scholarly journals Impact of replacing sedentary behaviour with other movement behaviours on depression and anxiety symptoms: a prospective cohort study in the UK Biobank

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
A. A. Kandola ◽  
B. del Pozo Cruz ◽  
D. P. J. Osborn ◽  
B. Stubbs ◽  
K. W. Choi ◽  
...  
Keyword(s):  
Sedentary Behaviour ◽  
Anxiety Symptom ◽  
Anxiety Symptoms ◽  
Vigorous Activity ◽  
Depression And Anxiety ◽  
Uk Biobank ◽  
Lower Odds ◽  
Symptom Scores ◽  
Light Activity

Abstract Background Sedentary behaviour is potentially a modifiable risk factor for depression and anxiety disorders, but findings have been inconsistent. To assess the associations of sedentary behaviour with depression and anxiety symptoms and estimate the impact of replacing daily time spent in sedentary behaviours with sleep, light, or moderate to vigorous physical activity, using compositional data analysis methods. Methods We conducted a prospective cohort study in 60,235 UK Biobank participants (mean age: 56; 56% female). Exposure was baseline daily movement behaviours (accelerometer-assessed sedentary behaviour and physical activity, and self-reported total sleep). Outcomes were depression and anxiety symptoms (Patient Health Questionnaire-9 and Generalised Anxiety Disorders-7) at follow-up. Results Replacing 60 min of sedentary behaviour with light activity, moderate-to-vigorous activity, and sleep was associated with lower depression symptom scores by 1.3% (95% CI, 0.4–2.1%), 12.5% (95% CI, 11.4–13.5%), and 7.6% (95% CI, 6.9–8.4%), and lower odds of possible depression by 0.95 (95% CI, 0.94–0.96), 0.75 (95% CI, 0.74–0.76), and 0.90 (95% CI, 0.90–0.91) at follow-up. Replacing 60 min of sedentary behaviour with moderate-to-vigorous activity and sleep was associated with lower anxiety symptom scores by 6.6% (95% CI, 5.5–7.6%) and 4.5% (95% CI, 3.7–5.2%), and lower odds of meeting the threshold for a possible anxiety disorder by 0.90 (95% CI, 0.89–0.90) and 0.97 (95%CI, 0.96–0.97) at follow-up. However, replacing 60 min of sedentary behaviour with light activity was associated with higher anxiety symptom scores by 4.5% (95% CI, 3.7–5.3%) and higher odds of a possible anxiety disorder by 1.07 (95% CI, 1.06–1.08). Conclusions Sedentary behaviour is a risk factor for increased depression and anxiety symptoms in adults. Replacing sedentary behaviour with moderate-to-vigorous activity may reduce mental health risks, but more work is necessary to clarify the role of light activity.

scholarly journals Digital phenotyping of complex psychological responses to the COVID-19 pandemic

2020 ◽  
Author(s):  
Thomas Hull ◽  
Jacob Levine ◽  
Niels Bantilan ◽  
Angel Desai ◽  
Maimuna S. Majumder
Keyword(s):  
Mental Health ◽  
Large Scale ◽  
Anxiety Symptom ◽  
The United States ◽  
Anxiety Symptoms ◽  
Response To Treatment ◽  
Depression Symptom ◽  
Depression And Anxiety ◽  
Psychological Reactions ◽  
Symptom Scores

Background: The novel coronavirus disease 2019 (COVID-19) has negatively impacted mortality, economic conditions, and mental health. A large scale study on psychological reactions to the pandemic to inform ongoing population-level symptom tracking and response to treatment is currently lacking.Methods: Average intake scores for standard depression and anxiety symptom scales were tracked from January 1, 2017 to June 9, 2020 for patients seeking treatment from a digital mental health service to gauge the relationship between COVID-19 and self-reported symptoms. We applied natural language processing (NLP) to unstructured therapy transcript data from patients seeking treatment during the height of the pandemic in the United States between March 1, 2020 and June 9, 2020 to identify words associated with COVID-19 mentions. This analysis was used to identify symptoms that were present beyond those assessed by standard depression and anxiety measures.Results: Depression and anxiety symptoms reported by 169,889 patients between January 1, 2017 and June 9, 2020 were identified. There was no detectable change in intake depression symptom scores. Intake anxiety symptom scores increased 1.42 scale points [95% CI: 1.18, 1.65] between March 15, 2020 and April 1, 2020, when scores peaked. In the transcript data of these 169,889 patients, plus an expanded sample of 49,267 patients without symptom reports, term frequency-inverse document frequency (tf-idf) identified 2,377 positively correlated and 661negatively correlated terms that were significantly (FDR<.01) associated with mentions of the virus. These terms were classifiable into 24 symptoms beyond those included in the diagnostic criteria for anxiety or depression.Conclusions: The COVID-19 pandemic may have increased intake anxiety symptoms for individuals seeking digital mental health treatment. NLP analyses suggest that standard symptom scales for depression and anxiety alone are inadequate to fully assess and track psychological reactions to the pandemic. Symptoms of grief, trauma, obsession-compulsion, agoraphobia, hypochondriasis, panic, and non- suicidal self-injury should be monitored as part of a new COVID-19 Syndrome category.

scholarly journals Role of Inflammation in Depression and Anxiety: Tests for Disorder Specificity, Linearity and Potential Causality of Association in the UK Biobank

2021 ◽  
Author(s):  
Zheng Ye ◽  
Nils Kappelmann ◽  
Sylvain Moser ◽  
George Davey Smith ◽  
Stephen Burgess ◽  
...  
Keyword(s):  
Anxiety Symptom ◽  
Experimental Studies ◽  
Mendelian Randomisation ◽  
Depression And Anxiety ◽  
Uk Biobank ◽  
Reactive Protein ◽  
Increased Risk ◽  
Symptom Scores ◽  
Using Data ◽  
The Uk

ABSTRACTBackgroundConcentrations of C-reactive protein (CRP), interleukin 6 (IL-6) and other inflammatory markers are elevated in people with depression and anxiety compared to controls, but evidence for disorder-specificity, linearity and potential causality is sparse.MethodsUsing data from up to 144,890 UK Biobank cohort participants, we tested associations of circulating CRP concentrations with depression and anxiety symptom scores and probable diagnosis, including tests for linearity, disorder-specificity and sex difference. We examined potential causality using 1-sample and 2-sample Mendelian randomisation (MR) analyses testing associations of genetically-predicted CRP concentration and IL-6 activity with depression and anxiety.FindingsCRP concentration was associated with depressive and anxiety symptom scores and with probable diagnoses of depression and generalised anxiety disorder (GAD) in a dose-response fashion. These associations were stronger for depression than for anxiety, and for women than for men although less consistently. MR analyses provided consistent results suggesting that genetically predicted higher IL-6 activity was associated with increased risk for depressive symptoms, while genetically-predicted higher CRP concentration was associated with decreased risks of depressive and anxiety symptoms.InterpretationAltered activity of the IL-6/IL-6R pathway could be causally linked to depression. The field now requires experimental studies of IL-6 modulation in humans and animal models to further examine causality, mechanisms and treatment potential. Such studies are also needed to elucidate mechanisms for divergent associations of genetically-predicted higher IL-6 activity (risk increasing) and higher CRP concentrations (protective) with depression/anxiety.FundingMQ (MQDS17/40); Wellcome Trust (201486/Z/16/Z).

Effectiveness of Cognitive Behavioral Couple Therapy on Reducing Depression and Anxiety Symptoms and Increasing Dyadic Adjustment and Marital Social Skills: An Exploratory Study

2020 ◽  
Vol 28 (4) ◽  
pp. 344-355
Author(s):  
Ricardo Silva Santos Durães ◽  
Tatiana Cohab Khafif ◽  
Francisco Lotufo-Neto ◽  
Antonio de Pádua Serafim
Keyword(s):  
Social Skills ◽  
Marital Conflict ◽  
Couple Therapy ◽  
Anxiety Symptoms ◽  
Dyadic Adjustment ◽  
Cognitive Behavioral ◽  
Depression And Anxiety ◽  
Communication Problems ◽  
Group 2

Several kinds of marital conflict might be solved through constructive communication, development of interaction skills, and behavioral and thought modification. The aim of this study was to show results of the application of a protocol based on cognitive behavioral couple therapy (CBCT) on dyadic adjustment, marital social skills, depression, and anxiety symptoms. The sample consisted of 32 participants (16 couples) divided in two groups by length of marriage: Group 1 (1–7 years) and Group 2 (8–12 years). All subjects recruited were older than 18 and reported having communication problems in their relationship. The ages were M = 30.4, SD = 4.13. The measures were Dyadic Adjustment Scale (DAS), Beck Depression Inventory–II (BDI-II), Beck Anxiety Inventory (BAI), Marital Social Skills Inventory (Inventário de Habilidades Sociais Conjugais [IHSC]), and the Sociodemographic Questionnaire. Participants were assessed pre- and postintervention and had a 6-month follow-up. The intervention consisted of twelve 50-min sessions per couple. Based on three time analyses, both groups obtained the following results: DAS ( p = .001), BDI-II ( p = .000), BAI ( p = .000), and IHSC ( p = .001). We conclude that the CBCT protocol developed for this study, resulted in statistically significant improvements in the couple’s relationship for all variables studied in both groups.

Who pays the price for high neuroticism? Moderators of longitudinal risks for depression and anxiety

2017 ◽  
Vol 47 (10) ◽  
pp. 1794-1805 ◽  
Author(s):  
J. R. Vittengl
Keyword(s):  
Anxiety Symptom ◽  
Social Problems ◽  
Economic Status ◽  
Significant Risk ◽  
The United States ◽  
Anxiety Symptoms ◽  
Depression And Anxiety ◽  
Socio Economic Status ◽  
Symptom Intensity ◽  
Physical Limitations

BackgroundHigh neuroticism is a well-established risk for present and future depression and anxiety, as well as an emerging target for treatment and prevention. The current analyses tested the hypothesis that physical, social and socio-economic disadvantages each amplify risks from high neuroticism for longitudinal increases in depression and anxiety symptoms.MethodA national sample of adults (n = 7108) provided structured interview and questionnaire data in the Midlife Development in the United States Survey. Subsamples were reassessed roughly 9 and 18 years later. Time-lagged multilevel models predicted changes in depression and anxiety symptom intensity across survey waves.ResultsHigh neuroticism predicted increases in a depression/anxiety symptom composite across retest intervals. Three disadvantage dimensions – physical limitations (e.g. chronic illness, impaired functioning), social problems (e.g. less social support, more social strain) and low socio-economic status (e.g. less education, lower income) – each moderated risks from high neuroticism for increases in depression and anxiety symptoms. Collectively, high scores on the three disadvantage dimensions amplified symptom increases attributable to high neuroticism by 0.67 standard deviations. In contrast, neuroticism was not a significant risk for increases in symptoms among participants with few physical limitations, few social problems or high socio-economic status.ConclusionsRisks from high neuroticism are not shared equally among adults in the USA. Interventions preventing or treating depression or anxiety via neuroticism could be targeted toward vulnerable subpopulations with physical, social or socio-economic disadvantages. Moreover, decreasing these disadvantages may reduce mental health risks from neuroticism.

scholarly journals Sleep symptoms and long-term outcome in adolescents with major depressive disorder: a naturalistic follow-up study

2019 ◽  
Vol 29 (5) ◽  
pp. 595-603 ◽  
Author(s):  
Anna S. Urrila ◽  
◽  
Olli Kiviruusu ◽  
Henna Haravuori ◽  
Linnea Karlsson ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Young Adulthood ◽  
Psychosocial Functioning ◽  
Anxiety Symptoms ◽  
Depression And Anxiety ◽  
Major Depressive ◽  
Term Outcome ◽  
Long Term Outcome

Abstract Sleep abnormalities in major depressive disorder (MDD) have been suggested to represent a vulnerability trait, which might predispose the individual to long-term psychiatric morbidity. In this study, we sought to assess whether the presence of sleep symptoms among adolescents with MDD is associated with poorer long-term outcome in young adulthood during naturalistic follow-up. Adolescent outpatients diagnosed with MDD (n = 166; age 13–19 years, 17.5% boys) were followed up during 8 years in naturalistic settings. N = 112 adolescents (16.1% boys) completed the 8-year assessment. Sleep symptoms and psychosocial functioning were assessed with structured clinical interviews, and depressive and anxiety symptoms with questionnaires. The severity of sleep symptoms at baseline was not associated with worse outcome at 8 years in terms of any of the outcome measures tested. In particular, the presence of a disturbed sleep–wake rhythm at baseline was associated with a more favourable outcome at 8 years: less depression and anxiety symptoms and higher level of psychosocial functioning. The presence of sleep symptoms in young adulthood was associated with the presence of current depression and anxiety symptoms and poorer psychosocial functioning. The presence of sleep symptoms at follow-up seems to be state-dependent: they are observed in conjunction with other psychiatric symptoms. Contrary to our hypothesis, our results suggest that sleep complaints among adolescents with MDD do not lead to poorer long-term clinical outcome in young adulthood. The link between sleep–wake rhythm disturbance and better long-term outcome needs to be confirmed and examined in detail in further studies, but here we speculate about possible explanations.

Depression and anxiety symptoms as predictors of mortality in PCI patients at 10 years of follow-up

2015 ◽  
Vol 23 (5) ◽  
pp. 552-558 ◽  
Author(s):  
Milan R van Dijk ◽  
Elisabeth MWJ Utens ◽  
Karolijn Dulfer ◽  
Mustafa NA Al-Qezweny ◽  
Robert-Jan van Geuns ◽  
...  
Keyword(s):  
Anxiety Symptoms ◽  
Depression And Anxiety ◽  
Predictors Of Mortality

scholarly journals Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts

2021 ◽  
Author(s):  
Yuri Milaneschi ◽  
Nils Kappelmann ◽  
Zheng Ye ◽  
Femke Lamers ◽  
Sylvain Moser ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Sleep Problems ◽  
Experimental Studies ◽  
Anxiety Symptoms ◽  
Self Report ◽  
Mendelian Randomisation ◽  
Depression And Anxiety ◽  
Uk Biobank ◽  
Increased Risk ◽  
The Uk

AbstractWe examined whether inflammation is uniformly associated with all depressive and anxiety symptoms, and whether these associations are potentially causal. Data was from 147,478 individuals from the UK Biobank (UKB) and 2,905 from the Netherlands Study of Depression and Anxiety (NESDA). Circulating C-reactive protein (CRP) was measured in both cohorts and interleukin-6 (IL-6) in NESDA. Genetic instruments for these proteins were obtained from published GWAS and UKB. Depressive and anxiety symptoms were assessed with self-report questionnaires. In NESDA, neurovegetative (appetite, sleep, psychomotor) symptoms were disaggregated as increased vs. decreased. In joint analyses, higher CRP was associated with depressive symptoms of depressed mood (OR = 1.06, 95% CI = 1.05–1.08), altered appetite (OR = 1.25, 95%CI = 1.23–1.28), sleep problems (OR = 1.05, 95%CI = 1.04–1.06), and fatigue (OR = 1.12, 95% CI = 1.11–1.14), and with anxiety symptoms of irritability (OR = 1.06, 95% CI = 1.05–1.08) and worrying control (OR = 1.03, 95% CI = 1.02–1.04). In NESDA, higher IL-6 was additionally associated with anhedonia (OR = 1.30, 95% CI = 1.12–1.52). Higher levels of both CRP (OR = 1.27, 95% CI = 1.13–1.43) and IL-6 (OR = 1.26, 95% CI = 1.07–1.49) were associated with increased sleep. Higher CRP was associated with increased appetite (OR = 1.21, 95% CI = 1.08–1.35) while higher IL-6 with decreased appetite (OR = 1.45, 95% CI = 1.18–1.79). In Mendelian Randomisation analyses, genetically predicted higher IL-6 activity was associated with increased risk of fatigue (estimate = 0.25, SE = 0.08) and sleep problems (estimate = 0.19, SE = 0.07). Inflammation was associated with core depressive symptoms of low mood and anhedonia and somatic/neurovegetative symptoms of fatigue, altered sleep and appetite changes. Less consistent associations were found for anxiety. The IL-6/IL-6R pathway could be causally linked to depression. Experimental studies are required to further evaluate causality, mechanisms, and usefulness of immunotherapies for depressive symptoms.

scholarly journals Trends in depression & anxiety symptom severity among mental health service attendees during the COVID-19 pandemic

2021 ◽  
Author(s):  
Rob Saunders ◽  
Joshua Eusty Jonathan Buckman ◽  
Judy Leibowitz ◽  
John Cape ◽  
Stephen Pilling
Keyword(s):  
Mental Health ◽  
Anxiety Symptom ◽  
Psychological Treatment ◽  
Depression And Anxiety ◽  
Treatment Services ◽  
Symptom Scores ◽  
Potential Benefits ◽  
Community Transmission ◽  
The Uk ◽  
Residual Confounding

BackgroundGeneral population surveys have shown that some groups, particularly young women experienced increased distress during nationally mandated restrictions to control the spread of COVID-19. However, there has been limited research on such trends among people with pre-existing mental health conditions, leaving mental health services ill equipped to plan for currents and future lockdowns.MethodsMean weekly scores on the GAD-7 and PHQ-9 between 01/01/2020-22/06/2020 (n=9,538 individuals) for all patients of two psychological treatment services in London, were compared to mean weekly scores from the same time periods in 2017-2019 (n=37,849). The proportion of scores which were above the clinical thresholds for ‘caseness’ each week were compared, and scores between groups based on gender, age group, and ethnicity, were also compared. ResultsConfirmed community transmission in the UK (26/02/2020-03/03/2020) and the announcement of the national ‘lockdown’ (23/03/2020) were associated with significant increases in anxiety symptom scores. ‘Lockdown’ was associated with a decrease in depression scores. These changes were not maintained during lockdown. Significant increases in depression and anxiety were observed at week 23, as restrictions were eased.LimitationsThis was an exploratory analysis in two services only. Residual confounding and selection biases cannot be ruled out.ConclusionsDifferences in the weekly average symptom scores were short-term; they did not continue throughout ‘lockdown’ as might have been expected, except among older people. Replication of this study in other settings and investigating the potential benefits of more regular reviews or more intensive treatments for older adults seeking support, are warranted.

scholarly journals Depressive and Anxiety Symptom Assessment in Adults with Polycystic Ovarian Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Wadha K. Almeshari ◽  
Alanoud K. Alsubaie ◽  
Reham I. Alanazi ◽  
Yara A. Almalki ◽  
Nazish Masud ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Low Income ◽  
Anxiety Symptom ◽  
Polycystic Ovarian Syndrome ◽  
Anxiety Symptoms ◽  
Reproductive Age ◽  
Depression And Anxiety ◽  
Cross Sectional ◽  
Income Status ◽  
Ovarian Syndrome

Background. Polycystic ovarian syndrome (PCOS) is an endocrinopathic disorder commonly affecting women in the reproductive age. These women have a possibility of developing depression and anxiety due to biochemical changes, concerns regarding physical appearance, and social pressure from infertility. Thus, the connection between PCOS, anxiety, and depression has a possible impact on patients’ quality of life. This study is aimed at assessing depression and anxiety symptoms among PCOS patients and their association with different socioeconomic aspects. Methods. A cross-sectional study was conducted to assess depression and anxiety symptoms on 250 PCOS patients which were selected through consecutive sampling technique. Arabic versions of the HAM-A and HAM-D questionnaires were used alongside a demographic sheet to determine the socioeconomic and fertility status. Results. Prevalence of anxiety symptoms was reported among 100 (40%) of women and was found to be significantly higher in single women with a prevalence of 59 (48%) ( χ 2 = 5.8 , p value <0.01). Also, lower-income status and unemployment were associated with a significantly higher prevalence of anxiety 18 (67%) ( χ 2 = 10.3 , p value =0.03) and 71 (45%) ( χ 2 = 4.5 , p value =0.03) women, respectively. Depressive symptoms were reported among 122 (49%) participants. Conclusion. Single marital status, low income, and unemployment were predictors of anxiety. Tension was noted to be the most common anxiety symptom among participants while depressed mood and psychological anxiety were the most reported depressive symptoms. It is important to note the link between anxiety, PCOS, and depression when deciding treatment plans for affected women.

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