Sources of variation and genetic profile of spontaneous, out-of-season ovulatory activity in the Chios sheep

Purpose: Investigative interviews are complex, dyadic, activities typically studied by focusing on developing techniques to improve witness performance. However, in field settings, interviewers are known to vary in their presentation of good interviewing practice. Thus, it is important to conduct research reflective of complex idiosyncrasies in witnesses, interviewers and unique pairings of both. This study explores such sources of variation in an by making use of a 'round-robin' design. Such methodology allows the statistical demonstration of individual difference and unique partner-generated variance in interview performance. Methods: In our study, a total of 45 witnesses were questioned about five real crime videos. After witnessing each event, witnesses were interviewed by a different interviewer (or a computer self-administered interview). In total, nine 'rounds' of interviews occurred, with five new witnesses being interviewed in the same five interview settings (resulting in 225 interviews). After each interview both interviewers and witnesses were asked to complete subjective interview experience ratings. The quality (grain size) and quantity of information in the statements was coded to index witness report accuracy. Results: Principally, the results demonstrate the degree to which witnesses and interviewers affect statement quality, and highlight the influence of unique interviewer-witness pairs. (Participant personality and interviewer behaviour were also analysed, but with limited effects). Conclusion: This study presents the useful round-robin methodology for studying interviewer-witness behaviour. Whilst the current personality and behavioural measures do not account for these individual differences, we advocate this methodology be adopted more widely to better understand interview performance.

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PREDICTIVE VALUE OF THE DYNAMIC DETERMINATION OF CIRCULATING TUMOR DNA ON PFS IN PATIENTS WITH EGFR MUTATED NSCLC, WITH OSIMERTINIB THERAPY

Problems in oncology ◽

10.37469/0507-3758-2020-66-2-135-142 ◽

2020 ◽

Vol 66 (2) ◽

pp. 135-142

Author(s):

Fedor Moiseenko ◽

Mariya Stepanova ◽

Nikita Volkov ◽

Albina Zhabina ◽

A. Myslik ◽

...

Keyword(s):

Predictive Value ◽

Molecular Genetic ◽

Predictive Marker ◽

Circulating Tumor Dna ◽

Qualitative Assessment ◽

Genetic Profile ◽

T790m Mutation ◽

Rare Mutations ◽

Effect Of Therapy ◽

Pcr Method

Aim: study of the predictive value of determining ctDNA during treatment with osimertinib in patients with NSCLC with EGFR mutation. Methods: The study included patients with metastatic EG-FR-associated NSCLC, in whom, with progression against the background of 1st - 2nd generation TKIs, the T790M mutation was detected. Patients received osimertinib therapy 80 mg/ day, daily, until progression. Before treatment, and then every 2 months, whole blood was taken to conduct a qualitative assessment of ctDNA in dynamics by the RT-PCR method. Results: From 2016 to 2019 in St. Petersburg Clinical Scientific and Practical Center of Specialized Types of Medical Care (Oncology), 22 patients were identified T790M associated progression of EGFR NSCLC. 81.9% (18/22) are women, 18.1% (4/22) are men. The average age is 61.2 years (50-75). 1/22 had smoking experience for more than 30 years. The molecular genetic profile in 16 is represented by ex19del, 5 L858R, 1 -a combination of rare mutations G719S+S768I. The effect of therapy was evaluated in 20/22 patients. PR and SD were registered in 9/20 (45%) and 10/20 (50%) patients, respectively. Median PFS - 16.7 months (cI 95%, 11,4-22,0). In 12/22 patients was observed the disappearance of ctDNA T790M after 2 months of osimertinib therapy. PFS is 18,9 months (95% CI, 14,8-19,7), in patients with no mutation detected in the second month of treatment compared with the group of patients in which the ctDNA was determined (PFS 8.0 months) (CI 95%, 4,2-11,8) (p=0.015). Correlation analysis did not reveal any clinical factors associated with the disappearance of ctDNA. Conclusions: The disappearance of ctDNA in plasma after 2 months of treatment with osimertinib is associated with an increase in PFS and can be considered as a predictive marker in patients with metastatic NSCLC EGFR T790M.

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Finger Printing of Rahmani, Chios Sheep Breeds and Their Crosses Using Random Amplified Polymorphic Dna (Rapd)

Journal of Agricultural Chemistry and Biotechnology ◽

10.21608/jacb.2016.40885 ◽

2016 ◽

Vol 7 (6) ◽

pp. 187-192

Author(s):

G. Mohamed ◽

M. Kamal El-Din ◽

S. Fahmy ◽

M. Sallam ◽

M. Awad-Allah

Keyword(s):

Random Amplified Polymorphic Dna ◽

Sheep Breeds ◽

Finger Printing ◽

Chios Sheep

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Immunogenetics of Celiac Disease: A Focus on Arab Countries

Current Molecular Medicine ◽

10.2174/1566524019666191024104930 ◽

2020 ◽

Vol 20 (4) ◽

pp. 275-285 ◽

Cited By ~ 1

Author(s):

Nadin Younes ◽

Salma Younes ◽

Ola. A. Alsharabasi ◽

Mohamed E. El Zowalaty ◽

Ibrahim Mustafa ◽

...

Keyword(s):

Celiac Disease ◽

Genetic Epidemiology ◽

Arab World ◽

Human Leukocyte ◽

Epidemiological Studies ◽

Arab Countries ◽

Global Perspective ◽

Genetic Profile ◽

Leukocyte Antigen ◽

Genetic And Environmental Factors

Celiac Disease (CD) is a complex immunogenic disease mainly triggered by gluten intake in genetically susceptible individuals with a prevalence of 1 in 100-300. CD results from the interplay between genetic and environmental factors. Genetic susceptibility is believed to play a prominent role in the pathogenicity of CD, mainly due to human leukocyte antigen (HLA)-related class II genes. Although CD is wellrecognized among Arab populations, there are few studies on the genetic epidemiology and prevalence of CD in the Arab countries. Therefore, the aim of this review was to highlight the importance of studying this disease in the Arab world in the context of a global perspective. Within the few studies published so far, it was found that Arab populations have a distinctive susceptibility genetic profile from other ethnic groups with the DQ2.5 and DQ8 genotypes that are considered the major genotypes that confer susceptibility among Arab patients with CD. Our findings will pave the way to perform further epidemiological studies that will help identify potential therapeutic targets against CD among Arab patients that are diagnosed with CD.

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Still Connecting with Society?

10.1093/oso/9780198758631.003.0005 ◽

2017 ◽

Cited By ~ 2

Author(s):

Elin Haugsgjerd Allern ◽

Tània Verge

Keyword(s):

Political Parties ◽

Ethnic Minorities ◽

Social Groups ◽

The Public ◽

Organized Interests ◽

Social Interests ◽

Sources Of Variation ◽

Cross Country ◽

Formal Status ◽

Formal Rules

How parties structure their interaction with social groups is a key determinant of their capacity to provide linkage between the institutions of government and the public at large. This chapter investigates the extent to which modern political parties use formal measures to connect to relevant societal interests and strengthen their anchorage in society. The analysis centres on parties’ use of formal rules governing affiliation and representation to link with externally organized interests and parties’ establishment of sub-organizations with representation rights within the party. The chapter authors develop and test several hypotheses concerning cross-country and within-country sources of variation in formal linkage and test them empirically. In addition, they examine whether formal status and representation rights shape parties’ ability to represent descriptively the associated latent social interests focusing on the case of women and ethnic minorities.

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Mapping of scatter in fatigue life assessment of welded structures—a round-robin study

Welding in the World ◽

10.1007/s40194-021-01099-y ◽

2021 ◽

Author(s):

Gustav Hultgren ◽

Mansoor Khurshid ◽

Peter Haglund ◽

Zuheir Barsoum

Keyword(s):

Fatigue Life ◽

Round Robin ◽

Life Assessment ◽

Fatigue Life Assessment ◽

Fatigue Life Estimation ◽

Box Structures ◽

Load Carrying ◽

Local Stresses ◽

Sources Of Variation ◽

Global And Local

AbstractA round-robin study has been carried out within a national project in Sweden with the addition of an international participant, where several industrial partners and universities are participating. The project aims to identify variation and sources of variation in welding production, map scatter in fatigue life estimation, and define and develop concepts to reduce these, in all steps of product development. The participating organisations were asked to carry out fatigue life assessment of welded box structures, which is a component in load-carrying structures. The estimations of fatigue life have also been compared with fatigue test results. Detailed drawings, loads and material data were also given to the participants. The participants were supposed to use assessment methods based on global and local stresses using the design codes or recommendations they currently use in-house. Differences were identified between both methods and participants using the same codes/recommendations. Applicability and conditions from the cases in the codes were also identified to be differently evaluated between the participants. It could be concluded that for the applied cases the nominal stress method often overestimated the fatigue life and had a high scatter in the estimations by different participants. The effective notch method is conservative in comparison to the life of tested components with little scatter between the results derived by the participants.

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Sources of variation in bourbon whiskey barrels: a review

Journal of the Institute of Brewing ◽

10.1002/jib.660 ◽

2021 ◽

Author(s):

Jarrad Gollihue ◽

Victoria G. Pook ◽

Seth DeBolt

Keyword(s):

Sources Of Variation

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Establishment of reference intervals for immunoassay analytes of adult population in Saudi Arabia

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2019-1049 ◽

2020 ◽

Vol 58 (8) ◽

pp. 1302-1313 ◽

Cited By ~ 3

Author(s):

Anwar Borai ◽

Kiyoshi Ichihara ◽

Abdulaziz Masaud ◽

Waleed Tamimi ◽

Suhad Bahijri ◽

...

Keyword(s):

Vitamin D ◽

Saudi Arabia ◽

Adult Population ◽

Reference Intervals ◽

Careful Consideration ◽

Upper Limits ◽

Sources Of Variation ◽

Vitamin D Supplements ◽

Saudi Arabians ◽

Abbott Architect

AbstractBackgroundThis is a second part of report on the IFCC global multicenter study conducted in Saudi Arabia to derive reference intervals (RIs) for 20 immunoassay analytes including five tumor makers, five reproductive, seven other hormones and three vitamins.MethodsA total of 826 apparently healthy individuals aged ≥18 years were recruited in three clinical laboratories located in western, central and eastern Saudi Arabia using the protocol specified for the global study. All serum specimens were measured using Abbott, Architect analyzers. Multiple regression analysis (MRA) was performed to explore sources of variation of each analyte: age, body mass index (BMI), physical exercise and smoking. The magnitude of variation of reference values (RVs) attributable to sex, age and region was calculated by ANOVA as a standard deviation ratio (SDR). RIs were derived by the parametric (P) method.ResultsMRA revealed that region, smoking and exercise were not relevant sources of variation for any analyte. Based on SDR and actual between-sex differences in upper limits (ULs), we chose to partition RIs by sex for all analytes except for α-fetoprotein and parathyroid hormone (PTH). Age-specific RIs were required in females for ferritin, estradiol, progesterone, testosterone, follitropin, luteotropin and prolactin (PRL). With prominent BMI-related increase, RIs for insulin and C-peptide were derived after excluding individuals with BMI > 32 kg/m2. Individuals taking vitamin D supplements were excluded in deriving RIs for vitamin D and PTH.ConclusionsRIs of major immunoassay analytes specific for Saudi Arabians were established in careful consideration of various biological sources of variation.

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