association of NRAMP1 gene polymorphisms with COPD clinical signs

A total of 51 goats, including seven clinical cases, from the first herd in Greece reported to have scrapie was examined to discern an association between scrapie susceptibility and polymorphisms of the gene encoding the prion protein (PrP). Each animal was evaluated for clinical signs of the disease, histopathological lesions associated with scrapie, the presence of detectable protease-resistant PrP in the brain and PrP genotype. Eleven different PrP genotypes encoding at least five unique predicted mature PrP amino acid sequences were found. These genotypes included the amino acid polymorphisms at codons 143 (H→R) and 240 (S→P) and ‘silent’ nucleotide alterations at codons 42 (a→g) and 138 (c→t). Additionally, novel caprine amino acid polymorphisms were detected at codons 21 (V→A), 23 (L→P), 49 (G→S), 154 (R→H), 168 (P→Q) and 220 (Q→H) and new silent mutations were found at codons 107 (g→a) and 207 (g→a). The following variants were found in scrapie-affected goats: VV21, LL23, GG49, SS49, HH143, HR143, RR154, PP168, PP240, SP240 and SS240. All scrapie-affected animals carried the HH143RR154 genotype, with the exception of two goats (HR143), both of which had detectable protease-resistant PrP but showed no clinical signs or histopathological lesions characteristic of scrapie.

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Lack of association between NRAMP1 gene polymorphisms and Trypanosoma cruzi infection

Tissue Antigens ◽

10.1034/j.1399-0039.2001.057004353.x ◽

2001 ◽

Vol 57 (4) ◽

pp. 353-357 ◽

Cited By ~ 11

Author(s):

J.E. Calzada ◽

A. Nieto ◽

M.A. López-Nevot ◽

J. Martín

Keyword(s):

Trypanosoma Cruzi ◽

Gene Polymorphisms ◽

Nramp1 Gene ◽

Cruzi Infection

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Frequency of NRAMP1 Gene Polymorphisms among Canadian First Nations Peoples Experiencing Endemic Tuberculosis

Mycobacterial Diseases ◽

10.4172/2161-1068.1000193 ◽

2015 ◽

Vol 05 (05) ◽

Cited By ~ 2

Author(s):

Linda A Larcombe ◽

Neeloffer Mookherjee ◽

Andrew M Lodge

Keyword(s):

First Nations ◽

Gene Polymorphisms ◽

Nramp1 Gene

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PD17-01 NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1 (NRAMP1) GENE POLYMORPHISMS AND RESPONSE TO BACILLUS CALMETTE-GUERIN THERAPY IN ASIAN NON-MUSCLE INVASIVE BLADDER CANCER PATIENTS

The Journal of Urology ◽

10.1016/j.juro.2015.02.658 ◽

2015 ◽

Vol 193 (4S) ◽

Cited By ~ 1

Author(s):

Jen-Hwei Sng ◽

Yew Koon Lim ◽

Zi Ting Wang ◽

Lata Raman Nee Mani ◽

Yiong Huak Chan ◽

...

Keyword(s):

Bladder Cancer ◽

Cancer Patients ◽

Gene Polymorphisms ◽

Natural Resistance ◽

Invasive Bladder Cancer ◽

Bacillus Calmette Guerin ◽

Muscle Invasive Bladder Cancer ◽

Nramp1 Gene ◽

Macrophage Protein ◽

Muscle Invasive

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A rapid method for the direct identification of paramyxovirus in canine CSF by ultracentrifugation and negative staining as a rule out for distemper

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100160522 ◽

1990 ◽

Vol 48 (3) ◽

pp. 594-595

Author(s):

W.L. Steffens ◽

M.B. Ard ◽

C.E. Greene ◽

A. Jaggy

Keyword(s):

Subacute Sclerosing Panencephalitis ◽

Clinical Signs ◽

Viral Disease ◽

Etiologic Agent ◽

Mucosal Inflammation ◽

Worldwide Distribution ◽

Negative Stain ◽

Viral Particles ◽

Systemic Manifestations ◽

Rule Out

Canine distemper is a multisystemic contagious viral disease having a worldwide distribution, a high mortality rate, and significant central neurologic system (CNS) complications. In its systemic manifestations, it is often presumptively diagnosed on the basis of clinical signs and history. Few definitive antemortem diagnostic tests exist, and most are limited to the detection of viral antigen by immunofluorescence techniques on tissues or cytologic specimens or high immunoglobulin levels in CSF (cerebrospinal fluid). Diagnosis of CNS distemper is often unreliable due to the relatively low cell count in CSF (<50 cells/μl) and the binding of blocking immunoglobulins in CSF to cell surfaces. A more reliable and definitive test might be possible utilizing direct morphologic detection of the etiologic agent. Distemper is the canine equivalent of human measles, in that both involve a closely related member of the Paramyxoviridae, both produce mucosal inflammation, and may produce CNS complications. In humans, diagnosis of measles-induced subacute sclerosing panencephalitis is through negative stain identification of whole or incomplete viral particles in patient CSF.

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Hormone Replacement Therapy and Voice

Perspectives of the ASHA Special Interest Groups ◽

10.1044/2019_pers-sig3-2018-0007 ◽

2019 ◽

Vol 4 (4) ◽

pp. 607-614

Author(s):

Jean Abitbol

Keyword(s):

Replacement Therapy ◽

Symptom Severity ◽

Low Dose ◽

Hormone Replacement ◽

Clinical Signs ◽

Female Voice ◽

Fat Cells ◽

High Pitch ◽

Endocrine Effects ◽

The Voice

The purpose of this article is to update the management of the treatment of the female voice at perimenopause and menopause. Voice and hormones—these are 2 words that clash, meet, and harmonize. If we are to solve this inquiry, we shall inevitably have to understand the hormones, their impact, and the scars of time. The endocrine effects on laryngeal structures are numerous: The actions of estrogens and progesterone produce modification of glandular secretions. Low dose of androgens are secreted principally by the adrenal cortex, but they are also secreted by the ovaries. Their effect may increase the low pitch and decease the high pitch of the voice at menopause due to important diminution of estrogens and the privation of progesterone. The menopausal voice syndrome presents clinical signs, which we will describe. I consider menopausal patients to fit into 2 broad types: the “Modigliani” types, rather thin and slender with little adipose tissue, and the “Rubens” types, with a rounded figure with more fat cells. Androgen derivatives are transformed to estrogens in fat cells. Hormonal replacement therapy should be carefully considered in the context of premenopausal symptom severity as alternative medicine. Hippocrates: “Your diet is your first medicine.”

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