scholarly journals Circulating miRNA-202-3p is a potential novel biomarker for diagnosis of type 1 gastric neuroendocrine neoplasms

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dou Dou ◽  
Xiao-kou Li ◽  
Qi-sheng Xia ◽  
Ying-ying Chen ◽  
Yuan-liang Li ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Matched Control ◽  
Future Research ◽  
Control Group ◽  
Neuroendocrine Neoplasms ◽  
Diagnostic Biomarkers ◽  
Standard Curve ◽  
Qrt Pcr ◽  
Age And Sex

Abstract Background Currently, there are no circulating diagnostic biomarkers for gastric neuroendocrine neoplasms (g-NENs). In previous studies, we found that miRNA-202-3p is overexpressed in the tumour tissue of type 1 g-NEN. We speculated that miRNA-202-3p is also likely to be highly expressed in circulating blood. Methods A total of 27 patients with type 1 g-NEN and 27 age- and sex-matched control participants were enrolled in this study. The miRNA-202-3p levels in serum obtained from the participants were measured by qRT‐PCR. The expression level of miRNA-202-3p in the samples was calculated by comparison with a standard curve. Results The clinical characteristics of the patients were similar to those of the patient samples in previous reports. Expression of miRNA-202-3p was significantly higher in the patient group (3.84 × 107 copies/nl) than in the control group (0.635 × 107 copies/nl). The area under the ROC curve (AUC) was 0.878 (95% CI: 0.788–0.968), and the optimal cut-off point was approximately 1.12 × 107 copies/nl. The sensitivity and specificity were 88.9% and 77.8%, respectively. Conclusion This study suggests that miRNA-202-3p is potentially useful as a biomarker of type 1 g-NEN; further investigation and verification should be performed in future research.

Enlargement of cerebrospinal fluid spaces in long-term benzodiazepine abusers

1987 ◽  
Vol 17 (4) ◽  
pp. 869-873 ◽  
Author(s):  
C. Schmauss ◽  
J.-C. Krieg
Keyword(s):  
Low Dose ◽  
Matched Control ◽  
Control Group ◽  
High Dose ◽  
Withdrawal Therapy ◽  
The Mean ◽  
Dose Dependent ◽  
Dose Dependent Effect ◽  
Age And Sex

SynopsisIn 17 benzodiazepine (BDZ) dependent in-patients a CT scan was performed before initiation of withdrawal therapy. The evaluation of the ventricular to brain ratio (VBR) by standardized and computerized measurements revealed significantly higher mean VBRs for both high-and low-dose BDZ-dependent patients compared to the mean VBR of an age- and sex-matched control group. In addition, the mean VBR of high-dose BDZ-dependent patients (N = 8) was significantly higher than the mean VBR of low-dose BDZ-dependent patients (N = 9). This difference could not be accounted for by the age of the patients or duration of BDZ-dependency and, therefore, suggests a dose-dependent effect of BDZs on the enlargement of internal CSF-spaces. On the other hand, higher values for the width of external CSF-spaces were found to be related to increasing age of the patients and duration of BDZ-dependency.

Increased Concentrations of Total IgM At Clinical Onset of Type 1 (Insulin-Dependent) Diabetes: Correlation with IgM Binding to Cells. The Belgian Diabetes Registry

1992 ◽  
Vol 38 (9) ◽  
pp. 1762-1767 ◽  
Author(s):  
T Decraene ◽  
C Vandewalle ◽  
D Pipeleers ◽  
F K Gorus
Keyword(s):  
Matched Control ◽  
Islet Cells ◽  
Insulin Dependent Diabetes ◽  
Diabetes Registry ◽  
Control Subjects ◽  
Clinical Onset ◽  
Natural Autoantibodies ◽  
Insulin Dependent ◽  
Age And Sex

Abstract Eighty patients with type 1 (insulin-dependent) diabetes (ages 0-39 years) were consecutively recruited by the Belgian Diabetes Registry. Sera obtained at clinically diagnosed onset (i.e., before start of insulin therapy or within 7 days of initial treatment) were analyzed for total IgM concentrations and for IgM binding to fixed rat splenocytes (IgM-LyAb) and permeabilized rat islet cells (IgM-ICAb). Comparison of results with those in age- and sex-matched control subjects, by fluorescence-activated cell-sorter analysis, indicated greater concentrations of IgM-LyAb and IgM-ICAb in sera from the patients. IgM antibodies reacted indiscriminately with islet beta and islet endocrine non-beta cells. The prevalence of IgM-ICAb, but not of IgM-LyAB, was significantly (P less than 0.05) higher in patients than in the control subjects. Of the ICAb-positive patients, 54% were also LyAb-positive, whereas none of the control subjects were doubly positive. IgM-ICAb and IgM-LyAb binding signals were positively correlated. Serum IgM concentrations were significantly (P less than 0.001) greater in patients than in control subjects and were significantly correlated with IgM-LyAb (P less than 0.001) and IgM-ICAb (P less than 0.01). The positivity for IgM binding was not, however, merely a reflection of total IgM, because no such correlation was found in sera from seven patients with Waldenström macroglobulinemia. Clinical onset of type 1 diabetes is apparently accompanied by increased production of IgM. The correlation between IgM concentrations and IgM binding to islet cells might reflect polyclonal activation or natural autoantibodies.

Migraine Patients Experience Poorer Subjective Well-Being/Quality of Life Even Between Attacks

Cephalalgia ◽  
1995 ◽  
Vol 15 (1) ◽  
pp. 31-36 ◽  
Author(s):  
CGH Dahlöf ◽  
E Dimenäs
Keyword(s):  
Migraine Patient ◽  
Matched Control ◽  
Well Being ◽  
Control Group ◽  
Subjective Well Being ◽  
Subjective Symptoms ◽  
Matched Control Group ◽  
Patients Experience ◽  
Age And Sex

The aim of the present study was to compare the general well-being of migraine patients between attacks with that of an age- and sex-matched control group. One hundred and forty-five consecutive and eligible patients at the Gothenburg Migraine Clinic were asked about their well-being and their complaints. Using three self-administered standardized questionnaires, the Minor Symptoms Evaluation Profile (MSEP), Subjective Symptoms Assessment Profile (SSAP) and the Psychological General Well-Being (PGWB) Index, evaluable responses were obtained from 138 migraine patients. Compared with control subjects, migraineurs perceived more symptoms and greater emotional distress as well as disturbed contentment, vitality and sleep. It is concluded that the general well-being of the migraine patient is impaired, even between the attacks.

scholarly journals Clinical Characteristics and Management of Functional Pancreatic Neuroendocrine Neoplasms: A Single Institution 20-Year Experience with 286 Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Yuqing Qu ◽  
Haoming Li ◽  
Xianling Wang ◽  
Yulong Chen ◽  
Qinghua Guo ◽  
...  
Keyword(s):  
Targeted Therapies ◽  
Clinical Characteristics ◽  
Chinese Patients ◽  
Neuroendocrine Neoplasms ◽  
Complex Spectrum ◽  
Rare Disorders ◽  
Pancreatic Neuroendocrine Neoplasms ◽  
Complex Disorders ◽  
Precise Diagnosis

Background. Functional pancreatic neuroendocrine neoplasms (PanNENs) are very rare disorders but have complex spectrum, including insulinoma, gastrinoma, glucagonoma, somatostatinoma, and VIPoma. Patients with PanNENs usually present with characteristic symptoms caused by corresponding hormone hypersecretion. It has always been challenging in dealing with such rare but complicated disorders. In this report, we analyzed the clinical characteristics of functional PanNENs in a large cohort of Chinese patients and summarized our clinical experience in diagnosis and treatment. Methods. The retrospective analysis was performed in patients with a definite diagnosis of functional PanNENs hospitalized in Chinese PLA General Hospital between 2000 and 2020. The clinical characteristics, surgical information, and pathological findings were extracted from their medical records and were analyzed. Results. Totally, 286 patients (gender: male 103 and female 183; age: 45.55 ± 15.23 years old) were diagnosed with definite functional PanNENs. The most frequent functional PanNENs were insulinoma (266/286) followed by glucagonoma (10/286), somatostatinoma (3/286), adrenocorticotropic hormone- (ACTH-) producing tumor (3/286), gastrinoma (2/286), and VIPoma (2/286). Nine patients were diagnosed with multiple endocrine neoplasia type 1 (MEN1) in which all the associated functional PanNENs were insulinomas. The duration from symptoms’ onset to confirmed diagnosis was 3.67 ± 4.28 years. Two hundred and eighty patients with tumor localized in pancreatic or with limited metastasis underwent surgery. The symptoms associated with hormonal oversecretion were improved significantly after surgery. Five patients with unresectable metastases or tumor recurrence after surgery were administrated with systemic chemotherapy or other targeted therapies. With these various therapies, the symptoms were also partially relieved. According to findings in pathological and immunochemical examination, all the functional PanNENs were categorized into NEN-G1 (41.95%), NEN-G2 (54.90%), NEN-G3 (3.15%), and NEC-G3 (0%). Conclusion. Patients with suspected functional PanNENs should have a systematic endocrine examination at diagnosis. Multidisciplinary collaborations are essential for precise diagnosis and tumor localization. A successful surgery or other targeted therapies can improve the prognosis of patients with such rare but complex disorders.

scholarly journals Corneal Epithelial Damage and Impaired Tear Functions in Patients with Inflamed Pinguecula

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Erkut Küçük ◽  
Uğur Yılmaz ◽  
Kürsad Ramazan Zor
Keyword(s):  
Matched Control ◽  
Tear Film ◽  
Control Group ◽  
Healthy Controls ◽  
Epithelial Defect ◽  
Epithelial Integrity ◽  
Corneal Epithelial ◽  
Matched Control Group ◽  
Age And Sex ◽  
Fellow Eyes

Purpose. In this study, we evaluated corneal epithelial integrity and tear film parameters in patients with inflamed pinguecula and compared these findings with their fellow eyes and with healthy controls. Methods. We evaluated the fluorescein staining properties and performed the tear break-up time (TBUT) test and Schirmer 2 test (ST2) measurements of 32 patients who had symptomatic unilateral inflamed pinguecula and compared the results with their fellow eyes and also with an age- and sex-matched control group. Results. Twenty-three eyes (72%) in the inflamed pinguecula group and 1 eye (3.1%) in the fellow eyes group had punctate epithelial staining (PES) or epithelial defect on the nasal cornea (p<0.001). There was no PES or epithelial defect in the control group. Eyes with inflamed pinguecula (n = 32) had lower TBUT and ST2 values compared to the control group (n = 32) (p<0.001 for both). Fellow eyes (n = 32) also had lower TBUT and ST2 values compared to the control group (p=0.003 for both). There was no difference in the TBUT and ST2 results between the eyes with inflamed pinguecula and fellow eyes (p=0.286 and p=0.951, respectively). Conclusion. A high percentage of eyes with inflamed pinguecula had nasal corneal epithelial staining or epithelial defect. We also found lower TBUT and ST2 results in eyes with inflamed pinguecula and the fellow eyes compared to the control group. These findings may be important in pathogenesis of pinguecula and pterygium and also in uncovering their relation.

scholarly journals Veleszületett csírahiánnyal társuló skeletalis eltérések vizsgálata

2019 ◽  
Vol 160 (6) ◽  
pp. 214-219
Author(s):  
I. Krisztina Mártha ◽  
Alina Cămărășan ◽  
Silvia Izabella Pop ◽  
Bernadette Kerekes Máthé
Keyword(s):  
Orthodontic Treatment ◽  
Matched Control ◽  
Daily Practice ◽  
Growth Direction ◽  
Control Group ◽  
X Ray ◽  
Skeletal Class ◽  
Measurement Results ◽  
The University ◽  
Age And Sex

Abstract: Introduction: The incidence of congenital hypodontia is increasing in daily practice. Early diagnosis of this dental disorder and the associated skeletal malocclusions is crucial for successful and stable final rehabilitation. Aim: Comparison of cephalometric findings of patients with hypodontia of 1–4 teeth with the measurement results of the control group without teeth agenesis. Material and method: We evaluated the lateral X-ray of 41 patients with 1–4 teeth agenesis selected from patients referred for orthodontic treatment to the Orthodontic Department of the University of Medicine and Pharmacy from Târgu Mureş within a two-year period. The results were compared with the values of the age and sex matched control group. Results: Bilateral upper incisor and lower bicuspid were missing in most of the hypodontia cases. When looking at the NSGn angle predicting the growth direction of the mandible, statistically significant differences were found between the male (p = 0.012), the front (p = 0.010) and the hypodontia group (p = 0.024) and the control group. Regarding the ANB angle, which shows the sagittal position of the maxilla to the mandible, statistically significant differences were found between the subgroups (women, men, anterior or posterior hypodontia) and the control group. Conclusion: Larger number of skeletal class 3 and vertical hypodivergent tendency were observed in the hypodontia group. Orv Hetil. 2019; 160(6): 214–219.

Fatigue and health-related quality of life in elderly patients with and without heart failure in primary healthcare

2007 ◽  
Vol 6 (3) ◽  
pp. 208-215 ◽  
Author(s):  
Lena Hägglund ◽  
Kurt Boman ◽  
Mona Olofsson ◽  
Christine Brulin
Keyword(s):  
Heart Failure ◽  
Primary Healthcare ◽  
Matched Control ◽  
Control Group ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Patient Groups ◽  
Age And Sex

Background Patients with heart failure (HF) in primary healthcare are in many respects not comparable to those in specialized care and the knowledge about different patient groups with and without HF is limited. Aims To compare fatigue and health-related quality of life (Hr-QoL) when adjusting for age, gender and social provision in patients with confirmed HF ( n=49) to a group of patients with symptoms indicating HF but without HF (NHF, n=59) and to an age-and sex-matched control-group ( n=40). Method A questionnaire including the Multidimensional Fatigue Inventory, the SF-36, and the Social Provisions Scale was used. Results The average age in all groups was 78 years. Patients in the HF and NHF groups reported worse physical QoL and more general and physical fatigue than the control group. HF patients had worse general health than the NHF group. Conclusion Elderly patients in primary healthcare with confirmed heart failure and patients with symptoms similar to heart failure perceived they had a significantly worse physical QoL and more general and physical fatigue than an age- and sex-matched control group. The similarities between the patient groups indicate the importance of the symptom experience for Hr-QoL.

Reinke's oedema and thyroid function

1991 ◽  
Vol 105 (4) ◽  
pp. 291-292 ◽  
Author(s):  
A. White ◽  
D. W. Sim ◽  
A. G. D. Maran
Keyword(s):  
Thyroid Function ◽  
Matched Control ◽  
Normal Population ◽  
Vocal Folds ◽  
Thyroid Stimulating Hormone ◽  
Aetiological Factor ◽  
Controlled Study ◽  
Control Group ◽  
Matched Control Group ◽  
Age And Sex

AbstractReinke's oedema (RO) of the vocal folds is a condition of unknown aetiology. Cigarette smoking and vocal abuse may contribute to its development. Hypo thy roidism has been described as an aetiological factor but, to date, no controlled study has been published confirming this association. This prospective, controlled study compared thyroid function in 61 consecutive RO patients with an age and sex matched control group (n = 65) without laryngeal disease. Thyroid function was assessed by measuring serum thyroid stimulating hormone (TSH), free thyroxine (T4) and tri-iodothyronine (T3). Hypothyroidism was diagnosed when TSH was above normal with a T3 and T4 below the normal range.Four RO patients were hypothyroid at the time of diagnosis, compared to five of the control group. Six RO patients had past or present hypothyroidism compared to seven of the controls. One RO patient and two controls were euthyroid with marginally elevated TSH levels. Although the incidence of hypothyroidism in this group of Reinke's oedema patients is higher than expected in a normal population, it is similar to that in an age and sex matched control group, reflecting the prevalence of hypothyroidism in middle aged women.This study suggests that hypothyroidism is not an aetiological factor in the development of Reinke's oedema.

Patients with Implanted Permanent Pacemakers: Baseline Characteristics and Coronary Angiographic Profile

2020 ◽  
Author(s):  
Ismail Alsuz ◽  
Mahdi Al-Zaidi
Keyword(s):  
Coronary Artery Disease ◽  
Blood Flow ◽  
Matched Control ◽  
Control Group ◽  
Study Group ◽  
Conduction Disturbances ◽  
Type Iv ◽  
Lv Dysfunction ◽  
Artery Disease

ABSTRACT Background: Etiology of severe cardiac conduction disturbances is frequently uncertain. The risk factors of both coronary artery disease and conduction defects often overlap. Considering this, the present study aimed to find the relationship between complete heart block and specific pathological coronary anatomy. Material and Methods: Seventy-eight patients, (39 patients with a permanent pacemaker and 39 matched control patients who underwent coronary angiography procedure) were studied. The lesions were classified into four types, according to the anatomy of blood supply to the different segments of the conduction system. Results: Type IV lesion was common in study group compared to matched control group where type III lesion was common. Lesions that compromise blood flow to septal branches (types II and IV) were common in study group and the lesion types that do not compromise blood flow (types I and III) were common in control group (p<0.001). Type 1 lesion were common in females (p<0.001). Type IV lesions were common in hypertensive, whereas, non- hypertensive and non-diabetic patients had type 1 lesions (p<0.001). Similarly, patients with LV dysfunction had type 4 lesion compared to the patients without LV dysfunction who had type 1 lesions (p<0.001) Conclusions: Patients with permanent pacemakers having coronary artery disease are more likely to have specific coronary angiographic findings. Therefore, the site of lesions and not the severity or extent of atherosclerosis is responsible for the conduction disturbances.

DOZ047.54: Fundoplication outcomes in children with esophageal atresia

2019 ◽  
Vol 32 (Supplement_1) ◽  
Author(s):  
E Chung ◽  
M van Lennep ◽  
R Saoji ◽  
A Jiwane ◽  
M W N Oomen ◽  
...  
Keyword(s):  
Esophageal Atresia ◽  
Matched Control ◽  
Cumulative Risk ◽  
Control Group ◽  
Postoperative Dysphagia ◽  
Long Gap ◽  
Type C ◽  
New Diagnosis ◽  
Age And Sex

Abstract Background In esophageal atresia (EA) patients, cumulative risk of having a fundoplication ranges from 0% to 45%, with long gap patients with recurrent strictures at even higher risk. However, there are no controlled trials evaluating the outcomes postfundoplication. We hypothesized that children with EA undergoing fundoplication will suffer from more postoperative dysphagia compared to non-EA patients as the fundoplication increases the resistance to esophageal bolus flow, which is already hampered by abnormal motility. Aims Our study aimed to compare outcomes in EA patients with age- and sex-matched control patients postfundoplication. Methods This was an international multicenter retrospective cohort study. All EA patients who had fundoplication between 2006 and 2017 during this period were included. Data were also collected from age- and sex-matched children without EA who underwent fundoplication. Results A total of 40 EA patients had fundoplication during this period. Of the EA patients 82.5% were type C, and 82.5% were long gap. Table 1 compares EA patients with controls. Significantly more EA patients were failing to thrive, on nasogastric/gastrostomy feeds at time of surgery and needed gastrostomy placement at time of fundoplication compared to controls. A total of 17.5% of EA patients developed infection and 22.5% a leak postfundoplication. EA patients had postoperative dysphagia and oral aversion significantly more often than controls. Of 90% of EA patients had recurrence of gastrointestinal or respiratory symptoms, 35% had recurrent strictures, 5% had a new diagnosis of eosinophilic esophagitis postfundoplication. Median time to symptom recurrence was 64 days (12–165 days), 90% were back on PPI and 7.5% had redofundoplication. Conclusions Our study is the first to examine postfundoplication outcomes in EA patients and compare these with a matched control group. EA patients had significantly more dysphagia and oral aversion postfundoplication and majority were back on PPI within two months of surgery. Based on these data, the role of fundoplication in EA patients should be reconsidered. Prospective data are urgently needed.

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