Elevated alanine aminotransferase and low aspartate aminotransferase/alanine aminotransferase ratio are associated with chronic kidney disease among middle-aged women: a cross-sectional study

Abstract Background Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) to ALT ratio (AST/ALT ratio) have been shown to be related to non-alcoholic fatty liver disease or insulin resistance, which was associated with chronic kidney disease (CKD). However, it is unclear whether ALT and AST/ALT ratio are associated with CKD. In this study, we examined the relationship of ALT and AST/ALT ratio to CKD among middle-aged females in Japan. Methods The present study included 29,133 women aged 40 to 64 years who had an annual health checkup in Japan during April 2013 to March 2014. Venous blood samples were collected to measure ALT, AST, gamma-glutamyltransferase (GGT), and creatinine levels. In accordance with previous studies, ALT > 40 U/L and GGT > 50 U/L were determined as elevated, AST/ALT ratio < 1 was regarded as low, and CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2 and/or proteinuria. Logistic regression model was used to calculate the odds ratio (OR) and 95% confidence interval (CI) for CKD. Results “Elevated ALT and elevated GGT” and “elevated ALT and non-elevated GGT” significantly increased the OR for CKD when compared with “non-elevated ALT and non-elevated GGT” (OR: 2.56, 95% CI: 2.10–3.12 and OR: 2.24, 95% CI: 1.81–2.77). Compared with “AST/ALT ratio ≥ 1 and non-elevated GGT”, “AST/ALT ratio < 1 and elevated GGT” and “AST/ALT ratio < 1 and non-elevated GGT” significantly increased the OR for CKD (OR: 2.73, 95% CI: 2.36–3.15 and OR: 1.68, 95% CI: 1.52–1.87). These findings still remained after adjustment for confounders. Conclusions Elevated ALT was associated with CKD regardless of GGT elevation. Moreover, low AST/ALT ratio was also associated with CKD independent of GGT elevation.

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FREQUENCY OF THYROID DYSFUNCTION IN CHRONIC KIDNEY DISEASE PATIENTS

Pakistan Postgraduate Medical Journal ◽

10.51642/ppmj.v31i03.392 ◽

2021 ◽

Vol 31 (03) ◽

pp. 142-145

Author(s):

Adil Mehmood ◽

Roshina Anjum ◽

Muhammad Shahbaz ◽

Rizwan Hafeez ◽

Zahra Fatima ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Thyroid Function ◽

Thyroid Dysfunction ◽

Venous Blood ◽

Cross Sectional Study ◽

Dopamine Antagonists ◽

Thyroid Function Tests ◽

Cross Sectional ◽

Female Ratio

Objectives: To determine the frequency of thyroid dysfunction in chronic kidney disease patients. Methods: It was a Cross-sectional Study at department of Medicine, Bahawal Victoria Hospital, Bahawalpur. Duration of the study was from 20th October 2018 to 19th April 2019. 72 patients with chronic kidney disease, 20 to 60 years of age and of both genders were included. Patients with known thyroid disorders or taking medication that can affect thyroid function (dopamine antagonists, antiepileptic, oral contraceptives, lithium, and glucocorticoids) were excluded. Venous blood sample was taken and sent to the laboratory for thyroid function tests. Results: Age of the patients included in this study was from 20 to 60 year and mean age was 41.97 ± 9.76 years. Most of them 42 (58.33%) were between 41 to 60 years of age. Out of 72 patients, 44 (61.11%) were male and 28 (38.89%) were female with male to female ratio of 1.6:1. Mean duration of disease in our study was 5.71 ± 2.50 years .Mean BMI was 27.75 ± 3.01 kg/m2.Thyroid dysfunction was present in 23 (31.94%) patients of chronic kidney disease. Conclusion: Thyroid dysfunction is frequently found in chronic kidney disease patients.

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Hubungan Kejadian Anemia dengan Penyakit Ginjal Kronik pada Pasien yang Dirawat di Bagian Ilmu Penyakit Dalam RSUP dr M Djamil Padang Tahun 2010.

Jurnal Kesehatan Andalas ◽

10.25077/jka.v5i3.574 ◽

2016 ◽

Vol 5 (3) ◽

Author(s):

Rahmat Hidayat ◽

Syaiful Azmi ◽

Dian Pertiwi

Keyword(s):

Chronic Kidney Disease ◽

Glomerular Filtration Rate ◽

Kidney Disease ◽

Glomerular Filtration ◽

Medical Record ◽

Filtration Rate ◽

Cross Sectional Study ◽

Cross Sectional ◽

Relationship Of ◽

The Relationship

AbstrakAnemia merupakan salah satu masalah utama pada pasien penyakit ginjal kronik. Tinggi rendahnya laju filtrasi glomerulus mempengaruhi kejadian anemia pada penyakit ginjal kronik. Tujuan penelitian ini adalah mengidentifikasi hubungan kejadian anemia dengan penyakit ginjal kronik pada pasien yang dirawat di Bagian Penyakit Dalam tahun 2010. Penelitian yang dilakukan merupakan survei analitik dengan menggunakan design penelitian cross sectional study. Penelitian menggunakan data sekunder yang diambil dari sub bagian Rekam Medik (Medical Record) RSUP dr. M Djamil Padang dari Juni–Desember 2012 dengan jumlah sampel adalah 67 pasien penyakit ginjal kronik. Ditemukan angka kejadian anemia pada pasien penyakit ginjal kronik sebesar 98,5% dengan rata-rata kadar Hb sebesar 7,3 g/dl dan rata-rata laju filtrasi glomerulus adalah 8,81 ml/menit/1.73m2. Dari hasil uji korelasi Pearson diperoleh hasil adanya hubungan kejadian anemia dengan penyakit ginjal kronik di RSUP dr M Djamil Padang dengan p = 0,00 (p < 0,05). Kesimpulan hasil penelitian ini adalah semakin rendah laju filtrasi glomerulus menunjukkan semakin rendah juga kadar hemoglobin pada pasien penyakit ginjal kronik.Kata kunci: anemia, penyakit ginjal kronik, laju filtrasi glomerulus AbstractAnemia is one of the major problems in patients with chronic kidney disease. High and low glomerular filtration rate affect the incidence of anemia in chronic kidney disease. The objective of this study was to identify the relationship of anemia on patients with chronic kidney disease in the Internal Medicine. The type of this research was analytic studies using a cross sectional study research design from June–December 2012 . This study used secondary data taken from Medical Record department of dr. M. Djamil hospital with samples of the entire medical record is 67 persons chronic kidney disease patients in 2010. The result found the incidence of anemia in chronic kidney disease patients was 98.5%, with an average hemoglobin level at 7.3 g/dl and mean glomerular filtration rate was 8.81 ml /min/1.73m2. Pearson correlation of test results obtained by the result of the relationship of anemia on patients with chronic kidney disease at dr M Djamil Padang Hospital with p = 0.00 (p <0,05). The low rate of glomerular filtration rate also showed by the low level of hemoglobin in patients with chronic kidney disease Keywords: anemia, chronic kidney disease, glomerular filtration rate

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Left ventricular global longitudinal strain in chronic kidney disease patients with and without renal replacement therapy: A cross-sectional study

Indian Heart Journal ◽

10.1016/j.ihj.2020.11.074 ◽

2020 ◽

Vol 72 ◽

pp. S26

Author(s):

Ramesh Sankaran ◽

S. Ramalakshmi ◽

Manish Babbu Uppupetai Ganeshbabbu ◽

M. Jayakumar ◽

T.R. Muralidharan ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Renal Replacement Therapy ◽

Kidney Disease ◽

Replacement Therapy ◽

Longitudinal Strain ◽

Global Longitudinal Strain ◽

Cross Sectional Study ◽

Left Ventricular ◽

Sectional Study ◽

Cross Sectional

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Gut Microbiome Composition Remains Stable in Individuals with Diabetes-Related Early to Late Stage Chronic Kidney Disease

Biomedicines ◽

10.3390/biomedicines9010019 ◽

2020 ◽

Vol 9 (1) ◽

pp. 19

Author(s):

Ashani Lecamwasam ◽

Tiffanie M. Nelson ◽

Leni Rivera ◽

Elif I. Ekinci ◽

Richard Saffery ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Relative Abundance ◽

Cross Sectional Study ◽

Early Event ◽

Sectional Study ◽

Cross Sectional ◽

Microbiome Composition ◽

Stool Samples ◽

Late Stages

(1) Background: Individuals with diabetes and chronic kidney disease display gut dysbiosis when compared to healthy controls. However, it is unknown whether there is a change in dysbiosis across the stages of diabetic chronic kidney disease. We investigated a cross-sectional study of patients with early and late diabetes associated chronic kidney disease to identify possible microbial differences between these two groups and across each of the stages of diabetic chronic kidney disease. (2) Methods: This cross-sectional study recruited 95 adults. DNA extracted from collected stool samples were used for 16S rRNA sequencing to identify the bacterial community in the gut. (3) Results: The phylum Firmicutes was the most abundant and its mean relative abundance was similar in the early and late chronic kidney disease group, 45.99 ± 0.58% and 49.39 ± 0.55%, respectively. The mean relative abundance for family Bacteroidaceae, was also similar in the early and late group, 29.15 ± 2.02% and 29.16 ± 1.70%, respectively. The lower abundance of Prevotellaceae remained similar across both the early 3.87 ± 1.66% and late 3.36 ± 0.98% diabetic chronic kidney disease groups. (4) Conclusions: The data arising from our cohort of individuals with diabetes associated chronic kidney disease show a predominance of phyla Firmicutes and Bacteroidetes. The families Ruminococcaceae and Bacteroidaceae represent the highest abundance, while the beneficial Prevotellaceae family were reduced in abundance. The most interesting observation is that the relative abundance of these gut microbes does not change across the early and late stages of diabetic chronic kidney disease, suggesting that this is an early event in the development of diabetes associated chronic kidney disease. We hypothesise that the dysbiotic microbiome acquired during the early stages of diabetic chronic kidney disease remains relatively stable and is only one of many risk factors that influence progressive kidney dysfunction.

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FGF-23 and Phosphate in Children with Chronic Kidney Disease: A Cross-Sectional Study in Kazakhstan

Medicina ◽

10.3390/medicina57010015 ◽

2020 ◽

Vol 57 (1) ◽

pp. 15

Author(s):

Altynay Balmukhanova ◽

Kairat Kabulbayev ◽

Harika Alpay ◽

Assiya Kanatbayeva ◽

Aigul Balmukhanova

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Fibroblast Growth Factor 23 ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Ckd Stage ◽

Advanced Stages ◽

Fgf 23 ◽

Stage 1

Background and objectives: Chronic kidney disease (CKD) in children is a complex medical and social issue around the world. One of the serious complications is mineral-bone disorder (CKD-MBD) which might determine the prognosis of patients and their quality of life. Fibroblast growth factor 23 (FGF-23) is a phosphaturic hormone which is involved in the pathogenesis of CKD-MBD. The purpose of the study was to determine what comes first in children with CKD: FGF-23 or phosphate. Materials and Methods: This cross-sectional study included 73 children aged 2–18 years with CKD stages 1–5. We measured FGF-23 and other bone markers in blood samples and studied their associations. Results: Early elevations of FGF-23 were identified in children with CKD stage 2 compared with stage 1 (1.6 (1.5–1.8) pmol/L versus 0.65 (0.22–1.08), p = 0.029). There were significant differences between the advanced stages of the disease. FGF-23 correlated with PTH (r = 0.807, p = 0.000) and phosphate (r = 0.473, p = 0.000). Our study revealed that the elevated level of FGF-23 went ahead hyperphosphatemia and elevated PTH. Thus, more than 50% of children with CKD stage 2 had the elevating level of serum FGF-23, and that index became increasing with the disease progression and it achieved 100% at the dialysis stage. The serum phosphate increased more slowly and only 70.6% of children with CKD stage 5 had the increased values. The PTH increase was more dynamic. Conclusions: FGF-23 is an essential biomarker, elevates long before other markers of bone metabolism (phosphate), and might represent a clinical course of disease.

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