Characteristics and Clinical Significance of Lipid Metabolism in Patients with Gastrointestinal Stromal Tumor

2021 ◽  
Author(s):  
Xiaoling Liu ◽  
Bende Liu ◽  
Jun Hu
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Clinical Significance ◽  
Serum Lipids ◽  
Blood Lipids ◽  
Blood Lipid ◽  
Stromal Tumor ◽  
Risk Levels ◽  
Union Hospital ◽  
S 100 ◽  
Blood Lipid Levels

Abstract Objective To investigate the characteristics and clinical significance of serum lipids in patients with gastrointestinal stromal tumor (GISTs).Methods The clinical and pathological data of 694 cases of GIST patients in Liyuan hospital and Union hospital from 2012 to 2016 were retrospectively analyzed. To compare the differences of blood lipid levels in patients with different risk levels.Results There was no significant correlation between preoperative lipid profile and some clinical features, including age, tumor frequency, CD117 or SMA positive or negative, and Ki67% < 5% or not (P ＞0.05). LDL-C, HDL-C and CHOL were significantly higher in women than men (P < 0.05). Compared to patients with tumor size over 5cm, TG, HDL-C and CHOL were significantly higher in those under 5cm (all P < 0.05). LDL-C, HDL-C and CHOL were higher in CD34 positive subjects than in negative ones. TG in the DOG-1 positive group was higher than that in negative one (P < 0.05). HDL-C was lower in S-100 positive subjects than in S-100 negative subjects (P < 0.05). Lipids indexes were correlated with the risk grade and tumor site of GISTs (P < 0.05). TG/HDL-C was significantly different in patients with GIST with different tumor sites, CD34 and DOG-1 positive or not (P < 0.05).Conclusion The clinical and pathological characteristics of the patients with GIST are closely related to the level of blood lipids. Blood lipids level can help judge benign or malignant of GIST to a certain extent.

scholarly journals Characteristics and clinical significance of lipid metabolism in patients with gastrointestinal stromal tumor

2022 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiaoling Liu ◽  
Jun Hu ◽  
Bende Liu
Keyword(s):  
Clinical Significance ◽  
Serum Lipids ◽  
Blood Lipids ◽  
High Specificity ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Specificity And Sensitivity ◽  
Union Hospital ◽  
S 100 ◽  
Blood Lipid Levels

Abstract Background To investigate the characteristics and clinical significance of serum lipids in patients with gastrointestinal stromal tumors (GISTs). Methods The clinical and pathological data of 694 GIST patients in Liyuan hospital and Union hospital from 2012 to 2016 were retrospectively analyzed. Blood lipid levels in patients with varying degrees of risk were compared. Results The findings showed that LDL-C, HDL-C, and CHOL increased significantly in women, and CD34 positive. In patients with tumors size less than 5 cm in diameter, TG, HDL-C, and CHOL were significantly higher. TG levels were significantly higher in DOG-1 (a marker and has a high specificity and sensitivity in the diagnosis of GIST) positive patients than in DOG-1 negative patients (P < 0.05). S-100 positive patients had lower HDL-C levels than S-100 negative patients (P < 0.05). Lipids indexes were found to be correlated with GIST risk stratification and tumor site (P < 0.05). TG/HDL-C was were significantly different among patients with GIST in different locations (P < 0.05). Conclusion The clinical and pathological characteristics of the patients with GIST are closely related to the level of blood lipids. To a certain extent, information about level of blood lipids can be helpful for distinguishing benign and malignant GIST.

scholarly journals Preoperatively diagnosed gastric collision tumor with mixed adenocarcinoma and gastrointestinal stromal tumor: a case report and literature review

2021 ◽  
Author(s):  
Kunihiko Matsuno ◽  
Yoshikazu Kanazawa ◽  
Daisuke Kakinuma ◽  
Nobutoshi Hagiwara ◽  
Fumihiko Ando ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Distal Gastrectomy ◽  
Submucosal Tumor ◽  
Smooth Muscle Actin ◽  
Collision Tumor ◽  
Stromal Tumor ◽  
Lower Body ◽  
Muscle Actin ◽  
First Case ◽  
S 100

AbstractReports of gastric collision tumors, comprising adenocarcinoma and gastrointestinal stromal tumor, are extremely rare. Here, we report the case of a 68-year-old male who was diagnosed with a lower-body, moderately differentiated, tubular-type adenocarcinoma and submucosal tumor and underwent an elective D2 distal gastrectomy. The tumor cells of the gastrointestinal stromal tumor were positive for H-caldesmon and CD117, weakly positive for smooth muscle actin and DOG-1, and negative for desmin, S-100 protein, CD31, and AE1/AE3. The tumor had grown into a mixed form of adenocarcinoma and gastrointestinal stromal tumor. Thus, we report the first case of a preoperatively diagnosed collision tumor in the stomach consisting of adenocarcinoma and gastrointestinal stromal tumor.

scholarly journals Optimal cut-off points after a daily meal corresponding to fasting goal levels of LDL-C and non-HDL-C in Chinese patients with coronary heart disease

2020 ◽  
Author(s):  
Li-Ling Guo ◽  
Yan-qiao Chen ◽  
Qiu-zhen Lin ◽  
Feng Tian ◽  
Qun-Yan Xiang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Blood Lipids ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Lipoprotein Cholesterol ◽  
Chinese Patients ◽  
C Statistic ◽  
Blood Lipid Levels

Abstract Background: Although the detection of non-fasting blood lipids has been recommended in patients with coronary heart disease (CHD), the non-fasting cut-off points corresponding to the fasting goals of LDL-C < 1.8 mmol/Land non-HDL-C < 2.6 mmol/L, respectively, have not been explored. Methods: This study enrolled 397 inpatients with CHD. One hundred and ninety-seven patients took statins for < 1 month (m) or did not take any statin before admission (i.e. CHD1 group), while 204 patients took statins for ≥ 1 m before admission (i.e. CHD2 group). Blood lipid levels were measured at 0 h, 2 h, and 4 h after a daily breakfast. Results: Non-fasting low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) levels significantly decreased after a daily meal ( P < 0.05). Both fasting and non-fasting LDL-C or non-HDL-C levels were significantly lower in the CHD2 group. The percent attainment of LDL-C < 1.8 mmol/L at 2 h or 4 h after a daily breakfast was significantly higher than that of its fasting point ( P < 0.05), whereas that of non-HDL-C < 2.6 mmol/L was significantly higher only at 4 h ( P < 0.05). Analysis of c-statistic showed that non-fasting cut-off points for LDL-C and non-HDL-C were 1.5 mmol/L and 2.4 mmol/L, corresponding to their fasting goal levels of 1.8 mmol/L and 2.6 mmol/L, respectively. When postprandial LDL-C and non-HDL-C goal attainments were re-evaluated by non-fasting cut-off points, there were no significant differences in percent attainment between fasting and non-fasting states. Conclusions: Determination ofnon-fasting cut-off points is important to evaluate the efficacy of cholesterol-lowering therapy if blood lipids are detected after a daily meal.

The effect of drought feeding with whole cottonseed, and vitamin therapy, on the serum lipids and liveweight changes of beef cattle in North-western Australia

1968 ◽  
Vol 19 (4) ◽  
pp. 657 ◽  
Author(s):  
JC O'Kelly ◽  
DW Robinson
Keyword(s):  
Western Australia ◽  
Serum Lipids ◽  
Blood Lipids ◽  
Blood Lipid ◽  
Serum Levels ◽  
Wet Season ◽  
Supplementation Period ◽  
Vitamin Therapy ◽  
Whole Cottonseed ◽  
North Western

An experiment with 79 Shorthorn cattle was carried out in the Kimberley region of north-western Australia, to study the influence of drought feeding with whole cottonseed, and of vitamin therapy, on blood lipid components and liveweight changes in cattle during the dry season. The blood serum levels of total, free, and esterified cholesterol, triglycerides, and phospholipids were elevated as a result of cottonseed supplementation, as compared with levels at the end of the following wet season. In general the levels of these blood lipids were higher in the animals fed on cottonseed for longer periods. Neither the level of free fatty acids nor the ratio of free to esterified cholesterol was affected significantly by cottonseed supplementation. Liveweight responses were proportional to the duration of the supplementation period. There were no differences in liveweight changes or the blood components measured which could be attributed to vitamin therapy.

Comparison of Frame Size and Body Mass Index Methods of Assessment in the Study of Blood Lipids

1992 ◽  
Vol 75 (3) ◽  
pp. 881-882 ◽  
Author(s):  
Thomas Battinelli ◽  
Ray E. Gleason
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Blood Lipids ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Frame Size ◽  
Significant Relationships ◽  
Health Fairs ◽  
Index Methods ◽  
Blood Lipid Levels

This study compared frame size and body mass index methods of assessment in relation to blood lipid levels. The data were obtained from the records of 84 men and 193 women who voluntarily participated in health fairs held at two suburban hospitals. Significant relationships and differences were found between the anthropometric and lipid variables studied. The two methods of classification denoted moderate association and reflected some divergence in classification between them.

scholarly journals Non-HDL-C Is More Stable Than LDL-C in Assessing the Percent Attainment of Non-fasting Lipid for Coronary Heart Disease Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Li-Ling Guo ◽  
Yan-qiao Chen ◽  
Qiu-zhen Lin ◽  
Feng Tian ◽  
Qun-Yan Xiang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Statin Therapy ◽  
Blood Lipids ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Short Term ◽  
C Statistic ◽  
Blood Lipid Levels

This study aimed to compare the percentage attainment of fasting and non-fasting LDL-C and non-HDL-C target levels in coronary heart disease (CHD) patients receiving short-term statin therapy. This study enrolled 397 inpatients with CHD. Of these, 197 patients took statins for &lt;1 month (m) or did not take any statin before admission (CHD1 group), while 204 patients took statins for ≥1 m before admission (CHD2 group). Blood lipid levels were measured at 0, 2, and 4 h after a daily breakfast. Non-fasting LDL-C and non-HDL-C levels significantly decreased after a daily meal (P &lt; 0.05). Both fasting and non-fasting LDL-C or non-HDL-C levels were significantly lower in the CHD2 group. The percentage attainment of LDL-C &lt;1.4 mmol/L at 2 and 4 h after a daily breakfast was significantly higher than that during fasting (P &lt; 0.05), but the percent attainment of non-fasting non-HDL-C &lt;2.2 mmol/L was close to its fasting value (P &gt; 0.05). Analysis of c-statistic showed that non-fasting cut-off points for LDL-C and non-HDL-C were 1.19 and 2.11 mmol/L, corresponding to their fasting goal levels of 1.4 and 2.2 mmol/L, respectively. When post-prandial LDL-C and non-HDL-C goal attainments were re-evaluated using non-fasting cut-off points, there were no significant differences in percentage attainment between fasting and non-fasting states. Non-HDL-C is more stable than LDL-C in assessing the percent attainment of non-fasting lipid for coronary heart disease patients. If we want to use LDL-C to assess the percent attainment of post-prandial blood lipids, we may need to determine a lower non-fasting cut-off point.

Soybean Phosphatides and Blood Lipids of Primates1

1979 ◽  
Vol 42 (2) ◽  
pp. 113-119 ◽  
Author(s):  
R. A. ROBBINS ◽  
A. L. BRANEN
Keyword(s):  
Phosphatidyl Choline ◽  
Blood Lipids ◽  
Blood Lipid ◽  
Macaca Nemestrina ◽  
Cholesterol Diet ◽  
Lipid Levels ◽  
Low Fat ◽  
Butter Oil ◽  
Low Fat Diet ◽  
Blood Lipid Levels

Ten pigtail monkeys (Macaca nemestrina) were used to study the effects of soybean phosphatides on blood lipid levels. Two monkeys were maintained on a control low-fat diet and eight monkeys were made hypercholesterolemic by feeding a diet containing 16% butter oil and 1% cholesterol for a 12-week period. Soybean phosphatides were administered to the animals by infusion or incorporation into the diet. All animals were placed on low-fat diets after 12 weeks and maintained on this diet for 5 weeks. Incorporation of 3% soybean phosphatides into the butter oil-cholesterol diet before the animals became hypercholesterolemic or a twice weekly infusion of 5 ml of a 10% emulsion of soybean phosphatides after the animals were hypercholesterolemic partially prevented increases in plasma total cholesterol, cholesterol esters and lipid phosphate induced by the butter oil-cholesterol diets. Alterations in the blood plasma lipoprotein patterns resulting from the butter oil-cholesterol diet were also prevented by these methods of phosphatide administration. Switching the animals to a diet containing phosphatides after the animals were already hypercholesterolemic was not effective in preventing alterations in blood lipid levels or lipoprotein patterns. Blood triglyceride levels were not affected by any of the treatments. The phosphatide treatments had no significant effect on the rate of decrease of blood lipid levels after placing the hypercholesterolemic animals on a low fat-low cholesterol diet. Studies of the turnover of phosphatidyl choline indicate that this phospholipid or its component parts is/are rapidly absorbed and that 10% of the radioactivity of a single oral dose of the phospholipid is released from the tissues of monkeys with a half life of about 2 days. Prior treatment with phosphatides appears to delay excretion of phosphatidyl choline. Possible mechanisms of the action of phosphatides on blood lipids are discussed.

Effects of diet on serum lipids of fetal, neonatal, and pregnant rabbits

1961 ◽  
Vol 201 (4) ◽  
pp. 611-616 ◽  
Author(s):  
Meyer Friedman ◽  
Sanford O. Byers
Keyword(s):  
Serum Lipids ◽  
Blood Lipid ◽  
Maternal Blood ◽  
Blood Cholesterol ◽  
Lipid Levels ◽  
Serum Phospholipid ◽  
Fetal Serum ◽  
Natural Milk ◽  
Suckling Rabbit ◽  
Blood Lipid Levels

The serum phospholipid, cholesterol, and triglyceride values of the fetal rabbit were determined and found to be significantly higher than similar values in the maternal host. Moreover, these fetal serum values could not be changed by altering the maternal blood lipid levels. The rise in serum cholesterol and phospholipid usually observed in the suckling rabbit could be prevented by omission of both triglyceride and cholesterol from its diet. The omission of cholesterol appeared to be most responsible for this phenomenon, because the omission solely of cholesterol from the diet of slightly older rabbits appeared capable of reducing their blood cholesterol from a level which had been elevated previously by their ingestion of cholesterol rich natural milk from lactating dams.

scholarly journals Concomitant Gastrointestinal Stromal Tumor of the Stomach and Gastric Adenocarcinoma in a Patient with Billroth 2 Resection

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Federico Sista ◽  
Valentina Abruzzese ◽  
Mario Schietroma ◽  
Gianfranco Amicucci
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Gastric Adenocarcinoma ◽  
Gastric Resection ◽  
Stromal Tumor ◽  
Simultaneous Occurrence ◽  
Review Of The Literature ◽  
Billroth Ii ◽  
First Case ◽  
Mesenchymal Neoplasm ◽  
S 100

Background. With this study we focus on the etiopathogenesis and on the therapy of the simultaneous occurrence of Gastric gastrointestinal stromal tumor (gGIST) and adenocarcinoma of the stomach in a patient with Billroth II gastric resection (BIIGR). We report the first case of this event and a review of the literature.Methods. A 70-year-old man with a BIIGR, affected by adenocarcinoma of the stomach, was successfully treated with total gastrectomy. The histological examination showed a gastric adenocarcinoma with a synchronous GIST sized 2 cm and S-100, CD117, and CD34 positive. The mutation of PDGFR gene was detected.Discussion. This tumor is a rare mesenchymal neoplasm of the gastrointestinal tract. Few cases of synchronous gastric adenocarcinoma and GIST are observed in the literature and no case in patients with BIIGR. Various hypotheses have been proposed to explain this occurrence. It is frequently attributed to Metallothioneins genes mutations or embryological abnormalities, but this has not been proven yet. We suggest a hypothesis about the etiopathogenesis of this event in a BIIGR patient.Conclusion. GIST may occur synchronously with gastric adenocarcinoma. This simultaneous occurrence needs more studies to be proven. The study of Cajal cells’ proliferation signalling is crucial to demonstrate our hypotesis.

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