scholarly journals Demographic, clinical, and laboratory factors associated with renal parenchymal injury in Iranian children with acute pyelonephritis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Daryoosh Fahimi ◽  
Leila Khedmat ◽  
Azadeh Afshin ◽  
Mohsen Jafari ◽  
Zakeyeh Bakouei ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Clinical Features ◽  
Acute Pyelonephritis ◽  
Pediatric Patients ◽  
Demographic Data ◽  
Factors Associated ◽  
Laboratory Markers ◽  
Low Bmi ◽  
Iranian Children ◽  
Parenchymal Injury

Abstract Background The association between renal parenchyma changes on dimercaptosuccinic acid (DMSA) scans and demographic, clinical, and laboratory markers was assessed in pediatric patients with acute pyelonephritis. Methods A retrospective study of 67 Iranian babies and children aged 1-month to 12-year with APN was conducted between 2012 and 2018. The presence of renal parenchymal involvement (RPI) during APN was determined using technetium-99m DMSA during the first 2 weeks of hospitalization. The association of DMSA results with demographic data, clinical features (hospitalization stay, fever temperature and duration), and laboratory parameters such as pathogen type, and hematological factors (ESR, CRP, BUN, Cr, Hb, and WBC) was evaluated. Results 92.5% of children with an average age of 43.76 ± 5.2 months were girls. Twenty-four children (35.8%) did not have renal parenchymal injury (RPI), while 26 (38.8%) and 17 (25.4%) patients showed RPI in one and both kidneys, respectively. There was no significant association between RPI and mean ESR, CRP, BUN, and WBC. However, there were significant associations between RPI and higher mean levels of Cr, Hb, and BMI. Conclusions Low BMI and Hb levels and increased Cr levels might be indicative of the presence of RPI in children with APN.

Predictive Factors of Early Mortality in Patients with Multiple Myeloma (MM). Multicentric Study in Chile (1998–2002).

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 5007-5007
Author(s):  
Guillermo F. Conte ◽  
Gaston L. Figueroa ◽  
Vivianne I. Lois ◽  
Maria E. Cabrera ◽  
Alvaro R. Leon ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Clinical Features ◽  
Demographic Data ◽  
Survival Rates ◽  
Staging System ◽  
Early Mortality ◽  
Stage Iii ◽  
Multicentric Study ◽  
Factors Associated ◽  
Medical Centers

Abstract There is no data about the prognosis of patients with MM in Chile, except mortality rate records. The objective of this study is to know the clinical features, survival rates and factors related to early mortality of cases with MM treated in six large medical centers in Chile. Method: Retrospective demographic data, clinical features and survival rate records of patients with MM were collected between 1998 and 2002. Survival curves were generated and a multivariate analysis of factors associated to early mortality was carried out. Results: Data of 245 patients was collected. A 51.8% of them corresponded to IgG myeloma, 25.3% to IgA and a 6.1% to light chains. Distribution according Durie and Salmon was: Stage I: 8.1%; Stage II: 12.7%; Stage III: 60.7% and 18.4% without information. It is pointed out that, among clinical features, a 50% of the cases presented anemia (Hb <10gr/dL), a 30% renal failure (creatininemia >2 mg/dL) and a 28% hypercalcemia (>10.5 mg/dL). The median survival was 33 months. A 20% of patients died within the six first months after diagnosis. The multivariate analysis identified three factors associated to early mortality (survival <6 months): males (p=0.016), beta2-microglobulin >3.5 mg/L (p=0.021) and albuminemia < 3.5 gr/dL (p=0.016). Conclusions: It was observed that, in Chilean population, patients with MM presented a short survival time, and a significative proportion of patients (20%) died within the first six months after the first diagnosis. More than a half of cases were diagnosed at an advanced stage. (Durie and Salmon: Stage III). Three factors associated to early mortality, two of which (beta2-microglobulin and albuminemia) are the foundations of the new international staging system, might be identified.

Characterization of Clinical and Radiological Features of Quasi-Moyamoya Disease among European Caucasians Including Surgical Treatment and Outcome

2016 ◽  
Vol 42 (5-6) ◽  
pp. 464-475 ◽  
Author(s):  
Güliz Acker ◽  
Susanne Goerdes ◽  
Peter Schmiedek ◽  
Marcus Czabanka ◽  
Peter Vajkoczy
Keyword(s):  
Rare Disease ◽  
Clinical Features ◽  
Moyamoya Disease ◽  
Pediatric Patients ◽  
Clinical Symptoms ◽  
Pediatric Population ◽  
Demographic Data ◽  
Associated Diseases ◽  
Wide Range

Background: Moyamoya disease (MMD) associated with a potentially underlying disease, such as genetic disorders or other coexisting hematological pathologies, is called quasi-MMD. This very rare disease has been characterized mainly in Asian countries, so far. As MMD reveals several significant ethnic differences, the question is raised whether characteristics of quasi-MMD would also vary among different ethnic backgrounds. Here, we report a series of 61 patients with quasi-MMD and highlight the specific clinical features of this rare disease among European Caucasians. Methods: We retrospectively identified 61 European Caucasians with quasi-MMD who were treated in our institution between 1997 and 2014. We analyzed demographic data, clinical symptoms, associated diseases, angiographic characteristics and functional hemodynamic studies. Results: Thirty-three percent of our patients were juvenile. We observed an overall female predominance of 2.8:1. Seventy-nine percent presented with a typical quasi-MMD with more pronounced unilateral and atypical quasi-MMD in pediatric population (unilateral/atypical: pediatric patients 20/15%, adults 7/7%). We identified a wide range of associated diseases. Overall, 84 and 8% of our cohort presented initially with ischemic and hemorrhagic manifestation, respectively. The hemorrhagic manifestation of quasi-MMD occurred however only in adults. Angiographic analysis revealed steno-occlusive involvement of the posterior circulation (in addition to the anterior circulation) in 31% with a higher involvement in pediatric patients (40%) compared to adults (27%). Conclusions: The characterization of our European Caucasian cohort reveals several differences when compared to reported Asian quasi-MMD cohorts and also compared to European Caucasian MMD cohort. We conclude that quasi-MMD represents a distinct disease with different ethnic clinical features.

scholarly journals Clinical features and risk factors associated with bacteremia of nontyphoidal salmonellosis in pediatric patients, 2010–2018

2021 ◽  
Vol 120 (1) ◽  
pp. 196-203
Author(s):  
Chieh-Ming Lee ◽  
Min-Sheng Lee ◽  
Te-Liang Yang ◽  
Kuan-Lin Lee ◽  
Ting-Yu Yen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Features ◽  
Pediatric Patients ◽  
Factors Associated

scholarly journals Factors Associated with In-hospital Mortality in Severe Burn Patients in Songklanagarind Hospital: A Retrospective Study

2020 ◽  
Author(s):  
Atthawit Mongkornwong ◽  
Rassamee Sangthong ◽  
Surasak Sangkhathat
Keyword(s):  
Retrospective Study ◽  
Demographic Data ◽  
Burn Patients ◽  
Severe Burn ◽  
Related Factors ◽  
Common Cause ◽  
Factors Associated ◽  
Major Burn ◽  
Blood Creatinine ◽  
Significant Factors

Objective: This study aimed to analyze the factors associated with mortality in burn patients in order to develop a nomogram for predicting mortality that can be used as a guideline to treat major burn patients.Material and Methods: This was a retrospective study done in Songhklanagarind Hospital, Hat Yai, Songkhla, Thailand. The study included major burn patients who were admitted to the burn unit or the intensive care unit between the years 2011 and 2018, and analyzed demographic data and significant factors associated with mortality.Results: A total of 127 major burn patients were treated during the study years, with a mean age of 33 years with an average total burn surface area (TBSA) of 43.5%. The most common cause of the burns was flame injury, and the most significant factors associated with mortality were TBSA >55.0%, blood creatinine >1.2 milligrams per deciliter (mg/dL) and face involvement.Conclusion: The 3 significant burn-related factors of TBSA >55.0%, blood creatinine >1.2 mg/dL and face involvement can be used to predict mortality using the nomogram created in this study.

scholarly journals CLINICAL FEATURES OF SEVERE COVID-19 WITH LETHAL OUTCOME IN VOLYN REGION RESIDENTS

2021 ◽  
Vol 29 (2) ◽  
pp. 16-24
Author(s):  
O. K. Yakovenko ◽  
O. G. Khanin ◽  
V. V. Lotysh ◽  
S. L. Gryf
Keyword(s):  
Renal Failure ◽  
Respiratory Failure ◽  
Clinical Features ◽  
Demographic Data ◽  
Demographic Factors ◽  
Lung Pathology ◽  
Severe Respiratory Failure ◽  
Lethal Outcome ◽  
Laboratory Markers ◽  
D Dimer

On March, 11 2020 WHO declared novel SARS-CoV-2 outbreak as pandemic (Coronavirus disease, COVID-19), which took away almost 4 million lives of our planet population. Management of severe COVID-19 represents the most challenging problem being associated with high level of mortality. Aim of the study: to assess the clinical features of severe COVID-19, demographic factors, laboratory markers and lung pathology findings associated with severe course and lethal outcome. Material and methods. In retrospective cohort survey we recruited 171 adult patients (age > 18 years) with severe COVID-19, admitted to 2nd infection disease department of municipal hospital �Volyn regional clinical hospital� (CE �Voklen�). 101 patients were discharged after completion of treatment. 70 patients died. In two groups (discharged or deceased) we analyzed demographic data, clinical diagnosis, comorbidity and complications, duration of disease and hospital stay, body temperature at admission, blood oxygen saturation at admission and during the course of treatment, major laboratory parameters (WBC, neutrophils, lymphocytes, thrombocytes, RBC, neutrophil/lymphocyte ration (NLR), C-RP, AST, ALT, creatinine, total protein, blood glucose and procalcitonin). Almost all patients were tested for D-dimer, lupus anticoagulant (LA) and blood gases. In part of deceased patients (n=10) an autopsy was performed with subsequent lung tissue histological examination. Results and discussion. Acute respiratory distress syndrome (ARDS) and severe respiratory failure were the major cause of death from COVID19. Concomitant conditions, which worsened the clinical course and prognosis: renal failure, thrombotic events, in part associated with elevation of D-dimer and LA, neoplasm, cardiovascular conditions and diabetes mellitus. Female sex and younger age were the demographic factors of favorable outcome. Leukocytosis, high NLR, increased creatinine (as an indicator of renal failure), hypoproteinemia and high serum glucose level were the laboratory markers of unfavorable prognosis. LA, associated with severe respiratory failure, stroke and vascular thrombosis, were found positive in 40 % of patients with severe COVID-19. Key words: COVID-19, severe course, mortality, prognosis factors.

scholarly journals RI SK FACTOR OF BACTEREMI A I N CHI LDREN WI TH PNEUMONIA

2015 ◽  
Vol 2 (1) ◽  
pp. 34
Author(s):  
Retno Asih
Keyword(s):  
Risk Factors ◽  
Developing Countries ◽  
Retrospective Study ◽  
Blood Culture ◽  
Hospital Admission ◽  
Clinical Features ◽  
Medical Records ◽  
Blood Cultures ◽  
Factors Associated ◽  
Increased Risk

Background: Pneumonia is known as a frequent cause of morbidity and mortality among children in developing countries. In children,it caused predominantly by bacteria. Bacteremia has been associated with severity and mortalitas of pneumonia. Identify factors caused bacteremia important to prevent severity and mortalitas of pneumonia. Objective: The objective of this study was to identify risk factors of bacteremia in children with pneumonia. Methods: A retrospective study was conducted in children with pneumonia in Dr. Soetomo Surabaya Hospital from January 2007 to December 2008. Blood cultures be performed on all of this patients. Factors associated with bacteremia were identified following review of medical records include clinical features, laboratory , radiology and blood culture results. Results: Frequency of bacteremia was 8,2% (36 patients) of 438 children with pneumonia. Interval from onset of symptoms to hospital admission more than 5 days (22.69 CI 95%), severe malnourished (OR 9.05 CI 95%), anemia (OR 2.44 CI 95%), leucocyt counts less than 5000/mm3 and more than 20.000/mm3 (OR 2.41 CI 95%) and paO2 less than 80 mmHg (OR 4.25 CI 95%) were at increased risk of bacteremia in children with pneumonia. Conclusion: Risk factors bacteremia in children with pneumonia included age under 1 year, symptoms more than 5 days, severe malnourished ,anemia, leucosyt counts less than 5000/mmand more than 20.000/mm3 and paO2 less than 80 mmHg.

scholarly journals Interval angioarchitectural evolution of brain arteriovenous malformations following rupture

2019 ◽  
Vol 131 (1) ◽  
pp. 96-103 ◽  
Author(s):  
Hengwei Jin ◽  
Stephanie Lenck ◽  
Timo Krings ◽  
Ronit Agid ◽  
Yibin Fang ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Digital Subtraction Angiography ◽  
Arteriovenous Malformations ◽  
Demographic Data ◽  
Digital Subtraction ◽  
Spontaneous Thrombosis ◽  
Factors Associated ◽  
Brain Arteriovenous Malformations ◽  
Delayed Phase

OBJECTIVEThe goal of this study was to describe changes in the angioarchitecture of brain arteriovenous malformations (bAVMs) between acute and delayed cerebral digital subtraction angiography (DSA) obtained after hemorrhage, and to examine bAVM characteristics predicting change.METHODSThis is a retrospective study of a prospective institutional bAVM database. The authors included all patients with ruptured bAVMs who had DSA in both acute and delayed phases, with no interval treatment of their bAVM, between January 2000 and April 2017. The authors evaluated the existence or absence of angioarchitectural changes. Demographic data, radiological characteristics of hemorrhages, and angioarchitectural features of the bAVMs of the two patients’ groups were analyzed. Univariate and multivariate logistic analyses were performed to identify predictors of angioarchitectural change.RESULTSA total of 42 patients were included in the series. Seventeen (40.5%) patients had angioarchitectural changes including bAVM only visible on the delayed DSA study (n = 8), spontaneous thrombosis of the AVM (n = 3), or alteration of the size or the opacification of the nidus (n = 6). The factors associated with angioarchitectural changes were a small nidus (3.8 ± 7.9 ml vs 6.1 ± 9.5 ml, p = 0.046), a superficial location (94.1% vs 5.9%, p = 0.016), and a single superficial draining vein (58.8% vs 24.0%, p = 0.029).CONCLUSIONSAngioarchitectural changes can be seen in 40% of ruptured bAVMs between the acute- and delayed-phase DSA. A small nidus, a superficial location, and a single superficial draining vein were statistically associated with the occurrence of angioarchitectural changes. These changes included either enlargement or spontaneous occlusion of the bAVM, as well as subsequent diagnosis of a bAVM following an initial negative DSA study.

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