scholarly journals Advanced HIV disease at presentation to care in Nairobi, Kenya: late diagnosis or delayed linkage to care?—a cross-sectional study

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Mia Liisa van der Kop ◽  
Lehana Thabane ◽  
Patricia Opondo Awiti ◽  
Samuel Muhula ◽  
Lennie Bazira Kyomuhangi ◽  
...  
Author(s):  
Louis Boafo Kwantwi ◽  
Christian Obirikorang ◽  
Margaret Agyei Frempong ◽  
Dan Yedu Quansah

Background: Surrogate markers have been identified to play significant role in the pathogenesis and prognosis of HIV infection. However, there is limited data on the utility of neopterin estimation in HIV infection. Therefore, the study sought to measure and ascertains the trends of serum neopterin and other biochemical parameters as indicators of predicting HIV disease progression and treatment response among HIV seropositive individuals. Methods: A cross-sectional study with 298 HIV seropositive individuals consisting of 165 HIV on highly active antiretroviral treatment and 136 naïve highly active antiretroviral patients. Venous blood was drawn for the assay of neopterin and the other biochemical parameters. Results: Neopterin was significantly lower (P<0.0001) in patients in the highly active antiretroviral therapy than those in the naïve highly active antiretroviral therapy group. Serum neopterin increased as the disease progresses and decreased as the duration of the therapy treatment increased (p=0.0001). At a cut of point of 54.5 nmol/L, neopterin gave a sensitivity of 97.5%, specificity of 95.9% and an area under the curve of 0.99. Conclusion: Neopterin has shown to be to be good marker in predicting HIV disease progression especially in patients with CD4 counts less than 200mm-3 and a useful indicator of patient’s response to therapy treatment.


2016 ◽  
Vol 28 (6) ◽  
pp. 584-593 ◽  
Author(s):  
Levy Muchemwa ◽  
Lakhi Shabir ◽  
Ben Andrews ◽  
Mwango Bwalya

Tuberculosis is recognised as one of the leading causes of severe sepsis among HIV-infected patients. Most patients with Mycobacterium tuberculosis bacteraemia have advanced HIV disease with CD4 counts less than 100 cells/μl and its presentation is non-specific in most instances. This was a cross-sectional study which was done by analyzing data from 201 adult HIV-infected patients who met the inclusion criteria for severe sepsis. The prevalence of Mycobacterium tuberculosis bactraemia in the study population was 34.8%. Severe sepsis caused by other etiologies was observed in 33 (16.4%) of the participants. Concomitant infection of Mycobacterium tuberculosis bactraemia with other organisms is not uncommon in patients with severe sepsis. This cohort of HIV-infected patients had severe immunosuppression with a median CD4 count of 51 (20–136) cells/μl with moderate anaemia, mean haemoglobin 8.0 (3.0) g/dl, and were generally underweight with a mean mid upper arm circumference (MUAC) of 21.0 (3.4) cm. Mycobacterium tuberculosis bacteraemia is very common in HIV-infected patients with advanced HIV disease who present with severe sepsis. Mycobacterium tuberculosis bacteraemia co-infection with aerobic organisms is not uncommon. Factors that were independently associated with Mycobacterium tuberculosis bacteraemia in our study population were MUAC and sodium level.


2019 ◽  
Author(s):  
Seifadn Ahmed Shallo ◽  
Mesfin Tassew

Abstract Background Evidences from previous studies claim that informing children about their HIV status has long term positive implications in the HIV disease management, children's quality of life and ART drug adherence. However, in many parts of the Sub-Saharan African Countries, the HIV status disclosure among children reaches from 0 to 69.2%. Since the issue of disclosure is complex and highly influenced by socio-cultural characters and perception of the community towards HIV disease, it is important to investigate the up to date evidence which will help in designing contextualized approaches for disclosure. The objective of the current study was to assess the HIV status disclosure and its associated factors among children on ART in West Shoa Zone, Ethiopia.Methods Institutional based quantitative cross-sectional study supplemented by qualitative was conducted from February to April /2019 among 247 caregivers and or their children.Results The mean age of the children was 11.11±SD2.8, and 43.6%, (95% CI: 37, 50.9) of the children were fully disclosed. The average age at disclosure was 11 ±SD2.12. The main reasons for the disclosure were for drug adherence and better self-care, while underage was the commonest reason for nondisclosure. Compared to the age (10-15) years, the child in the age (6-9) was 97% [AOR: 0.027, 95% CI: 0.003, 0.22, P<0.001] less likely to be disclosed. Female children were 2.7 times more likely to be disclosed compared to males children [AOR: 2.73, 95% CI: 1.24, 6, P<0.013].Conclusion The current finding reveals that the HIV status disclosure is generally low, and the decision to disclose or not to do so is affected by many factors like child age, and child sex. This will affect directly or indirectly the child drug adherence, treatment outcome and also disease transmission.


2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Catherine G. Sutcliffe ◽  
Jane N. Mutanga ◽  
Nkumbula Moyo ◽  
Jessica L. Schue ◽  
Mutinta Hamahuwa ◽  
...  

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Emanuel Catumbela ◽  
Alberto Freitas ◽  
Fernando Lopes ◽  
Maria del Carmen Torres Mendoza ◽  
Carlos Costa ◽  
...  

2010 ◽  
Vol 20 (1) ◽  
pp. 10-14 ◽  
Author(s):  
Evelyn R. Klein ◽  
Barbara J. Amster

Abstract A study by Yaruss and Quesal (2002), based on responses from 134 of 239 ASHA accredited graduate programs, indicated that approximately 25% of graduate programs in the United States allow students to earn their degree without having coursework in fluency disorders and 66% of programs allow students to graduate without clinical experience treating people who stutter (PWS). It is not surprising that many clinicians report discomfort in treating PWS. This cross-sectional study compares differences in beliefs about the cause of stuttering between freshman undergraduate students enrolled in an introductory course in communicative disorders and graduate students enrolled and in the final weeks of a graduate course in fluency disorders.


Vacunas ◽  
2020 ◽  
Vol 21 (2) ◽  
pp. 95-104 ◽  
Author(s):  
Y.M. AlGoraini ◽  
N.N. AlDujayn ◽  
M.A. AlRasheed ◽  
Y.E. Bashawri ◽  
S.S. Alsubaie ◽  
...  

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