A comparative study of time-specific oxidative stress after acute myocardial infarction in patients with and without diabetes mellitus

Chronic disease burdens continue to rise in highly dense urban environments where clustering of type II diabetes mellitus, acute myocardial infarction, stroke, or any combination of these three conditions is occurring. Many individuals suffering from these conditions will require longer-term care and access to clinics which specialize in managing their illness. With Singapore as a case study, we utilized census data in an agent-modeling approach at an individual level to estimate prevalence in 2020 and found high-risk clusters with >14,000 type II diabetes mellitus cases and 2000–2500 estimated stroke cases. For comorbidities, 10% of those with type II diabetes mellitus had a past acute myocardial infarction episode, while 6% had a past stroke. The western region of Singapore had the highest number of high-risk individuals at 173,000 with at least one chronic condition, followed by the east at 169,000 and the north with the least at 137,000. Such estimates can assist in healthcare resource planning, which requires these spatial distributions for evidence-based policymaking and to investigate why such heterogeneities exist. The methodologies presented can be utilized within any urban setting where census data exists.

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Urinary 1-Hydroxypyrene is Associated with Oxidative Stress and Inflammatory Biomarkers in Acute Myocardial Infarction

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph110909024 ◽

2014 ◽

Vol 11 (9) ◽

pp. 9024-9037 ◽

Cited By ~ 11

Author(s):

Fernando Freitas ◽

Natália Brucker ◽

Juliano Durgante ◽

Guilherme Bubols ◽

Rachel Bulcão ◽

...

Keyword(s):

Oxidative Stress ◽

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Inflammatory Biomarkers

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Relation of Chronic and Acute Glycemic Control on Mortality in Acute Myocardial Infarction With Diabetes Mellitus

The American Journal of Cardiology ◽

10.1016/j.amjcard.2005.03.040 ◽

2005 ◽

Vol 96 (2) ◽

pp. 183-186 ◽

Cited By ~ 58

Author(s):

Jie J. Cao ◽

Michael Hudson ◽

Michelle Jankowski ◽

Fred Whitehouse ◽

W. Douglas Weaver

Keyword(s):

Diabetes Mellitus ◽

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Glycemic Control

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Newly diagnosed and previously known diabetes mellitus and short-term outcomes in patients with acute myocardial infarction

Coronary Artery Disease ◽

10.1097/mca.0000000000000036 ◽

2013 ◽

pp. 1

Author(s):

Chang Wei ◽

Li Tian ◽

Jun Zhu ◽

Lisheng Liu ◽

Yan Liang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Newly Diagnosed ◽

Short Term

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Abstract 265: Uroetensin II Protects Cardiomyocytes from Apoptosis Induced by Oxidative Stress through Cystathionine-γ-Lyase (CSE)/Hydrogen Sulfide Pathway

Circulation Research ◽

10.1161/res.115.suppl_1.265 ◽

2014 ◽

Vol 115 (suppl_1) ◽

Author(s):

Hui Gong ◽

Zhidan Chen ◽

Xiaoyi Zhang ◽

Jie Zhang ◽

Yang Li ◽

...

Keyword(s):

Oxidative Stress ◽

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Erk Signaling ◽

Cardiac Protection ◽

Health Control ◽

Cardiology Department ◽

Apoptotic Protein ◽

Induced Apoptosis ◽

H2s Production

Plasma UII has been observed to be raised in patients with acute myocardial infarction, a lower UII response is associated with more severe injury of myocardium, suggesting a possible cardioprotective role for this peptide. In the present study, we studied plasma UII concentration of thirty patients admitted to the Cardiology Department with acute myocardial infartion.The results showed that plasma UII was sharply increased in patients compared to that in health control within one week after admission. We then explore whether UII could protect cardiomyocytes from injury induced by oxidative stress. Cultured cardiomyocyte were treated with H2O2 to induce oxidative stress, and the influence of UII on H2O2-induced apoptosis was observed. The results showed that UII pretreatment significantly reduced the number of TUNEL-positive cardiomyocytes induced by H2O2, and it partly abolished the upregulation of pro-apoptotic protein Bax and the down-regulation of anti-apoptotic protein Bcl-2. siRNA targeted to urotensin receptor (UT) greatly inhibited these effects. H2S has been reported to exert protective effect on cardiomyocytes, we detected the effect of UII on H2S production and CSE (Major H2S-producing enzyme) expressions in cardiomyocytes exposed to H2O2.The present data revealed that UII increased the H2S production by enhancing the expression of CSE by activating the ERK signaling in cardiomyocytes exposed to H2O2. Si-CSE or ERK inhibitor not only greatly inhibited the upregulation of CSE or the phosphorylation of ERK induced by UII but also reversed UII-induced-upregulation of H2S production and anti-apoptosis in cadiomyocytes exposed to H2O2. In conclusion, UII rapidly promoted the phosphorylation of ERK, increased CSE exression and induced H2S production, which in turn enhanced the p-ERK level to protect cardiomyocytes from apoptosis under ischemic or oxidative stress. The increased plasma UII level in patients may be critical for cardiac protection in patients at early-phase of acute myocardial infarction.

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Study on oxidative stress and antioxidant level in patients of acute myocardial infarction before and after regular treatment

Bangladesh Medical Research Council Bulletin ◽

10.3329/bmrcb.v40i2.25226 ◽

2015 ◽

Vol 40 (2) ◽

pp. 79-84 ◽

Cited By ~ 10

Author(s):

T Bashar ◽

N Akhter

Keyword(s):

Oxidative Stress ◽

Risk Factors ◽

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Vitamin E ◽

Plasma Vitamin ◽

Regular Treatment ◽

Before And After ◽

The Difference ◽

Plasma Vitamin E

In acute myocardial infarction (AMI), lack of oxygen delivery to myocardium leads to generation of reactive oxygen species (ROS) which play an important role in the pathogenesis of AMI. Endogenous anti-oxidants protect the myocardial tissues from the deleterious effect of free radical mediate injury. The study evaluates the extent of oxidative stress and antioxidant status against ROS in AMI patients and amelioration of oxidative stress after regular treatment and also assesses the association between oxidative stress and risk factors for atherosclerosis like dyslipidemia and diabetes mellitus (DM).The study was conducted on 72 AMI patients and age and sex matched 18 healthy controls. Patients were assigned to four groups, AMI without dyslipidemia or DM, with dyslipidemia, with DM and with both dyslipidemia and DM. Plasma malondialdehyde (MDA) and GSH content and vitamin E levels were determined on admission into hospital and on the 5th day of treatment. Plasma MDA level increased significantly (p<0.001) and erythrocyte GSH and plasma vitamin E levels were decreased (p<0.001) in all the groups of patients as compared to control. On the 5th day of regular treatment MDA level reduced (p<0.001) and GSH and vitamin E levels increased (p<0.001) in patients. The plasma MDA level was significantly higher (p<0.001) in patients with both dyslipidemia and DM or with only DM in comparison to patients without dyslipidemia and DM. The difference in the GSH level between patients with risk factors and without risk factors was not significant. It may be conclude that an imbalance exists between oxidant and antioxidant molecules in AMI patients which shift towards oxidative side and regular treatment restores this balance. There may be some association between oxidative stress in AMI and risk factors like dyslipidemia and diabetes mellitus.Bangladesh Med Res Counc Bull 2014; 40 (2): 79-84

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