scholarly journals Choroidal and peripapillary changes in high myopic eyes with Stickler syndrome

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Olivia Xerri ◽  
Federico Bernabei ◽  
Elise Philippakis ◽  
Cyril Burin-Des-Roziers ◽  
Pierre-Olivier Barale ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Axial Length ◽  
Retinal Thickness ◽  
Fundus Photography ◽  
Stickler Syndrome ◽  
Lower Prevalence ◽  
Peripapillary Atrophy ◽  
Temporal Location ◽  
Myopic Maculopathy ◽  
Sd Oct

Abstract Background To compare different clinical and Spectral-Domain Optical Coherence Tomography (SD-OCT) features of high myopic eyes with Stickler syndrome (STL) with matched controls. Methods Patients with genetically confirmed STL with axial length ≥ 26 mm and controls matched for axial length were included. The following data were obtained from SD-OCT scans and fundus photography: choroidal and retinal thickness (respectively, CT and RT), peripapillary atrophy area (PAA), presence of posterior staphyloma (PS). Results Twenty-six eyes of 17 patients with STL and 25 eyes of 19 controls were evaluated. Compared with controls, patients with STL showed a greater CT subfoveally, at 1000 μm from the fovea at both nasal and temporal location, and at 2000 and 3000 μm from the fovea in nasal location (respectively, 188.7±72.8 vs 126.0±88.7 μm, 172.5±77.7 vs 119.3±80.6 μm, 190.1±71.9 vs 134.9±79.7 μm, 141.3±56.0 vs 98.1±68.5 μm, and 110.9±51.0 vs 67.6±50.7 μm, always P< 0.05). Furthermore, patients with STL showed a lower prevalence of PS (11.5% vs 68%, P< 0.001) and a lower PAA (2.2±2.1 vs 5.4±5.8 mm2, P=0.03), compared with controls. Conclusions This study shows that high myopic patients with STL show a greater CT, a lower PAA and a lower prevalence of PS, compared with controls matched for axial length. These findings could be relevant for the development and progression of myopic maculopathy in patients with STL.

scholarly journals Assessment of Global and Local Alterations in Retinal Layer Thickness in Ins2 (Akita) Diabetic Mice by Spectral Domain Optical Coherence Tomography

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Andrew W. Francis ◽  
Justin Wanek ◽  
Mahnaz Shahidi
Keyword(s):  
Optical Coherence Tomography ◽  
Mouse Model ◽  
Layer Thickness ◽  
Retinal Thickness ◽  
Normative Values ◽  
Retinal Layer ◽  
Wild Type ◽  
Global And Local ◽  
Akita Mice ◽  
Sd Oct

Purpose/Aim. The Ins2 (Akita) mouse is a spontaneous diabetic mouse model with a heterozygous mutation in the insulin 2 gene that results in sustained hyperglycemia. The purpose of the study was to assess global and local retinal layer thickness alterations in Akita mice by analysis of spectral domain optical coherence tomography (SD-OCT) images.Materials and Methods. SD-OCT imaging was performed in Akita and wild-type mice at 12 and 24 weeks of age. Inner retinal thickness (IRT), outer retinal thickness (ORT), total retinal thickness (TRT), and photoreceptor outer segment length (OSL) were measured. Mean global thickness values were compared between Akita and wild-type mice. Local thickness variations in Akita mice were assessed based on normative values in wild-type mice.Results. Akita mice had higher blood glucose levels and lower body weights (p<0.001). On average, IRT, ORT, and TRT were approximately 2% lower in Akita mice than in wild-type mice (p≤0.02). In Akita mice, the percent difference between retinal areas with thickness below and above normative values for IRT, ORT, and TRT was 22%, 32%, and 38%, respectively.Conclusions. These findings support the use of the Akita mouse model to study the retinal neurodegenerative effects of hyperglycemia.

Changes of outer retinal thickness with increasing age in normal eyes

2020 ◽  
Vol 1 (2) ◽  
pp. 108-112
Author(s):  
Zi-Jing Li ◽  
◽  
Jian-Hui Xiao ◽  
Peng Zeng ◽  
Xiang Gao ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Outer Segment ◽  
Retinal Thickness ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Retinal Layer ◽  
External Limiting Membrane ◽  
The Cost ◽  
The Relationship ◽  
Sd Oct

AIM: To comprehensively investigate the relationship between outer retinal layer thickness and age in normal eyes. METHODS: One hundred normal eyes of 100 subjects who underwent spectral-domain optical coherence tomography (SD-OCT) were included in this retrospective study. The distances between the external limiting membrane (ELM) line and the photoreceptor inner segment/outer segment (IS/OS) line (ELM-IS/OS), the IS/OS line and the cone outer segment tips (COST) line (IS/OS-COST), the COST line and the retinal pigment epithelium (RPE) complex (COST-RPE) and the full retinal thickness (RT) were measured at the fovea and on four quarters. The relationship between thickness and age or sex was then analysed. CONCLUSION: In normal eyes, the RT thickness on the nasal quarter and the ELM-IS/OS thickness were significantly and negatively correlated with age. The IS/OS-COST and COST-RPE thicknesses were not significantly correlated with age or sex.

Effects of Retinal Angiography on Optical Coherence Tomography Measurements

2015 ◽  
Vol 234 (3) ◽  
pp. 160-166 ◽  
Author(s):  
Young-Joon Jo ◽  
Hyung-Bin Lim ◽  
Soo-Hyun Lee ◽  
Jung-Yeul Kim
Keyword(s):  
Optical Coherence Tomography ◽  
Indocyanine Green ◽  
Retinal Thickness ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Interclass Correlation ◽  
Significant Difference ◽  
Before And After ◽  
Sd Oct

Purpose: To evaluate the effects of retinal angiography, using fluorescein and indocyanine green dyes, on optical coherence tomography (OCT) measurements. Methods: In total, 76 eyes from 76 consecutive patients were included. Macular cube 512 × 128 combination scanning and optic disc 200 × 200 scanning using spectral-domain (SD)-OCT were performed twice, before and after retinal angiography, with fluorescein or indocyanine green. Signal strength, regional retinal thickness of the 9 Early Treatment Diabetic Retinopathy Study subfields, total macular volume, and retinal nerve fiber layer thickness obtained before and after angiography were compared. Repeatability was also investigated. Results: Comparing the results of OCT measured before and after retinal angiography, there was no statistically significant difference in any parameter assessed. The interclass correlation values for each measurement were all >0.808 (range 0.808-0.999). Conclusion: Retinal angiography using fluorescein and indocyanine green dyes has no significant effect on OCT measurements.

scholarly journals Macular Thickness and Volume Assessed by Spectral-Domain Optical Coherence Tomography in Patients With Coronavirus Disease 2019: A Case-Control Study

2020 ◽  
Author(s):  
Mojtaba Abrishami ◽  
Fariba Tohidinezhad ◽  
Zahra Emamverdian ◽  
Ramin Daneshvar ◽  
Neda Saeedian ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Thickness ◽  
Spectral Domain ◽  
Case Group ◽  
Special Focus ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Significant Difference ◽  
Normal Controls ◽  
Sd Oct

Abstract Purpose: To quantify the retinal thickness and volume using spectral-domain optical coherence tomography (SD-OCT) analysis in the macular region of patients with Coronavirus Disease 2019 (COVID-19).Methods: In a comparative cross-sectional, observational study, patients recovered from COVID-19 were included. All included subjects had a reverse transcription-polymerase chain reaction (RT-PCR) - confirmed diagnosis of COVID-19. Macular SD-OCT was performed at least two weeks after recovery from systemic COVID-19. Inner, outer and full retinal thicknesses and volumes were measured in COVID-19 recovered patients versus age-matched normal controls.Results: Twenty-five patients (11 male) with a mean age of 36.4 ± 11 years and 60 healthy controls (31 males) with a mean age of 39.3 ± 7.7 years were enrolled in the study. There was no statistically significant difference in the retinal thickness or volume measures between the two groups. However, the thickness in the case group was minimally more than the controls. Conclusion: Retinal thickness in COVID-19 patients may be higher than healthy subjects. Comprehensive ocular examination with special focus on posterior segment manifestations should be considered in these patients.

scholarly journals Characterizing right-angled vessel in macular telangiectasia type 2 with structural optical coherence tomography

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yoo-Ri Chung ◽  
Young Ho Kim ◽  
Jaeryung Oh ◽  
Seong-Woo Kim ◽  
Christopher Seungkyu Lee ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Cross Sectional Study ◽  
Fundus Photography ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Macular Telangiectasia ◽  
Advanced Phase ◽  
Tertiary Hospitals ◽  
Sd Oct

AbstractWe investigated the structural findings on spectral-domain optical coherence tomography (SD-OCT) related to the presence of right-angled vessels (RAV) in patients with macular telangiectasia (MacTel) type 2 with severity 3 in Korea. A retrospective multicenter cross-sectional study was conducted in six tertiary hospitals in Korea; the study included 116 MacTel type 2 eyes with severity 3. The SD-OCT findings were compared between eyes with RAV on fundus photography or fluorescein angiography and those without RAV. Logistic regression was performed to determine factors associated with the presence of RAV. Fifty eyes presented with RAV and 61 eyes without RAV. More eyes presented with only inner retinal (IR) cavities on SD-OCT among eyes without RAV than among those with RAV (P < 0.001). However, eyes with RAV presented with IR disorganization, outer retinal (OR) cavity, and ellipsoid zone (EZ) disruption more frequently than eyes without RAV did (all P < 0.001). These SD-OCT findings were significantly associated with the presence of RAV. The presence of RAV was closely related to IR disorganization, OR cavities, and EZ disruption on SD-OCT. These findings suggest an advanced phase of MacTel type 2.

scholarly journals High-Resolution Optical Coherence Tomography Retinal Imaging: A Case Series Illustrating Potential and Limitations

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Olena Puzyeyeva ◽  
Wai Ching Lam ◽  
John G. Flanagan ◽  
Michael H. Brent ◽  
Robert G. Devenyi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Retinal Pigment ◽  
Central Retinal Artery Occlusion ◽  
Case Series ◽  
Age Related Macular Degeneration ◽  
Fundus Photography ◽  
Optical Coherence ◽  
Age Related ◽  
Sd Oct

Purpose. To present a series of retinal disease cases that were imaged by spectral domain optical coherence tomography (SD-OCT) in order to illustrate the potential and limitations of this new imaging modality.Methods. The series comprised four selected cases (one case each) of age-related macular degeneration (ARMD), diabetic retinopathy (DR), central retinal artery occlusion (CRAO), and branch retinal vein occlusion (BRVO). Patients were imaged using the Heidelberg Spectralis (Heidelberg Engineering, Germany) in SD-OCT mode. Patients also underwent digital fundus photography and clinical assessment.Results. SD-OCT imaging of a case of age-related macular degeneration revealed a subfoveal choroidal neovascular membrane with detachment of the retinal pigment epithelium (RPE) and neurosensory retina. Using SD-OCT, the cases of DR and BRVO both exhibited macular edema with cystoid spaces visible in the outer retina.Conclusions. The ability of SD-OCT to clearly and objectively elucidate subtle morphological changes within the retinal layers provides information that can be used to formulate diagnoses with greater confidence.

scholarly journals Association of macular thickness with parapapillary atrophy in myopic eyes

2020 ◽  
Author(s):  
Helong Piao ◽  
Yue Guo ◽  
Jun Young Ha ◽  
Mi Sun Sung ◽  
Sang Woo Park
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Axial Length ◽  
Choroidal Thickness ◽  
Automatic Segmentation ◽  
Linear Regression Analysis ◽  
Peripheral Region ◽  
Macular Thickness ◽  
Parapapillary Atrophy ◽  
Sd Oct

Abstract Background: To investigate whether macular structure could be affected by axial elongation and to determine the association between macular intraretinal thickness and the microstructure of β-zone parapapillary atrophy (PPA) in myopic eyes.Methods: The study recruited 113 healthy myopic subjects (113 eyes). Images of the macula, subfoveal choroid, and optic nerve head were acquired using spectral-domain optical coherence tomography (SD-OCT). An automatic segmentation algorithm was used to segment the macular images into 7 intraretinal layers. PPA widths with and without Bruch’s membrane (PPA+BM and PPA-BM, respectively) were evaluated. Linear regression analysis was performed to evaluate the association between macular intraretinal thickness and axial length and the microstructure of PPA.Results: An increase in axial length was associated with a decrease in whole macular thickness of the peripheral region and an increase in whole macular thickness of the central region. Thickness alterations of the macular intraretinal layers were most apparent in the peripheral region. A significant correlation was found between PPA-BM width and macular intraretinal layer thickness, whereas no significant correlation was found between PPA+BM width and macular intraretinal layer thickness. Moreover, both PPA+BM and PPA-BM widths significantly correlated with subfoveal choroidal thickness.Conclusions: Macular intraretinal layer thickness may be affected by PPA-BM width. These findings indicate that the microstructure of PPA should be considered when evaluating the macula in patient with myopia and glaucoma.

scholarly journals Assessing Errors Inherent in OCT-Derived Macular Thickness Maps

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Daniel Odell ◽  
Adam M. Dubis ◽  
Jackson F. Lever ◽  
Kimberly E. Stepien ◽  
Joseph Carroll
Keyword(s):  
Axial Length ◽  
Retinal Thickness ◽  
Normal Subjects ◽  
Macular Thickness ◽  
Ideal Observer ◽  
Factors Affecting ◽  
Data Collection And Analysis ◽  
Thickness Measurements ◽  
Retinal Pathologies ◽  
Sd Oct

SD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of macular thickness maps. Forty-three patients with various retinal pathologies and 113 normal subjects were imaged using Cirrus HD-OCT. Reduced B-scan density was associated with increased interpolation error in ETDRS macular thickness plots. Correcting for individual differences in axial length revealed modest errors in retinal thickness maps, while more pronounced errors were observed when the ETDRS plot was not positioned at the center of the fovea (which can occur as a result of errant fixation). Cumulative error can exceed hundreds of microns, even under “ideal observer” conditions. This preventable error is particularly relevant when attempting to compare macular thickness maps to normative databases or measuring the area or volume of retinal features.

Sign in / Sign up

Export Citation Format

Share Document