scholarly journals The novel roles of circRNAs in human cancer

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Qingfeng Shang ◽  
Zhi Yang ◽  
Renbing Jia ◽  
Shengfang Ge
Keyword(s):  
Human Cancer ◽  
The Novel

scholarly journals Enriching the Arsenal of Pharmacological Tools against MICAL2

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7519
Author(s):  
Ivana Barravecchia ◽  
Elisabetta Barresi ◽  
Camilla Russo ◽  
Francesca Scebba ◽  
Chiara De Cesari ◽  
...  
Keyword(s):  
Human Cancer ◽  
Biological Activities ◽  
Microvascular Endothelial Cells ◽  
The Novel ◽  
Invasive Front ◽  
Structure Activity ◽  
Molecule Inhibitor ◽  
Cancer Types ◽  
Cytoskeleton Dynamics ◽  
New Compounds

Molecule interacting with CasL 2 (MICAL2), a cytoskeleton dynamics regulator, are strongly expressed in several human cancer types, especially at the invasive front, in metastasizing cancer cells and in the neo-angiogenic vasculature. Although a plethora of data exist and stress a growing relevance of MICAL2 to human cancer, it is worth noting that only one small-molecule inhibitor, named CCG-1423 (1), is known to date. Herein, with the aim to develop novel MICAL2 inhibitors, starting from CCG-1423 (1), a small library of new compounds was synthetized and biologically evaluated on human dermal microvascular endothelial cells (HMEC-1) and on renal cell adenocarcinoma (786-O) cells. Among the novel compounds, 10 and 7 gave interesting results in terms of reduction in cell proliferation and/or motility, whereas no effects were observed in MICAL2-knocked down cells. Aside from the interesting biological activities, this work provides the first structure–activity relationships (SARs) of CCG-1423 (1), thus providing precious information for the discovery of new MICAL2 inhibitors.

scholarly journals ReactomeGSA - Efficient Multi-Omics Comparative Pathway Analysis

2020 ◽  
Author(s):  
Johannes Griss ◽  
Guilherme Viteri ◽  
Konstantinos Sidiropoulos ◽  
Vy Nguyen ◽  
Antonio Fabregat ◽  
...  
Keyword(s):  
B Cell ◽  
Plasma Cells ◽  
Human Cancer ◽  
The Novel ◽  
Web Interface ◽  
Tumour Immunity ◽  
Specific Subset ◽  
Public Data ◽  
Pathway Analyses

AbstractPathway analyses are key methods to analyse ‘omics experiments. Nevertheless, integrating data from different ‘omics technologies and different species still requires considerable bioinformatics knowledge.Here we present the novel ReactomeGSA resource for comparative pathway analyses of multi-omics datasets. ReactomeGSA can be used through Reactome’s existing web interface and the novel ReactomeGSA R Bioconductor package with explicit support for scRNA-seq data. Data from different species is automatically mapped to a common pathway space. Public data from ExpressionAtlas and Single Cell ExpressionAtlas can be directly integrated in the analysis. ReactomeGSA thereby greatly reduces the technical barrier for multi-omics, cross-species, comparative pathway analyses.We used ReactomeGSA to characterise the role of B cells in anti-tumour immunity. We compared B cell rich and poor human cancer samples from five TCGA transcriptomics and two CPTAC proteomics studies. There, B cell-rich lung adenocarcinoma samples lack the otherwise present activation through NFkappaB. This may be linked to the presence of a specific subset of tumour associated IgG+ plasma cells that lack NFkappaB activation in scRNA-seq data from human melanoma. This showcases how ReactomeGSA can derive novel biomedical insights by integrating large multi-omics datasets.

scholarly journals Synthesis of Novel Biologically Active Proflavine Ureas Designed on the Basis of Predicted Entropy Changes

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4860
Author(s):  
Ladislav Janovec ◽  
Eva Kovacova ◽  
Martina Semelakova ◽  
Monika Kvakova ◽  
Daniel Kupka ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Line ◽  
Biologically Active ◽  
Standard Entropy ◽  
The Novel ◽  
Urea Derivatives ◽  
Human Cancer Cell Lines ◽  
Pharmacological Model

A novel series of proflavine ureas, derivatives 11a–11i, were synthesized on the basis of molecular modeling design studies. The structure of the novel ureas was obtained from the pharmacological model, the parameters of which were determined from studies of the structure-activity relationship of previously prepared proflavine ureas bearing n-alkyl chains. The lipophilicity (LogP) and the changes in the standard entropy (ΔS°) of the urea models, the input parameters of the pharmacological model, were determined using quantum mechanics and cheminformatics. The anticancer activity of the synthesized derivatives was evaluated against NCI-60 human cancer cell lines. The urea derivatives azepyl 11b, phenyl 11c and phenylethyl 11f displayed the highest levels of anticancer activity, although the results were only a slight improvement over the hexyl urea, derivative 11j, which was reported in a previous publication. Several of the novel urea derivatives displayed GI50 values against the HCT-116 cancer cell line, which suggest the cytostatic effect of the compounds azepyl 11b–0.44 μM, phenyl 11c–0.23 μM, phenylethyl 11f–0.35 μM and hexyl 11j–0.36 μM. In contrast, the novel urea derivatives 11b, 11c and 11f exhibited levels of cytotoxicity three orders of magnitude lower than that of hexyl urea 11j or amsacrine.

The novel targets for anti-angiogenesis of genistein on human cancer cells

2005 ◽  
Vol 69 (2) ◽  
pp. 307-318 ◽  
Author(s):  
Shu-Jem Su ◽  
Trai-Ming Yeh ◽  
Woei-Jer Chuang ◽  
Chung-Liang Ho ◽  
Kee-Lung Chang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
The Novel ◽  
Human Cancer Cells ◽  
Novel Targets

The novel HDAC inhibitor NDACI054 sensitizes human cancer cells to radiotherapy

2013 ◽  
Vol 109 (1) ◽  
pp. 126-132 ◽  
Author(s):  
Stephanie Hehlgans ◽  
Katja Storch ◽  
Inga Lange ◽  
Nils Cordes
Keyword(s):  
Cancer Cells ◽  
Hdac Inhibitor ◽  
Human Cancer ◽  
The Novel ◽  
Human Cancer Cells

Do mycoplasmas cause human cancer?

2001 ◽  
Vol 47 (8) ◽  
pp. 691-697 ◽  
Author(s):  
Nevio Cimolai
Keyword(s):  
Tissue Culture ◽  
Molecular Mechanisms ◽  
Human Cancer ◽  
Epidemiological Studies ◽  
Respiratory Pathogen ◽  
The Novel ◽  
The 1960S ◽  
In Vitro Data

A linkage between mycoplasmas and malignancy was mainly proposed in the 1960s when human-associated mycoplasmas were becoming of interest given the novel characterization of the human respiratory pathogen Mycoplasma pneumoniae. Associations with leukemia and other malignancies, however, were largely ascribed to tissue-culture contamination, which is now recognized as a significant potential problem in molecular biology circles. A few epidemiological studies, however, continue to raise concern over such a linkage. As well, in vitro data have demonstrated the potential for some mycoplasmas to induce karyotypic changes and malignant transformation during chronic tissue-culture infestation. As cellular and molecular mechanisms for such transformation become studied, a resurgence of interest in this area is inevitable. A role for mycoplasmas in malignancy of any sort is conjectural, but there remains a need to continue with focussed epidemiological and laboratory investigations.Key words: mycoplasma, cancer, oncogenesis, leukemia.

The novel anthraquinone derivative IMP1338 induces death of human cancer cells by p53-independent S and G2/M cell cycle arrest

2016 ◽  
Vol 79 ◽  
pp. 308-314 ◽  
Author(s):  
Hyun Kyung Choi ◽  
Hwani Ryu ◽  
A-rang Son ◽  
Bitna Seo ◽  
Sang-Gu Hwang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Human Cancer ◽  
The Novel ◽  
M Cell ◽  
Anthraquinone Derivative ◽  
Human Cancer Cells ◽  
Cycle Arrest

scholarly journals Engraftment of allotransplantated tumour cells in adult rag2 mutant Xenopus tropicalis

2021 ◽  
Author(s):  
Dieter Tulkens ◽  
Dionysia Dimitrakopoulou ◽  
Tom Van Nieuwenhuysen ◽  
Marthe Boelens ◽  
Suzan Demuynck ◽  
...  
Keyword(s):  
Human Cancer ◽  
Genetic Diseases ◽  
Genetically Engineered ◽  
Tumour Cells ◽  
Xenopus Tropicalis ◽  
Tumour Suppressor Genes ◽  
The Novel ◽  
Knock Out ◽  
Early Embryos ◽  
Tumour Formation

Modelling human genetic diseases and cancer in lab animals has been greatly aided by the emergence of genetic engineering tools such as TALENs and CRISPR/Cas9. We have previously demonstrated the ease with which genetically engineered Xenopus models (GEXM) can be generated. This included the induction of autochthonous tumour formation by injection of early embryos with Cas9 recombinant protein loaded with sgRNAs targeting multiple tumour suppressor genes. What has been lacking so far is the possibility to propagate the induced cancers via transplantation. In this paper we describe the generation of a rag2-/- knock-out line in Xenopus tropicalis that is deficient in functional T- and B-cells. This line was validated by means of an allografting experiment with a primary tp53-/- donor tumour. In addition, we optimized available protocols for sub-lethal gamma irradiation of X. tropicalis froglets. Irradiated animals also allowed stable, albeit transient, engraftment of transplanted tp53-/- tumour cells. The novel X. tropicalis rag2-/- line and the irradiated wild type froglets will further expand the experimental toolbox in this diploid amphibian, and help to establish it as a versatile and relevant model for exploring human cancer.

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