Randomised controlled trial of different energy formulas in healthy term infants: Effects on later growth, body composition, bone health and cardiovascular?

2012 ◽  
Author(s):  
MS Fewtrell
Keyword(s):  
Body Composition ◽  
Randomised Controlled Trial ◽  
Bone Health ◽  
Controlled Trial ◽  
Term Infants ◽  
Randomised Controlled

scholarly journals Protocol of a randomised controlled trial assessing the impact of physical activity on bone health in children with inflammatory bowel disease

BMJ Open ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. e036400
Author(s):  
Jérémy Vanhelst ◽  
Stéphanie Coopman ◽  
Julien Labreuche ◽  
Claire Dupont ◽  
Valérie Bertrand ◽  
...  
Keyword(s):  
Physical Activity ◽  
Inflammatory Bowel Disease ◽  
Randomised Controlled Trial ◽  
Bone Health ◽  
Bowel Disease ◽  
Controlled Trial ◽  
Whole Body ◽  
Paediatric Patients ◽  
Inflammatory Bowel ◽  
Randomised Controlled

IntroductionLow bone mineral density (BMD) is a frequent issue in children and adolescents with inflammatory bowel disease (IBD). Several studies in healthy populations have reported a positive impact of physical activity (PA) on bone health. Recently, an observational study in paediatric patients with IBD showed a significant positive relationship between daily PA and BMD. However, intervention studies investigating a causal relationship between PA and BMD are warranted to confirm these results. The aim of this randomised controlled trial will be to investigate the effect of a PA programme on BMD in paediatric patients with IBD.Methods and analysisThis trial is a multicentre (four centres), randomised, controlled, blinded end-point study. Eighty children with IBD will be randomly assigned in a 1:1 ratio to receive a programme with adapted physical exercises (intervention group) or usual PA (control group) during a 9-month period. The primary outcome is the change from baseline at 9 months (the end of the study) in whole-body BMD assessed by dual-energy X-ray absorptiometry. Secondary efficacy outcomes include the changes from baseline at 9 months in: BMD assessed in the lumbar spine and trochanter; daily PA (time spent in moderate-to-vigorous PA); body composition (fat mass and fat-free mass); fatigue resistance; quality of life and activity of IBD.Ethics and disseminationThe study was approved by the Research Ethics Committee in France (Comité de Protection des Personnes, Sud-Ouest and Outre-Mer III, Bordeaux, France, No 2018/27). All procedures will be performed according to the ethical standards of the Helsinki Declaration of 1975, as revised in 2008, and the European Union’s Guidelines for Good Clinical Practice. Written informed consent will be obtained from the parents or legal guardian and from the children. Research findings will be disseminated in peer-reviewed journals and scientific meetings.Trial registration numberNCT03774329.

scholarly journals Dose–response effects of aerobic exercise on body composition among colon cancer survivors: a randomised controlled trial

2017 ◽  
Vol 117 (11) ◽  
pp. 1614-1620 ◽  
Author(s):  
Justin C Brown ◽  
Babette S Zemel ◽  
Andrea B Troxel ◽  
Michael R Rickels ◽  
Nevena Damjanov ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Body Composition ◽  
Randomised Controlled Trial ◽  
Cancer Survivors ◽  
Aerobic Exercise ◽  
Dose Response ◽  
Controlled Trial ◽  
Randomised Controlled

scholarly journals Pre- and post-term growth in pre-term infants supplemented with higher-dose DHA: a randomised controlled trial

2011 ◽  
Vol 105 (11) ◽  
pp. 1635-1643 ◽  
Author(s):  
Carmel T. Collins ◽  
Maria Makrides ◽  
Robert A. Gibson ◽  
Andrew J. McPhee ◽  
Peter G. Davis ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Birth Weight ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Dietary Fatty Acids ◽  
Arachidonic Acid Content ◽  
Feeding Practice ◽  
Term Infants ◽  
Chain Pufa ◽  
Randomised Controlled

The effect of the dietary n-3 long-chain PUFA, DHA (22 : 6n-3), on the growth of pre-term infants is controversial. We tested the effect of higher-dose DHA (approximately 1 % dietary fatty acids) on the growth of pre-term infants to 18 months corrected age compared with standard feeding practice (0·2–0·3 % DHA) in a randomised controlled trial. Infants born < 33 weeks gestation (n 657) were randomly allocated to receive breast milk and/or formula with higher DHA or standard DHA according to a concealed schedule stratified for sex and birth-weight ( < 1250 and ≥ 1250 g). The dietary arachidonic acid content of both diets was constant at approximately 0·4 % total fatty acids. The intervention was from day 2 to 5 of life until the infant's expected date of delivery (EDD). Growth was assessed at EDD, and at 4, 12 and 18 months corrected age. There was no effect of higher DHA on weight or head circumference at any age, but infants fed higher DHA were 0·7 cm (95 % CI 0·1, 1·4 cm; P = 0·02) longer at 18 months corrected age. There was an interaction effect between treatment and birth weight strata for weight (P = 0·01) and length (P = 0·04). Higher DHA resulted in increased length in infants born weighing ≥ 1250 g at 4 months corrected age and in both weight and length at 12 and 18 months corrected age. Our data show that DHA up to 1 % total dietary fatty acids does not adversely affect growth.

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