scholarly journals Carry-over effects of urban larval environments on the transmission potential of dengue-2 virus

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Michelle V. Evans ◽  
Justine C. Shiau ◽  
Nicole Solano ◽  
Melinda A. Brindley ◽  
John M. Drake ◽  
...  
Keyword(s):  
Transmission Potential ◽  
Carry Over

scholarly journals Carry-over effects of larval microclimate on the transmission potential of a mosquito-borne pathogen

2017 ◽  
Author(s):  
Michelle V. Evans ◽  
Justine C. Shiau ◽  
Nicole Solano ◽  
Melinda A. Brindley ◽  
John M. Drake ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Environmental Temperature ◽  
Vector Competence ◽  
Transmission Model ◽  
Effect Of Temperature ◽  
Transmission Potential ◽  
Dengue Transmission ◽  
Strong Positive Relationship ◽  
Carry Over ◽  
Models Of Disease

AbstractClimate shapes the transmission of mosquito-borne pathogens through impacts on both the vector and the pathogen. In addition to direct effects of the environment, carry-over effects from previous life history stages can influence mosquito traits relevant to disease transmission. While this has been explored in a laboratory setting, the net effect of temperature-mediated carry-over effects due to relevant environmental variation in the larval stage is ambiguous. Here, we use data collected from a semi-field experiment investigating dengue dynamics inAedes albopictusacross a natural environmental gradient to parameterize a dengue transmission model. We rearedAe. albopictusacross three different land classes characterized by their proportion of impervious surface. Emerged females were offered a dengue infectious bloodmeal, kept at a constant 27 °C, and assayed for infection, dissemination, and infectiousness 21 days post infection. Incorporating carry-over effects of larval environment on measures of vector competence resulted in lower predicted dengue transmission potential across land class and season, however a strong positive relationship with larval environmental temperature remained. Given the significant impact of carry-over effects, future mechanistic models of disease transmission should include both direct and carry-over effects of environmental temperature.

scholarly journals Evidence for carry-over effects of predator exposure on pathogen transmission potential

2015 ◽  
Vol 282 (1821) ◽  
pp. 20152430 ◽  
Author(s):  
Olivier Roux ◽  
Amélie Vantaux ◽  
Benjamin Roche ◽  
Koudraogo B. Yameogo ◽  
Kounbobr R. Dabiré ◽  
...  
Keyword(s):  
Larval Development ◽  
Species Interactions ◽  
Disease Ecology ◽  
Pathogen Transmission ◽  
Natural Food ◽  
Mosquito Vector ◽  
Anopheles Coluzzii ◽  
Adult Size ◽  
Transmission Potential ◽  
Carry Over

Accumulating evidence indicates that species interactions such as competition and predation can indirectly alter interactions with other community members, including parasites. For example, presence of predators can induce behavioural defences in the prey, resulting in a change in susceptibility to parasites. Such predator-induced phenotypic changes may be especially pervasive in prey with discrete larval and adult stages, for which exposure to predators during larval development can have strong carry-over effects on adult phenotypes. To the best of our knowledge, no study to date has examined possible carry-over effects of predator exposure on pathogen transmission. We addressed this question using a natural food web consisting of the human malaria parasite Plasmodium falciparum , the mosquito vector Anopheles coluzzii and a backswimmer, an aquatic predator of mosquito larvae. Although predator exposure did not significantly alter mosquito susceptibility to P. falciparum , it incurred strong fitness costs on other key mosquito life-history traits, including larval development, adult size, fecundity and longevity. Using an epidemiological model, we show that larval predator exposure should overall significantly decrease malaria transmission. These results highlight the importance of taking into account the effect of environmental stressors on disease ecology and epidemiology.

Minimizing Carry-Over Effects After Treatment Failure and Maximizing Therapeutic Outcome

2014 ◽  
Vol 222 (3) ◽  
pp. 171-178 ◽  
Author(s):  
Mareile Hofmann ◽  
Nathalie Wrobel ◽  
Simon Kessner ◽  
Ulrike Bingel
Keyword(s):  
Treatment Failure ◽  
Human Subjects ◽  
Subsequent Treatment ◽  
Clinical Samples ◽  
Administration Route ◽  
Healthy Human ◽  
Negative Experiences ◽  
Analgesic Treatment ◽  
Balanced Design ◽  
Carry Over

According to experimental and clinical evidence, the experiences of previous treatments are carried over to different therapeutic approaches and impair the outcome of subsequent treatments. In this behavioral pilot study we used a change in administration route to investigate whether the effect of prior treatment experience on a subsequent treatment depends on the similarity of both treatments. We experimentally induced positive or negative experiences with a topical analgesic treatment in two groups of healthy human subjects. Subsequently, we compared responses to a second, unrelated and systemic analgesic treatment between both the positive and negative group. We found that there was no difference in the analgesic response to the second treatment between the two groups. Our data indicate that a change in administration route might reduce the influence of treatment history and therefore be a way to reduce negative carry-over effects after treatment failure. Future studies will have to validate these findings in a fully balanced design including larger, clinical samples.

Does CBT for Psychosis Have an Impact on Delusions by Improving Reasoning Biases and Negative Self-Schemas?

2018 ◽  
Vol 226 (3) ◽  
pp. 152-163 ◽  
Author(s):  
Stephanie Mehl ◽  
Björn Schlier ◽  
Tania M. Lincoln
Keyword(s):  
Behavioral Therapy ◽  
Theoretical Models ◽  
Self Esteem ◽  
Secondary Outcome ◽  
Intervention Effect ◽  
Produce Change ◽  
Attribution Biases ◽  
Carry Over ◽  
Implicit And Explicit ◽  
Reasoning Biases

Abstract. Cognitive-behavioral therapy for psychosis (CBTp) builds on theoretical models that postulate reasoning biases and negative self-schemas to be involved in the formation and maintenance of delusions. However, it is unclear whether CBTp induces change in delusions by improving these proposed causal mechanisms. This study reports on a mediation analysis of a CBTp effectiveness trial in which delusions were a secondary outcome. Patients with psychosis were randomized to individualized CBTp (n = 36) or a waiting list condition (WL; n = 34). Reasoning biases (jumping to conclusions, theory of mind, attribution biases) and self-schemas (implicit and explicit self-esteem; self-schemas related to different domains) were assessed pre- and post-therapy/WL. The results reveal an intervention effect on two of four measures of delusions and on implicit self-esteem. Nevertheless, the intervention effect on delusions was not mediated by implicit self-esteem. Changes in explicit self-schemas and reasoning biases did also not mediate the intervention effects on delusions. More focused interventions may be required to produce change in reasoning and self-schemas that have the potential to carry over to delusions.

Investigation on the control of multiphase flow behavior in a continuous casting tundish during ladle change

2020 ◽  
Vol 117 (6) ◽  
pp. 619
Author(s):  
Rui Xu ◽  
Haitao Ling ◽  
Haijun Wang ◽  
Lizhong Chang ◽  
Shengtao Qiu
Keyword(s):  
Multiphase Flow ◽  
Flow Behavior ◽  
Rolled Strip ◽  
Impact Zone ◽  
Steel Cleanliness ◽  
Carry Over ◽  
Slag Carry Over ◽  
Hot Rolled ◽  
Turbulence Inhibitor ◽  
The Impact

The transient multiphase flow behavior in a single-strand tundish during ladle change was studied using physical modeling. The water and silicon oil were employed to simulate the liquid steel and slag. The effect of the turbulence inhibitor on the slag entrainment and the steel exposure during ladle change were evaluated and discussed. The effect of the slag carry-over on the water-oil-air flow was also analyzed. For the original tundish, the top oil phase in the impact zone was continuously dragged into the tundish bath and opened during ladle change, forming an emulsification phenomenon. By decreasing the liquid velocities in the upper part of the impact zone, the turbulence inhibitor decreased considerably the amount of entrained slag and the steel exposure during ladle change, thereby eliminating the emulsification phenomenon. Furthermore, the use of the TI-2 effectively lowered the effect of the slag carry-over on the steel cleanliness by controlling the movement of slag droplets. The results from industrial trials indicated that the application of the TI-2 reduced considerably the number of linear inclusions caused by ladle change in hot-rolled strip coils.

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