Urinary albumin excretion and prevalence of microalbuminuria in a general Chinese population: a cross-sectional study

ObjectiveMicroalbuminuria (MAU) has been described as a risk factor for metabolic syndrome (MetS). However, the association between MetS components with MAU and 24-hour urinary albumin excretion (UAE) has not been clearly explained in the general Chinese population. We aimed to analyse the associations between MAU and high–normal 24-hour UAE with MetS and its components.DesignCross-sectional observational study.SettingFour selected counties/districts in China’s Shandong and Jiangsu Provinces.ParticipantsA total of 2261 participants aged 18–69 years were included in this study. Participants with missing physical examination data or incomplete urine collection were not included in the analysis.ResultsThe prevalence of MAU was 9%, and the mean 24-hour UAE was 18 mg/d. The prevalence of MAU was significantly higher for the MetS, high blood pressure (BP), high triglyceride (TG) levels, low high-density lipoprotein cholesterol (HDL-C) and hyperglycaemia groups but not for the central obesity group. Both MAU and mean 24-hour UAE were significantly increased in association with a number of MetS components. The adjusted prevalence OR (POR) for MetS with MAU was 2.95 (95% CI 2.15 to 4.04) compared with those without MAU. MAU was significantly associated with three components of MetS: high BP (POR=1.86, 95% CI 1.31 to 2.64), high TG levels (POR=1.80, 95% CI 1.31 to 2.46) and hyperglycaemia (POR=1.84, 95% CI 1.34 to 2.53). No significant association between MAU and central obesity or low HDL-C was found. The presence of MetS gradually increased according to the normal-range 24-hour UAE quartiles: POR=1.00, POR=1.22, POR=1.14 and POR=2.02, respectively. Hyperglycaemia also increased significantly according to the normal-range 24-hour UAE quartiles.ConclusionsMAU and elevated 24-hour UAE within the normal range were closely associated with MetS in the Chinese population, which may provide a basis for the development of early interventions to decrease the effects of MetS.

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Relationship between lifestyle factors and hyperhomocysteinemia in general Chinese population: a cross-sectional study

Postgraduate Medicine ◽

10.1080/00325481.2017.1255126 ◽

2016 ◽

Vol 129 (2) ◽

pp. 216-223 ◽

Cited By ~ 8

Author(s):

Shuang Chen ◽

Xiaofan Guo ◽

Siyuan Dong ◽

Zhao Li ◽

Yingxian Sun

Keyword(s):

Chinese Population ◽

Cross Sectional Study ◽

Lifestyle Factors ◽

Sectional Study ◽

Cross Sectional ◽

General Chinese Population

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Association between depressive symptoms and arterial stiffness: a cross-sectional study in the general Chinese population

BMJ Open ◽

10.1136/bmjopen-2019-033408 ◽

2020 ◽

Vol 10 (2) ◽

pp. e033408 ◽

Cited By ~ 2

Author(s):

Liming Peng ◽

Sisi Bi ◽

Xiangwei Liu ◽

Tianyi Long ◽

Yixia Zhao ◽

...

Keyword(s):

Diabetes Mellitus ◽

Depressive Symptoms ◽

Arterial Stiffness ◽

Chinese Population ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Beta Coefficient ◽

The Relationship ◽

General Chinese Population

ObjectivesTo determine the independent relationship between depressive symptoms and arterial stiffness in the general Chinese population, and to explore possible interactive factors in the relationship.DesignA cross-sectional study.Setting and participantsConsecutive participants who received routine health physical examination in an affiliated hospital of a comprehensive university in Hunan Province, China, between September 2013 and March 2014 were examined. After exclusion of subjects not meeting the criteria, a total of 1334 subjects aged 22–77 years were recruited for final analysis.MeasuresThe Patient Health Questionnaire-9 was employed to assess the degree of depressive symptoms: 0–4 no depressive symptoms, 5–9 mild depressive symptoms and 10–27 moderate to severe depressive symptoms. Brachial-ankle pulse wave velocity (baPWV) was measured to determine arterial stiffness.ResultsThere was a slight increase in baPWV across elevated degrees of depressive symptoms (p=0.025). Multivariate linear regression analysis revealed that mild depressive symptoms and moderate to severe depressive symptoms were independently associated with baPWV compared with no depressive symptoms after adjusting for baseline confounders (beta-coefficient: 40.3, 95% CI 6.6 to 74.1; beta-coefficient: 87.7, 95% CI 24.0 to 151.5, respectively). Further stratified analyses indicated that the relationship between degree of depressive symptoms and baPWV was predominant in subjects who had normal or normal-high blood pressure, or combined with hypertension (p for interaction=0.016), or in subjects with diabetes mellitus (p for interaction=0.004), examined in multivariate linear regressions. In addition, after adjustment, a significant association between moderate to severe depressive symptoms and baPWV was also found in female subjects younger than 60 years, although the interactive effect was not significant (p for interaction=0.056).ConclusionsDepressive symptoms are independently associated with arterial stiffness, especially in subjects whose blood pressures are beyond the optimal range and combined with diabetes mellitus.

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Independent associations of blood pressure and body mass index with interatrial block: a cross-sectional study in general Chinese population

BMJ Open ◽

10.1136/bmjopen-2019-029463 ◽

2019 ◽

Vol 9 (7) ◽

pp. e029463 ◽

Cited By ~ 3

Author(s):

Guozhe Sun ◽

Ying Zhou ◽

Ning Ye ◽

Shaojun Wu ◽

Yingxian Sun

Keyword(s):

Blood Pressure ◽

Chinese Population ◽

Cross Sectional Study ◽

P Wave ◽

Regression Analyses ◽

Sectional Study ◽

Cross Sectional ◽

Wave Duration ◽

P Wave Duration ◽

General Chinese Population

ObjectivesThis current study was performed to characterise the independent associations of obesity and hypertension with interatrial block (IAB) after adjusting for cardiovascular risk factors, echocardiographic left atrial diameter (LAD) and left ventricular mass index (LVMI) in a large general Chinese population.DesignA cross-sectional study.Setting and participantsA total of 11 956 permanent residents (≥35 years of age) from Liaoning Province in China were included in this study. Following the completion of a questionnaire, the enrolled participants were subjected to physical examinations, laboratory analyses, ECG and echocardiogram. Linear and logistic regression analyses were performed to evaluate the associations of hypertension and obesity with IAB.Outcome measuresIAB was defined as a prolongation of the P wave duration ≥120 ms on a digital 12-lead ECG.ResultsThe prevalence of IAB in hypertensive individuals was higher than the normotensive in both men (9.5 vs 5.9%; p<0.001) and women (6.6 vs 3.6%; p<0.001). In addition, the prevalence of IAB exhibited a sharp increase with advancing body mass index (BMI) in both men (from 4.9% to 13.0%) and women (from 3.5% to 6.9%) (ps- for trend <0.001). Multiple relevant clinical covariates, echocardiographic LAD and LVMI were adjusted in the multivariate linear and logistic regression analyses. The results revealed that systolic blood pressure, diastolic blood pressure and BMI were all independently associated with P wave duration (β=0.02, 0.09 and 0.25, respectively; all ps <0.005). Furthermore, hypertension was found to be independently associated with IAB (OR=1.27; p=0.018), while both overweight and obesity exhibited higher odds of IAB (OR=1.42 and 1.67, respectively; ps <0.005), compared with BMI <24.0 kg/m2.ConclusionsThe key findings of this study highlighted that hypertension and overweight/obesity were independently and significantly associated with IAB in general Chinese population.

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Adipokine Profile and Urinary Albumin Excretion in Isolated Growth Hormone Deficiency

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2009-1919 ◽

2010 ◽

Vol 95 (2) ◽

pp. 693-698 ◽

Cited By ~ 21

Author(s):

Carla R. P. Oliveira ◽

Roberto Salvatori ◽

Rafael A. Meneguz-Moreno ◽

Manuel H. Aguiar-Oliveira ◽

Rossana M. C. Pereira ◽

...

Keyword(s):

Risk Factors ◽

Urinary Albumin Excretion ◽

Receptor Gene ◽

Serum Levels ◽

Cross Sectional Study ◽

Urinary Albumin ◽

Hormone Deficiency ◽

Cross Sectional ◽

Albumin Excretion ◽

Reactive Protein

Abstract Background: GH deficiency (GHD) is often associated with cardiovascular risk factors, including abdominal fat accumulation, hypercholesterolemia, and increased C-reactive protein. Despite the presence of these risk factors, adults with congenital lifetime isolated GHD (IGHD) due to an inactivating mutation in the GHRH receptor gene do not have premature atherosclerosis. Objective: The aim was to study the serum levels of adiponectin and leptin (antiatherogenic and atherogenic adipokine, respectively), and the urinary albumin excretion (UAE) in these IGHD individuals. Design and Patients: We conducted a cross-sectional study of 20 IGHD individuals (seven males; age, 50.8 ± 14.6 yr) and 22 control subjects (eight males; age, 49.9 ± 11.5 yr). Main Outcome Measures: Anthropometric factors, body composition, blood pressure, serum adiponectin, leptin, and UAE were measured. Results: Adiponectin was higher [12.8 (7.1) vs. 9.7 (5) ng/ml; P = 0.041] in IGHD subjects, whereas no difference was observed in leptin [7.3 (6.3) vs. 9.3 (18.7 ng/ml] and UAE [8.6 (13.8) vs. 8.5 (11.1) μg/min]. Conclusions: Subjects with lifetime untreated IGHD have an adipokine profile with high adiponectin and normal leptin levels that may delay vascular damage and lesions of the renal endothelium.

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