Prevalence and predictors of Toxoplasma gondii infection in pregnant women from Dhamar, Yemen

Abstract Background Toxoplasmosis is a common and serious parasitic infection caused by the ubiquitous obligatory intracellular protozoan organism, Toxoplasma gondii. Although infection with T. gondii is usually asymptomatic in healthy individuals, it can lead to severe pathological effects in congenital cases and immunocompromised patients. This study aimed to determine the seroprevalence of T. gondii and its predictors among pregnant women seeking prenatal and medical care at the general maternal and child health facility in Dhamar district of Dhamar governorate, Yemen. Methods A total of 420 pregnant women were randomly selected for this cross-sectional study. Participants were screened for anti-T. gondii antibodies (i.e. immunoglobulin M; IgM and immunoglobulin G; IgG) using electrochemiluminescence immunoassay. Demographic, socioeconomic, obstetric and behavioural data were collected using a pretested questionnaire via face-to-face interview. Univariate and multivariate analyses were used to identify the independent predictors of T. gondii seroprevalence. Results The overall seroprevalence of anti-T. gondii antibodies (IgG and/or IgM) among the participants was 21.2% (89/420; 95% CI = 17.3–25.1). Anti-T. gondii IgG antibodies were detected in 20.0% (84/420) of the women of which 12.9% (54/420) were positive for only IgG and 7.1% (30/420) were positive for both IgG and IgM antibodies. Moreover, 5 women (1.2%) were reactive only for IgM antibodies. Significant associations between T. gondii seroprevalence and history of spontaneous abortion (P < 0.001), raw vegetables consumption (P = 0.036), and presence of cats in household (P = 0.049) were reported. Multivariate analysis confirmed that history of spontaneous abortion (AOR = 4.04; 95% CI = [2.46, 6.63]) and presence of cats in household (AOR = 1.77; 95% CI = [1.02, 3.07]) are significant predictors of T. gondii seroprevalence among the studied participants. Conclusion The study found a high seroprevalence (21.2%) of T. gondii infection during pregnancy in Dhamar district, which is significantly associated with adverse pregnancy outcomes. The provision of adequate maternal healthcare and health education pertaining to the prevention of T. gondii infection is therefore imperative to curtail the prevalence of infection among the studied population.

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Brucellosis Serostatus among Pregnant Women with Spontaneous Abortion and Stillbirth

Current Women s Health Reviews ◽

10.2174/1573404817666210421115252 ◽

2021 ◽

Vol 17 ◽

Author(s):

Ezatollah Rafiei Alavi ◽

Niloofar Rafiei Alavi ◽

Romina Rafiei Alavi ◽

Ermia Farokhi

Keyword(s):

Pregnant Women ◽

Spontaneous Abortion ◽

Cross Sectional Study ◽

Case Group ◽

Cross Sectional ◽

Still Birth ◽

Rural Living ◽

Dairy Consumption ◽

Education Levels ◽

History Of

Background: Brucellosis in pregnancy is associated with serious outcomes ranging from abortion to neonatal development problems. Objective: The aim of this study is to evaluate the seroprevalence of brucellosis antibodies among pregnant women presented with spontaneous abortion and still birth. Methods: In this cross-sectional study, 80 cases (still birth or spontaneous abortion) and 80 healthy pregnant women were serologically examined for brucellosis antibodies using Coombs, Wright and 2-mercaptoethanol (2ME) brucella agglutination tests. The questionnaire consisting of the following data was prepared for all the participants: gestational age, age, history of abortion, parity, source of dairy consumption, contact with livestock, urban or rural living setup, serological outcomes and education levels. Results: The two groups were not significantly different in term of brucellosis test. Patients in case group with and without infection were not significant in terms of contact with livestock, place of residence, dairy consumption and history of abortion. However, education level was significantly different in the two, seropositive and seronegative, groups. Conclusion: Our study did not find significant number of brucellosis seropositive cases associated with stillbirth and spontaneous abortion. Further studies with greater samples are therefore recommended.

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Toxoplasma gondii infection in pregnant women: a cross-sectional study in Matehuala City, Mexico

BMJ Open ◽

10.1136/bmjopen-2019-033995 ◽

2020 ◽

Vol 10 (8) ◽

pp. e033995

Author(s):

Ada-Agustina Sandoval-Carrillo ◽

Angel Antonio Vértiz-Hernández ◽

Jose-Manuel Salas-Pacheco ◽

Olga Edith González-Lugo ◽

Elizabeth-Irasema Antuna-Salcido ◽

...

Keyword(s):

Risk Factors ◽

Toxoplasma Gondii ◽

Pregnant Women ◽

Protective Factor ◽

Cross Sectional Study ◽

Secondary Outcome ◽

Sectional Study ◽

Cross Sectional ◽

Infection Age ◽

Igm Antibodies

ObjectivesThis study aimed to determine the seroprevalence of Toxoplasma gondii (T. gondii) infection in pregnant women in Matehuala City, Mexico; and the associated risk factors.DesignA cross-sectional study.SettingMatehuala City, Mexico.Participants311 pregnant women.Primary and secondary outcome measuresSera of women were analysed for anti-T. gondii IgG and IgM antibodies by commercially available immunoassays. Bivariate and multivariate analyses were used to assess the association between T. gondii seroprevalence and the characteristics of the pregnant women.ResultsThirteen (4.2%) of the 311 pregnant women studied were positive for anti-T. gondii IgG antibodies. No anti-T. gondii IgM antibodies were found in anti-T. gondii IgG seropositive women. No association between seropositivity and history of blood transfusion, transplantation, caesarean sections, deliveries, miscarriages or number of pregnancies was found. Logistic regression analysis of sociodemographic, behavioural and housing variables showed that availability of potable water at street represented a risk factor for T. gondii infection (age-adjusted OR=2.18; 95% CI: 1.05 to 4.53; p=0.03), whereas being born in Mexico was a protective factor for infection (age-adjusted OR=0.01; 95% CI: 0.001 to 0.35; p=0.008).ConclusionsIn this first study on the seroepidemiology of T. gondii infection in pregnant women in Matehuala, we conclude that the seroprevalence of T. gondii infection is low and similar to those reported in pregnant women in other Mexican cities. However, the seroprevalence found is lower than those reported in pregnant women in other countries in the Americas and Europe. Two risk factors associated with T. gondii infection were identified. Results of the present study may help for the optimal planning of preventive measures against toxoplasmosis in pregnant women.

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Malaria in Pregnancy in Endemic Regions of Colombia: High Frequency of Asymptomatic and Peri-Urban Infections in Pregnant Women with Malaria

Infectious Diseases in Obstetrics and Gynecology ◽

10.1155/2020/2750258 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Ana-María Vásquez ◽

Lina Zuluaga-Idárraga ◽

Margarita Arboleda ◽

Luz-Yáned Usuga ◽

Carolina Gallego-Marin ◽

...

Keyword(s):

Antenatal Care ◽

Pregnant Women ◽

Cross Sectional Study ◽

Malaria In Pregnancy ◽

Limited Information ◽

Cross Sectional ◽

History Of ◽

Placental Blood ◽

Adverse Pregnancy ◽

In Pregnancy

Background. Malaria in pregnancy (MiP) has been associated with adverse pregnancy outcomes. There is limited information on MiP in low transmission regions as Colombia. This study aimed to describe the epidemiology of MiP through active surveillance of infections by microscopy and polymerase chain reaction (PCR). Methods. A cross-sectional study was conducted between May 2016 and January 2017 in five municipalities (Apartadó, Turbo, El Bagre, Quibdó, and Tumaco) in Colombia. Pregnant women self-presenting at health centers for antenatal care visits, seeking medical care for suspected malaria, or delivery, were enrolled. Diagnosis of Plasmodium spp was made in peripheral and placental blood samples by microscopy and PCR. Results. A total of 787 pregnant women were enrolled; plasmodial infection was diagnosed by microscopy in 4.2% (95% CI 2.8-5.6; 33/787) or by nPCR in 5.3% (95% CI 3.8-6.9; 42/787) in peripheral blood. Most of the infections were caused by P. falciparum (78.5%), and 46% were afebrile (asymptomatic). Women in the first and second trimester of pregnancy were more likely to be infected (aOR=3.06, 95%CI=1.6−5.8). To live in the urban/peri-urban area (aOR=3.04, 95%CI=1.4−6.56), to have a history of malaria during last year (aOR=5.45, 95%IC=2.16−13.75), and the infrequent bed net usage (aOR=2.8, 95%CI=1.31−5.97) were associated with the infection. Pregnant infected women had a higher risk of anaemia (aOR=2.18, 95%CI=1.15−4.12) and fever (aOR=14.2, 95%CI=6.89−29.8). Conclusion. The screening for malaria during antenatal care in endemic areas of Colombia is highly recommended due to the potential adverse effects of Plasmodium spp. infection in pregnancy and as an important activity for the surveillance of asymptomatic infections in the control of malaria.

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The Perception of Mothers on Malaria, Toxoplasmosis and their Pathological Consequences in the Mother and Baby in Biyem-Assi Yaounde

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2021/v33i1530993 ◽

2021 ◽

pp. 123-137

Author(s):

Judith Lum Ndamukong-Nyanga ◽

Todjom Chysine Lucile ◽

Kitio Falone Linda ◽

Signi, Demanou Teubow Dolly-Misper

Keyword(s):

Pregnant Women ◽

Spontaneous Abortion ◽

Parasitic Infection ◽

Cross Sectional Study ◽

Sub Saharan Africa ◽

Childbearing Age ◽

Cross Sectional ◽

The World ◽

Level Of Knowledge ◽

Sub Saharan

Malaria is a parasitic disease that causes morbidity and mortality in many areas of the world especially in Sub-Saharan Africa and particularly in Cameroon. It is characterised by febrile manifestation, liver inflammation and anaemia. Toxoplasmosis is another parasitic infection caused by an obligate intracellular parasite (Toxoplasma gondii) and is found in many countries of the world. It causes spontaneous abortion in pregnant women and hydrocephally in new- born babies. Malaria and Toxoplasmosis co-infections can cause serious pathological consequences on both mother and fœtus. The aim of this study was to determine the prevalence of malaria, toxoplasmosis, and malaria and toxoplasmosis coinfection in pregnant women during ante natal consultations at Biyem - Assi hospital and to assess their knowledge of the pathological consequences of malaria, toxoplasmosis, and coinfection on the mother and baby. It was a cross-sectional study. Blood samples were collected by finger-prinking and structured questionnaires were administered to 226 pregnant women. The results showed that 39.38 %, 23 % and 8.4 % of women tested positive for malaria, toxoplasmosis and coinfection respectively. The most commonly cited consequence of theses infections was spontaneous abortion. The results obtained showed a significant association between the level of education and the level of knowledge of women about toxoplasmosis and coinfection of toxoplasmosis and malaria (p < 0.05). The level of knowledge of the pregnant woman is not satisfactory as regards toxoplasmosis and co-infection but quite good as regards malaria. The studies have revealed the need for continouos education on toxoplasmosis for pregnant women and girls of childbearing age, and more comprehensive preventive measures. The implementation of public health and education policies that take into account economic, social, environmental and cultural differences are of prime importance.

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Low seroprevalence of Toxoplasma gondii IgG and IgM antibodies in pregnant women of northern Durango, Mexico

10.21203/rs.2.13146/v1 ◽

2019 ◽

Author(s):

Rolando Adair Facio Campos ◽

Cosme Alvarado Esqu ◽

Edgar Olivas

Keyword(s):

Toxoplasma Gondii ◽

Health Services ◽

Pregnant Women ◽

Meat Consumption ◽

Cross Sectional Study ◽

Igg Antibodies ◽

Cross Sectional ◽

Igm Antibodies ◽

Commercial Kits ◽

Almost All

Abstract Toxoplasmosis is caused by intracellular parasite Toxoplasma gondii (T. gondii) a zoonotic disease that infects almost all warm-blooded animals, including humans. In addition, T. gondii infection can result in serious and life-threatening consequences for the developing fetus or newborn, including spontaneous abortion, congenital blindness, hydrocephalus, mental retardation, and even death. The aim of this research was to estimate the frequency of seropositivity to IgM and IgG antibodies against T. gondii in pregnant women attended in the health services of the “Lagunera” region of Durango State in the period of January 2018 - October 2018. A cross-sectional study was conducted on 434 pregnant women who used the health services of Durango State. Serum was analyzed for T. gondii infection by detecting IgG and IgM anti-T. gondii antibodies using commercial kits through the immunological technique of ELISA. In addition, a standardized questionnaire was applied to evaluate risk factors and sociodemographic characteristics of the participants. From 434 participants, 4 were detected with IgG antibodies (0.92%) and none of these had a positive result to IgM antibodies (0%). Dry meat consumption (OR = 13.5; 95% CI 0.94 – 192.58; p= 0.055) and other types of meat consumption (OR = 15.61; 95% CI 1.08 – 224.05; p= 0.043) were associated factors to infection. The results showed a lower seroprevalence of antibodies against T. gondii than any other study reported before. In addition, our results indicate the majority of the population studied is at risk of having a primary T. gondii infection.

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Seroprevalence of Immunoglobulin G (IgG) and Immunoglobulin M (IgM) and Risk Factors of Toxoplasmosis for A sample of Pregnant Women in Baghdad

AL-Kindy College Medical Journal ◽

10.47723/kcmj.v13i2.92 ◽

2019 ◽

Vol 13 (2) ◽

pp. 40-45

Author(s):

Huda Sahib Abdul Mohammed Al-Rawazq

Keyword(s):

Risk Factors ◽

Toxoplasma Gondii ◽

Pregnant Women ◽

Immunoglobulin G ◽

Clinical Manifestations ◽

Immunoglobulin M ◽

Enzyme Linked Immunosorbent Assay ◽

Cross Sectional ◽

Igm Antibodies ◽

Wide Range

Background: Toxoplasmosis is a very common infection caused by the obligate intracellular protozoan parasite. This parasite is called Toxoplasma gondii widely distributed around the world . Toxoplasma gondii can be vertically transmitted to the fetus during pregnancy and may cause wide range of clinical manifestations in the offspring. Objective: To determine seroprevalence Immunoglobulin G (IgG) and Immunoglobulin M (IgM ) to toxoplasma gondii among pregnant women and to identify the risk factors. Type of the study: A cross-sectional study. Methods: A total of 110 blood samples of pregnant women were collected from private laboratory for Dr. luay Ibrahim to Pathogenesis Analyses in Baghdad Al-Mansour- 14 Ramadan street . Which obtained during the period from 1st March 2016 till the 30th June 2016. Data was collected by using direct interviewing questionnaire sheet concerning their ages of pregnant women between (less than 20 to more than 40 years old), place of residence ( urban, rural), level of education (illiteracy, literacy), number of pervious abortion (one, two, three or more), contact with ( cat and other domestic animal or no animal in house). The diagnosis is based on IgG and IgM antibodies of Toxoplasma gondii were measured using a commercial Kit ( Cobas Toxo IgG, Toxo IgM) according to the Roche Diagnostic manufacturer's instructions. Each blood was analyzed for the presence of Toxoplasma gondii by identifying serum IgG and IgM antibodies using Enzyme-linked Immunosorbent Assay (ELISA). Results: A total of 110 pregnant women were enrolled and screened for the presence of anti- toxoplasma IgG and IgM antibodies. The seroprevalence of Toxoplasma gondii IgG and IgM antibodies result revealed that 40 (63.4 %) of 110 pregnant women were positive for anti-toxoplasma-antibody IgG and 70 (63.6 %) of 110 were negative for anti-toxoplasma-antibody-IgG while revealed that 16 (13.6 %) of 110 pregnant women were positive for anti-toxoplasma-antibody IgM and 94 (86.4 %) of 110 were negative for anti-toxoplasma-antibody IgM. Conclusions: the present study shows that anti-Toxoplasma IgG Ab are higher than anti-Toxoplasma IgM Ab in pregnant women between the age group 20 to 30 years in literacy educational level and rural area also recorded the highest rates of seropositivity among women with only one previously abortion in contact with cats are more affected.

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The association between subclinical hypothyroidism and TPOAb positivity with infertility in a population-based study: Tehran thyroid study (TTS)

BMC Endocrine Disorders ◽

10.1186/s12902-021-00773-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Batul Birjandi ◽

Fahimeh Ramezani Tehrani ◽

Atieh Amouzegar ◽

Maryam Tohidi ◽

Razieh Bidhendi Yarandi ◽

...

Keyword(s):

Thyroid Autoimmunity ◽

Population Based ◽

Cross Sectional Study ◽

Cross Sectional ◽

Population Based Study ◽

History Of ◽

Autoimmune Condition ◽

Biochemical Measurements ◽

Adverse Pregnancy ◽

Adjusted Logistic Regression

Abstract Background Thyroid autoimmunity(TAI) is the most prevalent autoimmune condition in women of fertile age. There are increasing data regarding the association of thyroid dysfunction and thyroid autoimmunity with adverse pregnancy outcomes but there is no consensus regarding infertility and TPOAb positivity; thus we aimed to evaluate the association between thyroid TPOAb positivity and infertility in females and males in a population-based study (TTS). Methods Cross-sectional study of 3197 female and male participants in Tehran Thyroid Study (TTS) at the framework of the Tehran Lipid and Glucose Study (TLGS). Data included biochemical measurements and a self-administered questionnaire. Results A total of 12,823 cases in phase 4, 3719 cases (2108 female and 1611 male) were analyzed. The mean TSH of the infertile female and male was 2.52 ± 2.68 μIU/ml and 3.24 ± 10.26 μIU/ml respectively. The TPO median(IQR) of women with and without a history of infertility were 6.05 (3.30–13.96)and 6.04 (3.17–11.15);(P = 0.613), they were 5.08 (3.20–125.68) and 5.31 (3.93–125.68);(P = 0.490) in male participants, respectively. Results of crude and adjusted logistic regression analysis of the development of infertility by thyroid function and TPOAb, except for fT4 in male subjects, depicted no association between infertility and other variables in both crude and adjusted models. Conclusion Based on the result, thyroid autoimmunity was not associated with infertility in both females and males.

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Trichomonas vaginalis Infection among Pregnant Women in Jimma University Specialized Hospital, Southwest Ethiopia

ISRN Infectious Diseases ◽

10.5402/2013/485439 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Abdurehman Eshete ◽

Zeleke Mekonnen ◽

Ahmed Zeynudin

Keyword(s):

Pregnant Women ◽

Trichomonas Vaginalis ◽

Cross Sectional Study ◽

Culture Technique ◽

Agar Culture ◽

Cross Sectional ◽

Sexually Transmitted ◽

Specialized Hospital ◽

Adverse Pregnancy ◽

Jimma University

Background. Trichomonas vaginalis is a sexually transmitted parasitic protozoan known to be responsible for an estimated 180 million new infections per year, making it the most prevalent nonviral sexually transmitted pathogen worldwide. Method. A cross-sectional study design was conducted on vaginal swabs by wet mount and Modified Columbia Agar culture technique in Jimma University Specialized Hospital (JUSH), ANC clinic, Jimma, Ethiopia. The study was done to assess the magnitude and associated risk factors of T. vaginalis infection from December to May, 2011/2012. Result. A total of 361 pregnant women were involved in this study. From these, 18 (4.98%) of the pregnant women were positive for T. vaginalis infection by Modified Columbian Agar culture technique. Education status (AOR = 0.186, 95% CI: 0.059–0.585, P<0.05), patients with dysuria (AOR = 0.180; 95% CI: 0.046–0.704, P<0.05) and dyspareunia (AOR = 0.152; 95% CI: 0.035–0.667, P<0.05) were significantly associated with T. vaginalis infection. Conclusion. The prevalence of T. vaginalis infection at 4.89% is relatively high among young reproductive aged women. Because this infection increases the risk of HIV transmission and is associated with adverse pregnancy outcomes, there is a need for increased provision of health information concerning T. vaginalis to the community, educating women, screening, and treatment of T. vaginalis infection in Ethiopia.

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Determinants of anemia among pregnant women: A hospital based cross sectional study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20193783 ◽

2019 ◽

Vol 8 (9) ◽

pp. 3609

Author(s):

P. Kalpana ◽

A. Kavitha

Keyword(s):

Pregnant Women ◽

Demographic Data ◽

Cross Sectional Study ◽

Hemoglobin Level ◽

Sectional Study ◽

Cross Sectional ◽

Lower Segment Cesarean Section ◽

Menstrual History ◽

History Of ◽

The Mean

Background: The objective was to study the determinants of anemia among pregnant women. There is a negative effect on the health of the mother and as well as that of the child due to anemia in women with pregnancy. Death rate is more in women who are pregnant and having anemia. The objective of this study was to study the determinants of anemia among pregnant women.Methods: A hospital based cross sectional study was carried out among 40 pregnant women over a period of six months. Demographic data like age, residence, occupation etc was recorded. Obstetric data like gravida, parity, previous LSCS was also recorded. The data was presented as means and student’s t test was applied.Results: The mean age was 23.43±3.4 years. Majority were young between the ages of 19-22 years. Majority belonged to urban residents i.e. 57.5%. 20% of the subjects were found to be illiterate. Majority of the mothers were housewives i.e. 82.5%. Majority were multi-gravida i.e. 60%. Majority had no history of abortions in the past i.e. 75%. Out of total 19 repeat pregnancies, majority i.e. 84.2% had lower segment cesarean section. Majority reported that they had normal menstrual history. The mean hemoglobin level was found out to be 7.94 gm/dl. It was found that the mean hemoglobin level did not differ significantly across age, residence, education, occupation, gravidity, history of abortions, type of delivery but differed significantly by abnormal menstrual cycle.Conclusions: Mean hemoglobin level was more in women with normal menstrual history compared to those women with abnormal menstrual history and this difference was found out to be statistically significant. Hence abnormal menses should be promptly treated, hemoglobin assessed.

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Assessment of Prevalence of Hypertension in pregnant women with its Complications: A Cross Sectional Study

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00659 ◽

2021 ◽

pp. 3805-3808

Author(s):

Hemalatha S. ◽

S. M. Shaheedha ◽

Ramakrishna Borra

Keyword(s):

Pregnant Women ◽

Cross Sectional Study ◽

World Health ◽

Chronic Hypertension ◽

Pregnancy Induced Hypertension ◽

Cross Sectional ◽

Mortality And Morbidity ◽

Gynecology And Obstetrics ◽

Induced Hypertension ◽

History Of

Introduction: World Health Organization has reported that pregnancy induced hypertension is one of the main causes for mortality and morbidity in maternal and fetal deaths. About 60% of deaths accounted of eclampsia. Aims and Objectives: To diagnose for hypertension in pregnant women. To evaluate the knowledge of pregnancy induced hypertension among the pregnant women. To investigate the complications reported in Pregnancy induced hypertension (PIH) women, during and after labor. Study area and period: The present study was conducted in Chittoor government hospital, Chittoor, during the period of Jan 2016 and Dec 2017. The information and materials required for the study have been collected from the gynecology and obstetrics departments of the respective hospital. Results: During the study period of Jan 2016 and Dec 2017, about 2234 number of pregnant women have visited the obstetrics and gynecology department. All the 2234 pregnant women were tested for blood pressure. Among which 198 women were found to have hypertension, which may be of early onset PIH or chronic hypertension (HTN). Different variables of the study population like period of gestation [<20 weeks, ≥20 weeks], previous cesarean section if present, previous preterm delivery if present, hypertension in previous pregnancy, history of paternal hypertension, history of abortions if have been, history of any still births, family history of PIH have been noted and reported in table 2. More than 8% of women were found to been falling in <20 weeks of gestational age (GA). Conclusion: The study included 2234 pregnant women, in which 198 women were diagnosed with hypertension. Thus, prior investigation and identification hypertension in pregnant women helps in better management of PIH and to overcome the complications that are reported due to PIH during and after labor. Better knowledge and treatment is required for managing hypertension in maternal women in gynecology and obstetrics department for maternal and fetal care.

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