scholarly journals New infrastructure to support clinical translational research at the US National Institutes of Health: role of the NIH Clinical Center

2012 ◽  
Vol 10 (S2) ◽  
Author(s):  
John I Gallin
2020 ◽  
Author(s):  
Joshua M Sharfstein ◽  
Yngvild Olsen

Abstract The National Institutes of Health is investing hundreds of millions of dollars into new research on opioids. As these studies yield insights and results, their results will have to change policy and practice before they can bend the curve of the epidemic. However, the US does not have a strong track record of translating evidence on drug policy into action. Three reasons for the translation gap are the historical legacy of drugs in the US, vested interests, and politics. Researchers can become engaged in policy and political processes to strengthen the US response.


2021 ◽  
pp. 030631272098593
Author(s):  
Madeleine Pape

In 2016 the US National Institutes of Health introduced a policy mandating consideration of Sex as a Biological Variable (SABV) in preclinical research. In this article, I ask what, precisely, is meant by the designation of sex as a ‘biological variable’, and how has its inclusion come to take the form of a policy mandate? Given the well documented complexity of ‘sex’ and the degree to which it is politically and scientifically contested, its enactment via policy as a biological variable is not a given. I explore how sex is multiply enacted in efforts to legitimate and realize the SABV policy and consider how the analytical lens of co-production sheds light on how and why this occurs. I show that the policy works to reassert scientific and political order by addressing two institutional concerns: the so-called reproducibility crisis in preclinical research, and pervasive gender inequality across the institution of biomedicine. From here, the entity that underpins this effort – sex as a biological variable – becomes more than one thing, with enactments ranging from an assigned category, to an outcome, to a causal biological force in its own right. Sex emerges as simultaneously entangled with yet distinct from gender, and binary (female/male) yet complex in its variation. I suggest that it is in the very attempt to delineate natural from social order, and in the process create the conditions to privilege a particular kind of science and account of embodied difference, that ontological multiplicity becomes readily visible. That this multiplicity goes unrecognized points to the unifying role of an overarching ideological commitment to sex as a presumed binary and biological scientific object, the institutional dominance of which is never guaranteed.


Author(s):  
Eggener Scott

Author(s):  
Rosamond C. Rodman

Expanding beyond the text of the Bible, this chapter explores instead a piece of political scripture, namely the Second Amendment of the US Constitution. Over the last half-decade, the Second Amendment has come to enjoy the status of a kind of scripture-within-scripture. Vaulted to a much more prominent status than it had held in the first 150 years or so of its existence, and having undergone a remarkable shift in what most Americans think it means, the Second Amendment provides an opportunity to examine the linguistic, racial, and gendered modes by which these changes were effected, paying particular attention to the ways in which white children and white women were conscripted into the role of the masculine, frontier-defending US citizen.


2020 ◽  
pp. 074391562098472
Author(s):  
Lu Liu ◽  
Dinesh K. Gauri ◽  
Rupinder P. Jindal

Medicare uses a pay-for-performance program to reimburse hospitals. One of the key input measures in the performance formula is patient satisfaction with their hospital care. Physicians and hospitals, however, have raised concerns especially about questions related to patient satisfaction with pain management during hospitalization. They report feeling pressured to prescribe opioids to alleviate pain and boost satisfaction survey scores for higher reimbursements. This over-prescription of opioids has been cited as a cause of current opioid crisis in the US. Due to these concerns, Medicare stopped using pain management questions as inputs in its payment formula. We collected multi-year data from six diverse data sources, employed propensity score matching to obtain comparable groups, and estimated difference-in-difference models to show that, in fact, pain management was the only measure to improve in response to pay-for-performance system. No other input measure showed significant improvement. Thus, removing pain management from the formula may weaken the effectiveness of HVBP program at improving patient satisfaction, which is one of the key goals of the program. We suggest two divergent paths for Medicare to make the program more effective.


2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 681-681
Author(s):  
Regina Shih

Abstract The prevalence of caregiving for an adult or child with special needs has increased significantly in the past five years (from 18.2% to over 21.3%), driven by an increase in the prevalence of caring for a family member or friend aged 50 and older. At the same time, care recipients have greater health and functional needs that necessitate care from others in comparison to 2015. These new 2020 data from the Caregiving in the US Survey by the National Alliance for Caregiving suggests that not only are more American adults taking on the role of caregiver, but they are doing so for increasingly complex care situations. This paper addresses the prevalence of caregiving including the demographics of family caregivers, relationship between the caregiver and the care recipient, health conditions of the care recipient, and living situations of care recipients and their caregivers.


2021 ◽  
pp. 096701062199722 ◽  
Author(s):  
Nivi Manchanda ◽  
Chris Rossdale

The past ten years have witnessed a revival in scholarship on militarism, through which scholars have used the concept to make sense of the embeddedness of warlike relations in contemporary liberal societies and to account for how the social, political and economic contours of those same societies are implicated in the legitimation and organization of political violence. However, a persistent shortcoming has been the secondary role of race and coloniality in these accounts. This article demonstrates how we might position racism and colonialism as integral to the functioning of contemporary militarism. Centring the thought and praxis of the US Black Panther Party, we argue that the particular analysis developed by Black Panther Party members, alongside their often-tense participation in the anti–Vietnam War movement, offers a strong reading of the racialized and colonial politics of militarism. In particular, we show how their analysis of the ghetto as a colonial space, their understanding of the police as an illegitimate army of occupation and, most importantly, Huey Newton’s concept of intercommunalism prefigure an understanding of militarism premised on the interconnections between racial capitalism, violent practices of un/bordering and the dissolving boundaries between war and police action.


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