scholarly journals Reversible infertility in male dog following prolonged treatment of Malassezia dermatitis with ketoconazole

2021 ◽  
Vol 63 (1) ◽  
Author(s):  
Anna Domosławska ◽  
Sławomir Zduńczyk
Keyword(s):  
Adverse Effects ◽  
Testosterone Level ◽  
Antifungal Agent ◽  
Sperm Quality ◽  
Previous Treatment ◽  
Prolonged Treatment ◽  
Prolonged Administration ◽  
Case Presentation ◽  
Low Testosterone ◽  
Possible Cause

Abstract Background Ketoconazole, an antifungal agent, adversely affects spermatogenesis in rodents, but knowledge on adverse effects of prolonged administration of ketoconazole on the fertility of male dogs is lacking. A case of reversible infertility with azoospermia in a male American Staffordshire terrier treated with ketoconazole is reported here. Case presentation A seven-year old male American Staffordshire terrier treated for 3 months with ketoconazole for a persistent Malassezia dermatitis displayed reduced libido and mating of 3 bitches had been unsuccessful. The dog was presented at the clinic 40 days after the treatment had been stopped. At first presentation, low libido and complete absence of sperm in the ejaculate (azoospermia) associated with low testosterone level were found. Repeated examinations revealed that sperm quality and testosterone level had restored 100 days after ketoconazole had been withdrawn. Thereafter, the dog successfully mated 2 bitches. Conclusion The treatment with ketoconazole for 3 months may have led to reversible infertility characterized by azoospermia. Therefore, owners of stud dogs should be informed of this risk prior to initiating such treatment and in case of infertility, previous treatment with ketoconazole should be considered as a possible cause.

Prolonged Administration of Arsenic Trioxide (Trisenox®) for Patients with Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML) at MD Anderson Cancer Center: A Phase II Study.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 4731-4731
Author(s):  
Miloslav Beran ◽  
Srdan Verstovsek ◽  
Steven M. Kornblau ◽  
Elihu H. Estey ◽  
Francis Giles ◽  
...  
Keyword(s):  
Arsenic Trioxide ◽  
Stable Disease ◽  
Chromosomal Abnormalities ◽  
Previous Treatment ◽  
Response Duration ◽  
Outpatient Setting ◽  
Prolonged Treatment ◽  
Cancer Center ◽  
Prolonged Administration ◽  
Grade 3

Abstract The value of prolonged administration of arsenic trioxide (ATO) was examined in patients (pts) with MDS and CMML. ATO (0.25 mg/kg) was given intravenously over 1 hour daily for five days followed by 0.25 mg/kg twice weekly for 11 weeks. Pts were assessed at 4 weeks, at the end of the first course, and then monthly. Pts with stable disease were eligible for further courses. The study included 14 RBC transfusion-dependent MDS pts (6 RA/RARS, 8 RAEB; 12 IPSS risk Low/Int1, 2 Int2/High), and 3 CMML pts. Median age was 67 years (range 46–84). Six pts had a history of previous treatment other than supportive care. 16 pts were evaluable for toxicity and response. One pt received 3 courses, 3 received 2 courses, and 13 received 1 course. Hematologic responses (IWG criteria) were observed in 4 pts (25%) and 9 (6 MDS,3 CMML) had stable disease: FAB Type of response Time to response Duration RA Minor erythroid 2 months 3 mo, RBC independence RAEB Major neutrophil and platelet 2 mo 3 mo RAEB BM blast decrease 18% to <5% 1 mo 14 mo, stable pancytopenia RAEB Hematologic/cytogenetic CR 1 mo 6 mo Hematologic/cytogenetic CR was achieved in one pt: a 76 year old male, RAEB-2, Int 2, complex chromosomal abnormalities, who had previously failed thalidomide for 6 months and thalidomide + cyclosporin A for 3 months. Of the 3 CMML pts, one had transient reduction of absolute monocyte counts during each of 2 courses; all 3 had stable disease. In 24 courses there were 6 febrile episodes in 4 patients, requiring admission, all in pts with pre-existing neutropenia; 1 Grade 3 and 1 Grade 4 thrombocytopenia, 1 Grade 3 neutropenia, all requiring dose modification; 1 episode of accelerated functional cardiac rhythm; and 1 anemia-precipitated congestive heart failure, which was unlikely related to the drug. There were 22 episodes of Grade 1 or 2 drug-related toxicities. Four responses of 3–7+ mo. duration were observed, including 1 CR, suggesting activity in an as yet undefined subgroup of MDS pts. No benefit of prolonged treatment was documented. ATO was safe in this outpatient setting for elderly patients. Observed low toxicity and documented activity support future trials of ATO in combination with other agents in treatment of MDS.

Free Testosterone Level And Quality of Cauda Epididymis Sperm of Local Rabbit That Given Commercial Feed Supplemented By Cod Fish Liver Oil

2016 ◽  
Vol 2 (3) ◽  
pp. 1
Author(s):  
Ni Gusti Ayu Manik Ermayanti ◽  
I Gusti Lanang Oka ◽  
I Gede Mahardika ◽  
I Putu Suyadnya
Keyword(s):  
Testosterone Level ◽  
Sperm Quality ◽  
Free Testosterone ◽  
Fish Liver ◽  
Testosterone Levels ◽  
Commercial Feed ◽  
One Way Anova ◽  
Free Testosterone Level ◽  
Range Test

This study was intended to determine the free testosterone levels and sperm quality of local rabbit that was given commercial feed supplemented cod fish liver oil.  The experiment design that was used in this research was Complete Random Design (CRD) with four experiments of feed, i.e. commercial feed without cod fish liver oil (R-0) as control, commercial feed + 1,5% cod fish liver oil (R-1), commercial feed + cod fish liver oil 3% (R-2), commercial feed + cod fish liver oil 4,5% (R-3). The each experiment included eight rabbits and feed experiment was given starting by 13 weeks to 26 weeks years old. The variable that observed was free testosterone level and sperm quality of local rabbit. The data that was obtained to be analyzed with One Way Anova and if its contrast was done more test with Duncan’s Multiple Range Test (DMRT). The result of this research was to show that supplementation of cod fish liver oil in commercial feed was to show the result that a real distinction of (P<0, 05) towards free testosterone level and sperm quality of local rabbit.

scholarly journals Androgenetic Alopecia in a Patient with Klinefelter Syndrome: Case Report and Literature Review

2020 ◽  
pp. 1-4
Author(s):  
Waleed Alsalhi ◽  
Antonella Tosti
Keyword(s):  
Case Report ◽  
Klinefelter Syndrome ◽  
Light Therapy ◽  
Androgenetic Alopecia ◽  
Follicle Cells ◽  
Androgen Deficiency ◽  
Case Presentation ◽  
Low Level Light Therapy ◽  
Chromosomal Disorder ◽  
Low Testosterone

<b><i>Introduction:</i></b> Klinefelter syndrome (KS) is defined as (a chromosomal disorder in which males have an extra X chromosome). KS presents clinically with signs of androgen deficiency including low testosterone. Androgenetic alopecia (AGA) develops as a response of the hair follicle cells to androgens in individuals with genetic predisposition. <b><i>Case Presentation:</i></b> We describe a 17-year-old male patient with KS who developed AGA with a Ludwig pattern. <b><i>Conclusion:</i></b> Our patient had a good response to oral minoxidil, finasteride, and low-level light therapy.

Vitamin C ameliorates the adverse effects of dexamethasone on sperm motility, testosterone level, and spermatogenesis indexes in mice

2018 ◽  
Vol 38 (4) ◽  
pp. 409-418 ◽  
Author(s):  
F Sadeghzadeh ◽  
MS Mehranjani ◽  
M Mahmoodi
Keyword(s):  
Adverse Effects ◽  
Vitamin C ◽  
Sperm Motility ◽  
Testosterone Level ◽  
Leydig Cells ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Control Group ◽  
The Mean ◽  
Vit C

Background: Dexamethasone (DEX) is a common medicine that is capable of causing malformation in the male reproductive system. The aim of this study was to investigate the effect of vitamin C (Vit-C) on spermatogenesis indexes and daily sperm production (DSP) in adult mice treated with DEX. Methods: Male Naval Medical Research Institute (NMRI) mice were divided into four groups: Control, DEX (7 mg/kg/day), Vit-C (100 mg/kg/day), and DEX +Vit-C and treated for 7 days with intraperitoneal injection. Results: A significant increase in the mean levels of serum and tissue malondialdehyde (MDA) and apoptosis of Leydig cells was found in the DEX group compared to the control group. Sperm motility, DSP, tubular differentiation index, meiotic index, spermatogenesis index, the mean number of spermatocytes, round and long spermatids, and Leydig cells, and also serum testosterone level decreased in the DEX group compared to the control group. The results of this study indicate that Vit-C can significantly prevent the adverse effects of DEX on the mean number of spermatocyte, spermatid, and Leydig cells, tubular differentiation, meiotic and spermatogenesis index, DSP, sperm motility, and the mean levels of serum MDA. Conclusion: In conclusion, our results showed that coadministration of Vit-C and DEX prevents the adverse effects of DEX on the spermatogenesis indexes and DSP.

scholarly journals Duplication of Inferior Vena Cava, Possible Cause of Internal Hernia? Literature Review and Rare Case Presentation

Chirurgia ◽  
2020 ◽  
Vol 115 (5) ◽  
pp. 665
Author(s):  
Cedric Kwizera ◽  
Daniel G. Popa ◽  
Marian Botoncea ◽  
Adrian Tudor ◽  
Gyorgy D. Szava ◽  
...  
Keyword(s):  
Literature Review ◽  
Inferior Vena Cava ◽  
Internal Hernia ◽  
Rare Case ◽  
Inferior Vena ◽  
Vena Cava ◽  
Case Presentation ◽  
Possible Cause

scholarly journals Normogonadotropic hypogonadism in men with obesity

2009 ◽  
Vol 6 (3) ◽  
pp. 39-42 ◽  
Author(s):  
L V Savel'eva ◽  
R V Rozhivanov ◽  
B O Shurdumova ◽  
V V Fadeev
Keyword(s):  
Testosterone Level ◽  
Healthy Subjects ◽  
Immunoreactive Insulin ◽  
Homa Index ◽  
Obese Patients ◽  
Functional Disorder ◽  
Testosterone Levels ◽  
Significant Difference ◽  
Low Testosterone ◽  
Index Calculation

Objective: to evaluate the preavalence and characteristics of hypogonadism in obese man. Research and Methods: Thestudy was performed in 31 obese man (aged 33 [22;44], BMI 40 [34,4;44,0]. Measurements during the study: chemistry panel, testosteroa and LH levels, immunoreactive insulin, HOMA index calculation. Statistically significant difference w as considered as p < 0,05. Results. Hypogonadism preavalence was 80,6%. The hypogonadism prevalence and testosterone level was more depended on age and obesity but less on duration. 100 % risk of hypogonadism w as observed in heavily obese patients. There w as no increase of LH levels. In man with low testosterone lev els HOMA index w as significantly higher со mpared to healthy subjects. Conclusion: The prevalence of normogonadotropic hypogonadism in obese men is extremely high and it represents an evidence of functional disorder of hypophyseal gonadal system. Thedecrease of testosterone levels is age-coinciding, but it is more pronounced in obese nan.

Low Testosterone Level as a Predictor of Poststroke Emotional Disturbances: Anger Proneness and Emotional Incontinence

2018 ◽  
Vol 27 (12) ◽  
pp. 3549-3554 ◽  
Author(s):  
Mun Hee Choi ◽  
Tae Sung Lim ◽  
Bok Seon Yoon ◽  
Keoung Sun Son ◽  
Ji Man Hong ◽  
...  
Keyword(s):  
Testosterone Level ◽  
Emotional Disturbances ◽  
Low Testosterone

Maternal iodine excess: an uncommon cause of acquired neonatal hypothyroidism

2018 ◽  
Vol 31 (9) ◽  
pp. 1061-1064 ◽  
Author(s):  
Tyler Hamby ◽  
Nayana Kunnel ◽  
John S. Dallas ◽  
Don P. Wilson
Keyword(s):  
Newborn Screening ◽  
Growth And Development ◽  
Short Term ◽  
Neonatal Hypothyroidism ◽  
Case Presentation ◽  
Iodine Excess ◽  
Excessive Iodine ◽  
Possible Cause

AbstractBackgroundExcessive iodine exposure is an often overlooked cause of neonatal hypothyroidism.Case presentationWe present an infant with iodine-induced hypothyroidism, which was detected at age 15 days by newborn screening. The infant’s iodine excess resulted from maternal intake of seaweed soup both during and after pregnancy. Treatment included discontinuation of seaweed soup, temporary interruption of breastfeeding and short-term levothyroxine therapy. By age 4 months, the infant’s hypothyroidism had resolved, and her growth and development were normal.ConclusionsThis case illustrates the importance of considering excess dietary iodine as a possible cause of hypothyroidism in infants.

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