scholarly journals Gene-enhanced tissue engineering for dental hard tissue regeneration: (1) overview and practical considerations

2006 ◽  
Vol 2 (1) ◽  
Author(s):  
Paul C Edwards ◽  
James M Mason
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Hard Tissue ◽  
Dental Hard Tissue

scholarly journals Electrospinning of Nanofibers for Tissue Engineering Applications

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Haifeng Liu ◽  
Xili Ding ◽  
Gang Zhou ◽  
Ping Li ◽  
Xing Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
Fiber Morphology ◽  
Hard Tissue ◽  
Nanoscale Material ◽  
Considerable Potential ◽  
Recent Interest ◽  
Material Fabrication

Electrospinning is a method in which materials in solution are formed into nano- and micro-sized continuous fibers. Recent interest in this technique stems from both the topical nature of nanoscale material fabrication and the considerable potential for use of these nanoscale fibres in a range of applications including, amongst others, a range of biomedical applications processes such as drug delivery and the use of scaffolds to provide a framework for tissue regeneration in both soft and hard tissue applications systems. The objectives of this review are to describe the theory behind the technique, examine the effect of changing the process parameters on fiber morphology, and discuss the application and impact of electrospinning on the fields of vascular, neural, bone, cartilage, and tendon/ligament tissue engineering.

Fabrication and in vitro biocompatibilities of fibrous biocomposites consisting of PCL and M13 bacteriophage-conjugated alginate for bone tissue engineering

2016 ◽  
Vol 4 (4) ◽  
pp. 656-665 ◽  
Author(s):  
Jae Yoon Lee ◽  
Jinhyo Chung ◽  
Woo-Jae Chung ◽  
GeunHyung Kim
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Hard Tissue ◽  
M13 Bacteriophage ◽  
Bioactive Component ◽  
M13 Phage

We propose a new biocomposite consisting of M13-phage-conjugated alginate and PCL micro/nanofibers, and it has potential to be used as an excellent bioactive component for hard tissue regeneration.

scholarly journals Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4802
Author(s):  
Min Guk Kim ◽  
Chan Ho Park
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Alveolar Bone ◽  
Critical Role ◽  
Periodontal Regeneration ◽  
Tissue Formation ◽  
Hard Tissue ◽  
Periodontal Tissues ◽  
Mineralized Tissues ◽  
Biomechanical Forces

The mineralized tissues (alveolar bone and cementum) are the major components of periodontal tissues and play a critical role to anchor periodontal ligament (PDL) to tooth-root surfaces. The integrated multiple tissues could generate biological or physiological responses to transmitted biomechanical forces by mastication or occlusion. However, due to periodontitis or traumatic injuries, affect destruction or progressive damage of periodontal hard tissues including PDL could be affected and consequently lead to tooth loss. Conventional tissue engineering approaches have been developed to regenerate or repair periodontium but, engineered periodontal tissue formation is still challenging because there are still limitations to control spatial compartmentalization for individual tissues and provide optimal 3D constructs for tooth-supporting tissue regeneration and maturation. Here, we present the recently developed strategies to induce osteogenesis and cementogenesis by the fabrication of 3D architectures or the chemical modifications of biopolymeric materials. These techniques in tooth-supporting hard tissue engineering are highly promising to promote the periodontal regeneration and advance the interfacial tissue formation for tissue integrations of PDL fibrous connective tissue bundles (alveolar bone-to-PDL or PDL-to-cementum) for functioning restorations of the periodontal complex.

scholarly journals Efficacy of Bacterial Nanocellulose in Hard Tissue Regeneration: A Review

Materials ◽  
2021 ◽  
Vol 14 (17) ◽  
pp. 4777
Author(s):  
Anuj Kumar ◽  
Sung-Soo Han
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Cellular Response ◽  
Future Research ◽  
Hydroxyl Groups ◽  
Hard Tissue ◽  
Engineering Applications ◽  
Bacterial Nanocellulose

Bacterial nanocellulose (BNC, as exopolysaccharide) synthesized by some specific bacteria strains is a fascinating biopolymer composed of the three-dimensional pure cellulosic nanofibrous matrix without containing lignin, hemicellulose, pectin, and other impurities as in plant-based cellulose. Due to its excellent biocompatibility (in vitro and in vivo), high water-holding capacity, flexibility, high mechanical properties, and a large number of hydroxyl groups that are most similar characteristics of native tissues, BNC has shown great potential in tissue engineering applications. This review focuses on and discusses the efficacy of BNC- or BNC-based biomaterials for hard tissue regeneration. In this review, we provide brief information on the key aspects of synthesis and properties of BNC, including solubility, biodegradability, thermal stability, antimicrobial ability, toxicity, and cellular response. Further, modification approaches are discussed briefly to improve the properties of BNC or BNC-based structures. In addition, various biomaterials by using BNC (as sacrificial template or matrix) or BNC in conjugation with polymers and/or fillers are reviewed and discussed for dental and bone tissue engineering applications. Moreover, the conclusion with perspective for future research directions of using BNC for hard tissue regeneration is briefly discussed.

scholarly journals Silk-Based Materials for Hard Tissue Engineering

Materials ◽  
2021 ◽  
Vol 14 (3) ◽  
pp. 674
Author(s):  
Vanessa J. Neubauer ◽  
Annika Döbl ◽  
Thomas Scheibel
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
Bone Tissue Regeneration ◽  
Mineralized Tissue ◽  
Hard Tissue ◽  
Material Stiffness ◽  
Physico Chemical ◽  
Natural Tissue ◽  
Hard Tissue Engineering

Hard tissues, e.g., bone, are mechanically stiff and, most typically, mineralized. To design scaffolds for hard tissue regeneration, mechanical, physico-chemical and biological cues must align with those found in the natural tissue. Combining these aspects poses challenges for material and construct design. Silk-based materials are promising for bone tissue regeneration as they fulfill several of such necessary requirements, and they are non-toxic and biodegradable. They can be processed into a variety of morphologies such as hydrogels, particles and fibers and can be mineralized. Therefore, silk-based materials are versatile candidates for biomedical applications in the field of hard tissue engineering. This review summarizes silk-based approaches for mineralized tissue replacements, and how to find the balance between sufficient material stiffness upon mineralization and cell survival upon attachment as well as nutrient supply.

Hierarchical and heterogeneous hydrogel system as a promising strategy for diversified interfacial tissue regeneration

2021 ◽  
Author(s):  
Liwen Zhang ◽  
Lei Fu ◽  
Xin Zhang ◽  
Linxin Chen ◽  
Qing Cai ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Hard Tissue ◽  
Promising Strategy ◽  
Hydrogel System

Despite breakthroughs in tissue engineering, a tremendous problem still lies in repairing the interfacial tissue which connects soft tissue to hard tissue, particularly including cartilage-bone, tendon/ligament-bone, and cementum-ligament-bone interfaces. The...

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

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