Socio-economic inequalities in the association between alcohol use disorder and depressive disorder among Thai adults: a population-based study

Abstract Background Previous evidence indicates significant associations between depressive disorders and alcohol use disorder (AUD) and their strong links with social conditions. This study aims to investigate the association between major depressive episode (MDE) and AUD across various socio-economic groups. Methods We analysed data from the 2014 Thai National Health Examination Survey containing a random sample of 13,177 adults aged > 20 years from the general population. The Alcohol Use Disorder Identification Test was used to classify respondents into non-problem drinking (score 0–7), hazardous drinking (score 8–15), and harmful-dependent drinking (score 16–40). MDE was identified using questions based on the DSM-IV. Adjusted odds ratios (AOR) and 95% confidence intervals (CI) were calculated using multinomial logistic regression to determine the strength of associations between MDE as a predictor and AUD as an outcome variable across different socio-economic levels. Results The prevalence of MDE, hazardous, and harmful-dependent drinking was 2.5, 10.3, and 1.9%, respectively. The association between MDE and AUD was modified by wealth index, education level and area of residence. AORs for the association between MDE and harmful-dependent drinking were high among those in the highest (AOR = 8.68, 95% CI: 5.34, 14.11) and lowest (AOR = 7.14, 95% CI: 3.71, 13.73) levels of wealth index but not significant among those in the middle level (AOR = 1.78, 95% CI: 0.74, 4.25). Education had the strongest effect on the relationship between MDE and harmful-dependent drinking (AOR = 16.0, 95% CI: 10.30, 24.90 among those completing secondary school or higher and AOR = 1.44, 95% CI: 0.63, 3.33 among those completing primary school only). The association between MDE and harmful-dependent drinking was higher among people who lived in urban areas (AOR = 8.50, 95% CI: 5.50, 13.13) compared to those living in rural areas (AOR = 4.73, 95% CI: 3.31, 6.77). Conclusion Socio-economic factors modify the association between alcohol use disorder and major depressive disorder among Thai people.

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Socio-economic inequalities in the association between alcohol-use disorder and depressive disorder among Thai adults: a population-based study

10.21203/rs.3.rs-15847/v3 ◽

2020 ◽

Author(s):

Sawitri Assanangkornchai ◽

Jiraluck Nontarak ◽

Wichai Aekplakorn ◽

Suwat Chariyalertsak ◽

Pattapong Kessomboon ◽

...

Keyword(s):

Alcohol Use ◽

Depressive Disorder ◽

Rural Areas ◽

Urban Areas ◽

Alcohol Use Disorder ◽

Multinomial Logistic Regression ◽

Wealth Index ◽

Outcome Variable ◽

Health Examination ◽

Major Depressive

Abstract Background: Previous evidence indicates significant associations between depressive disorders and alcohol use disorder (AUD) and their strong links with social conditions. This study aims to investigate the association between major depressive episode (MDE) and AUD across various socio-economic groups.Methods: We analysed data from the 2014 Thai National Health Examination Survey containing a random sample of 13,177 adults aged >20 years from the general population. The Alcohol Use Disorder Identification Test was used to classify respondents into non-problem drinking (score 0-7), hazardous drinking (score 8-15), and harmful-dependent drinking (score 16-40). MDE was identified using questions based on the DSM-IV. Adjusted odds ratios (AOR) and 95% confidence intervals (CI) were calculated using multinomial logistic regression to determine the strength of associations between MDE as a predictor and AUD as an outcome variable across different socio-economic levels.Results: The prevalence of MDE, hazardous, and harmful-dependent drinking was 2.5%, 10.3%, and 1.9%, respectively. The association between MDE and AUD was modified by wealth index, education level and area of residence. AORs for the association between MDE and harmful-dependent drinking were high among those in the highest (AOR=8.68, 95% CI: 5.34, 14.11) and lowest (AOR=7.14, 95% CI: 3.71, 13.73) levels of wealth index but not significant among those in the middle level (AOR=1.78, 95% CI: 0.74, 4.25). Education had the strongest effect on the relationship between MDE and harmful-dependent drinking (AOR=16.0, 95% CI: 10.30, 24.90 among those completing secondary school or higher and AOR=1.44, 95% CI: 0.63, 3.33 among those completing primary school only). The association between MDE and harmful-dependent drinking was higher among people who lived in urban areas (AOR=8.50, 95% CI: 5.50, 13.13) compared to those living in rural areas (AOR=4.73, 95% CI: 3.31, 6.77).Conclusion: Socio-economic factors modify the association between alcohol use disorder and major depressive disorder among Thai people.

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Socio-economic inequalities in the association between alcohol use disorder and depressive disorder among Thai adults: a population-based study

10.21203/rs.3.rs-15847/v4 ◽

2020 ◽

Author(s):

Sawitri Assanangkornchai ◽

Jiraluck Nontarak ◽

Wichai Aekplakorn ◽

Suwat Chariyalertsak ◽

Pattapong Kessomboon ◽

...

Keyword(s):

Alcohol Use ◽

Depressive Disorder ◽

Rural Areas ◽

Urban Areas ◽

Alcohol Use Disorder ◽

Multinomial Logistic Regression ◽

Wealth Index ◽

Outcome Variable ◽

Health Examination ◽

Major Depressive

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Socio-economic inequalities in the association between alcohol-use disorder and depressive disorder among Thai adults: a population-based study

10.21203/rs.3.rs-15847/v2 ◽

2020 ◽

Author(s):

Sawitri Assanangkornchai ◽

Jiraluck Nontarak ◽

Wichai Aekplakorn ◽

Suwat Chariyalertsak ◽

Pattapong Kessomboon ◽

...

Keyword(s):

Alcohol Use ◽

Depressive Disorder ◽

Rural Areas ◽

Urban Areas ◽

Alcohol Use Disorder ◽

Multinomial Logistic Regression ◽

Wealth Index ◽

Outcome Variable ◽

Health Examination ◽

Major Depressive

Abstract Background: Previous evidence indicates significant associations between alcohol use disorder (AUD) and depressive disorders and their strong links with social conditions. This study aims to investigate the association between AUD and major depressive episode (MDE) across various socio-economic groups.Methods: We analysed data from the 2014 Thai National Health Examination Survey containing a random sample of 13,177 adults aged >20 years from the general population. The Alcohol Use Disorder Identification Test was used to classify respondents into non-problem drinking (score 0-7), hazardous drinking (score 8-15), and harmful-dependent drinking (score 16-40). MDE was identified using questions based on the DSM-IV. Adjusted odds ratios (AOR) and 95% confidence intervals (CI) were calculated using multinomial logistic regression to determine the strength of associations between MDE as a predictor and AUD as an outcome variable across different socio-economic levels.Results: The prevalence of MDE, hazardous, and harmful-dependent drinking was 2.5%, 10.3%, and 1.9%, respectively. The association between MDE and AUD was modified by wealth index, education level and area of residence. AORs for the association between MDE and harmful-dependent drinking were high among those in the highest (AOR=6.89, 95% CI: 4.13, 11.48) and lowest (AOR=6.14, 95% CI: 3.33, 11.34) levels of wealth index but marginally significant among those in the middle level (AOR=2.58, 95% CI: 1.00, 6.67). Education had the strongest effect on the relationship between MDE and harmful-dependent drinking (AOR=15.19, 95% CI: 9.5, 24.29 among those completing secondary school or higher and AOR=1.23, 95% CI: 0.55, 2.76 among those completing primary school only). The association between MDE and harmful-dependent drinking was higher among people who lived in urban areas (AOR=7.37, 95% CI: 4.53, 12.00) compared to those living in rural areas (AOR=4.23, 95% CI: 3.10, 5.77).Conclusion: Socio-economic factors modify the association between alcohol use disorder and major depressive disorder among Thai people.

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Socio-economic inequalities in the association between alcohol-use disorder and depressive disorder among Thai adults: a population-based study

10.21203/rs.3.rs-15847/v1 ◽

2020 ◽

Author(s):

Sawitri Assanangkornchai ◽

Jiraluck Nontarak ◽

Wichai Aekplakorn ◽

Suwat Chariyalertsak ◽

Pattapong Kessomboon ◽

...

Keyword(s):

Alcohol Use ◽

Depressive Disorder ◽

Alcohol Use Disorder ◽

Depressive Disorders ◽

Alcohol Use Disorders ◽

Wealth Index ◽

Population Based ◽

Health Examination ◽

Population Based Study ◽

Dsm Iv

Abstract Purpose Previous evidence indicates significant associations between alcohol-use disorders (AUD) and depressive disorders and their strong links with social conditions. This study aims to investigate the association between AUD and major depressive episode (MDE) across various socio-economic groups. Methods Data from the 2014 Thai National Health Examination Survey was obtained containing a random sample of 13,177 adults aged > 20 years from the whole population. The Alcohol-Use Disorders Identification Test (AUDIT) was used to classify respondents into non-problem, hazardous drinking (score 8-15) and harmful-dependent drinking (score 16-40). MDE was identified using questions based on the DSM-IV. Adjusted odds ratios (AOR) and 95% confidence intervals (CI) were calculated using logistic regression to determine the strength of associations. Results The prevalence of hazardous, harmful-dependent drinking and MDE was 10.3%, 1.9% and 2.5%, respectively. The association between MDE and AUD was modified by education level, wealth index and area of residence, with education having the largest effect (AOR=1.23, 95% CI: 0.55, 2.76 among those completing primary school only and AOR=15.19, 95% CI: 9.5, 24.29 among those completing secondary school or higher). Conclusion Socio-economic factors modify the association between alcohol-use disorder and depressive disorder among Thai people.

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Repetitive Transcranial Magnetic Stimulation for Comorbid Major Depressive Disorder and Alcohol Use Disorder

Brain Sciences ◽

10.3390/brainsci12010048 ◽

2021 ◽

Vol 12 (1) ◽

pp. 48

Author(s):

Victor M. Tang ◽

Bernard Le Foll ◽

Daniel M. Blumberger ◽

Daphne Voineskos

Keyword(s):

Major Depressive Disorder ◽

Transcranial Magnetic Stimulation ◽

Alcohol Use ◽

Depressive Disorder ◽

Magnetic Stimulation ◽

Alcohol Use Disorder ◽

Repetitive Transcranial Magnetic Stimulation ◽

Executive Dysfunction ◽

Common Symptom ◽

Major Depressive

Major depressive disorder (MDD) and alcohol use disorder (AUD) are leading causes of disability, and patients are frequently affected by both conditions. This comorbidity is known to confer worse outcomes and greater illness severity. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation method that has demonstrated antidepressant effects. However, the study of rTMS for patients with MDD and commonly associated comorbidities, such as AUD, has been largely overlooked, despite significant overlap in clinical presentation and neurobiological mechanisms. This narrative review aims to highlight the interrelated aspects of the literature on rTMS for MDD and rTMS for AUD. First, we summarize the available evidence on the effectiveness of rTMS for each condition, both most studied through stimulation of the dorsolateral prefrontal cortex (DLPFC). Second, we describe common symptom constructs that can be modulated by rTMS, such as executive dysfunction, that are transdiagnostic across these disorders. Lastly, we describe promising approaches in the personalization and optimization of rTMS that may be applicable to both AUD and MDD. By bridging the gap between research efforts in MDD and AUD, rTMS is well positioned to be developed as a treatment for the many patients who have both conditions concurrently.

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Clinical Outcomes of the First 2 Years of Implementation of the Integrated Care Pathway for Concurrent Major Depressive Disorder and Alcohol Use Disorder

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.251 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S79-S79 ◽

Cited By ~ 1

Author(s):

A.V. Samokhvalov ◽

S. Awan ◽

B. Le Foll ◽

C. Probst ◽

P. Voore ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Symptoms ◽

Alcohol Use ◽

Depressive Disorder ◽

Integrated Care ◽

Alcohol Use Disorder ◽

Care Pathway ◽

Retention Rates ◽

Major Depressive ◽

Integrated Care Pathway

BackgroundBoth major depressive disorder (MDD) and alcohol use disorder are highly prevalent, often comorbid and cause significant socioeconomic burden. At CAMH, we have developed and integrated care pathway (ICP) to treat these disorders and evaluated its effectiveness in comparison to treatment as usual (TAU)MethodsChart review; descriptive statistics, c2 and t-tests, linear mixed effects models, Kaplan–Meier and log-rank analyses.ResultsOverall, 81 patients were enrolled into ICP. Comparisons of treatment retention rates between ICP patients and matched historical controls (n = 81) showed significantly lower dropout rate in ICP cohort (18.5% vs. 69.1%, P < 0.001, Fig. 1). The ICP patients demonstrated significant reduction in depressive symptoms severity (QIDS: 14.6 vs. 10.0, P < 0.001; BDI 26.3 vs. 16.2, P < 0.001), reduction in the amount of alcohol consumed weekly from 44.6 standard drinks at baseline to 12.6 (P < 0.001) by the end of treatment, which was significantly better compared to controls (56.9 vs. 25.2, P < 0.001), P = 0.014 (Fig. 2).ConclusionsThe ICP is a feasible approach to treatment of concurrent AUD and MDD with significantly higher retention rates than TAU. Patients demonstrate improvements on several levels including depressive symptoms, and changes in alcohol drinking patterns.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Correlates of major depressive disorder with and without comorbid alcohol use disorder nationally in the veterans health administration

American Journal on Addictions ◽

10.1111/ajad.12219 ◽

2015 ◽

Vol 24 (5) ◽

pp. 419-426 ◽

Cited By ~ 14

Author(s):

Gihyun Yoon ◽

Ismene L. Petrakis ◽

Robert A. Rosenheck

Keyword(s):

Major Depressive Disorder ◽

Alcohol Use ◽

Depressive Disorder ◽

Alcohol Use Disorder ◽

Veterans Health Administration ◽

Veterans Health ◽

Health Administration ◽

Major Depressive

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A Randomized, Controlled, Pilot Study of Acamprosate Added to Escitalopram in Adults With Major Depressive Disorder and Alcohol Use Disorder

Journal of Clinical Psychopharmacology ◽

10.1097/jcp.0b013e3182726764 ◽

2012 ◽

Vol 32 (6) ◽

pp. 787-796 ◽

Cited By ~ 9

Author(s):

Janet Witte ◽

Kate Bentley ◽

Anne Eden Evins ◽

Alisabet J. Clain ◽

Lee Baer ◽

...

Keyword(s):

Major Depressive Disorder ◽

Pilot Study ◽

Alcohol Use ◽

Depressive Disorder ◽

Alcohol Use Disorder ◽

Major Depressive ◽

Randomized Controlled

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Determinants of BCG vaccination coverage in Ethiopia: a cross-sectional survey

BMJ Open ◽

10.1136/bmjopen-2018-023634 ◽

2019 ◽

Vol 9 (2) ◽

pp. e023634 ◽

Cited By ~ 3

Author(s):

Asmamaw Ketemaw Tsehay ◽

Getasew Tadesse Worku ◽

Yihun Mulugeta Alemu

Keyword(s):

Vaccination Coverage ◽

Rural Areas ◽

Urban Areas ◽

Wealth Index ◽

Outcome Variable ◽

Antenatal Visit ◽

Sampling Frame ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Bcg Vaccination

ObjectiveThe objective of this study is to assess the determinants of BCG vaccination in Ethiopia from 2016 Ethiopia Demographic and Health Survey (EDHS).SettingSince Ethiopia has nine regional states and two administrative cities, sample was taken from all the divisions. The population-based sample was intended to provide estimates of key indicators for the country.ParticipantThe sampling frame used for the 2016 EDHS is the Ethiopia Population and Housing Census. From 15 683 women recorded in EDHS dataset, women with no child (n=10 379) were excluded from the study. Therefore, the total sample size for this study was 5304 women. The outcome variable was BCG immunisation status of children.ResultOut of the study participants (n=5304), the majority were in between 20 and 34 years of age (73.8%). The median age of the respondents was 28.4 (SD=±6.5) years old. Prevalence of BCG vaccination was 63.6% (n=3373) and BCG vaccination coverage in urban residents was higher (88%) than rural residents (57.3%). Mothers’ age between 20 up to 34 (Adjusted odds ratio (AOR)=1.48; 95% CI: 1.13 to 1.93) and between 35 up to 49 (AOR=1.83; 95% CI: 1.35 to 2.46) were more likely to vaccinate their child’s than those mothers’ age less than 20. Mothers settled in urban areas were two times more likely to vaccinate their child’s than those living in rural areas (AOR=1.94; 95% CI: 1.45 to 2.60). Mothers with greater antenatal visits show higher BCG vaccination, Antenatal Care (ANC) 4 and above (AOR=3.48; 95% CI: 2.91 to 4.15). BCG vaccination is higher for mothers delivered at non-governmental organisation health facility than home (AOR=2.9; 95% CI: 1.69 to 4.96). Maternal occupation and wealth index also had a significant association with BCG vaccination.ConclusionBCG vaccination coverage, in this study, was lower and determinant factors for BCG vaccination were residence, mother’s age, place of delivery, mother’s antenatal visit, wealth index and mother’s occupation.

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Immunological Disturbances and Neuroimaging Findings in Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD) Comorbid Patients

Current Topics in Medicinal Chemistry ◽

10.2174/1568026620666200228093935 ◽

2020 ◽

Vol 20 (9) ◽

pp. 759-769

Author(s):

Andriana Kakanakova ◽

Stefan Popov ◽

Michael Maes

Keyword(s):

Major Depressive Disorder ◽

Alcohol Use ◽

Depressive Disorder ◽

Alcohol Use Disorder ◽

Imaging Techniques ◽

High Rate ◽

Gamma Aminobutyric Acid ◽

Major Depressive ◽

Dorsolateral Prefrontal ◽

Substance Abuse Disorders

: Mood disorders and Major Depressive Disorder, in particular, appear to be some of the most common psychiatric disorders with a high rate of comorbidity most frequently of anxiety or substance abuse disorders (alcohol use disorder). In both cases – MDD and AUD, a number of immunological disturbances are observed, such as chronic mild inflammation response, increased level of cytokines, hypercortisolaemia, which lead to specific changes in brain neurotransmitter functions. : Some of the contemporary brain imaging techniques are functional magnetic resonance imaging (fMRI) and magnetic spectroscopy which are most commonly used to assess the brain metabolism and functional connectivity changes such as altered responses to emotional stimuli in MDD or overactivation of ventromedial prefrontal areas during delayed and underactivation of dorsolateral prefrontal regions during impulsive reward decisions in AUD and dysfunction of gamma-aminobutyric acid (GABA) and/or glutamate neurotransmitter systems, low NAA and myo-Inositol in both MDD and AUD.

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