scholarly journals Inhaled anti-asthma therapies following hormone therapy in women: a nationwide cohort study

2021 ◽  
pp. 00611-2021
Author(s):  
Erik Soeren Halvard Hansen ◽  
Kristian Aasbjerg ◽  
Amalie Lykkemark Moeller ◽  
Amani Meaidi ◽  
Elisabeth Juul Gade ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hormone Therapy ◽  
Household Income ◽  
Inhaled Corticosteroids ◽  
Research Question ◽  
Population Based ◽  
Odds Ratios ◽  
Level Of Education ◽  
Beneficial Effects ◽  
Therapy Initiation

Research questionDoes menopausal hormone therapy with exogenous estrogens and progestogens change the use of inhaled anti-asthma medications in women with asthma?MethodsIn a population-based, matched cohort study using the Danish registries, we included women with asthma aged 45–65 years from June 1, 1995 to June 30, 2018. We investigated whether hormone therapy with estrogen and/or progestogens was associated with changes in use of inhaled anti-asthma therapies in the 12 months following initiation. We used exposure density matching to match exposed subjects with unexposed subjects on age, household income and level of education. An exposed subject was defined as receiving hormone therapy. We calculated mean dose of medications and odds ratios of increases in the 12 months following hormone therapy initiation.ResultsWe included 139 483 women with asthma, of whom 116 014 (83.2%) were unexposed subjects and 23 469 (16.8%) exposed subjects. Mean age was 53.0 (sd 5.2) years. Initiation of HT was not consistently associated with increased mean doses of inhaled corticosteroids, or long- and short-acting beta2-agonists. Women receiving systemic estrogens had increased odds ratios of large increases (>100 µg) in inhaled corticosteroids at six months (1.09; 95%CI 1.04–1.13; p<0.001) and nine months (1.07; 95%CI 1.03–1.12; p<0.001). Progestogens were protective against increases in inhaled corticosteroids at six and nine months (OR 0.87; 95%CI 0.82–0.93; p<0.001 and 0.86; 95%CI 0.81–0.91; p<0.001).ConclusionInitiation of hormone therapy did not change the use of inhaled medications in asthma. However, detrimental effects of estrogen, as well as beneficial effects of progestogens, cannot be excluded.

scholarly journals Menopausal hormone therapy and colorectal cancer: a linkage between nationwide registries in Norway

BMJ Open ◽  
2017 ◽  
Vol 7 (11) ◽  
pp. e017639 ◽  
Author(s):  
Edoardo Botteri ◽  
Nathalie C Støer ◽  
Solveig Sakshaug ◽  
Sidsel Graff-Iversen ◽  
Siri Vangen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Hormone Therapy ◽  
Population Based ◽  
Menopausal Hormone Therapy ◽  
Anatomic Site ◽  
Oral Formulations ◽  
Norwegian Population ◽  
Progestin Therapy ◽  
Rate Ratios

ObjectivesWith the present study, we aimed to investigate the association between menopausal hormone therapy (HT) and risk of colorectal cancer (CRC).SettingCohort study based on the linkage of Norwegian population-based registries.ParticipantsWe selected 466822 Norwegian women, aged 55–79, alive and residing in Norway as of 1 January 2004, and we followed them from 2004 to 2008. Each woman contributed person-years at risk as non-user, current user and/or past HT user.Outcome measuresThe outcome of interest was adenocarcinoma of the colorectal tract, overall, by anatomic site and stage at diagnosis. Incidence rate ratios (RRs) with 95% CIs were estimated by Poisson regression and were used to evaluate the association between HT and CRC incidence.ResultsDuring the median follow-up of 4.8 years, 138 655 (30%) women received HT and 3799 (0.8%) incident CRCs occurred. Current, but not past, use of HT was associated with a lower risk of CRC (RR 0.88; 95% CI 0.80 to 0.98). RRs for localised, regionally advanced and metastatic CRC were 1.13 (95% CI 0.91 to 1.41), 0.81 (95% CI 0.70 to 0.94) and 0.79 (95% CI 0.62 to 1.00), respectively. RRs for current use of oestrogen therapy (ET) were 0.91 (95% CI 0.80 to 1.04) while RR for current use of combined oestrogen–progestin therapy (EPT) was 0.85 (95% CI 0.70 to 1.03), as compared with no use of HT. The same figures for ET and EPT in oral formulations were 0.83 (95% CI 0.68 to 1.03) and 0.86 (95% CI 0.71 to 1.05), respectively.ConclusionsIn our nationwide cohort study, HT use lowered the risk of CRC, specifically the most advanced CRC.

scholarly journals Prevalence and risk factors for wheeze, decreased forced expiratory volume in 1 s and bronchoconstriction in young children living in Havana, Cuba: a population-based cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. e034192
Author(s):  
Ramón Suárez-Medina ◽  
Silvia Venero-Fernández ◽  
Vilma Alvarez-Valdés ◽  
Nieves Sardiñas-Baez ◽  
Carmona Cristina ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Young Children ◽  
Low Income ◽  
Inhaled Corticosteroids ◽  
Population Based ◽  
Forced Expiratory Volume ◽  
First Year ◽  
Middle Income ◽  
Middle Income Countries

ObjectivesAsthma has not been extensively studied in low-income and middle-income countries, where risk factors and access to treatment may differ from more affluent countries. We aimed to identify the prevalence of asthma and local risk factors in Havana, Cuba.SettingFour municipalities in Havana, Cuba.ParticipantsA population-based cohort study design of young children living in Havana, Cuba. Children were recruited from primary care centres at age 12–15 months.Primary and secondary outcome measuresData on wheeze in the past 12 months, asthma treatment and environmental exposures collected regularly until the age of 6 years, when forced expiratory volume in 1 s (FEV1) and reversibility to aerosolised salbutamol were also measured.Results1106 children provided data at the age of 6 years old. The prevalence of wheeze in the previous 12 months was 422 (38%), and 294 (33%) of the study population had bronchodilatation of 12% or more in FEV1after administration of inhaled salbutamol. In the previous 12 months, 182 (16%) of the children had received inhaled corticosteroids, 416 (38%) salbutamol inhalers and 283 (26%) a course of systemic steroids.Wheeze in the first year and a family history of asthma were both positively associated with bronchodilatation to inhaled salbutamol (1.94%; 95% CI 0.81 to 3.08 and 1.85%; CI 0.14 to 3.57, respectively), while paracetamol use in the first year was associated with wheeze at 6 years (OR 1.64, 95% CI 1.14 to 2.35). There were large differences in FEV1, bronchodilatation and risk of wheeze across different geographical areas.ConclusionsAsthma is common in young children living in Havana, and the high prevalence of systemic steroids administrated is likely to reflect the underuse of regular inhaled corticosteroids. If replicated in other comparable low-income and middle-income countries, this represents an important global public health issue.

scholarly journals Menopausal hormone therapy and biliary tract cancer: a population-based matched cohort study in Sweden

2019 ◽  
Vol 58 (3) ◽  
pp. 290-295 ◽  
Author(s):  
C. Kilander ◽  
J. Lagergren ◽  
P. Konings ◽  
O. Sadr-Azodi ◽  
N. Brusselaers
Keyword(s):  
Cohort Study ◽  
Hormone Therapy ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Population Based ◽  
Menopausal Hormone Therapy ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Tract Cancer

Menopausal hormone therapy and risk of melanoma: a population‐based cohort study

2021 ◽  
Author(s):  
N.C. Støer ◽  
E. Botteri ◽  
M. Busund ◽  
R. Ghiasvand ◽  
S. Vangen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hormone Therapy ◽  
Population Based ◽  
Menopausal Hormone Therapy

scholarly journals Sociodemographic characteristics and frequency of consuming home-cooked meals and meals from out-of-home sources: cross-sectional analysis of a population-based cohort study

2018 ◽  
Vol 21 (12) ◽  
pp. 2255-2266 ◽  
Author(s):  
Susanna Mills ◽  
Jean Adams ◽  
Wendy Wrieden ◽  
Martin White ◽  
Heather Brown
Keyword(s):  
Cohort Study ◽  
Educational Attainment ◽  
Household Income ◽  
Occupational Status ◽  
Population Based ◽  
Sociodemographic Characteristics ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Sectional Analysis ◽  
Lower Educational Attainment

AbstractObjectiveTo identify sociodemographic characteristics associated with frequency of consuming home-cooked meals and meals from out-of-home sources.DesignCross-sectional analysis of a population-based cohort study. Frequency of consuming home-cooked meals, ready meals, takeaways and meals out were derived from a participant questionnaire. Sociodemographic characteristics regarding sex, age, ethnicity, working overtime and socio-economic status (SES; measured by household income, educational attainment, occupational status and employment status) were self-reported. Sociodemographic differences in higher v. lower meal consumption frequency were explored using logistic regression, adjusted for other key sociodemographic variables.SettingCambridgeshire, UK.SubjectsFenland Study participants (n 11 326), aged 29–64 years at baseline.ResultsEating home-cooked meals more frequently was associated with being female, older, of higher SES (measured by greater educational attainment and household income) and not working overtime. Being male was associated with a higher frequency of consumption for all out-of-home meal types. Consuming takeaways more frequently was associated with lower SES (measured by lower educational attainment and household income), whereas eating out more frequently was associated with higher SES (measured by greater educational attainment and household income) and working overtime.ConclusionsSociodemographic characteristics associated with frequency of eating meals from different out-of-home sources varied according to meal source. Findings may be used to target public health policies and interventions for promoting healthier diets and dietary-related health towards people consuming home-cooked meals less frequently, such as men, those with lower educational attainment and household income, and overtime workers.

scholarly journals Concordance in the recording of stroke across UK primary and secondary care datasets: a population-based cohort study

BJGP Open ◽  
2020 ◽  
pp. BJGPO.2020.0117
Author(s):  
Ann Dorothy Morgan ◽  
Sarah-Jo Sinnott ◽  
Liam Smeeth ◽  
Caroline Minassian ◽  
Jennifer Quint
Keyword(s):  
Myocardial Infarction ◽  
Primary Care ◽  
Cohort Study ◽  
Time Window ◽  
Research Question ◽  
Population Based ◽  
Hospital Episode Statistics ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
Hospital Records

Background: Previous work has demonstrated that the recording of acute health outcomes, such as myocardial infarction, may be suboptimal in primary healthcare databases. Aim: The aim of this analysis is to assess the completeness and accuracy of the recording of stroke in UK primary care. Design and setting: This is a population-based longitudinal cohort study. Methods: Cases of stroke were identified separately in Clinical Practice Research Datalink (CPRD) primary care records and linked Hospital Episode Statistics (HES). The recording of events in the same patient across the two datasets was compared. The reliability of strategies to identify fatal strokes in primary care and hospital records was also assessed. Results: Of the 75,674 stroke events that were identified in either CPRD or HES data during the period of our study, 54,929 (72.6%) were recorded in CPRD and 51,013 (67.4%) were recorded in HES. Two fifths (n=30,268) of all recorded strokes were found in both datasets (allowing for a time window of 120 days). Among these “matched” strokes the subtype was recorded accurately in approximately 75% of CPRD records (compared to coding in HES): however, 43.5% of ischaemic strokes in HES were coded as “non-specific” strokes in CPRD data. Furthermore, 48% had same day-recordings, and 56% were date-matched within ±1 day. Conclusion: The completeness and accuracy of stroke recording is improved by the use of linked hospital and primary care records. For studies that have a time-sensitive research question, we strongly recommend the use of linked, as opposed to stand-alone, CPRD data.

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