scholarly journals Regular inhaled corticosteroids in adult-onset asthma and the risk for future cancer: a population-based cohort study with proper person-time analysis

2015 ◽  
pp. 489 ◽  
Author(s):  
Victor C. Kok ◽  
Hsu-Kai Huang ◽  
Tsung-Ming Chao ◽  
Ya-Fang Hong ◽  
Jorng-Tzong Horng
Keyword(s):  
Cohort Study ◽  
Inhaled Corticosteroids ◽  
Population Based ◽  
Adult Onset ◽  
Time Analysis

Pubertal BMI change and adult‐onset asthma in men: Population‐based cohort study in Sweden

2019 ◽  
Vol 50 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Bright I. Nwaru ◽  
Claes Ohlsson ◽  
Maria Bygdell ◽  
Jari Martikainen ◽  
Jenny M. Kindblom
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
Adult Onset

scholarly journals Prevalence and risk factors for wheeze, decreased forced expiratory volume in 1 s and bronchoconstriction in young children living in Havana, Cuba: a population-based cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. e034192
Author(s):  
Ramón Suárez-Medina ◽  
Silvia Venero-Fernández ◽  
Vilma Alvarez-Valdés ◽  
Nieves Sardiñas-Baez ◽  
Carmona Cristina ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Young Children ◽  
Low Income ◽  
Inhaled Corticosteroids ◽  
Population Based ◽  
Forced Expiratory Volume ◽  
First Year ◽  
Middle Income ◽  
Middle Income Countries

ObjectivesAsthma has not been extensively studied in low-income and middle-income countries, where risk factors and access to treatment may differ from more affluent countries. We aimed to identify the prevalence of asthma and local risk factors in Havana, Cuba.SettingFour municipalities in Havana, Cuba.ParticipantsA population-based cohort study design of young children living in Havana, Cuba. Children were recruited from primary care centres at age 12–15 months.Primary and secondary outcome measuresData on wheeze in the past 12 months, asthma treatment and environmental exposures collected regularly until the age of 6 years, when forced expiratory volume in 1 s (FEV1) and reversibility to aerosolised salbutamol were also measured.Results1106 children provided data at the age of 6 years old. The prevalence of wheeze in the previous 12 months was 422 (38%), and 294 (33%) of the study population had bronchodilatation of 12% or more in FEV1after administration of inhaled salbutamol. In the previous 12 months, 182 (16%) of the children had received inhaled corticosteroids, 416 (38%) salbutamol inhalers and 283 (26%) a course of systemic steroids.Wheeze in the first year and a family history of asthma were both positively associated with bronchodilatation to inhaled salbutamol (1.94%; 95% CI 0.81 to 3.08 and 1.85%; CI 0.14 to 3.57, respectively), while paracetamol use in the first year was associated with wheeze at 6 years (OR 1.64, 95% CI 1.14 to 2.35). There were large differences in FEV1, bronchodilatation and risk of wheeze across different geographical areas.ConclusionsAsthma is common in young children living in Havana, and the high prevalence of systemic steroids administrated is likely to reflect the underuse of regular inhaled corticosteroids. If replicated in other comparable low-income and middle-income countries, this represents an important global public health issue.

scholarly journals Inhaled anti-asthma therapies following hormone therapy in women: a nationwide cohort study

2021 ◽  
pp. 00611-2021
Author(s):  
Erik Soeren Halvard Hansen ◽  
Kristian Aasbjerg ◽  
Amalie Lykkemark Moeller ◽  
Amani Meaidi ◽  
Elisabeth Juul Gade ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hormone Therapy ◽  
Household Income ◽  
Inhaled Corticosteroids ◽  
Research Question ◽  
Population Based ◽  
Odds Ratios ◽  
Level Of Education ◽  
Beneficial Effects ◽  
Therapy Initiation

Research questionDoes menopausal hormone therapy with exogenous estrogens and progestogens change the use of inhaled anti-asthma medications in women with asthma?MethodsIn a population-based, matched cohort study using the Danish registries, we included women with asthma aged 45–65 years from June 1, 1995 to June 30, 2018. We investigated whether hormone therapy with estrogen and/or progestogens was associated with changes in use of inhaled anti-asthma therapies in the 12 months following initiation. We used exposure density matching to match exposed subjects with unexposed subjects on age, household income and level of education. An exposed subject was defined as receiving hormone therapy. We calculated mean dose of medications and odds ratios of increases in the 12 months following hormone therapy initiation.ResultsWe included 139 483 women with asthma, of whom 116 014 (83.2%) were unexposed subjects and 23 469 (16.8%) exposed subjects. Mean age was 53.0 (sd 5.2) years. Initiation of HT was not consistently associated with increased mean doses of inhaled corticosteroids, or long- and short-acting beta2-agonists. Women receiving systemic estrogens had increased odds ratios of large increases (>100 µg) in inhaled corticosteroids at six months (1.09; 95%CI 1.04–1.13; p<0.001) and nine months (1.07; 95%CI 1.03–1.12; p<0.001). Progestogens were protective against increases in inhaled corticosteroids at six and nine months (OR 0.87; 95%CI 0.82–0.93; p<0.001 and 0.86; 95%CI 0.81–0.91; p<0.001).ConclusionInitiation of hormone therapy did not change the use of inhaled medications in asthma. However, detrimental effects of estrogen, as well as beneficial effects of progestogens, cannot be excluded.

Stroke after adult-onset epilepsy: A population-based retrospective cohort study

2015 ◽  
Vol 43 ◽  
pp. 93-99 ◽  
Author(s):  
Braxton B. Wannamaker ◽  
Dulaney A. Wilson ◽  
Angela M. Malek ◽  
Anbesaw W. Selassie
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Population Based ◽  
Adult Onset
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