The Renalase Asp37Glu polymorphism is not associated with hypertension and cardiovascular events in an urban-based prospective cohort: the Malmö Diet and cancer study

Pulse wave velocity is an established marker of early vascular aging but may also help identifying individuals with supernormal vascular aging. We tested the hypothesis that individuals with the largest difference (Δ-age) between chronological and vascular age show the lowest rate of cardiovascular events and may thus be defined as supernormal vascular aging. Vascular age was defined as the predicted age in the best fitting multivariable regression model including classical risk factors and treatment and pulse wave velocity, in a subset of the Reference Values for Arterial Stiffness Collaboration Database (n=3347). Δ-age was then calculated as chronological age minus vascular age, and the 10th and 90th percentiles were used to define early (Δ-age<−5.7 years), normal (Δ-age −5.7 to 6.8 years) and supernormal vascular aging (Δ-age>6.8 years). The risk for fatal and nonfatal cardiovascular events associated with vascular aging categories was investigated in the Malmö Diet and Cancer Study cohort (n=2642). In the Malmö Diet and Cancer Study Cohort (6.6-year follow-up, 286 events), Δ-age was significantly ( P <0.01) and inversely associated with cardiovascular events. Compared with normal vascular aging, supernormal vascular aging had lower risk (hazard ratio, 0.59 [95% CI, 0.41–0.85]), whereas early vascular aging had higher risk (hazard ratio, 2.70 [95% CI, 1.55–4.70]) of cardiovascular events, in particular coronary events. There was no significant association with all-cause mortality. This study represents the first validation of the clinical significance of the supernormal vascular aging concept, based on prospective data. Its further characterization may help discovering novel protective molecular pathways and providing preventive strategies for successful vascular aging.

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CHROMOSOME 9P21 CDKN2A/CDKN2B GENE VARIATION EXPLAINS 12% OF INCIDENT CARDIOVASCULAR EVENTS IN THE POPULATION BUT DOES NOT ADD INCREMENTAL VALUE ON RISK PREDICTION BEYOND TRADITIONAL RISK FACTORS- THE MALMö DIET AND CANCER STUDY

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(12)61677-5 ◽

2012 ◽

Vol 59 (13) ◽

pp. E1676

Author(s):

Klas Gränsbo ◽

Peter Almgren ◽

Marketa Sjögren ◽

Gustav Smith ◽

Gunnar Engström ◽

...

Keyword(s):

Risk Factors ◽

Risk Prediction ◽

Cardiovascular Events ◽

Chromosome 9P21 ◽

Gene Variation ◽

Cancer Study ◽

Incremental Value ◽

Diet And Cancer ◽

Traditional Risk Factors ◽

Cdkn2b Gene

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Cardiovascular event risk in relation to dietary fat intake in middle-aged individuals: data from The Malmö Diet and Cancer Study

European Journal of Cardiovascular Prevention & Rehabilitation ◽

10.1097/hjr.0b013e3282a56c45 ◽

2007 ◽

Vol 14 (5) ◽

pp. 701-706 ◽

Cited By ~ 27

Author(s):

Margret Leosdottir ◽

Peter M. Nilsson ◽

Jan-Åke Nilsson ◽

Göran Berglund

Keyword(s):

Cardiovascular Disease ◽

Cardiovascular Event ◽

Cardiovascular Events ◽

Saturated Fat ◽

Fat Intake ◽

Cancer Study ◽

Unsaturated Fat ◽

Event Risk ◽

Diet And Cancer ◽

Total Fat

Background and design The hypothesis that diets rich in total and saturated fat and poor in unsaturated fats increase the risk for cardiovascular disease is still vividly debated. The aim of this study was to examine whether total fat, saturated fat, or unsaturated fat intakes are independent risk factors for cardiovascular events in a large population-based cohort. Methods 28098 middle-aged individuals (61% women) participated in the Malmö Diet and Cancer Study between 1991 and 1996. In this analysis, individuals with an earlier history of cardiovascular disease were excluded. With adjustments made for confounding by age and various anthropometric, social, dietary, and life-style factors, hazard ratios (HR) were estimated for individuals categorized by quartiles of fat intake [HR (95% confidence interval, CI), Cox's regression model]. Results No trend towards higher cardiovascular event risk for women or men with higher total or saturated fat intakes, was observed. Total fat: HR (95% CI) for fourth quartile was 0.98 (0.77-1.25) for women, 1.02 (0.84-1.23) for men; saturated fat: 0.98 (0.71-1.33) for women and 1.05 (0.83-1.34) for men. Inverse associations between unsaturated fat intake and cardiovascular event risk were not observed. Conclusions In relation to risks of cardiovascular events, our results do not suggest any benefit from a limited total or saturated fat intake, nor from relatively high intake of unsaturated fat. Eur J Cardiovasc Prev Rehabil14:701-706 © 2007 The European Society of Cardiology

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Blood Cadmium Levels and Incident Cardiovascular Events during Follow-up in a Population-Based Cohort of Swedish Adults: The Malmö Diet and Cancer Study

Environmental Health Perspectives ◽

10.1289/ehp.1509735 ◽

2016 ◽

Vol 124 (5) ◽

pp. 594-600 ◽

Cited By ~ 46

Author(s):

Lars Barregard ◽

Gerd Sallsten ◽

Björn Fagerberg ◽

Yan Borné ◽

Margaretha Persson ◽

...

Keyword(s):

Cardiovascular Events ◽

Population Based ◽

Cancer Study ◽

Blood Cadmium ◽

Diet And Cancer ◽

Blood Cadmium Levels

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Skin autofluorescence is associated with higher risk of cardiovascular events in Chinese adults with type 2 diabetes: A prospective cohort study from the Hong Kong Diabetes Biobank

Journal of Diabetes and its Complications ◽

10.1016/j.jdiacomp.2021.108015 ◽

2021 ◽

pp. 108015

Author(s):

Qiao Jin ◽

Eric S.H. Lau ◽

Andrea O.Y. Luk ◽

Risa Ozaki ◽

Elaine Y.K. Chow ◽

...

Keyword(s):

Type 2 Diabetes ◽

Cohort Study ◽

Hong Kong ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Cardiovascular Events ◽

Skin Autofluorescence ◽

Chinese Adults

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Atrial natriuretic peptide and type 2 diabetes development, evidence of causal association from the prospective Malmo diet and cancer study

European Heart Journal ◽

10.1093/eurheartj/eht310.p5048 ◽

2013 ◽

Vol 34 (suppl 1) ◽

pp. P5048-P5048

Author(s):

A. Jujic ◽

P. Nilsson ◽

G. Engstrom ◽

B. Hedblad ◽

O. Melander ◽

...

Keyword(s):

Type 2 Diabetes ◽

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Causal Association ◽

Cancer Study ◽

Diabetes Development ◽

Diet And Cancer ◽

Atrial Natriuretic

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Lipoprotein Particle Predictors of Arterial Stiffness after 17 Years of Follow Up: The Malmö Diet and Cancer Study

International Journal of Vascular Medicine ◽

10.1155/2020/4219180 ◽

2020 ◽

Vol 2020 ◽

pp. 1-9

Author(s):

Jacob Hartz ◽

Ronald M. Krauss ◽

Mikael Göttsater ◽

Olle Melander ◽

Peter Nilsson ◽

...

Keyword(s):

Cardiovascular Risk ◽

High Risk ◽

Arterial Stiffness ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Lipid Lowering ◽

Cancer Study ◽

Lipoprotein Particle ◽

Ldl Particles ◽

Diet And Cancer

Background. Central arterial stiffness is a surrogate of cardiovascular risk and predicts cardiovascular mortality. Apolipoprotein B lipoproteins are also established cardiovascular risk factors. It is not known whether specific lipoprotein subclasses measured in the Malmö Diet and Cancer Study and previously shown to be associated with coronary heart disease also predict arterial stiffening after a mean period of 17 years. Methods. Lipoprotein particle analysis was performed on 2,505 men and women from Malmö, Sweden, from 1991 to 1994, and arterial stiffness was assessed by carotid-femoral pulse wave velocity (c-fPWV) on this same cohort from 2007 to 2012. Associations between c-fPWV and lipoprotein particles were determined with multiple linear regression, controlling for sex, presence of diabetes, waist-to-hip circumference, and smoking status at baseline, as well as heart rate (measured at the carotid artery), mean arterial pressure, antihypertensive and lipid-lowering medications, C-reactive protein (CRP), and age at the time of c-fPWV measurement. Results. The results confirm that triglycerides (TG) and high-density lipoprotein cholesterol (HDL-c) but not low-density lipoprotein cholesterol (LDL-c) predict c-fPWV. We identify a positive predictive association for very small, small, and medium (high risk), but not large LDL particles. There was a negative association for large HDL particles. The relationships between c-fPWV and high-risk LDL particles were unaffected by adjusting for LDL-c or CRP and were only mildly attenuated by adjusting for the homeostatic model for insulin resistance (HOMA-IR). Due to the collinearity of very small, small, and medium LDL particles and dyslipidemia (elevated TG and decreased HDL-c), the observed relationship between c-fPWV and high-risk LDL particles became insignificant after controlling for the concentration of HDL-c, large cholesterol-rich HDL particles, and TG. Conclusions. The development of central arterial stiffness previously associated with combined dyslipidemia may be mediated in part by LDL particles, particularly the very small-, small-, and medium-sized LDL particles.

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Anthropometric factors and ovarian cancer risk in the Malmö Diet and Cancer Study

Cancer Epidemiology ◽

10.1016/j.canep.2011.01.003 ◽

2011 ◽

Vol 35 (5) ◽

pp. 432-437 ◽

Cited By ~ 9

Author(s):

Jenny Brändstedt ◽

Björn Nodin ◽

Jonas Manjer ◽

Karin Jirström

Keyword(s):

Ovarian Cancer ◽

Cancer Risk ◽

Ovarian Cancer Risk ◽

Cancer Study ◽

Diet And Cancer

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Statin use, HMGCR expression, and breast cancer survival – The Malmö Diet and Cancer Study

Scientific Reports ◽

10.1038/s41598-019-57323-9 ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 3

Author(s):

Olöf Bjarnadottir ◽

Maria Feldt ◽

Maria Inasu ◽

Pär-Ola Bendahl ◽

Karin Elebro ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Cancer Survival ◽

Cox Regression ◽

Histological Grade ◽

Breast Cancer Patients ◽

Cancer Study ◽

Drug Register ◽

Diet And Cancer ◽

Statin Use

AbstractStatins, commonly used to treat hypercholesterolemia, have also been proposed as anti-cancer agents. The identification of a predictive marker is essential. The 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR), which is inhibited by statins, might serve as such a marker. Thorough antibody validation was performed for four different HMGCR antibodies. Tumor expression of HMGCR (#AMAb90619, CL0260, Atlas Antibodies, Stockholm, Sweden) was evaluated in the Malmö Diet and Cancer Study breast cancer cohort. Statin use and cause of death data were retrieved from the Swedish Prescribed Drug Register and Swedish Death Registry, respectively. Breast cancer-specific mortality (BCM) according to statin use and HMGCR expression were analyzed using Cox regression models. Three-hundred-twelve of 910 breast cancer patients were prescribed statins; 74 patients before and 238 after their breast cancer diagnosis. HMGCR expression was assessable for 656 patients; 119 showed negative, 354 weak, and 184 moderate/strong expressions. HMGCR moderate/strong expression was associated with prognostically adverse tumor characteristics as higher histological grade, high Ki67, and ER negativity. HMGCR expression was not associated with BCM. Neither was statin use associated with BCM in our study. Among breast cancer patients on statins, no or weak HMGCR expression predicted favorable clinical outcome. These suggested associations need further testing in larger cohorts.

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