scholarly journals Characteristics and clinical significance of lipid metabolism in patients with gastrointestinal stromal tumor

2022 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiaoling Liu ◽  
Jun Hu ◽  
Bende Liu
Keyword(s):  
Clinical Significance ◽  
Serum Lipids ◽  
Blood Lipids ◽  
High Specificity ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Specificity And Sensitivity ◽  
Union Hospital ◽  
S 100 ◽  
Blood Lipid Levels

Abstract Background To investigate the characteristics and clinical significance of serum lipids in patients with gastrointestinal stromal tumors (GISTs). Methods The clinical and pathological data of 694 GIST patients in Liyuan hospital and Union hospital from 2012 to 2016 were retrospectively analyzed. Blood lipid levels in patients with varying degrees of risk were compared. Results The findings showed that LDL-C, HDL-C, and CHOL increased significantly in women, and CD34 positive. In patients with tumors size less than 5 cm in diameter, TG, HDL-C, and CHOL were significantly higher. TG levels were significantly higher in DOG-1 (a marker and has a high specificity and sensitivity in the diagnosis of GIST) positive patients than in DOG-1 negative patients (P < 0.05). S-100 positive patients had lower HDL-C levels than S-100 negative patients (P < 0.05). Lipids indexes were found to be correlated with GIST risk stratification and tumor site (P < 0.05). TG/HDL-C was were significantly different among patients with GIST in different locations (P < 0.05). Conclusion The clinical and pathological characteristics of the patients with GIST are closely related to the level of blood lipids. To a certain extent, information about level of blood lipids can be helpful for distinguishing benign and malignant GIST.

Characteristics and Clinical Significance of Lipid Metabolism in Patients with Gastrointestinal Stromal Tumor

2021 ◽  
Author(s):  
Xiaoling Liu ◽  
Bende Liu ◽  
Jun Hu
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Clinical Significance ◽  
Serum Lipids ◽  
Blood Lipids ◽  
Blood Lipid ◽  
Stromal Tumor ◽  
Risk Levels ◽  
Union Hospital ◽  
S 100 ◽  
Blood Lipid Levels

Abstract Objective To investigate the characteristics and clinical significance of serum lipids in patients with gastrointestinal stromal tumor (GISTs).Methods The clinical and pathological data of 694 cases of GIST patients in Liyuan hospital and Union hospital from 2012 to 2016 were retrospectively analyzed. To compare the differences of blood lipid levels in patients with different risk levels.Results There was no significant correlation between preoperative lipid profile and some clinical features, including age, tumor frequency, CD117 or SMA positive or negative, and Ki67% < 5% or not (P ＞0.05). LDL-C, HDL-C and CHOL were significantly higher in women than men (P < 0.05). Compared to patients with tumor size over 5cm, TG, HDL-C and CHOL were significantly higher in those under 5cm (all P < 0.05). LDL-C, HDL-C and CHOL were higher in CD34 positive subjects than in negative ones. TG in the DOG-1 positive group was higher than that in negative one (P < 0.05). HDL-C was lower in S-100 positive subjects than in S-100 negative subjects (P < 0.05). Lipids indexes were correlated with the risk grade and tumor site of GISTs (P < 0.05). TG/HDL-C was significantly different in patients with GIST with different tumor sites, CD34 and DOG-1 positive or not (P < 0.05).Conclusion The clinical and pathological characteristics of the patients with GIST are closely related to the level of blood lipids. Blood lipids level can help judge benign or malignant of GIST to a certain extent.

Comparison of Frame Size and Body Mass Index Methods of Assessment in the Study of Blood Lipids

1992 ◽  
Vol 75 (3) ◽  
pp. 881-882 ◽  
Author(s):  
Thomas Battinelli ◽  
Ray E. Gleason
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Blood Lipids ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Frame Size ◽  
Significant Relationships ◽  
Health Fairs ◽  
Index Methods ◽  
Blood Lipid Levels

This study compared frame size and body mass index methods of assessment in relation to blood lipid levels. The data were obtained from the records of 84 men and 193 women who voluntarily participated in health fairs held at two suburban hospitals. Significant relationships and differences were found between the anthropometric and lipid variables studied. The two methods of classification denoted moderate association and reflected some divergence in classification between them.

scholarly journals Non-HDL-C Is More Stable Than LDL-C in Assessing the Percent Attainment of Non-fasting Lipid for Coronary Heart Disease Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Li-Ling Guo ◽  
Yan-qiao Chen ◽  
Qiu-zhen Lin ◽  
Feng Tian ◽  
Qun-Yan Xiang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Statin Therapy ◽  
Blood Lipids ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Short Term ◽  
C Statistic ◽  
Blood Lipid Levels

This study aimed to compare the percentage attainment of fasting and non-fasting LDL-C and non-HDL-C target levels in coronary heart disease (CHD) patients receiving short-term statin therapy. This study enrolled 397 inpatients with CHD. Of these, 197 patients took statins for &lt;1 month (m) or did not take any statin before admission (CHD1 group), while 204 patients took statins for ≥1 m before admission (CHD2 group). Blood lipid levels were measured at 0, 2, and 4 h after a daily breakfast. Non-fasting LDL-C and non-HDL-C levels significantly decreased after a daily meal (P &lt; 0.05). Both fasting and non-fasting LDL-C or non-HDL-C levels were significantly lower in the CHD2 group. The percentage attainment of LDL-C &lt;1.4 mmol/L at 2 and 4 h after a daily breakfast was significantly higher than that during fasting (P &lt; 0.05), but the percent attainment of non-fasting non-HDL-C &lt;2.2 mmol/L was close to its fasting value (P &gt; 0.05). Analysis of c-statistic showed that non-fasting cut-off points for LDL-C and non-HDL-C were 1.19 and 2.11 mmol/L, corresponding to their fasting goal levels of 1.4 and 2.2 mmol/L, respectively. When post-prandial LDL-C and non-HDL-C goal attainments were re-evaluated using non-fasting cut-off points, there were no significant differences in percentage attainment between fasting and non-fasting states. Non-HDL-C is more stable than LDL-C in assessing the percent attainment of non-fasting lipid for coronary heart disease patients. If we want to use LDL-C to assess the percent attainment of post-prandial blood lipids, we may need to determine a lower non-fasting cut-off point.

Soybean Phosphatides and Blood Lipids of Primates1

1979 ◽  
Vol 42 (2) ◽  
pp. 113-119 ◽  
Author(s):  
R. A. ROBBINS ◽  
A. L. BRANEN
Keyword(s):  
Phosphatidyl Choline ◽  
Blood Lipids ◽  
Blood Lipid ◽  
Macaca Nemestrina ◽  
Cholesterol Diet ◽  
Lipid Levels ◽  
Low Fat ◽  
Butter Oil ◽  
Low Fat Diet ◽  
Blood Lipid Levels

Ten pigtail monkeys (Macaca nemestrina) were used to study the effects of soybean phosphatides on blood lipid levels. Two monkeys were maintained on a control low-fat diet and eight monkeys were made hypercholesterolemic by feeding a diet containing 16% butter oil and 1% cholesterol for a 12-week period. Soybean phosphatides were administered to the animals by infusion or incorporation into the diet. All animals were placed on low-fat diets after 12 weeks and maintained on this diet for 5 weeks. Incorporation of 3% soybean phosphatides into the butter oil-cholesterol diet before the animals became hypercholesterolemic or a twice weekly infusion of 5 ml of a 10% emulsion of soybean phosphatides after the animals were hypercholesterolemic partially prevented increases in plasma total cholesterol, cholesterol esters and lipid phosphate induced by the butter oil-cholesterol diets. Alterations in the blood plasma lipoprotein patterns resulting from the butter oil-cholesterol diet were also prevented by these methods of phosphatide administration. Switching the animals to a diet containing phosphatides after the animals were already hypercholesterolemic was not effective in preventing alterations in blood lipid levels or lipoprotein patterns. Blood triglyceride levels were not affected by any of the treatments. The phosphatide treatments had no significant effect on the rate of decrease of blood lipid levels after placing the hypercholesterolemic animals on a low fat-low cholesterol diet. Studies of the turnover of phosphatidyl choline indicate that this phospholipid or its component parts is/are rapidly absorbed and that 10% of the radioactivity of a single oral dose of the phospholipid is released from the tissues of monkeys with a half life of about 2 days. Prior treatment with phosphatides appears to delay excretion of phosphatidyl choline. Possible mechanisms of the action of phosphatides on blood lipids are discussed.

Effects of diet on serum lipids of fetal, neonatal, and pregnant rabbits

1961 ◽  
Vol 201 (4) ◽  
pp. 611-616 ◽  
Author(s):  
Meyer Friedman ◽  
Sanford O. Byers
Keyword(s):  
Serum Lipids ◽  
Blood Lipid ◽  
Maternal Blood ◽  
Blood Cholesterol ◽  
Lipid Levels ◽  
Serum Phospholipid ◽  
Fetal Serum ◽  
Natural Milk ◽  
Suckling Rabbit ◽  
Blood Lipid Levels

The serum phospholipid, cholesterol, and triglyceride values of the fetal rabbit were determined and found to be significantly higher than similar values in the maternal host. Moreover, these fetal serum values could not be changed by altering the maternal blood lipid levels. The rise in serum cholesterol and phospholipid usually observed in the suckling rabbit could be prevented by omission of both triglyceride and cholesterol from its diet. The omission of cholesterol appeared to be most responsible for this phenomenon, because the omission solely of cholesterol from the diet of slightly older rabbits appeared capable of reducing their blood cholesterol from a level which had been elevated previously by their ingestion of cholesterol rich natural milk from lactating dams.

Optimal blood lipid levels counterbalance high polygenic risk of coronary artery disease in 130 000 individuals

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
G Botta ◽  
A Bolli ◽  
P Di Domenico
Keyword(s):  
Genetic Risk ◽  
Significant Interaction ◽  
Blood Lipids ◽  
Blood Lipid ◽  
Lipid Levels ◽  
High Genetic Risk ◽  
Increased Risk ◽  
Artery Disease ◽  
Cad Risk ◽  
Blood Lipid Levels

Abstract Background Coronary artery disease (CAD) is a complex multifactorial disease leading cause of morbidity and mortality worldwide. Identifying individuals at high risk is crucial to guide life-style and therapeutics interventions. Polygenic Risk Score (PRS) is a weighted sum of common genetic variants that showed to be able to identify a population at greater than threefold risk of CAD compared to the average. Notably, individuals at high genetic risk who adhere to a healthy lifestyle displayed between two and three-fold relative risk reduction, compared to individuals with a poor lifestyle. Despite such evidences, a systematic assessment of the interplay between PRS and CAD risk factors such as blood lipid levels in contributing to the overall CAD risk is still lacking. Methods We analysed in more than 130.0000 individuals of the UK Biobank the association of incident CAD with PRS and blood lipids (LDL, TC, HDL, TC:HDL, LDL:HDL) using a Cox Proportional Hazard Model. We defined three populations: i) Carriers: PRS &gt;95%, Reminders: PRS ≤95% and Reference: PRS ≤95% with optimal blood lipid levels. Carriers and Remainders were stratified by blood lipid levels according to international guidelines. We investigated a potential interaction between blood lipids and PRS and assessed the relative increased risk magnitude in Carriers and Reminders for different blood lipid levels. Results Carriers showed between two and three fold increased risk of incident CAD compared to Reminders at each non-optimal blood lipid level and their ratios. Carriers with LDL between 130 and 160 mg/dL showed higher CAD risk (HR 3.65, 95% CI 2.85–4.63) than Reminders with LDL above 190 mg/dL (HR 2.73, 95% CI 2.18–3.40). Despite that, Carriers displayed non significant increased risk respect to the Reference population for the following blood lipid thresholds: LDL &lt;115 mg/dL, TC &lt;200 mg/dL, HDL &gt;70 mg/dL, LDL:HDL &lt;2.0 and TC:HDL &lt;3.5. The association between LDL cholesterol and CAD was modified by the PRS due to significant interaction (P-value &lt;0.005). The magnitude of increased CAD risk by LDL was higher in Carriers (HR 1.64 95% CI 1.45–1.86 per LDL level) compared to Reminders (HR 1.40, 95% CI 1.34–1.46 per LDL level). Conclusion Using the largest prospective genotyped cohort available to date, we identified for the first time a significant interaction between LDL and genetics in determining CAD incidence. This result have deep implications in a CAD primary prevention perspective. For example individuals with high PRS and borderline-high LDL levels (130–159 mg/dL) are not currently considered to be at elevated risk, despite having higher CAD risk than Remainders with statin-recommended LDL level (&gt;190 mg/dL). Finally, the evidence that optimal lipid levels counterbalance high genetic risk opens new scenarios in the research of targeted risk reduction in the era of precision medicine. Association between PRS and lipid levels Funding Acknowledgement Type of funding source: Public grant(s) – EU funding. Main funding source(s): EIT Health

POSTPRANDIAL LIPEMIC RESPONSE IN INFANTS AND CHILDREN

PEDIATRICS ◽  
1950 ◽  
Vol 5 (4) ◽  
pp. 621-625
Author(s):  
W. ROBERT ELGHAMMER ◽  
JOHN M. REICHERT ◽  
HERBERT F. PHILIPSBORN
Keyword(s):  
Vitamin A ◽  
Clinical Significance ◽  
Blood Lipid ◽  
Capillary Blood ◽  
Lipid Levels ◽  
Time Saving ◽  
Blood Specimens ◽  
Postprandial Lipemic Response ◽  
In Infants And Children ◽  
Blood Lipid Levels

The chylomicrograph is a simple and time-saving method of serially determining [See Table II in source pdf] neutral blood lipid levels. It is of value in studying chronic intestinal indigestion. The clinical significance of the chylomicrograph is equal to that of the vitamin A curve. The advantages of the chylomicrograph over the vitamin A curve are its simplicity, rapidity, availability and use of capillary blood specimens.

scholarly journals Non-HDL-C is  more stable  than LDL-C in assessing the percent attainment of non-fasting lipid for coronary heart disease patients

2020 ◽  
Author(s):  
Li-ling Guo ◽  
Yan-qiao Chen ◽  
Qiu-zhen Lin ◽  
Feng Tian ◽  
Li-yuan Zhu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Statin Therapy ◽  
Blood Lipids ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Short Term ◽  
C Statistic ◽  
Blood Lipid Levels

Abstract Background: This study aimed to compare the percentage attainment of fasting and non-fasting LDL-C and non-HDL-C target levels in coronary heart disease (CHD) patients receiving short-term statin therapy.Methods: This study enrolled 397 inpatients with CHD. Of these, 197 patients took statins for < 1 month (m) or did not take any statin before admission (CHD1 group), while 204 patients took statins for ≥ 1 m before admission (CHD2 group). Blood lipid levels were measured at 0 h, 2 h, and 4 h after a daily breakfast.Results: Non-fasting LDL-C and non-HDL-C levels significantly decreased after a daily meal (P < 0.05). Both fasting and non-fasting LDL-C or non-HDL-C levels were significantly lower in the CHD2 group. The percentage attainment of LDL-C < 1.4 mmol/L at 2 h and 4 h after a daily breakfast was significantly higher than that during fasting (P < 0.05), but the percent attainment of non-fasting non-HDL-C < 2.2 mmol/L was close to its fasting value (P > 0.05). Analysis of c-statistic showed that non-fasting cut-off points for LDL-C and non-HDL-C were 1.19 mmol/L and 2.11 mmol/L, corresponding to their fasting goal levels of 1.4 mmol/L and 2.2 mmol/L, respectively. When postprandial LDL-C and non-HDL-C goal attainments were re-evaluated using non-fasting cut-off points, there were no significant differences in percentage attainment between fasting and non-fasting states.Conclusions: Non-HDL-C is more stable than LDL-C in assessing the percent attainment of non-fasting lipid for coronary heart disease patients. If we want to use LDL-C to assess the percent attainment of postprandial blood lipids, we may need to determine a lower non-fasting cut-off point.

scholarly journals Effects of Xuezhikang (Red Yeast Rice) on Blood lipids, Hemorheology and the Expression of P65 and Tissue Factor in Atherosclerotic Rats

2019 ◽  
Vol 2 (1) ◽  
pp. 10
Author(s):  
Yabing Yang ◽  
Meilin Liu
Keyword(s):  
Treatment Group ◽  
Tissue Factor ◽  
Blood Lipids ◽  
Blood Rheology ◽  
Blood Lipid ◽  
Red Yeast Rice ◽  
Lipid Levels ◽  
Red Yeast ◽  
Significant Difference ◽  
Blood Lipid Levels

Objective: To observe the effects of Xuezhikang (red yeast rice) on blood lipids, blood rheology, and expression of P65 and tissue factor, and to explore the anti-atherosclerosis effect and related mechanisms of Xuezhikang (red yeast rice). Methods: 32 Wistar rats were randomly divided into normal control group, Xuezhikang treatment group, lovastatin treatment group and atherosclerosis model group (8 in each group). blood lipids, blood rheology, malondialdehyde (MDA), total antioxidant capacity (t-AOc), and expression of aortic tissue factor (tF) and P65 were measured in each group. results: (1) Both Xuezhikang and lovastatin could reduce blood lipid levels, but there was no significant difference between the two groups; (2) Both Xuezhikang and lovastatin can improve the hemorheology of atherosclerotic rats, but the difference between the two groups is not signifcant; (3) Compared with lovastatin, Xuezhikang inhibited the expression of TF and P65 in aorta of rats with atherosclerosis; (4) Compared with lovastatin, the Xuezhikang group had lower MDA levels and higher T-AOC. Conclusion: Xuezhikang can improve blood lipid levels and hemorheology in rats with atherosclerosis. Compared with lovastatin, Xuezhikang has stronger effects on inhibiting oxidative stress and down-regulating the expression of tissue factor and P65.

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