scholarly journals Fabrication of monodisperse magnetic nanorods for improving hyperthermia efficacy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Shan Zhao ◽  
Nanjing Hao ◽  
John X. J. Zhang ◽  
P. Jack Hoopes ◽  
Fridon Shubitidze ◽  
...  
Keyword(s):  
Hydrothermal Reaction ◽  
Local Heating ◽  
Treatment Strategies ◽  
Ferrous Ions ◽  
Magnetic Nanorods ◽  
Normal Tissues ◽  
Aspect Ratios ◽  
Rectal Cancers ◽  
One Step ◽  
Shape Controlling

Abstract Background Hyperthermia is one of the promising cancer treatment strategies enabled by local heating with the use of tumor-targeting magnetic nanoparticles (MNP) under a non-invasive magnetic field. However, one of the remaining challenges is how to achieve therapeutic levels of heat (without causing damages to regular tissues) in tumors that cannot be effectively treated with anti-tumor drug delivery. Results In this work, we report a facile method to fabricate magnetic nanorods for hyperthermia by one-step wet chemistry synthesis using 3-Aminopropyltrimethoxysilane (APTMS) as the shape-controlling agent and ferric and ferrous ions as precursors. By adjusting the concentration of APTMS, hydrothermal reaction time, ratios of ferric to ferrous ions, magnetic nanorods with aspect ratios ranging from 4.4 to 7.6 have been produced. At the clinically recommended field strength of 300 Oe (or less) and the frequency of 184 kHz, the specific absorption rate (SAR) of these nanorods is approximately 50 % higher than that of commercial Bionized NanoFerrite particles. Conclusions This increase in SAR, especially at low field strengths, is crucial for treating deep tumors, such as pancreatic and rectal cancers, by avoiding the generation of harmful eddy current heating in normal tissues.

scholarly journals Hitting the Bull’s-Eye: Mesothelin’s Role as a Biomarker and Therapeutic Target for Malignant Pleural Mesothelioma

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 3932
Author(s):  
Dannel Yeo ◽  
Laura Castelletti ◽  
Nico van Zandwijk ◽  
John E. J. Rasko
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Treatment Options ◽  
Survival Rates ◽  
Treatment Strategies ◽  
Pleural Mesothelioma ◽  
Normal Tissues ◽  
Drug Conjugates ◽  
Aggressive Cancer ◽  
Immunotherapy Target ◽  
Bull's Eye

Malignant pleural mesothelioma (MPM) is an aggressive cancer with limited treatment options and poor prognosis. MPM originates from the mesothelial lining of the pleura. Mesothelin (MSLN) is a glycoprotein expressed at low levels in normal tissues and at high levels in MPM. Many other solid cancers overexpress MSLN, and this is associated with worse survival rates. However, this association has not been found in MPM, and the exact biological role of MSLN in MPM requires further exploration. Here, we discuss the current research on the diagnostic and prognostic value of MSLN in MPM patients. Furthermore, MSLN has become an attractive immunotherapy target in MPM, where better treatment strategies are urgently needed. Several MSLN-targeted monoclonal antibodies, antibody–drug conjugates, immunotoxins, cancer vaccines, and cellular therapies have been tested in the clinical setting. The biological rationale underpinning MSLN-targeted immunotherapies and their potential to improve MPM patient outcomes are reviewed.

scholarly journals Hydrothermal synthesis of nanocrystalline hydroxyapatite–graphene nanosheet on Ti-6Al-7Nb: mechanical and in vitro corrosion performance

2021 ◽  
Vol 32 (4) ◽  
Author(s):  
Oktay Yigit ◽  
Burak Dikici ◽  
Niyazi Ozdemir
Keyword(s):  
Hydrothermal Reaction ◽  
Hybrid Coatings ◽  
Stoichiometric Ratio ◽  
Corrosion Performance ◽  
Graphene Nanosheet ◽  
Graphene Layers ◽  
Nanocrystalline Hydroxyapatite ◽  
One Step ◽  
Nano Size

AbstractThe hybrid coatings containing the graphene nano-sheet (GNS) and nano-hydroxyapatite (nHA) phases have been successfully synthesized on Ti6Al7Nb alloys by a one-step hydrothermal method. The hydrothermal reaction was carried out for 24 h at 200 °C. The GNS ratio has been altered as 1, 3, 5 and 7 wt.% in the coatings and, the results have compared with non- GNS containing coatings. The effect of the GNS ratio on the microstructure, hardness, and in vitro corrosion responses has been investigated in detail. The characterizations of the coatings were carried out by SEM, EDS, AFM, XRD and, FTIR. The corrosion behavior of the hybrid coatings was compared in Kokubo’s solution at 37 °C by using potentiodynamic polarization tests. The results showed that the hydroxyapatite phases were deposed on the graphene layers with nano-size nucleation with its Ca/P stoichiometric ratio. The best hydrophilicity (~52°) property has been obtained in nHA/3GNS coatings. In addition, the corrosion rates of coatings increased in the following order: nHA/3GNS < nHA/1GNS < nHA/7GNS < nHA/5GNS < only nHA.

One-step synthesis of silver nanoplates with high aspect ratios: using coordination of silver ions to enhance lateral growth

RSC Advances ◽  
2016 ◽  
Vol 6 (98) ◽  
pp. 95768-95773 ◽  
Author(s):  
Young Min Park ◽  
Byung Gon Lee ◽  
Jong-Il Weon ◽  
Mun Ho Kim
Keyword(s):  
Silver Ions ◽  
Lateral Growth ◽  
Silver Nanoplates ◽  
Aspect Ratios ◽  
One Step

A coordination-based strategy was employed to produce Ag nanoplates with high aspect ratios. Ag nanoplates were synthesized in the presence of acetonitrile, which served both as the co-solvent and as the ligand to form complexes with the Ag+ ions.

Activation and β-FeOOH modification of sepiolite in one-step hydrothermal reaction and its simulated solar light catalytic reduction of Cr(VI)

2017 ◽  
Vol 135 ◽  
pp. 547-553 ◽  
Author(s):  
Zhihui Xu ◽  
Hongmei Jiang ◽  
Yaqun Yu ◽  
Jiangyan Xu ◽  
Jianru Liang ◽  
...  
Keyword(s):  
Hydrothermal Reaction ◽  
Catalytic Reduction ◽  
Solar Light ◽  
Simulated Solar Light ◽  
One Step

Effect of one-step hydrothermal reaction conditions on the crystal growth of nano-/micro-MoS2

Ionics ◽  
2021 ◽  
Author(s):  
Xiangyun Qiu ◽  
Tao Zhang ◽  
Zuoqiang Dai ◽  
Ru Cao ◽  
Tao Wei
Keyword(s):  
Crystal Growth ◽  
Hydrothermal Reaction ◽  
Reaction Conditions ◽  
One Step

scholarly journals Rational Design for Mn3O4@carbon Foam Nanocomposite with 0D@3D Structure for Boosting Electrochemical Performance

2020 ◽  
Author(s):  
Zhu Yihan ◽  
Dongfeng Wang ◽  
Xuehua Yan ◽  
Yanli Li ◽  
Wending Zhou ◽  
...  
Keyword(s):  
Electrochemical Performance ◽  
Current Density ◽  
Rational Design ◽  
Hydrothermal Reaction ◽  
3D Structure ◽  
Carbon Foam ◽  
Transfer Path ◽  
3D Architecture ◽  
One Step ◽  
Mn3o4 Nanoparticles

Abstract A rational strategy was developed to prepare a nanocomposite with 0D/3D architecture. The composite containing Mn3O4 nanoparticles (0D) and carbon foam (3D) could be applied as an electrode material for supercapacitor by taking advantage of high conductivity of carbon foam (CF) and high pseudocapacitance of Mn3O4 nanoparticles. CF was prepared by a carbonization method using melamine foam, and then Mn3O4 nanoparticles were combined with carbon foam by a one-step hydrothermal method to prepare Mn3O4@CF nanocomposite. The 0D@3D hierarchical structure of Mn3O4@CF nanocomposite using CF as a 3D growing skeleton prevents agglomeration and increases reactive sites of Mn3O4 nanoparticles. In addition, CF as a conductive skeleton shortens the charge transfer path. The synergistic effect between CF and Mn3O4 improves the electrochemical performance of CF. Three Mn3O4@CF composites were prepared by adjusting the mass of the reactants in the processes of hydrothermal reaction. The Mn3O4 nanoparticles are uniformly grown on the CF surface with a diameter of 18 nm. Mn3O4@CF-2 composite has a specific capacitance of 212.8 F/g at a current density of 1 A/g, which is much higher than that of pristine CF (79.1 F/g) and Mn3O4 (112.7 F/g). The cyclic stability of Mn3O4@CF-2 is retained as 86.1% of initial capacitance after 2000 cycles at the current density of 1 A/g. It proves the feasibility of the as-mentioned strategy and broadens the application of carbon foam in supercapacitor.

scholarly journals Contribution of Human Retroviruses to Disease Development—A Focus on the HIV– and HERV–Cancer Relationships and Treatment Strategies

Viruses ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 852
Author(s):  
Ching-Hsuan Liu ◽  
Nicole Grandi ◽  
Lalitha Palanivelu ◽  
Enzo Tramontano ◽  
Liang-Tzung Lin
Keyword(s):  
Treatment Strategies ◽  
Kaposi Sarcoma ◽  
Antiretroviral Drugs ◽  
Endogenous Retroviruses ◽  
T Lymphotropic Virus ◽  
Normal Tissues ◽  
Non Hodgkin Lymphoma ◽  
Causative Agents ◽  
Immunodeficiency Syndrome ◽  
Molecular Patterns

Animal retroviruses are known for their transforming potential, and this is also true for the ones hosted by humans, which have gathered expanding attention as one of the potent causative agents in various disease, including specific cancer types. For instance, Human T Lymphotropic virus (HTLV) is a well-studied class of oncoviruses causing T cell leukemia, while human immunodeficiency virus (HIV) leads to acquired immunodeficiency syndrome (AIDS), which is linked to a series of defining cancers including Kaposi sarcoma, certain types of non-Hodgkin lymphoma, and cervical cancer. Of note, in addition to these “modern” exogenous retroviruses, our genome harbors a staggering number of human endogenous retroviruses (HERVs). HERVs are the genetic remnants of ancient retroviral germline infection of human ancestors and are typically silenced in normal tissues due to inactivating mutations and sequence loss. While some HERV elements have been appropriated and contribute to human physiological functions, others can be reactivated through epigenetic dysregulations to express retroviral elements and promote carcinogenesis. Conversely, HERV replication intermediates or protein products can also serve as intrinsic pathogen-associated molecular patterns that cause the immune system to interpret it as an exogenous infection, thereby stimulating immune responses against tumors. As such, HERVs have also been targeted as a potential internal strategy to sensitize tumor cells for promising immunotherapies. In this review, we discuss the dynamic role of human retroviruses in cancer development, focusing on HIV and HERVs contribution. We also describe potential treatment strategies, including immunotherapeutic targeting of HERVs, inhibiting DNA methylation to expose HERV signatures, and the use of antiretroviral drugs against HIV and HERVs, which can be employed as prospective anti-cancer modalities.

scholarly journals A highly selective and sensitive H2S sensor at low temperatures based on Cr-doped α-Fe2O3 nanoparticles

RSC Advances ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 4150-4156 ◽  
Author(s):  
Dongyang Xue ◽  
Rui Zhou ◽  
Xiaoping Lin ◽  
Xiaochuan Duan ◽  
Qiuhong Li ◽  
...  
Keyword(s):  
Low Temperature ◽  
Low Temperatures ◽  
Hydrothermal Reaction ◽  
High Sensitivity ◽  
Fe2o3 Nanoparticles ◽  
Sensitivity And Selectivity ◽  
One Step

Cr-doped α-Fe2O3 nanoparticles were synthesized by one-step hydrothermal reaction and showed high sensitivity and selectivity to H2S at low temperature.

scholarly journals Facile one-step synthesis of quaternary AgInZnS quantum dots and their applications for causing bioeffects and detecting Cu2+

RSC Advances ◽  
2020 ◽  
Vol 10 (16) ◽  
pp. 9172-9181 ◽  
Author(s):  
Xiao-Le Han ◽  
Qingyu Li ◽  
Hao Hao ◽  
Chenyin Liu ◽  
Run Li ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Optical Properties ◽  
Hydrothermal Reaction ◽  
Water Soluble ◽  
Step Method ◽  
One Step

Water-soluble AgInZnS quantum dots were synthesized with glutathione as a stabilizer by a facile one-step method based on a hydrothermal reaction at 110 °C. It exhibited excellent optical properties, which can be used as sensor to detect Cu2+.

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