scholarly journals The utility of basic blood counts, WBC histogram and C-reactive protein in detecting malaria

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jun Nishimura ◽  
Parag Dharap ◽  
Sebastien Raimbault
Keyword(s):  
Blood Cells ◽  
Malaria Infection ◽  
Monsoon Season ◽  
Characteristic Curve ◽  
White Blood Cells ◽  
C Reactive Protein ◽  
Control Groups ◽  
Reactive Protein ◽  
Hematology Analyzer ◽  
And Control

Abstract Background Hematology analyzers display abnormal parameters during malaria infection providing insightful information for suspecting and assessing malaria infection. The goal of this study is to demonstrate the potential of a three-part differential hematology analyzer to assess malaria, provide information about the parasitemia, and discuss the importance of combining C-reactive protein (CRP) with hematology parameters to obtain further information about the malaria infection. Methods The present study shows the results of a case–control study during the monsoon season of years 2018 and 2019 in Mumbai, India. The study considers 1008 non-malaria febrile cases, 209 P. vivax and 31 P. falciparum positive malaria samples, five cases of mixed P. vivax and P. falciparum infection, and three co-infection cases of P. vivax and dengue. Raw data from the three-part analyzer LC-667G CRP (HORIBA) and the corresponding microscopic findings (golden standard for diagnosis of malaria) were obtained for each sample. Results The medians of platelet counts (PLT) were 102.5, 109.0, and 223.0 × 103/µL, while CRP medians were 67.4, 81.4 and 10.4 mg/L in P. vivax, P. falciparum and control groups respectively (p < 0.001 in Mann–Whitney U tests between malaria and control groups). Compared with negative samples, platelets counting less than 161.5 × 103/µL were observed on malaria patients (OR 19.12, 95% CI 11.89–30.75). Especially in P. vivax cases, an abnormal peak was frequently observed in the white blood cells (WBC) histogram around the 37fL channel. The events counted around that channel showed a linear correlation with the counting of red blood cells infected predominantly with larger parasitic forms. Parameters like CRP (rs = 0.325, p < 0.001), WBC (rs = 0.285, p < 0.001) and PLT (rs = − 0.303, p < 0.001) were correlated with the parasitemia of P. vivax samples. Between the malaria and dengue groups, the highest area under the receiver operating characteristic curve was observed on CRP (0.867, CRP ≥ 26.85 mg/L). Conclusions A three-part differential hematology analyzer has the potential to not only trigger malaria diagnosis confirmation but also assess the severity of the infection when CRP is considered.

scholarly journals Utility of procalcitonin, C-reactive protein and white blood cells alone and in combination for the prediction of clinical outcomes in community-acquired pneumonia

2015 ◽  
Vol 53 (4) ◽  
Author(s):  
Andriy Zhydkov ◽  
Mirjam Christ-Crain ◽  
Robert Thomann ◽  
Claus Hoess ◽  
Christoph Henzen ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Clinical Outcomes ◽  
Blood Cells ◽  
White Blood Cells ◽  
Community Acquired Pneumonia ◽  
Adverse Clinical Outcome ◽  
C Reactive Protein ◽  
Prognostic Information ◽  
Reactive Protein

AbstractThe added value of biomarkers, such as procalcitonin (PCT), C-reactive protein (CRP), and white blood cells (WBC), as adjuncts to clinical risk scores for predicting the outcome of patients with community-acquired pneumonia (CAP) is in question. We investigated the prognostic accuracy of initial and follow-up levels of inflammatory biomarkers in predicting death and adverse clinical outcomes in a large and well-defined cohort of CAP patients.We measured PCT, CRP and WBC on days 1, 3, 5, and 7 and followed the patients over 30 days. We applied multivariate regression models and area under the curve (AUC) to investigate associations between these biomarkers, the clinical risk score CURB-65, and clinical outcomes [i.e., death and intensive care unit (ICU) admission].Of 925 patients with CAP, 50 patients died and 118 patients had an adverse clinical outcome. None of the initial biomarker levels significantly improved the CURB-65 score for mortality prediction. Follow-up biomarker levels showed significant independent association with mortality at days 3, 5, and 7 and with improvements in AUC. Initial PCT and CRP levels were independent prognostic predictors of adverse clinical outcome, and levels of all biomarkers during the course of disease provided additional prognostic information.This study provides robust insights into the added prognostic value of inflammatory markers in CAP. Procalcitonin, CRP, and to a lesser degree WBC provided some prognostic information on CAP outcomes, particularly when considering their kinetics at days 5 and 7 and when looking at adverse clinical outcomes instead of mortality alone.

scholarly journals Evaluation of Signs of Skin Aging in Patients with Metabolic Syndrome after Substitution Therapy with Antioxidants. Summary of the Doctoral Thesis

2021 ◽  
Author(s):  
◽  
Jana Janovska ◽  
Keyword(s):  
Adult Population ◽  
Interleukin 1 ◽  
Skin Aging ◽  
Retinol Binding Protein ◽  
Antioxidant Defenses ◽  
C Reactive Protein ◽  
Control Groups ◽  
Skin Changes ◽  
Reactive Protein ◽  
And Control

Skin aging is a complex biological phenomenon consisting of two overlapping components: internal (true aging) and external. OS, which is believed to play a central pathogenic role in the development of MetS, is a state of prooxidant / antioxidant imbalance in which the net amount of Reactive Oxygen Species (ROS) exceeds the body's antioxidant defenses. Excess ROS can cause lipid, protein oxidation, and oxidative damage to DNA. MetS is a syndrome, of which main symptoms are obesity, insulin resistance (IR), dyslipidemia and hypertension or high blood pressure. About a third of the adult population in developing countries is currently classified as having MetS according to various criteria (Moore and Chaudhary, and Akinyemiju, 2017). The use of AO has been observed to reduce the OS and inflammatory response involved in the development of MetS (Soory, 2012). The effects of selenium on the expression and secretion of inflammatory and OS biomarkers have been studied in vitro and in vivo in experimental MetS models as well as in humans. There are many studies in the literature on various parameters influenced by blood selenium (Se) levels, such as C-reactive protein, interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and retinol-binding protein (Rayman, 2000; Alissa and Bahijri, and Ferns, 2003). Intake of Se and other AOs is associated with lower C-reactive protein (CRP) in women, indicating a possible anti-inflammatory effect of dietary AO. The above is also relevant in Latvia but has not been studied. There are patients with diabetes, light skin phototype, MetS, cardiovascular diseases in Latvia, but visual changes do not give a complete picture of the aging processes in the skin. Aim of the study. To study the signs of skin photoaging and evaluate the effectiveness of AO therapy in patients with MetS in the Latvian population. Tasks of the study: 1. Evaluate MetS symptoms and skin parameters in MetS patients and control groups. 2. Identify and describe the signs of skin aging in the group of MetS patients (visually, as well as using dermatoscopic and histological examination). 3. Evaluate the skin changes after organic selenium substitution. 4. Evaluate the interrelationships between MetS symptoms, OS parameters and skin changes in MetS patients and control groups. Hypothesis: AO substitution improves skin aging parameters in MetS patients.

Acute Hemodynamic Responses to Combined Exercise and Sauna

2020 ◽  
Vol 41 (12) ◽  
pp. 824-831 ◽  
Author(s):  
Joonas Antero Rissanen ◽  
Keijo Häkkinen ◽  
Jari Antero Laukkanen ◽  
Arja Häkkinen
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Endurance Exercise ◽  
Plasma Volume ◽  
Blood Cells ◽  
White Blood Cells ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Positive Effects ◽  
Volume Measurements

AbstractThis study investigated acute hemodynamic, plasma volume and immunological responses to four loading protocols: sauna only, and sauna after endurance, strength or combined endurance and strength exercise. Twenty-seven healthy, slightly prehypertensive men (age 32.7±6.9 years) were measured at PRE, MID (after exercise), POST, POST30min and POST24h. The measurements consisted systolic and diastolic blood pressure, heart rate, body temperature and concentrations of high-sensitive C-reactive protein, white blood cells and plasma volume measurements. Endurance+sauna showed significant decreases in systolic blood pressure at POST (–8.9 mmHg), POST30min (–11.0 mmHg) and POST24h (–4.6 mmHg). At POST30min, significant decreases were also observed in sauna (–4.3 mmHg) and combined+sauna (–7.5 mmHg). Diastolic blood pressure decreased significantly from -5.4 to –3.9 mmHg at POST in all loadings. Plasma volume decreased significantly at MID in all exercise loadings and at POST in endurance+sauna and strength+sauna. Plasma volume increased significantly (p < 0.01) in endurance+sauna and combined+sauna at POST24h. White blood cells increased following all exercise+sauna loadings at MID, POST and POST30min, whereas high sensitive C-reactive protein showed no changes at any measurement point. The combination of endurance exercise and sauna showed the greatest positive effects on blood pressure. Both loadings including endurance exercise increased plasma volume on the next day.

scholarly journals Su1095 – Serum C Reactive Protein and White Blood Cells Count As Early Predictor of Complication in Mayor Abdominal Surgery

2019 ◽  
Vol 156 (6) ◽  
pp. S-1438
Author(s):  
Bernardo Borraez-Segura ◽  
Manuel Mena ◽  
Felipe Anduquia ◽  
Natalia Hurtado ◽  
Santiago Bedoya ◽  
...  
Keyword(s):  
Abdominal Surgery ◽  
Blood Cells ◽  
White Blood Cells ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Early Predictor

scholarly journals Transient leukocytosis in Emergency Room: an overlooked issue

2017 ◽  
Vol 11 (1) ◽  
pp. 41
Author(s):  
Giampiera Bertolino ◽  
Federica Quaglia ◽  
Luigia Scudeller ◽  
Iride Ceresa ◽  
Carlo L. Balduini
Keyword(s):  
Differential Diagnosis ◽  
Emergency Room ◽  
Blood Cells ◽  
Leukocyte Count ◽  
White Blood Cells ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Reliable Marker ◽  
Wbc Count ◽  
Clinical Records

Leukocytosis is regarded as a reliable marker of a serious disorder requiring hospitalization. However, leukocytosis often disappears once the patient is admitted to a medical ward; differential diagnosis of leukocytosis is often overlooked in the busy Emergency Room (ER) routine. We retrospectively evaluated the clinical records of 565 consecutive patients admitted to the Department of Internal Medicine (DIM) after examination in ER. Mean leukocyte count was 11.4×109/L in ER and 10.1×109/L in DIM (P&lt;0.001). Leukocytosis was found in 53.1% of patients in ER, but in 33% of these it was no longer evident on the following day, unrelated to baseline white blood cells (WBC) count, age, sex, diagnosis, C-reactive protein level and early antibiotic treatment. A reduction in WBC count larger than 40% from baseline occurred in 13.6% of all subjects, and in 31.7% of those with transient leukocytosis. Leukocytosis in ER is frequent, but it is often transient and not associated with an infectious cause. Other causes, including psychological stress caused by the ER access itself, should be considered in the differential diagnosis.

scholarly journals Prediction of Treatment Outcome with Inflammatory Biomarkers after 2 Months of Therapy in Pulmonary Tuberculosis Patients: Preliminary Results

Pathogens ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 789
Author(s):  
Simona Stefanescu ◽  
Relu Cocoș ◽  
Adina Turcu-Stiolica ◽  
Elena-Silvia Shelby ◽  
Marius Matei ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Characteristic Curve ◽  
White Blood Cells ◽  
Inflammatory Biomarkers ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Tuberculosis Patients ◽  
Preliminary Results ◽  
Reactive Protein ◽  
Antituberculosis Treatment

Pro-inflammatory mediators play an important role in the pathogenesis of pulmonary tuberculosis. Consecutively, 26 pulmonary tuberculosis patients were enrolled in our study based on the exclusion criteria. We have used Spearman’s correlation analysis, hierarchical clustering and regression modelling to evaluate the association of 11 biomarkers with culture status after antituberculosis treatment. The results of our study demonstrated that six inflammatory biomarkers of 11, C-reactive protein (CRP), white blood cells (WBC), neutrophils, interferon gamma inducible protein 10, C-reactive protein (CRP) to albumin ratio (CAR) and neutrophil to albumin ratio (NAR), were significantly associated with culture negativity. The predictive ability of a composite model of seven biomarkers was superior to that of any single biomarker based on area under the receiver operating characteristic curve (AUC) analysis, indicating an excellent prediction efficacy (AUC:0.892; 95% CI:0.732-1.0). We also found that the highest significant trends and lower levels of CRP and IP-10 were observed in the two-month treated tuberculosis (TB) patients. We believe that our study may be valuable in providing preliminary results for an additional strategy in monitoring and management of the clinical outcome of pulmonary tuberculosis. Using a panel of predictors added a superior value in predicting culture status after anti-TB therapy.

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