scholarly journals Regional homogeneity alterations in multi-frequency bands in tension-type headache: a resting-state fMRI study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Shuxian Zhang ◽  
Huayun Li ◽  
Qinyan Xu ◽  
Chao Wang ◽  
Xue Li ◽  
...  
Keyword(s):  
Frequency Band ◽  
Neural Activity ◽  
Tension Type Headache ◽  
Regional Homogeneity ◽  
Group Differences ◽  
Superior Frontal Gyrus ◽  
Frequency Bands ◽  
Spontaneous Neural Activity ◽  
Type Headache ◽  
The Right

Abstract Objectives In this study, we aimed to investigate the spontaneous neural activity in the conventional frequency band (0.01−0.08 Hz) and two sub-frequency bands (slow-4: 0.027–0.073 Hz, and slow-5: 0.01–0.027 Hz) in tension-type headache (TTH) patients with regional homogeneity (ReHo) analyses. Methods Thirty-eight TTH patients and thirty-eight healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (RS-fMRI) scanning to investigate abnormal spontaneous neural activity using ReHo analysis in conventional frequency band (0.01−0.08 Hz) and two sub-frequency bands (slow-4: 0.027–0.073 Hz and slow-5: 0.01–0.027 Hz). Results In comparison with the HC group, patients with TTH exhibited ReHo increases in the right medial superior frontal gyrus in the conventional frequency band (0.01−0.08 Hz). The between group differences in the slow-5 band (0.01–0.027 Hz) highly resembled the differences in the conventional frequency band (0.01−0.08 Hz); even the voxels with increased ReHo were spatially more extensive, including the right medial superior frontal gyrus and the middle frontal gyrus. In contrast, no region showed significant between-group differences in the slow-4 band (0.027–0.073 Hz). The correlation analyses showed no correlation between the ReHo values in TTH patients and VAS scores, course of disease and number of seizures per month in conventional band (0.01−0.08 Hz), slow-4 band (0.027–0.073 Hz), as well as in slow-5 band (0.01–0.027 Hz). Conclusions The results showed that the superior frontal gyrus and middle frontal gyrus were involved in the integration and processing of pain signals. In addition, the abnormal spontaneous neural activity in TTH patients was frequency-specific. Namely, slow-5 band (0.01–0.027 Hz) might contain additional useful information in comparison to slow-4 band (0.027−0.073 Hz). This preliminary exploration might provide an objective imaging basis for the understanding of the pathophysiological mechanism of TTH.

scholarly journals The Potential Advantages of Tai Chi Chuan in Promoting Inhibitory Control and Spontaneous Neural Activity in Young Adults

2021 ◽  
Vol 15 ◽  
Author(s):  
Qi-Qi Shen ◽  
Heng-Chan Yin ◽  
Lei Cui ◽  
Jing-Yi Zhang ◽  
Dong-Ling Wang ◽  
...  
Keyword(s):  
Inhibitory Control ◽  
Neural Activity ◽  
Tai Chi ◽  
Control Performance ◽  
Tai Chi Chuan ◽  
Superior Frontal Gyrus ◽  
Cohen’S D ◽  
Spontaneous Neural Activity ◽  
The Right ◽  
Cohen's D

Tai Chi Chuan (TCC) is assumed to exert beneficial effects on functional brain activity and cognitive function in elders. Until now, empirical evidence of TCC induced intra-regional spontaneous neural activity and inhibitory control remains inconclusive. Whether the effect of TCC is better than that of other aerobic exercises is still unknown, and the role of TCC in younger adults is not yet fully understood. Here we used resting-state functional MRI (fMRI) to investigate the effects of 8-week TCC (n = 12) and brisk walking (BW, n = 12) on inhibitory control and fractional amplitude of low-frequency fluctuations (fALFF). The results found that TCC had significant effects on inhibitory control performance and spontaneous neural activity that were associated with significantly increased fALFF in the left medial superior frontal gyrus (Cohen’s d = 1.533) and the right fusiform gyrus (Cohen’s d = 1.436) and decreased fALFF in the right dorsolateral superior frontal gyrus (Cohen’s d = 1.405) and the right paracentral lobule (Cohen’s d = 1.132).TCC exhibited stronger effects on spontaneous neural activity than the BW condition, as reflected in significantly increased fALFF in the left medial superior frontal gyrus (Cohen’s d = 0.862). There was a significant positive correlation between the increase in fALFF in the left medial superior frontal gyrus and the enhancement in inhibitory control performance. The change in fALFF in the left medial superior frontal gyrus was able to explain the change in inhibitory control performance induced by TCC. In conclusion, our results indicated that 8 weeks of TCC intervention could improve processing efficiency related to inhibitory control and alter spontaneous neural activity in young adults, and TCC had potential advantages over BW intervention for optimizing spontaneous neural activity.

scholarly journals Frequency-Specific Regional Homogeneity Alterations in Tourette Syndrome

2020 ◽  
Vol 11 ◽  
Author(s):  
Yu-Ting Lou ◽  
Xiao-Long Li ◽  
Ye Wang ◽  
Gong-Jun Ji ◽  
Yu-Feng Zang ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Executive Control ◽  
Regional Homogeneity ◽  
Control Network ◽  
Healthy Children ◽  
Executive Control Network ◽  
Superior Frontal Gyrus ◽  
Frequency Bands ◽  
The Right ◽  
Local Synchronization

Tourette syndrome (TS) is a developmental neuropsychiatric disorder with onset during childhood. Because of its complex spectrum of phenotypes, the underlying pathophysiology of TS is still unclear. Resting-state functional magnetic resonance imaging demonstrated aberrant spontaneous neural synchronization in conventional frequency band (0.01–0.08 Hz) in TS. No published studies have reported abnormalities of local synchronization across different frequency bands. We estimated the alterations of local synchronization across five bands ranging from 0 to 0.25 Hz. Seventy-nine children with TS and 63 age-, sex-, and handedness-matched healthy children were recruited. Frequency-specific regional homogeneity (ReHo) and independent component analysis were used to identify functional alterations between TS and healthy children. TS patients showed significantly increased ReHo in the left precentral gyrus and decreased ReHo in the right operculum. Abnormal ReHo alterations of the superior frontal gyrus, superior parietal gyrus, anterior cingulate gyrus, putamen, superior temporal gyrus, and operculum were observed in different frequency bands. TS patients showed increased connectivity of the right superior frontal gyrus within the left executive control network. In addition, a significantly negative correlation was found between Yale Global Tic Severity Scale (YGTSS) vocal score and ReHo values of the right operculum in the highest frequency bands (0.198–0.25 Hz), while a significant positive correlation was found between YGTSS motor score and altered connectivity of the right superior frontal gyrus. The present study revealed frequency-specific abnormal alterations of ReHo in the whole brain and altered connectivity within the executive control network of TS children. Its neural importance and clinical practicability require further investigation.

scholarly journals Abnormal Neural Activity in Different Frequency Bands in Parkinson’s Disease With Mild Cognitive Impairment

2021 ◽  
Vol 13 ◽  
Author(s):  
Siming Rong ◽  
Piao Zhang ◽  
Chentao He ◽  
Yan Li ◽  
Xiaohong Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Frequency Dependence ◽  
Frequency Band ◽  
Neural Activity ◽  
Rating Scale ◽  
Frequency Bands ◽  
The Right

Background: Abnormal spontaneous neural activity is often found in patients with Parkinson’s disease with mild cognitive impairment (PD-MCI). However, the frequency dependence of neuronal interaction activities, especially the fractional amplitude of low-frequency fluctuation (fALFF) and degree centrality (DC), in PD-MCI is still unclear. Thus, this study aimed to explore the frequency dependence of PD-MCI based on fALFF and DC maps.Methods: Twenty-four patients with PD-MCI, 42 PD patients with normal cognition (PD-NC), and 33 healthy controls (HCs) were enrolled. Neuropsychological assessments and resting-state functional MRI (rs-fMRI) were performed. The fALFF and DC values in the conventional, slow4 and slow5 frequency bands were compared among the groups.Results: In the conventional frequency band, the DC value in the left precentral area was decreased in PD-MCI patients, while that in the right fusiform area was increased in PD-NC patients compared with HCs. Regarding fALFFs, both the PD-MCI and PD-NC patients had decreased values in the right precentral area compared with those of the HCs. The fALFFs did not differ between PD-MCI and PD-NC patients. The fALFF results in the slow4 subfrequency band were consistent with those in the conventional frequency band. In the slow5 band, the DC value in the left middle temporal lobe was higher in PD-MCI patients than in PD-NC patients and was positively correlated with the performance of the PD-MCI patients on the Montreal Cognitive Assessment (MoCA). Additionally, both PD-MCI and PD-NC patients showed lower fALFF values in the bilateral putamen than the HCs, and the fALFF in the bilateral putamen was negatively correlated with the Hoehn and Yahr stages of PD-MCI. The fALFF in the left putamen was negatively correlated with the scores of PD-MCI patients on the Movement Disorder Society-Unified Parkinson Disease Rating Scale Part III (MDS-UPRDS-III).Conclusion: Our results suggested that abnormal neuronal activities, such as fALFF and DC, are dependent on frequency in PD-MCI. Some subfrequency bands could distinguish PD-MCI from PD. Our findings may be helpful for further revealing the frequency-dependent resting functional disruption in PD-MCI.

Chronic Tension-Type Headache Treated with Acupuncture, Physical Training and Relaxation Training. Between-Group Differences

Cephalalgia ◽  
2006 ◽  
Vol 26 (11) ◽  
pp. 1320-1329 ◽  
Author(s):  
E Söderberg ◽  
J Carlsson ◽  
E Stener-Victorin
Keyword(s):  
Treatment Period ◽  
Physical Training ◽  
Relaxation Training ◽  
Tension Type Headache ◽  
Group Differences ◽  
Clinical Implications ◽  
Chronic Tension Type Headache ◽  
Headache Diary ◽  
Type Headache ◽  
Time Point

The aim of this study was to compare acupuncture, relaxation training and physical training in the treatment of chronic tension-type headache (CTTH). The study comprised 90 consecutive patients with CTTH who were randomly allocated to acupuncture, relaxation training or physical training. Headache intensity, headache-free days and headache-free periods were registered using a visual analogue scale and a headache diary. The measurements were made 4 weeks before, immediately after, and 3 and 6 months after the treatment period. Immediately after the last treatment, the number of headache-free periods and of headache-free days was higher in the relaxation group compared with the acupuncture group. There were no other significant differences between the groups at any time point. The clinical implications of our findings are that relaxation training induced the most pronounced effects directly after the treatment period, compared with acupuncture and physical training.

The Movement-Related Potential in Children with Migraine and Tension-Type Headache

Cephalalgia ◽  
2002 ◽  
Vol 22 (2) ◽  
pp. 125-131 ◽  
Author(s):  
BW Müller ◽  
G Sartory ◽  
A Tackenberg
Keyword(s):  
Contingent Negative Variation ◽  
Index Finger ◽  
Tension Type Headache ◽  
Healthy Children ◽  
Related Potentials ◽  
Adults And Children ◽  
Type Headache ◽  
The Right

Migraine is characterized by an elevated contingent negative variation (CNV) in adults and children. In the present study the movement-related potential preceding self-initiated movements, the Bereitschaftspotential, was investigated in 30 children (mean age 12 years) who were suffering from migraine and tension-type headache and in 16 healthy age-matched controls. Children pressed a button 80 times with the right index finger while movement-related potentials were recorded from frontal and central electrodes. Whereas healthy children evidenced positive movement-related potentials at left and midline positions, children with migraine and tension-type headache showed negative movement-related potentials at midline leads without lateralization. Negativity was even more pronounced in cases of migraine with than without aura symptoms.

The Reproducibility of Cephalic Pain Pressure Thresholds in Control Subjects and Headache Patients

Cephalalgia ◽  
1997 ◽  
Vol 17 (7) ◽  
pp. 748-755 ◽  
Author(s):  
T Sand ◽  
JA Zwart ◽  
G Helde ◽  
G Bovim
Keyword(s):  
Pain Intensity ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Cervicogenic Headache ◽  
Tension Type Headache ◽  
Control Subjects ◽  
Cephalic Pain ◽  
Type Headache ◽  
The Right ◽  
Headache Patients

Pain pressure thresholds (PPT) were measured at 13 cephalic points bilaterally in 30 headache patients (10 with tension-type headache, 10 with migraine and 10 with cervicogenic headache) and 10 control subjects on three different days. During the sessions, the subjects reported their pain intensity on the right and left sides of the head on a visual analogue scale (VAS). The variability between days was estimated as a coefficient of repeatability (CR=2 standard deviations of intraindividual differences). The mean CR across all 13 locations was larger in headache patients (2.0 kg/cm2) than in controls (1.68 kg/cm2). Variability (CR) was larger in headache patients as compared to control subjects for 11 of the 13 points (p=0.02). Reliability was better in controls (intraclass correlation coefficients (ICC) ranging from 0.55 to 0.85) than in headache patients (ICC ranging from 0.43 to 0.78). A moderate negative association between PPT and pain intensity was demonstrated. The intraindividual PPT difference (PPT on the most painful occasions-PPT on the least painful occasions) was negative at 12 of 13 cephalic points (p=0.003, across-location mean difference: -0.20 kg/cm2). The PPT differed significantly from one day to the next. A part of this variation was presumably related to the circumstances around the procedure; thresholds were lower when the subjects came directly to algometry without any preceding medical examination at all 13 points (p=0.0002). These results have implications for the planning of future algometer studies. The sample size that is required in studies of headache patients is greater than that in studies of healthy subjects, especially when patients suffer from pain during the PPT session. Particular attention should be paid to circumstances (e.g. preceding medical investigations) around the algometry procedure in order to reduce variability.

scholarly journals Brain Frequency-Specific Changes in the Spontaneous Neural Activity Are Associated With Cognitive Impairment in Patients With Presbycusis

2021 ◽  
Vol 13 ◽  
Author(s):  
Fuxin Ren ◽  
Wen Ma ◽  
Wei Zong ◽  
Ning Li ◽  
Xiao Li ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Auditory Cortex ◽  
Neural Activity ◽  
Auditory Processing ◽  
Low Frequency ◽  
Frontal Eye Field ◽  
Functional Coupling ◽  
Frequency Bands ◽  
Spontaneous Neural Activity ◽  
Key Nodes

Presbycusis (PC) is characterized by preferential hearing loss at high frequencies and difficulty in speech recognition in noisy environments. Previous studies have linked PC to cognitive impairment, accelerated cognitive decline and incident Alzheimer’s disease. However, the neural mechanisms of cognitive impairment in patients with PC remain unclear. Although resting-state functional magnetic resonance imaging (rs-fMRI) studies have explored low-frequency oscillation (LFO) connectivity or amplitude of PC-related neural activity, it remains unclear whether the abnormalities occur within all frequency bands or within specific frequency bands. Fifty-one PC patients and fifty-one well-matched normal hearing controls participated in this study. The LFO amplitudes were investigated using the amplitude of low-frequency fluctuation (ALFF) at different frequency bands (slow-4 and slow-5). PC patients showed abnormal LFO amplitudes in the Heschl’s gyrus, dorsolateral prefrontal cortex (dlPFC), frontal eye field and key nodes of the speech network exclusively in slow-4, which suggested that abnormal spontaneous neural activity in PC was frequency dependent. Our findings also revealed that stronger functional connectivity between the dlPFC and the posterodorsal stream of auditory processing, as well as lower functional coupling between the PCC and key nodes of the DMN, which were associated with cognitive impairments in PC patients. Our study might underlie the cross-modal plasticity and higher-order cognitive participation of the auditory cortex after partial hearing deprivation. Our findings indicate that frequency-specific analysis of ALFF could provide valuable insights into functional alterations in the auditory cortex and non-auditory regions involved in cognitive impairment associated with PC.

scholarly journals Effects of the DRD4 −521 C/T SNP on Local Neural Activity and Functional Connectivity in Children With ADHD

2022 ◽  
Vol 12 ◽  
Author(s):  
Huan Zhang ◽  
Binrang Yang ◽  
Gang Peng ◽  
Linlin Zhang ◽  
Diangang Fang
Keyword(s):  
Functional Connectivity ◽  
Brain Function ◽  
Rating Scale ◽  
Low Frequency ◽  
Regional Homogeneity ◽  
Frequency Fluctuation ◽  
Behavioral Performance ◽  
Superior Frontal Gyrus ◽  
Middle Occipital Gyrus ◽  
The Right

Objective: The present study aimed to investigate the effects of the dopamine receptor D4 (DRD4) −521 C/T single-nucleotide polymorphism on brain function among children with attention deficit hyperactivity disorder (ADHD) and to evaluate whether brain function is associated with behavioral performance among this demographic.Methods: Using regional homogeneity, fractional amplitude low-frequency fluctuation, and functional connectivity as measurement indices, we compared differences in resting-state brain function between 34 boys with ADHD in the TT homozygous group and 37 boys with ADHD in the C-allele carrier group. The Conners' Parent Rating Scale, the SNAP-IV Rating Scale, the Stroop Color Word Test, the go/no-go task, the n-back task, and the working memory index within the Wechsler Intelligence Scale for Children-Fourth Edition were selected as comparative indicators in order to test effects on behavioral performance.Results: We found that TT homozygotes had low behavioral performance as compared with C-allele carriers. The regional homogeneity for TT homozygotes decreased in the right middle occipital gyrus and increased in the right superior frontal gyrus as compared with C-allele carriers. In addition, the right middle occipital gyrus and the right superior frontal gyrus were used as the seeds of functional connectivity, and we found that the functional connectivity between the right middle occipital gyrus and the right cerebellum decreased, as did the functional connectivity between the right superior frontal gyrus and the angular gyrus. No statistically significant differences were observed in the respective brain regions when comparing the fractional amplitudes for low-frequency fluctuation between the two groups. Correlation analyses demonstrated that the fractional amplitude low-frequency fluctuation in the precentral gyrus for TT homozygotes were statistically significantly correlated with working memory.Conclusions: We found differing effects of DRD4 −521 C/T polymorphisms on brain function among boys with ADHD. These findings promote our understanding of the genetic basis for neurobiological differences observed among children with ADHD, but they must be confirmed in larger samples.

Pain is more widespread and referred to trigeminal areas in occipital neuralgia

2014 ◽  
Vol 22 (3) ◽  
pp. 438-445
Author(s):  
Omar Franklin Molina ◽  
Zeila Coelho Santos ◽  
Bruno Ricardo Huber Simião ◽  
Sonia Maria Paiva Torres ◽  
Ricardo Léllis Marçal ◽  
...  
Keyword(s):  
Tension Type Headache ◽  
Referred Pain ◽  
Craniomandibular Disorders ◽  
Occipital Neuralgia ◽  
Temporal Area ◽  
Parietal Area ◽  
Post Test ◽  
Type Headache ◽  
The Right

Objetctive. Evaluate local and referred pain in occipital neuralgia. Method. Charts review of 32 occipital neuralgia, 16 migraine with­out aura and 102 tension-type headache individuals, respectively. Criteria for craniomandibular disorders, bruxism, headaches. Ques­tionnaires to assess pain sites and descriptors for headaches. Results. Common areas of local/referred pain in occipital neuralgia were the temporal, frontal, occipital, sub-occipital, retro-orbital, cervical and vertex (78.1% cases). Common areas of referred pain in tension-type headache were located in the bilateral temporal and frontal areas (65=63.7%). Other areas of referred pain in tension-type headache were the cervical, vertex, sub-occipital and parietal areas (21.6%). Common areas of local and referred pain in migraine (62.5%) were located in the right anterior temporal area, right anterior temporal, parietal and occipital, left anterior temporal and parietal area, frontal and cervical areas. The median of painful anatomic zones were occipi­tal neuralgia 3.5, tension-type headache 2.0, migraine 2.0; and Con­trols 0.5 (Kruskal-Wallis statistics with post-test p<0.0001). Conclu­sions. Pain in occipital neuralgia was reported in a more widespread anatomic area and in more anatomic zones as compared to migraine and tension-type headache. The latter was reported usually bilaterally in the frontal and temporal areas.

scholarly journals Somatosensory temporal discrimination remains intact in tension-type headache whereas it is disrupted in migraine attacks

Cephalalgia ◽  
2016 ◽  
Vol 37 (13) ◽  
pp. 1241-1247 ◽  
Author(s):  
Doga Vuralli ◽  
H Evren Boran ◽  
Bulent Cengiz ◽  
Ozlem Coskun ◽  
Hayrunnisa Bolay
Keyword(s):  
Healthy Volunteers ◽  
Sensory Processing ◽  
Temporal Discrimination ◽  
Tension Type Headache ◽  
Controlled Study ◽  
Left Hand ◽  
Right Hand ◽  
Type Headache ◽  
The Right ◽  
Headache Patients

Background and objective Somatosensory temporal discrimination was recently reported as prolonged during migraine attacks, which is consistent with disrupted sensorial perception in migraine. However, knowledge about central sensory processing in tension-type headache is still lacking. This prospective, controlled study aimed to investigate somatosensory temporal discrimination thresholds in tension-type headache. Methods The study included 10 tension-type headache patients, 10 migraine patients and 10 healthy volunteers without headache. Somatosensory temporal discrimination thresholds were evaluated during the headache attacks of tension-type headache and migraine patients. Results Somatosensory temporal discrimination thresholds of tension-type headache patients (39.0 ± 5.5 ms for the right hand and 40.6 ± 4.6 ms for the left hand) were significantly lower than those of episodic migraine patients (137.1 ± 35.8 ms for the right hand and 118.4 ± 34.3 ms for the left hand, p < 0.0001 and p < 0.0001 respectively), and comparable to those of healthy volunteers (38.6 ± 5.3 ms for the right hand and 38.3 ± 7.2 ms for the left hand, p = 0.79 and p = 0.45 respectively). Conclusion Central sensory processing, as tested by somatosensory temporal discrimination, was remarkably disrupted during the headache attacks in migraineurs, whereas it remained intact in the tension-type headache patients.

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