scholarly journals High risk groups for severe COVID-19 in a whole of population cohort in Australia

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bette Liu ◽  
Paula Spokes ◽  
Wenqiang He ◽  
John Kaldor
Keyword(s):  
Socioeconomic Status ◽  
New South ◽  
Severe Disease ◽  
Risk Groups ◽  
Prevention Strategies ◽  
Complete Case ◽  
Relative Risks ◽  
South Wales ◽  
Hazard Ratios

Abstract Background Increasing age is the strongest known risk factor for severe COVID-19 disease but information on other factors is more limited. Methods All cases of COVID-19 diagnosed from January–October 2020 in New South Wales Australia were followed for COVID-19-related hospitalisations, intensive care unit (ICU) admissions and deaths through record linkage. Adjusted hazard ratios (aHR) for severe COVID-19 disease, measured by hospitalisation or death, or very severe COVID-19, measured by ICU admission or death according to age, sex, socioeconomic status and co-morbidities were estimated. Results Of 4054 confirmed cases, 468 (11.5%) were classified as having severe COVID-19 and 190 (4.7%) as having very severe disease. After adjusting for sex, socioeconomic status and comorbidities, increasing age led to the greatest risk of very severe disease. Compared to those 30–39 years, the aHR for ICU or death from COVID-19 was 4.45 in those 70–79 years; 8.43 in those 80–89 years; 16.19 in those 90+ years. After age, relative risks for very severe disease associated with other factors were more moderate: males vs females aHR 1.40 (95%CI 1.04–1.88); immunosuppressive conditions vs none aHR 2.20 (1.35–3.57); diabetes vs none aHR 1.88 (1.33–2.67); chronic lung disease vs none aHR 1.68 (1.18–2.38); obesity vs not obese aHR 1.52 (1.05–2.21). More comorbidities was associated with significantly greater risk; comparing those with 3+ comorbidities to those with none, aHR 5.34 (3.15–9.04). Conclusions In a setting with high COVID-19 case ascertainment and almost complete case follow-up, we found the risk of very severe disease varies by age, sex and presence of comorbidities. This variation should be considered in targeting prevention strategies.

scholarly journals A population-based longitudinal study of Clostridium difficile infection-related hospitalization in mid-age and older Australians

2016 ◽  
Vol 145 (3) ◽  
pp. 575-582 ◽  
Author(s):  
Y. CHEN ◽  
K. GLASS ◽  
B. LIU ◽  
T.V. RILEY ◽  
R. KORDA ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Cox Regression ◽  
New South ◽  
Population Based ◽  
Crude Incidence ◽  
Median Hospital Stay ◽  
Hospitalization Rates ◽  
South Wales ◽  
Hazard Ratios

SUMMARYClostridium difficile is the principal cause of infectious diarrhoea in hospitalized patients. We investigated the incidence and risk factors for hospitalization due to C. difficile infection (CDI) in older Australians. We linked data from a population-based prospective cohort study (the 45 and Up Study) of 266 922 adults aged ⩾45 years recruited in New South Wales, Australia to hospitalization and death records for 2006–2012. We estimated the incidence of CDI hospitalization and calculated days in hospital and costs per hospitalization. We also estimated hazard ratios (HR) for CDI hospitalization using Cox regression with age as the underlying time variable. Over a total follow-up of 1 126 708 person-years, 187 adults had an incident CDI hospitalization. The crude incidence of CDI hospitalization was 16·6/100 000 person-years, with a median hospital stay of 6 days, and a median cost of AUD 6102 per admission. Incidence increased with age and year of follow-up, with a threefold increase for 2009–2012. After adjustment, CDI hospitalization rates were significantly lower in males than females (adjusted HR 0·6, 95% confidence interval 0·4–0·7). CDI hospitalization rates increased significantly over 2009–2012. There is a need to better understand the increasing risk of CDI hospitalization in women.

Contrasting temporal trends in lung cancer incidence by socioeconomic status among women in New South Wales, Australia, 1985–2009

Lung Cancer ◽  
2017 ◽  
Vol 108 ◽  
pp. 55-61 ◽  
Author(s):  
Xue Qin Yu ◽  
Qingwei Luo ◽  
Clare Kahn ◽  
Paul Grogan ◽  
Dianne L. O’Connell ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Socioeconomic Status ◽  
Cancer Incidence ◽  
New South ◽  
New South Wales ◽  
Temporal Trends ◽  
Lung Cancer Incidence ◽  
South Wales

The Distribution of Phytophthora cinnamomi Rands at Two Sites in Southern Western Australia and at Durras in South-Eastern New South Wales.

1982 ◽  
Vol 30 (2) ◽  
pp. 139 ◽  
Author(s):  
WM Blowes ◽  
WA Heather ◽  
N Malajczuk ◽  
SR Shea
Keyword(s):  
Western Australia ◽  
Phytophthora Cinnamomi ◽  
New South ◽  
New South Wales ◽  
Native Forest ◽  
Prevention Strategies ◽  
South Eastern ◽  
Isolation Techniques ◽  
South Wales ◽  
Western Australian

Native forest at Durras in south-eastern New South Wales and Jarrahdale in south-western Western Australia was examined for the presence of Phytophthora cinnamomi by two sampling and isolation techniques. With the lupin seeding baiting technique, randomly selected samples of soil and fine roots collected from the New South Wales site yielded P. cinnamomi when baited, while similar baiting of comparable samples from Western Australia failed. Direct plating of samples of upper roots and root collars of recently dead Banksia grandis from Western Australian sites yielded P. cinnamomi, while this organism was not isolated from comparable samples of chlorotic Macrozamia communis collected at the New South Wales site. The results suggest that the form of occurrence of P. cinnamomi and its association with disease in Australia vary in different situations. Viewing each situation independently might ensure the adoption of control/prevention strategies appropriate to all.

scholarly journals Returning to Unpaid Work after Stroke: The Psychosocial Outcomes in Stroke Cohort Study

2019 ◽  
Vol 47 (1-2) ◽  
pp. 1-7
Author(s):  
Cheryl Carcel ◽  
Sara Farnbach ◽  
Beverley M. Essue ◽  
Qiang Li ◽  
Nick Glozier ◽  
...  
Keyword(s):  
Sex Differences ◽  
Cohort Study ◽  
New South ◽  
Psychosocial Outcomes ◽  
Unpaid Work ◽  
Stroke Recovery ◽  
Paid Work ◽  
Unpaid Care ◽  
South Wales

Background: While returning to paid work is a crucial marker of stroke recovery, little is known about the differences in unpaid work by sex following stroke. We aimed to determine the sex differences in participation in unpaid work 12 months after stroke. Methods: Psychosocial outcomes in stroke were a prospective, multicentre observational study that recruited individuals, 18–64 years, within 28 days of stroke from New South Wales, Australia. Unpaid work was defined as ≥5 h per week of one or more of: unpaid domestic work for the household; unpaid care of others; looking after own children without pay or looking after someone else’s children without pay. Data was collected before stroke, 28 days (baseline), 6 and 12 months follow-up. Results: Eighty per cent of women and 52% of men engaged in ≥5 h per week of unpaid work before stroke. At 12 months after, 69% of women and 53% of men completed ≥5 h of unpaid work per week. For women, there was a significant association between participation in unpaid work at 12 months and having financially dependent children (OR 2.67; 95% CI 1.08–6.59). A return to unpaid work in men was associated with participation in unpaid work before stroke (OR 3.74; 95% CI 2.14–6.53). Conclusions: More women are engaged in unpaid work before and at 12 months after stroke, but there is a reduction in the proportion of women returning to unpaid work at 12 months not seen in men. Consideration may need to be given to the development of rehabilitation strategies targeted at the specific needs of stroke survivors.

Hematopoietic cell transplantation comorbidity index predicts transplantation outcomes in pediatric patients

Blood ◽  
2011 ◽  
Vol 117 (9) ◽  
pp. 2728-2734 ◽  
Author(s):  
Angela R. Smith ◽  
Navneet S. Majhail ◽  
Margaret L. MacMillan ◽  
Todd E. DeFor ◽  
Sonata Jodele ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Cell Transplantation ◽  
Pediatric Patients ◽  
Hematopoietic Cell Transplantation ◽  
Risk Groups ◽  
Hematopoietic Cell ◽  
Relative Risks ◽  
Innovative Therapies ◽  
Comorbidity Index

Abstract Quantifying the risk of hematopoietic cell transplantation (HCT)–related mortality for pediatric patients is challenging. The HCT-specific comorbidity index (HCT-CI) has been confirmed as a useful tool in adults, but has not yet been validated in children. We conducted a retrospective cohort study of 252 pediatric patients undergoing their first allogeneic HCT between January 2008 and May 2009. Pretransplantation comorbidities were scored prospectively using the HCT-CI. Median age at transplantation was 6 years (range, 0.1-20) and median follow-up was 343 days (range, 110-624). HCT-CI scores were distributed as follows: 0, n = 139; 1-2, n = 52; and 3+, n = 61. The 1-year cumulative incidence of nonrelapse mortality (NRM) increased (10%, 14%, and 28%, respectively; P < .01) and overall survival (OS) decreased (88%, 67%, and 62%, respectively; P < .01) with increasing HCT-CI score. Multivariate analysis showed that compared with score 0, those with scores of 1-2 and 3+ had relative risks of NRM of 1.5 (95% confidence interval, 0.5-4.3, P = .48) and 4.5 (95% confidence interval, 1.7-12.1, P < .01), respectively. These results indicate that the HCT-CI score predicts NRM and OS in pediatric patients undergoing HCT and is a useful tool to assess risk, guide counseling in the pretransplantation setting, and devise innovative therapies for the highest risk groups.

Health Burden of PM2.5 and Socioeconomic Status in the New South Wales Greater Metropolitan Region

2018 ◽  
Vol 2017 (1) ◽  
pp. 645
Author(s):  
Edward Jegasothy ◽  
Richard Broome ◽  
Martin Cope ◽  
Kathryn Emmerson ◽  
Margaret I. Rolfe ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
New South ◽  
New South Wales ◽  
Metropolitan Region ◽  
Health Burden ◽  
South Wales

Australian trends in mortality by socioeconomic status using NSW small area data, 1970–89

1995 ◽  
Vol 27 (4) ◽  
pp. 409-419 ◽  
Author(s):  
Susan Quine ◽  
Richard Taylor ◽  
Lillian Hayes
Keyword(s):  
Socioeconomic Status ◽  
Local Government ◽  
Census Data ◽  
New South ◽  
Common Trend ◽  
South Wales ◽  
Males And Females ◽  
Socioeconomic Differentials ◽  
Industrialised Countries ◽  
The Relationship

SummaryThis ecological study examines trends in socioeconomic differentials in mortality in New South Wales, Australia, over a 20-year period (1970–89). The proportion unskilled was used as the indicator of socioeconomic status and its selection justified. Using census data aggregated by Local Government Area, the relationship between mortality and socioeconomic status was examined using quintiles based on the proportion unskilled in the population. Local Government Areas were also sorted into quintiles using mortality rates (0–74 years) to describe change in mortality differentials over time. Socioeconomic differentials were more evident in the relatively homogeneous Local Government Areas within the Sydney Statistical Division than in the remaining NSW Statistical Divisions which are more heterogeneous and predominantly rural. Although there has been an overall decline in mortality for males and females, and for high and low status groups, over this period the relative socioeconomic differentials have not declined. For the most recent period (1985–89) there appears to be some widening of differentials for males. The NSW state trends are generally similar to those reported for Britain and for other industrialised countries, suggesting that this is a common trend and that policies to reduce inequalities have not been effective.

Sign in / Sign up

Export Citation Format

Share Document