scholarly journals The effects of phosphocreatine disodium salts plus blueberry extract supplementation on muscular strength, power, and endurance

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
John Paul V. Anders ◽  
Tyler J. Neltner ◽  
Robert W. Smith ◽  
Joshua L. Keller ◽  
Terry J. Housh ◽  
...  
Keyword(s):  
Placebo Group ◽  
Exercise Performance ◽  
Muscular Strength ◽  
Minimal Important Difference ◽  
Average Power ◽  
Creatine Supplementation ◽  
Peak Torque ◽  
Before And After ◽  
Group A ◽  
Percent Decline

Abstract Background Numerous studies have demonstrated the efficacy of creatine supplementation for improvements in exercise performance. Few studies, however, have examined the effects of phosphocreatine supplementation on exercise performance. Furthermore, while polyphenols have antioxidant and anti-inflammatory properties, little is known regarding the influence of polyphenol supplementation on muscular strength, power, and endurance. Thus, the purpose of the present study was to compare the effects of 28 days of supplementation with phosphocreatine disodium salts plus blueberry extract (PCDSB), creatine monohydrate (CM), and placebo on measures of muscular strength, power, and endurance. Methods Thirty-three men were randomly assigned to consume either PCDSB, CM, or placebo for 28 days. Peak torque (PT), average power (AP), and percent decline for peak torque (PT%) and average power (AP%) were assessed from a fatigue test consisting of 50 maximal, unilateral, isokinetic leg extensions at 180°·s− 1 before and after the 28 days of supplementation. Individual responses were assessed to examine the proportion of subjects that exceeded a minimal important difference (MID). Results The results demonstrated significant (p < 0.05) improvements in PT for the PCDSB and CM groups from pre- (99.90 ± 22.47 N·m and 99.95 ± 22.50 N·m, respectively) to post-supplementation (119.22 ± 29.87 N·m and 111.97 ± 24.50 N·m, respectively), but no significant (p = 0.112) change for the placebo group. The PCDSB and CM groups also exhibited significant improvements in AP from pre- (140.18 ± 32.08 W and 143.42 ± 33.84 W, respectively) to post-supplementation (170.12 ± 42.68 W and 159.78 ± 31.20 W, respectively), but no significant (p = 0.279) change for the placebo group. A significantly (p < 0.05) greater proportion of subjects in the PCDSB group exceeded the MID for PT compared to the placebo group, but there were no significant (p > 0.05) differences in the proportion of subjects exceeding the MID between the CM and placebo groups or between the CM and PCDSB groups. Conclusions These findings indicated that for the group mean responses, 28 days of supplementation with both PCDSB and CM resulted in increases in PT and AP. The PCDSB, however, may have an advantage over CM when compared to the placebo group for the proportion of individuals that respond favorably to supplementation with meaningful increases in muscular strength.

scholarly journals Effects of 4-Week Creatine Supplementation Combined with Complex Training on Muscle Damage and Sport Performance

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1640 ◽  
Author(s):  
Chia-Chi Wang ◽  
Chu-Chun Fang ◽  
Ying-Hsian Lee ◽  
Ming-Ta Yang ◽  
Kuei-Hui Chan
Keyword(s):  
Placebo Group ◽  
Muscle Damage ◽  
Muscular Strength ◽  
Creatine Supplementation ◽  
Training Programme ◽  
Sport Performance ◽  
Repetition Maximum ◽  
Before And After ◽  
Complex Training

Creatine supplementation has an ergogenic effect in an acute complex training bout, but the benefits of chronic creatine supplementation during long-term complex training remain unknown. The study aimed to evaluate the effects of 4-week complex training combined with creatine supplementation on sport performances and muscle damage biomarkers. Thirty explosive athletes were assigned to the creatine or placebo group, which consumed 20 g of creatine or carboxymethyl cellulose, respectively, per day for 6 days followed by 2 g of the supplements until the end of the study. After 6 days of supplementation, subjects performed tests of one repetition maximum (1-RM) strength of half squat and complex training bouts to determine the optimal individual post-activation potentiation time. Thereafter, all subjects performed a complex training programme consisting of six sets of 5-RM half squats and plyometric jumps 3 times per week for 4 weeks. Body composition, 30-m sprint and jump performances were assessed before and after the training period. Moreover, blood creatine kinase (CK) activity was analysed at the first and the last training bout. After the training, the 1-RM strength in the creatine group was significantly greater than in the placebo group (p < 0.05). CK activity after the complex training bout in the creatine group was significantly reduced compared with the placebo group (p < 0.05). No differences were noted for other variables. This study concluded that creatine supplementation combined with complex training improved maximal muscular strength and reduced muscle damage during training.

Influence of Oral Creatine Supplementation of Muscle Torque during Repeated Bouts of Maximal Voluntary Exercise in Man

1993 ◽  
Vol 84 (5) ◽  
pp. 565-571 ◽  
Author(s):  
Paul L. Greenhaff ◽  
Anna Casey ◽  
Anthony H. Short ◽  
Roger Harris ◽  
Karin Soderlund ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Lactate ◽  
Creatine Supplementation ◽  
Exercise Bout ◽  
Peak Torque ◽  
Voluntary Exercise ◽  
Plasma Ammonia ◽  
Muscle Torque ◽  
Before And After ◽  
Lactate Levels

1. The present experiment was undertaken to investigate the influence of oral creatine supplementation, shown previously to increase the total creatine content of human skeletal muscle (Harris RC, Soderlund K, Hultman E. Clin Sci 1992; 83: 367–74), on skeletal muscle isokinetic torque and the accumulation of plasma ammonia and blood lactate during five bouts of maximal exercise. 2. Twelve subjects undertook five bouts of 30 maximal voluntary isokinetic contractions, interspersed with 1 min recovery periods, before and after 5 days of placebo (4 × 6 g of glucose/day, n = 6) or creatine (4 × 5 g of creatine plus 1 g of glucose/day, n = 6) oral supplementation. Muscle torque production and plasma ammonia and blood lactate accumulation were measured during and after exercise on each treatment 3. No difference was seen when comparing muscle peak torque production during exercise before and after placebo ingestion. After creatine ingestion, muscle peak torque production was greater in all subjects during the final 10 contractions of exercise bout 1 (P <0.05), throughout the whole of exercise bouts 2 (P <0.01), 3 (P <0.05) and 4 (P = 0.057) and during contractions 11–20 of the final exercise bout (P <0.05), when compared with the corresponding measurements made before creatine ingestion. Plasma ammonia accumulation was lower during and after exercise after creatine ingestion. No differences were found when comparing blood lactate levels. 4. There is evidence to suggest that the decrease in the degree of muscle torque loss after dietary creatine supplementation may be a consequence of a creatine-induced acceleration of skeletal muscle phosphocreatine resynthesis. It is postulated that an increased availability of phosphocreatine would maintain better the required rate of ATP demand during contraction. This is supported by the observed lower accumulation of plasma ammonia during exercise after creatine ingestion.

scholarly journals Four-week of local electromyostimulaiton training on fingerboard increases the isokinetic wrist strength and endurance

2020 ◽  
Vol 24 (3) ◽  
pp. 127-134
Author(s):  
Dicle Aras ◽  
Selçuk Gül ◽  
Fırat Akça ◽  
Mehmet Gülü ◽  
Özkan Güler ◽  
...  
Keyword(s):  
Body Weight ◽  
Physical Therapy ◽  
Essential Role ◽  
Average Power ◽  
Peak Torque ◽  
Muscular Fitness ◽  
Physically Active ◽  
Left Wrist ◽  
Before And After ◽  
Flexion And Extension

Background and Study Aim: Electromyostimulaiton (EMS) has been used for both physical therapy and strength improvements for a few decades. This study aimed to investigate the effects of a four-week local-EMS training performed on a fingerboard (FT) in wrist strength and endurance. Material and Methods:  Sixteen physically active, non-climber students were divided into EMS+FT and FT groups. Each group performed the same training program about 25 min a day, 3 days a week for four weeks. The EMS+FT implementation was performed with a signal width of 260 ms and a frequency of 60 Hz. Before and after training, isokinetic measurements were collected. The parameters used in the research during flexion and extension at 60 and 180°/sec were; Peak Torque (PT), Peak Torque/Body Weight (PT/BW), and Average Power (AP). Results: The EMS+FT group showed statistically significant alterations in all of the parameters (p<0.01 and p<0.05) except in the left wrist AP during flexion and extension at 180°/sec. However, the FT group showed significant changes in only wright wrist AP during extension at 60°/sec, and wright and left wrist AP during flexion at 180°/sec, and left wrist PT during extension at 180°/sec. Conclusions: Accordingly, it could be inferred that FT done by using EMS for four weeks improve the isokinetic wrist strength and endurance significantly. Muscular fitness has an essential role in climbing performance, and this study points that EMS trainings on fingerboard could be used to enhance the climbing performance.

scholarly journals The effects of BCAA and creatine supplementation on anaerobic capacity and ball kicking speed in male football players

2021 ◽  
Keyword(s):  
Peak Power ◽  
Average Power ◽  
Anaerobic Capacity ◽  
Creatine Supplementation ◽  
Football Players ◽  
Performance Tests ◽  
Fatigue Index ◽  
Tests And Measurements ◽  
Before And After ◽  
Branched Chain

Background and objective: The use of nutritional supplements has increased in recent years. This study analyzes the effects of Branched-Chain Amino Acids (BCAA) and creatine (CR) supplementation on anaerobic capacity and ball kicking speed in football players. Material and methods: 24 volunteer-active male amateur football players between 18--26 were recruited for this study. Football players were randomly divided into three groups as BCAA (n = 8), CR (n = 8), and placebo (PLA) (n = 8). Experimental groups were given 5 g BCAA and 2 g creatine before and after exercise, whereas the placebo group ingested bran, performance tests and measurements were performed, and results were assessed. Results: BCAA group average power (pre: 530.70 ± 53.73 W vs. post: 567.65 ± 66.68 W; p = 0.028), CR group minimum power (pre: 413.75 ± 51.13 W vs. post: 462.82 ± 71.93 W; p = 0.043) increased, while there were decreases in peak power (pre: 659.34 ± 121.03 W vs. post: 613.20 ± 124.24 W; p = 0.043) and fatigue index (pre: 6.55 ± 2.12 W/s vs. post: 4.34 ± 2.37 W/s; p = 0.043) parameters of PLA group (p < 0.05). There were statistically significant differences in the BCAA group in rest, pre-and post-supplementation; CR group in pre-and post-supplementation; PLA group in rest, pre-and post-supplementation (p < 0.05). Conclusions: BCAA and creatine consumption do not affect recovery rates in football players regarding obtained data. But, regarding other findings of this study, BCAA and creatine supplementation improves anaerobic capacity, provides strength endurance against fatigue, and prevents the decrement of ball-kicking speed in exhaustion.

scholarly journals Piptadenia gonoacantha-based natural dermocosmetic: a clinical trial

2021 ◽  
Vol 43 ◽  
pp. e1-43676
Author(s):  
Luciano Côrtes Paiva ◽  
Karen Vieira da Silva ◽  
Gabriel Feu Guarçoni de Almeida ◽  
Eliana Amaro de Carvalho Caldeira ◽  
Carlos Eduardo Soares Gazzinelli Cruz ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Placebo Group ◽  
Intervention Group ◽  
Clinical Phase ◽  
Phase Ii Clinical Trials ◽  
Phase Study ◽  
Significant Difference ◽  
Before And After ◽  
Group A

The use of phytotherapy expands the possibility of therapeutic resources for the population, often offering reduced costs when compared to the pharmaceutical industry. In this perspective, the JACBIO® dermocosmetic ointment revealed, in non-clinical trials, its antibacterial and healing potential, with a great stimulating effect in increasing the production of images. This work aimed to carry out the clinical phase study on dermal toxicity, in serious humans, by applying JACBIO®, based on extracts from the leaves of Piptadenia gonoacantha (Pau Jacaré). The phase I randomized clinical trial was carried out with 28 clinically healthy patients at a public university in Minas Gerais, with no period from August to December 2018. The toxicological trial was developed with the intervention group that received a JACBIO® dermatological ointment and the Placebo group. From the experimental protocol, participants were followed for four weeks. An analysis between the ointment and placebo groups, without reference to anticholinergic and cardiovascular events, showed no statistically significant difference. Likewise, there was no difference in laboratory results performed before and after treatment, both for the placebo group and for the intervention group. A low toxicity of the product indicates that this adjustment is safe and serves as a basis for phase II clinical trials in patients with lesions.

Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans

1996 ◽  
Vol 271 (5) ◽  
pp. E821-E826 ◽  
Author(s):  
A. L. Green ◽  
E. Hultman ◽  
I. A. Macdonald ◽  
D. A. Sewell ◽  
P. L. Greenhaff
Keyword(s):  
Skeletal Muscle ◽  
Serum Insulin ◽  
Creatine Supplementation ◽  
Insulin Concentration ◽  
Carbohydrate Ingestion ◽  
Before And After ◽  
Group A ◽  
Muscle Creatine ◽  
Cr Concentration ◽  
Group B

This study investigated the effect of carbohydrate (CHO) ingestion on skeletal muscle creatine (Cr) accumulation during Cr supplementation in humans. Muscle biopsy, urine, and plasma samples were obtained from 24 males before and after ingesting 5 g Cr in solution (group A) or 5 g Cr followed, 30 min later, by 93 g simple CHO in solution (group B) four times each day for 5 days. Supplementation resulted in an increase in muscle phosphocreatine (PCr), Cr, and total creatine (TCr; sum of PCr and Cr) concentration in groups A and B, but the increase in TCr in group B was 60% greater than in group A (P < 0.01). There was also a corresponding decrease in urinary Cr excretion in group B (P < 0.001). Creatine supplementation had no effect on serum insulin concentration, but Cr and CHO ingestion dramatically elevated insulin concentration (P < 0.001). These findings demonstrate that CHO ingestion substantially augments muscle Cr accumulation during Cr feeding in humans, which appears to be insulin mediated.

Study the Relationship Between Estrogen Hormone and Calcium in Normal Females Before and After Menopause in Baghdad / Iraq

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Sameerah Mustafa ◽  
Asal Tawfeeq ◽  
Hadeel Hasan
Keyword(s):  
Oral Contraceptive ◽  
Healthy Controls ◽  
Serum Samples ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
Menopausal Women ◽  
Before And After ◽  
Group A ◽  
Group B ◽  
Age Range

This study involved the collection of (90) samples of women serum which included (30) serum samples collected from women before menopause (reproductive women) in the age range of (22-43) years and were considered as (group A- control). While, (group B) included (30) serum samples collected from women using oral contraceptive pills between the ages of (22-43) years old. Whereas, another (30) serum samples were collected from women after menopause between the ages of (43-54) years and were considered as (group C). All of the collected serum samples were subjected to a number of serological and chemical tests for the measurement of (E2, HDL, LDL and Ca). Then, the obtained data were statistical analyzed and results showed a significant decrease (p˂ 0.05) in (E2 ,Ca and HDL) levels in menopausal women compared to that of the normal healthy controls. While, there were non-significant decrease (p> 0.05) in (E2, Ca and HDL) levels in women taking oral contraceptive when compared to the normal healthy controls. On the other hand, a significant increase (p˂ 0.05) was recorded in LDL level in menopausal women compared to that of the normal healthy controls whereas, no-significant increase (p˃ 0.05) in the LDL level in women taking oral contraceptives when compared to the control women.

Melatonin Improves Lipid Profile and Ameliorates Lipid Peroxidation in Patients with Chronic Kidney Disease.

2018 ◽  
pp. 38-45
Keyword(s):  
Lipid Peroxidation ◽  
Placebo Group ◽  
Lipid Profile ◽  
Kidney Diseases ◽  
Oxidized Ldl ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Before And After ◽  
Inhibit Lipid Peroxidation ◽  
Controlled Clinical Study

Dyslipidemia and oxidative modifications of lipid are frequently associated in patients with chronic kidney diseases (CKD) and considered the most important risk factors for cardiovascular events. Melatonin is a well-known potent antioxidant and has beneficial effect on lipid metabolism. the study was designed to evaluate if Melatonin could improve lipid profile and ameliorates lipid peroxidation. This single blind placebo controlled clinical study carried out on 41 patients with CKD who were randomized into two groups, control groups (n=20) those who received placebo cap and melatonin group those who received 5mg melatonin (n=21). Lipid profile [total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C)] and parameters of lipid peroxidation [oxidized LDL (oxLDL) and malondialdehyde (MDA) were measured before and after 12 weeks of the treatment. After 12 weeks of treatment, melatonin significantly increased HDL-C and decreased LDL-C compared to the initial value. The elevation in HDL-C and reduction in LDL-C were significantly different from that in placebo group. Also, both oxLDL and MDA levels significantly lowered by melatonin compared to the baseline and to the placebo group. Collectively, the results of our study showed that melatonin has advantageous effect on lipid profile and inhibit lipid peroxidation in patients with CKD.

A Comparative Study of Amalaki Choorna along with Madhu and Vata Twak Kashaya Yoni Pichu Dharana in the Management of Shweta Pradara

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Renuka M. Tenahalli
Keyword(s):  
Vitamin C ◽  
Early Stage ◽  
Pathological Condition ◽  
Before And After ◽  
Group A ◽  
Phosphorus Iron ◽  
Group B ◽  
Busy Schedule ◽  
Iron And Calcium

Shweta Pradara (Leucorrhoea) is the disease which is characterized by vaginal white discharge. Vaginal white discharge this symptom is present in both physiological and pathological condition, when it becomes pathological it disturbs routine life style of the woman. Most of the women in the early stage will not express the symptoms because of hesitation and their busy schedule. If it is not treated it may leads to chronic diseases like PID (Garbhashaya Shotha etc.) Charaka mentioned Amalaki Choorna along with Madhu and Vata Twak Kashaya Yoni Pichu Dharana. This treatment is used in Shweta Pradara shown positive results, hence a study was under taken to assess its clinical efficacy. 30 diagnosed patients of Shweta Pradara were randomly selected, allocated in three groups. Group A and Group B received Amalaki Choorna with Madhu and Vata Twak Kashaya Yoni Pichu Dharana respectively and Group C received Amalaki Choorna with Madhu followed by Vata Twak Kashaya Yoni Pichu Dharana for 15 days. The patients were assessed for the severity of the symptoms subjectively and objectively before and after the treatment and at the end of the follow up. Data from each group were statistically analyzed and were compared. No side effects were noted and it may be considered as an effective alternative medicine in Shweta Pradara (leucorrhea). Amalaki is rich in natural source of vitamin C and contains phosphorus, iron and calcium. Honey contains carbohydrate, vitamin C, phosphorus iron and calcium. All together these help to increase Hb% and immunity. Vata Twak Kashaya contains tannin which helps to maintain normal pH of the vagina.

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