Analysis of vancomycin use and associated risk factors in a university teaching hospital: a prospective cohort study

Introduction: Postoperative nausea and vomiting are frequent adverse effects of anesthesia and surgery. Impact is greater in pediatric populations compared to adults and the reported incidences are heterogeneous. Objective: To describe the incidence of postoperative vomiting in a pediatric population and to identify associated risk factors. Materials and methods: This prospective cohort study included 190 children aged 3 to 12 years undergoing surgery and anesthesia in a maternal and child health clinic in Bucaramanga (Colombia). The main outcome variable was postoperative vomiting. Data were analyzed using bivariate, multivariate analysis and logistic regression to assess the associated risk factors. Results: The overall incidence of postoperative vomiting was 18.95% (95% CI: 13.32 - 24.57), with a higher incidence at home vs. hospital (12.63% vs. 9.47%). After adjustment, associated risk factors were anesthesia time longer than 45 minutes (OR: 2.33; 95% CI: 1.10-4.90) and postoperative use of opioids (OR: 4.17; 95% IC: 1.65-10.5). The incidence of postoperative vomiting was higher in patients who underwent emergency surgery. Conclusion: This is the first study in Colombia that evaluates the incidence of postoperative vomiting in children. The incidence in our pediatric population is within the ranges reported worldwide. Associated risk factors were anesthesia time longer than 45 minutes and postoperative use of opioids. Further research is required in order to study emergency surgery as a potential risk factor.

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Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study

10.1101/2021.04.26.21256110 ◽

2021 ◽

Author(s):

Ismail M Osmanov ◽

Ekaterina Spiridonova ◽

Polina Bobkova ◽

Aysylu Gamirova ◽

Anastasia Shikhaleva ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Allergic Diseases ◽

Long Term Outcomes ◽

Persistent Symptoms ◽

Associated Risk Factors

Background The long-term sequelae of coronavirus disease 2019 (Covid-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with Covid-19 and associated risk factors. Methods This is a prospective cohort study of children (18 years old and younger) admitted with confirmed Covid-19 to Z.A. Bashlyaeva Children's Municipal Clinical Hospital in Moscow, Russia. Children admitted to the hospital during the first wave of the pandemic, between April 2, 2020 and August 26, 2020, were included. Telephone interview using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) Covid-19 Health and Wellbeing paediatric follow up survey. Persistent symptoms (>5 months) were further categorised by system(s) involved. Findings Overall, 518 of 853 (61%) of eligible children were available for the follow-up assessment and included in the study. Median age was 10.4 years (IQR, 3-15.2) and 270 (52.1%) were girls; median follow-up since hospital discharge was 256 (223-271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%,) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: age "6-11 years" (odds ratio 2.74 (95% confidence interval 1.37 to 5.75) and "12-18 years" (2.68, 1.41 to 5.4), and a history of allergic diseases (1.67, 1.04 to 2.67). Interpretation A quarter of children experienced persistent symptoms months after hospitalization with acute covid-19 infection, with almost one in ten experiencing multi-system involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up. Our findings highlight the need for replication and further investigation of potential mechanisms as well as clinical support to improve long term outcomes in children. Funding None.

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Cumulative Incidence of SARS-CoV-2 Infection and Associated Risk Factors Among Frontline Health Care Workers in Paris, France: The SEROCOV Prospective Cohort Study

SSRN Electronic Journal ◽

10.2139/ssrn.3781650 ◽

2021 ◽

Author(s):

Pierre Hausfater ◽

David Boutolleau ◽

Karine Lacombe ◽

Alexandra Beurton ◽

Margaux Dumont ◽

...

Keyword(s):

Risk Factors ◽

Health Care ◽

Cohort Study ◽

Prospective Cohort Study ◽

Health Care Workers ◽

Cumulative Incidence ◽

Prospective Cohort ◽

Care Workers ◽

Associated Risk Factors

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Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study

European Respiratory Journal ◽

10.1183/13993003.01341-2021 ◽

2021 ◽

pp. 2101341

Author(s):

Ismail M Osmanov ◽

Ekaterina Spiridonova ◽

Polina Bobkova ◽

Aysylu Gamirova ◽

Anastasia Shikhaleva ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Allergic Diseases ◽

Older Age ◽

Persistent Symptoms ◽

Associated Risk Factors

BackgroundThe long-term sequelae of coronavirus disease 2019 (Covid-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with Covid-19 and associated risk factors.MethodsThis is a prospective cohort study of children (≤18 years old) admitted with confirmed Covid-19. Children admitted to the hospital between April 2, 2020 and August 26, 2020, were included. Telephone interview using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) Covid-19 Health and Wellbeing paediatric follow-up survey. Persistent symptoms (>5 months) were further categorised by system(s) involved.Findings518 of 853 (61%) of eligible children were available for the follow-up assessment and included in the study. Median age was 10.4 years (IQR, 3–15.2) and 270 (52.1%) were girls; median follow-up since hospital discharge was 256 (223–271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%,) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age “6–11 years” (odds ratio 2.74 (95% confidence interval 1.37 to 5.75) and “12–18 years” (2.68, 1.41 to 5.4); and a history of allergic diseases (1.67, 1.04 to 2.67).InterpretationA quarter of children experienced persistent symptoms months after hospitalization with acute covid-19 infection, with almost one in ten experiencing multi-system involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.

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Duration of Colonization by Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Healthy Newborns and Associated Risk Factors: A Prospective Cohort Study

Open Forum Infectious Diseases ◽

10.1093/ofid/ofy312 ◽

2018 ◽

Vol 5 (12) ◽

Cited By ~ 2

Author(s):

María Jesús Rodríguez-Revuelta ◽

Lorena López-Cerero ◽

Lara Serrano ◽

Salud Luna-Lagares ◽

Alvaro Pascual ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Caesarean Section ◽

Prospective Cohort Study ◽

Median Duration ◽

Prospective Cohort ◽

Coli Isolate ◽

Factors Associated ◽

Extended Spectrum ◽

Associated Risk Factors

Abstract Duration of colonization by extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) and factors associated with it were studied in 20 newborns in Seville, Spain. Median duration of colonization was 7.5 months; factors associated with prolonged colonization were delivery by caesarean section, colonization of the mother, and phylogroup B2 Eschericha coli isolate.

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