The impact of body weight and diabetes on new-onset atrial fibrillation: a nationwide population based study

Abstract Background Being obese or underweight, and having diabetes are important risk factors for new-onset atrial fibrillation (AF). However, it is unclear whether there is any interaction between body weight and diabetes in regard to development of new-onset AF. We aimed to evaluate the role of body weight status and various stage of diabetes on new-onset AF. Methods This was a nationwide population based study using National Health Insurance Service (NHIS) data. A total of 9,797,418 patients who underwent national health check-ups were analyzed. Patients were classified as underweight [body mass index (BMI) < 18.5], normal reference group (18.5 ≤ BMI < 23.0), upper normal (23.0 ≤ BMI < 25.0), overweight (25.0 ≤ BMI < 30.0), or obese (BMI ≥ 30.0) based on BMI. Diabetes were categorized as non-diabetic, impaired fasting glucose (IFG), new-onset diabetes, diabetes < 5 years, and diabetes ≥ 5 years. Primary outcome end point was new-onset AF. New-onset AF was defined as one inpatient or two outpatient records of International Classification of Disease, Tenth Revision (ICD-10) codes in patients without prior AF diagnosis. Results During 80,130,161 patient*years follow-up, a total of 196,136 new-onset AF occurred. Obese [hazard ration (HR) = 1.327], overweight (HR = 1.123), upper normal (HR = 1.040), and underweight (HR = 1.055) patients showed significantly increased risk of new-onset AF compared to the normal reference group. Gradual escalation in the risk of new-onset AF was observed along with advancing diabetic stage. Body weight status and diabetes were independently associated with new-onset AF and at the same time, had synergistic effects on the risk of new-onset AF with obese diabetic patients having the highest risk (HR = 1.823). Conclusions Patients with obesity, overweight, underweight, and diabetes had significantly increased risk of new-onset AF. Body weight status and diabetes had synergistic effects on the risk of new-onset AF. The risk of new-onset AF increased gradually with advancing diabetic stage. This study suggests that maintaining optimal body weight and glucose homeostasis might prevent new-onset AF.

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Are sleep duration and sleep quality associated with diet quality, physical activity, and body weight status? A population-based study of Canadian children

Can J Public Health ◽

10.17269/cjph.106.4892 ◽

2015 ◽

Vol 106 (5) ◽

pp. e277-e282 ◽

Cited By ~ 42

Author(s):

Mohammad K. A. Khan ◽

Yen Li Chu ◽

Sara F. L. Kirk ◽

Paul J. Veugelers

Keyword(s):

Physical Activity ◽

Body Weight ◽

Sleep Quality ◽

Sleep Duration ◽

Diet Quality ◽

Weight Status ◽

Population Based ◽

Population Based Study ◽

Body Weight Status

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Is overweight/obesity a risk factor for atopic allergic disease in prepubertal children? A case–control study

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2021-0051 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Aysel Vehapoglu ◽

Zeynep Ebru Cakın ◽

Feyza Ustabas Kahraman ◽

Mustafa Atilla Nursoy ◽

Ali Toprak

Keyword(s):

Body Weight ◽

Allergic Disease ◽

Weight Status ◽

Normal Weight ◽

Overweight And Obesity ◽

University Hospital ◽

Healthy Children ◽

Prepubertal Children ◽

Body Weight Status ◽

Increased Risk

Abstract Objectives It is unclear whether body weight status (underweight/normal weight/overweight/obese) is associated with allergic disease. Our objective was to investigate the relationship between body weight status (body mass index; BMI) and atopic allergic disease in prepubertal children, and to compare children with atopic allergic diseases with non atopic healthy children. Methods A prospective cross sectional study of 707 prepubertal children aged 3–10 years was performed; the participants were 278 atopic children with physician-diagnosed allergic disease (allergic rhinitis and asthma) (serum total IgE level >100 kU/l and eosinophilia >4%, or positivity to at least one allergen in skin test) and 429 non atopic healthy age- and sex-matched controls. Data were collected between December 2019 and November 2020 at the Pediatric General and Pediatric Allergy Outpatient Clinics of Bezmialem Vakıf University Hospital. Results Underweight was observed in 11.6% of all participants (10.8% of atopic children, 12.2% of healthy controls), and obesity in 14.9% of all participants (18.0% of atopic children, 12.8% of controls). Obese (OR 1.71; 95% CI: 1.08–2.71, p=0.021), and overweight status (OR 1.62; 95% CI: 1.06–2.50, p=0.026) were associated with an increased risk of atopic allergic disease compared to normal weight in pre-pubertal children. This association did not differ by gender. There was no relationship between underweight status and atopic allergic disease (OR 1.03; 95% CI: 0.63–1.68, p=0.894). Conclusions Overweight and obesity were associated with an increased risk of atopic allergic disease compared to normal weight among middle-income and high-income pre pubertal children living in Istanbul.

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Weight control behaviors according to body weight status and accuracy of weight perceptions among Korean women: a nationwide population-based survey

Scientific Reports ◽

10.1038/s41598-019-45596-z ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 3

Author(s):

Boyoung Park ◽

Ha Na Cho ◽

Eunji Choi ◽

Da Hea Seo ◽

Nam-Soon Kim ◽

...

Keyword(s):

Body Weight ◽

Weight Control ◽

Weight Status ◽

Population Based ◽

Korean Women ◽

Weight Control Behaviors ◽

Weight Perceptions ◽

Body Weight Status ◽

Population Based Survey

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Usefulness of CHADS2 and CHA2DS2-VASc Scores in the Prediction of New-Onset Atrial Fibrillation: A Population-Based Study

The American Journal of Medicine ◽

10.1016/j.amjmed.2016.02.029 ◽

2016 ◽

Vol 129 (8) ◽

pp. 843-849 ◽

Cited By ~ 51

Author(s):

Walid Saliba ◽

Naomi Gronich ◽

Ofra Barnett-Griness ◽

Gad Rennert

Keyword(s):

Atrial Fibrillation ◽

Population Based ◽

Population Based Study ◽

Onset Atrial Fibrillation ◽

New Onset

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Relations of body weight status in early adulthood and weight changes until middle age with metabolic syndrome in the Chinese population

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20174810 ◽

2017 ◽

Vol 4 (11) ◽

pp. 4011

Author(s):

Liancheng Zhao ◽

Huanhuan Liu ◽

Long Zhou ◽

Ying Li ◽

Min Guo ◽

...

Keyword(s):

Metabolic Syndrome ◽

Body Weight ◽

Weight Gain ◽

Weight Change ◽

Chinese Population ◽

Weight Status ◽

Early Adulthood ◽

Weight Changes ◽

Body Weight Status ◽

Increased Risk

Background: The evidences for the relationship between long-term weight gain and metabolic syndrome (MetS) in Chinese population were limited. Therefore, this study aims to explore the association of body weight status in early adulthood and weight changes with MetS.Methods: Data from China Multicenter Collaborative Study of Cardiovascular Epidemiology including 12808 participants aged 35–59 were used. Participants were surveyed for cardiovascular risk factors and a self-reported weight at age 25, which was defined as early adulthood. Weight change was calculated as the difference between baseline weight and early adulthood weight. MetS was defined according to AHA/NHLBI definition in 2009. Multivariate logistic regression model was used to examine the association between early adulthood weight status, weight change and MetS.Results: Mean age of participants was 46.7 years, including 6134 men and 6674 women. The overall prevalence of MetS was 21.8%. After adjusted for age, sex and other confounding factors, both BMI at 25 age and weight gain were positively associated with the risk of MetS. Being overweight (BMI, 24–27.9 kg m-2) or obese (BMI ≥28 kg m-2) at early adulthood was related to an increased risk of MetS, the odds ratio (OR) and 95%confidence interval (CI) was 3.24 (2.82–3.72) and 13.31 (8.72–20.31). In addition, weight gain was also associated with higher risk of MetS (P for trend<0.01).Conclusions: Overweight and obesity in early adulthood and weight gain were both independently related to an increased risk of MetS in the middle-aged Chinese men and women.

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Chrono-Nutrition: The Relationship between Time-of-Day Energy and Macronutrient Intake and Children’s Body Weight Status

Journal of Biological Rhythms ◽

10.1177/0748730419838908 ◽

2019 ◽

Vol 34 (3) ◽

pp. 332-342 ◽

Cited By ~ 4

Author(s):

Sofia Vilela ◽

Andreia Oliveira ◽

Milton Severo ◽

Carla Lopes

Keyword(s):

Body Weight ◽

Weight Status ◽

Eating Behaviors ◽

Population Based ◽

Time Of Day ◽

Macronutrient Intake ◽

Body Weight Status ◽

Daily Food ◽

Z Scores ◽

Eating Occasions

The time of eating has been considered to have an important role in weight regulation. However, it is unknown if there are specific daily patterns of energy and macronutrient distribution that could be more beneficial for metabolic outcomes, especially obesity. This study aimed to assess the effect of time-of-day energy and macronutrient intake at 4 y of age on the weight status at 7 y of age. The study sample included 1961 children from the population-based birth cohort Generation XXI, with data on 3-day food diaries at 4 y and body mass index (BMI) z-scores at 7 y. Dietary patterns based on the collected data were obtained for the distribution of energy and macronutrients across eating occasions. Having a relatively higher energy intake at lunch and supper (OR = 1.19, 95% CI = 1.05 to 1.34) or at mid-afternoon (OR = 1.18, 95% CI = 1.05 to 1.34) at 4 y was associated with higher odds of becoming overweight/obese at 7 y. A relatively higher intake of fat at lunch was positively associated with later children’s odds for being overweight or obese (OR = 1.17, 95% CI = 1.03 to 1.32). These associations were independent of the effect on children’s eating behaviors related to appetite. Our results also show a detrimental relation between skipping breakfast and eating late in the day and children’s body weight. Considering all daily eating occasions, a higher proportion of energy and macronutrient intake at the main meals and a lower proportion during the afternoon and evening seems to be more beneficial for children’s weight. These results emphasize the important role of daily food intake rhythm on excessive weight gain in childhood.

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Atrial fibrillation is associated with increased risk of lethal ventricular arrhythmias

Scientific Reports ◽

10.1038/s41598-021-97335-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yun Gi Kim ◽

Yun Young Choi ◽

Kyung-Do Han ◽

Kyongjin Min ◽

Ha Young Choi ◽

...

Keyword(s):

Atrial Fibrillation ◽

Ventricular Arrhythmias ◽

Population Based ◽

Cardiac Events ◽

Population Based Study ◽

Increased Risk ◽

Adverse Cardiac Events ◽

Korean National Health Insurance ◽

New Onset

AbstractAtrial fibrillation (AF) is associated with various major adverse cardiac events such as ischemic stroke, heart failure, and increased overall mortality. However, its association with lethal ventricular arrhythmias such as ventricular tachycardia (VT), ventricular flutter (VFL), and ventricular fibrillation (VF) is controversial. We conducted this study to determine whether AF can increase the risk of VT, VFL, and VF. We utilized the Korean National Health Insurance Service database for this nationwide population-based study. This study enrolled people who underwent a nationwide health screen in 2009 for whom clinical follow-up data were available until December 2018. Primary outcome endpoint was the occurrence of VT, VFL, or VF in people who were and were not diagnosed with new-onset AF in 2009. We analyzed a total of 9,751,705 people. In 2009, 12,689 people were diagnosed with new-onset AF (AF group). The incidence (events per 1000 person-years of follow-up) of VT, VFL, and VF was 2.472 and 0.282 in the AF and non-AF groups, respectively. After adjustment for covariates, new-onset AF was associated with 4.6-fold increased risk (p < 0.001) of VT, VFL, and VF over 10 years of follow-up. The risk of VT, VFL, and VF was even higher if identification of AF was based on intensified criteria (≥ 2 outpatient records or ≥ 1 inpatient record; hazard ratio = 5.221; p < 0.001). In conclusion, the incidence of VT, VFL, and VF was significantly increased in people with new-onset AF. The potential risk of suffering lethal ventricular arrhythmia in people with AF should be considered in clinical practice.

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Significance and agreement between obesity anthropometric measurements and indices in adults: a population-based study from the United Arab Emirates

BMC Public Health ◽

10.1186/s12889-021-11650-7 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ibrahim Mahmoud ◽

Nabil Sulaiman

Keyword(s):

United Arab Emirates ◽

Weight Status ◽

Population Based ◽

Overweight And Obesity ◽

Anthropometric Measurements ◽

Poor Agreement ◽

Population Based Study ◽

Body Weight Status ◽

Cardiometabolic Risks ◽

Prevalence Of Obesity

Abstract Background The rates of overweight and obese adults in the United Arab Emirates (UAE) have increased dramatically in recent decades. Several anthropometric measurements are used to assess body weight status. Some anthropometric measurements might not be convenient to use in certain communities and settings. The objective of this study was to assess the agreement of four anthropometric measurements and indices of weight status and to investigate their associations with cardiometabolic risks. Methods The study design was a cross-section population-based study. Adults living in the Northern Emirates were surveyed. Fasting blood samples, blood pressure readings and anthropometric measurements were also collected. Results A total of 3531 subjects were included in this study. The prevalence of obesity/overweight was 66.4% based on body mass index (BMI), 61.7% based on waist circumference (WC), 64.6% based on waist–hip ratio (WHR) and 71% based on neck circumference (NC). There were moderate agreements between BMI and WC and between WC and WHR, with kappa (k) ranging from 0.41 to 0.60. NC showed poor agreement with BMI, WC and WHR, with k ranging from 0 to 0.2. Overweight and obesity based on BMI, WC and WHR were significantly associated with cardiometabolic risks. Conclusion Overall, there was a moderate to a poor agreement between BMI, WC, WHR and NC. Particularly, NC showed poor agreement with BMI, WC and WHR. BMI and WC showed better performance for identifying cardiometabolic risks than WHR and NC.

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