scholarly journals Mutual relationships between SARS-CoV-2 test numbers, fatality and morbidity rates

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Piotr Korneta ◽  
Janusz Zawiła-Niedźwiecki ◽  
Jarosław Domański
Keyword(s):  
Power Law ◽  
Piecewise Linear ◽  
Probabilistic Approach ◽  
Rank Correlation ◽  
Correlation Coefficients ◽  
Piecewise Linear Approximation ◽  
Mortality And Morbidity ◽  
Abc Classification ◽  
Line Slope ◽  
And Control

Abstract Background The number of SARS-CoV-2 tests conversely to other factors, such as age of population or comorbidities, influencing SARS-CoV-2 morbidity and fatality rates, can be increased or decreased by decision makers depending on the development of the pandemic, operational capacity, and financial restraints. The key objective of this study is to identify and describe, within the probabilistic approach, the relationships between SARS-CoV-2 test numbers and the mortality and morbidity rates. Methods The study is based on a statistical analysis of 1058 monthly observations relating to 107 countries, from six different continents, in an 11-month period from March 2020 to January 2021. The variable utilised can be defined as the number of tests performed in a given country in 1 month, to the number of cases reported in a prior month and morbidities and mortalities per 1 million population. The probabilities of different mortality and morbidity rates for different test numbers were determined by moving percentiles and fitted by the power law and by the three-segment piecewise-linear approximation based on Theil Sen trend lines. Results We have identified that for a given probability the dependence of mortality and morbidity rates on SARS-CoV-2 test rates follows a power law and it is well approximated by the three Theil Sen trend lines in the three test rate ranges. In all these ranges Spearman rho and Kendall tau-b rank correlation coefficients of test numbers and morbidity with fatality rates have values between − 0.5 and − 0.12 with p-values below 0.002. Conclusions According to the ABC classification: the most important, moderately important, and relatively unimportant ranges of test numbers for managing and control have been indicated based on the value of the Theil Sen trend line slope in the three SARS-CoV-2 test rate ranges identified. Recommendations for SARS-CoV-2 testing strategy are provided.

scholarly journals Prevention and Control of Tuberculosis Relying on a Tuberculosis Dynamic Model Based on the Cases of American

2020 ◽  
Author(s):  
Yan Wu ◽  
Meng Huang ◽  
Ximei Wang ◽  
Yong Li ◽  
Lei Jiang ◽  
...  
Keyword(s):  
Dynamic Model ◽  
Prevention And Control ◽  
Rank Correlation ◽  
Correlation Coefficients ◽  
Latin Hypercube Sampling ◽  
The Sustainable Development ◽  
United State ◽  
Partial Rank Correlation ◽  
And Control ◽  
Protection Period

Abstract Background: Tuberculosis (TB) which is a preventable and curable disease, is claimed as the second largest number of fatalities and there are 9,025 cases reported in the United State in 2018. Many researches have done a lot of research and achieved remarkable results, but TB is also a serious problem for human being.The study is a further exploration. Methods: In the paper, we propose a new dynamic model to study the transmission dynamics of TB, then use global differential evolution and local sequential quadratic programming (DESQP) optimization algorithm to estimate parameters of the model. Finally, we use Latin hypercube sampling (LHS) and partial rank correlation coefficients (PRCC) to analyze the influence of parameters on the basic reproduction number (R0) and the total infectious (including the diagnosed, undiagnosed and incomplete treatment infectious), respectively. Results: By the research, the basic reproduction is computed as 2.3597 which means TB will be epidemic in US. The diagnosed rate is 0.6082 which means the undiagnosed will be diagnosed after 1.6442 years. The diagnosed will be recovered with an average of 1.9912 years, especially, some diagnosed will end the treatment after 1.7550 years, for some reasons. By the study, it’s shown that there are 2.4% of the recovered will be reactivated and 13.88% of the newborn will be vaccination. However, the immunity will be lose after about 19.6078 years. Conclusion: Through the results of this study, we give some suggestions to help prevent and control the TB epidemic in the United State, such as prolonging the protection period of the vaccine by developing new and more effective vaccines to prevent TB, using the chemoprophylaxis for incubation patients to prevent their conversion into active TB; raising people’s awareness of prevention and control of TB and treatment after illness; isolation treatment for the infected to reduce the spread of TB. According to the latest report, in the announcement came at the first WHO Global Ministerial Conference on Ending Tuberculosis in the Sustainable Development Era, we predict that it’s difficult to control TB in 2030.

scholarly journals The Prevention and Control of Tuberculosis: An Analysis Based On a Tuberculosis Dynamic Model Derived from the Cases of Americans

2020 ◽  
Author(s):  
Yan Wu ◽  
Meng Huang ◽  
Ximei Wang ◽  
Yong Li ◽  
Lei Jiang ◽  
...  
Keyword(s):  
United States ◽  
Dynamic Model ◽  
Prevention And Control ◽  
Rank Correlation ◽  
Correlation Coefficients ◽  
Latin Hypercube Sampling ◽  
The United States ◽  
Human Beings ◽  
Severe Problem ◽  
And Control

Abstract Background: Tuberculosis (TB), a preventable and curable disease, is claimed as the second largest number of fatalities, and there are 9,025 cases reported in the United States in 2018. Many researchers have done a lot of research and achieved remarkable results, but TB is still a severe problem to the human beings. The study is a further exploration of the prevention and control of tuberculosis.Methods: In the paper, we propose a new dynamic model to study the transmission dynamics of TB, and then use global differential evolution and local sequential quadratic programming (DESQP) optimization algorithm to estimate parameters of the model. Finally, we use Latin hypercube sampling (LHS) and partial rank correlation coefficients (PRCC) to analyze the influence of parameters on the basic reproduction number (R0) and the total infectious (including the diagnosed, undiagnosed and incomplete treatment infectious), respectively.Results: According to the research, the basic reproduction is computed as 2.3597, which means TB will be an epidemic in the US. The diagnosed rate is 0.6082, which means the undiagnosed will be diagnosed after 1.6442 years. The diagnosed will recover after an average of 1.9912 years. Moreover, some diagnosed will end the treatment after 1.7550 years for some reason. From the study, it’s shown that 2.4% of the recovered will be reactivated, and 13.88% of the newborn will be vaccinated. However, the immune system will be lost after about 19.6078 years.Conclusion: Through the results of this study, we give some suggestions to help prevent and control the TB epidemic in the United States, such as prolonging the protection period of the vaccine by developing new and more effective vaccines to prevent TB; using the Chemoprophylaxis for incubation patients to prevent their conversion into active TB; raising people’s awareness of the prevention and control of TB and treatment after illness; isolating the infected to reduce the spread of TB. According to the latest report in the announcement that came at the first WHO Global Ministerial Conference on Ending tuberculosis in the Sustainable Development Era, we predict that it is challenging to control TB in 2030.

scholarly journals A Preliminary Study on Dependence of Mercury Distribution on the Degree of Coalification in Ningwu Coalfield, Shanxi, China

Energies ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 3119
Author(s):  
Yinjiao Su ◽  
Xuan Liu ◽  
Yang Teng ◽  
Kai Zhang
Keyword(s):  
Linear Correlation ◽  
Bituminous Coal ◽  
Rank Correlation ◽  
Correlation Coefficients ◽  
Chemical Extraction ◽  
Mercury Distribution ◽  
Sequential Chemical Extraction ◽  
Average Proportion ◽  
Total Proportion ◽  
The Relationship

Mercury (Hg) is a toxic trace element emitted from coal conversion and utilization. Samples with different coal ranks and gangue from Ningwu Coalfield are selected and investigated in this study. For understanding dependence of mercury distribution characteristics on coalification degree, Pearson regression analysis coupled with Spearman rank correlation is employed to explore the relationship between mercury and sulfur, mercury and ash in coal, and sequential chemical extraction method is adopted to recognize the Hg speciation in the samples of coal and gangue. The measured results show that Hg is positively related to total sulfur content in coal and the affinity of Hg to different sulfur forms varies with the coalification degree. Organic sulfur has the biggest impact on Hg in peat, which becomes weak with increasing the coalification degree from lignite to bituminous coal. Sulfate sulfur is only related to Hg in peat or lignite as little content in coal. However, the Pearson linear correlation coefficients of Hg and pyritic sulfur are relatively high with 0.479 for lignite, 0.709 for sub-bituminous coal and 0.887 for bituminous coal. Hg is also related to ash content in coal, whose Pearson linear correlation coefficients are 0.504, 0.774 and 0.827 respectively, in lignite, sub-bituminous coal and bituminous coal. Furthermore, Hg distribution is directly depended on own speciation in coal. The total proportion of F2 + F3 + F4 is increased from 41.5% in peat to 87.4% in bituminous coal, but the average proportion of F5 is decreased from 56.8% in peat to 12.4% in bituminous coal. The above findings imply that both Hg and sulfur enrich in coal largely due to the migration from organic state to inorganic state with the increase of coalification degree in Ningwu Coalfield.

scholarly journals Cord Blood Extracellular Vesicles Analyzed by Flow Cytometry with Thresholding Using 405 nm or 488 nm Laser Leads to Concurrent Results

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1320
Author(s):  
Kristýna Pekárková ◽  
Jakub Soukup ◽  
Marie Kostelanská ◽  
Jan Širc ◽  
Zbyněk Straňák ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Cord Blood ◽  
Extracellular Vesicles ◽  
Correlation Coefficients ◽  
Flow Cytometer ◽  
Liquid Biopsies ◽  
Physiological Conditions ◽  
Flow Cytometric ◽  
Term Births ◽  
And Control

Extracellular vesicles (EVs) from liquid biopsies are extensively analyzed by flow cytometry, a technology that is continuously evolving. Thresholding utilizing a violet 405 nm laser side scatter (VSSC) has recently been implemented. Here, we collected set of large EV (lEV) samples from cord blood, which we analyzed using a standard flow cytometer improved via a 405 nm laser side scatter. Samples were analyzed using two distinct thresholding methods—one based on VSSC, and one based on VSSC combined with fluorescence thresholding on stained phosphatidylserine. Through these thresholding methods, we compared lEVs from pre-term births and control cord blood. Double-labeled lEVs with platelet CD36+/CD41+, activated platelet CD41+/CD62P+ and endothelial CD31+/CD105+ antibodies were used. Apart from comparing the two groups together, we also correlated measured lEVs with the thresholding methods. We also correlated the results of this study with data analyzed in our previous study in which we used a conventional 488 nm laser SSC. We did not find any difference between the two cord blood groups. However, we found highly concurrent data via our correlation of the thresholding methods, with correlation coefficients ranging from 0.80 to 0.96 even though the numbers of detected lEVs differed between thresholding methods. In conclusion, our approaches to thresholding provided concurrent data and it seems that improving the cytometer with the use of a VSSC increases its sensitivity, despite not being particularly critical to the validity of flow cytometric studies that compare pathological and physiological conditions in liquid biopsies.

scholarly journals Quenched topological boundary modes can persist in a trivial system

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Ching Hua Lee ◽  
Justin C. W. Song
Keyword(s):  
Probability Density ◽  
Power Law ◽  
Localized States ◽  
Topological Phase ◽  
Boundary Mode ◽  
Temporal Boundary ◽  
And Control ◽  
Topological Boundary

AbstractTopological boundary modes can occur at the spatial interface between a topological and gapped trivial phase and exhibit a wavefunction that exponentially decays in the gap. Here we argue that this intuition fails for a temporal boundary between a prequench topological phase that possess topological boundary eigenstates and a postquench gapped trivial phase that does not possess any eigenstates in its gap. In particular, we find that characteristics of states (e.g., probability density) prepared in a topologically non-trivial system can persist long after it is quenched into a gapped trivial phase with spatial profiles that appear frozen over long times postquench. After this near-stationary window, topological boundary mode profiles decay albeit, slowly in a power-law fashion. This behavior highlights the unusual features of nonequilibrium protocols enabling quenches to extend and control localized states of both topological and non-topological origins.

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