scholarly journals Foot function and strength of patients with diabetes grouped by ulcer risk classification (IWGDF)

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Jane S. S. P. Ferreira ◽  
João P. Panighel ◽  
Érica Q. Silva ◽  
Renan L. Monteiro ◽  
Ronaldo H. Cruvinel Júnior ◽  
...  
Keyword(s):  
Treatment Strategies ◽  
Foot Deformities ◽  
Diabetic Patients ◽  
Foot Pain ◽  
Foot Health ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
Foot Function ◽  
Group 2 ◽  
Stratification System

Abstract Background The stratification system from the International Working Group on the Diabetic Foot (IWGDF) was used to classify the participants as to the ulcer risk. However, it is not yet known what the classification groups’ individual deficits are regarding sensitivity, function, and musculoskeletal properties and mechanics. This makes it difficult to design proper ulcer prevention strategies for patients. Thus, this study aimed to investigate the foot function, foot strength and health of people with diabetes mellitus (DM)—with or without DPN—while considering the different ulcer risk classifications determined by the IWGDF. Methods The subject pool comprised 72 people with DM, with and without DPN. The patients were divided into three groups: Group 0 (G0), which comprised diabetic patients without DPN; Group 1 (G1), which comprised patients with DPN; and Group 2 (G2), which comprised patients with DPN who had foot deformities. The health and foot function of the subjects’ feet were assessed using a foot health status questionnaire (FHSQ-BR) that investigated four domains: foot pain, foot function, footwear, and general foot health. The patients’ foot strength was evaluated using the maximum force under each subject’s hallux and toes on a pressure platform (emed q-100, Novel, Munich, Germany). Results Moderate differences were found between G0 and G1 and G2 for the foot pain, foot function, general foot health, and footwear. There was also a small but significant difference between G0 and G2 in regards to hallux strength. Conclusion Foot health, foot function and strength levels of people with DM and DPN classified by the ulcer risk are different and this must be taken into account when evaluating and developing treatment strategies for these patients.

Current state-of-the-art antiplatelet and anticoagulation therapy in diabetic patients with coronary artery disease

2021 ◽  
Author(s):  
Johny Nicolas ◽  
Victor Razuk ◽  
Gennaro Giustino ◽  
Roxana Mehran
Keyword(s):  
Diabetes Mellitus ◽  
Complex Disease ◽  
Anticoagulation Therapy ◽  
Treatment Strategies ◽  
Diabetic Patients ◽  
Current State ◽  
Organ Systems ◽  
Patients With Diabetes ◽  
The Status ◽  
Artery Disease

Diabetes mellitus is a complex disease that leads to long-term damage to various organ systems. Among the numerous cardiovascular disease-related complications, thrombotic events frequently occur in patients with diabetes. Although guidelines exist for treating and preventing most diabetes-related co-morbidities, the evidence on antithrombotic therapy in primary and secondary prevention is limited due to the scarcity of randomized trials dedicated to patients with diabetes mellitus. Most of the available data are derived from studies that only included a small proportion of patients with diabetes. The present review provides an overview of the status of knowledge on antiplatelet and anticoagulation therapy in patients with diabetes, focusing on the risk–benefit balance of these therapies and future treatment strategies.

scholarly journals A Comparative Study of Anxiety among Diabetic Patients

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Vandana N Solanki
Keyword(s):  
Comparative Study ◽  
Research Design ◽  
T Test ◽  
Diabetic Patients ◽  
Test Results ◽  
Anxiety Test ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
And Gender

The study was intended to examine the effect of Anxiety on diabetic patients. Aim: The aim was to estimate the prevalence of anxiety in patients with diabetes and to determine the association of anxiety with area and gender. Sample: The sample consists of 160 diabetic patients from different hospital in Rajkot district area. The sample was selected from randomly. Design: 2*2 research design was used the present study. Tools: Anxiety was measured through a questionnaire ‘Sinha’s Comprehensive Anxiety Test (SCAT) was used. Test developed by A.K.P Sinha and L.N.K Sinha in (1995).The data was analyzed by the t test. Results: There will be no significant difference between Gender and Types of Area in relation to their Anxiety. Conclusions: Our study demonstrates a higher prevalence of anxiety in diabetic patients. No factor was significantly associated with anxiety.

scholarly journals Foot Health Status Questionnaire (FHSQ) in Spanish People with Type 2 Diabetes Mellitus: Preliminary Values Study

2020 ◽  
Vol 17 (10) ◽  
pp. 3643
Author(s):  
Francisco Javier Domínguez-Muñoz ◽  
Miguel Angel Garcia-Gordillo ◽  
Rodrigo Anibal Diaz-Torres ◽  
Miguel Ángel Hernandez-Mocholi ◽  
Santos Villafaina ◽  
...  
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Health Status ◽  
Foot Pain ◽  
Foot Health ◽  
Foot Function ◽  
Foot Health Status Questionnaire

Background and objectives: Type 2 Diabetes Mellitus (T2DM) is a chronic disease characterized by hyperglycemia. T2DM affects millions of people, and has a lot of complications such as impaired sensation in the feet. Moreover, it is important to know the health of the feet of people with T2DM. The aim of this study is to know the preliminary values of the Foot Health Status Questionnaire (FHSQ) in people with T2DM. Materials and Methods: A total of 87 patients with T2DM with an average age of 65.56 years, divided in 54 men and 33 women, participated in this cross-sectional study. The main outcome was the health of the foot as measured by the FHSQ questionnaire. This questionnaire collects data on eight dimensions: Foot Pain, Foot Function, Shoe, General Foot Health, General Health, Physical Activity, Social Capacity, and Vigor. Results: Patients with T2DM have lower values in Foot Pain; median values in General Foot Health and high values in Foot Function, Shoe, Physical Activity and Social Capacity. Some of these dimensions are affected by age, diabetes control, Body Mass Index (BMI), and years of diagnosis. Females with T2DM have more problems than males in the Shoe, General Foot Health, Physical Activity and Vigor dimensions. Conclusions: this research gives us preliminary values of the FHSQ in Spanish patients with T2DM and divided by gender, age, diabetes control, BMI, and years of diagnosis in people with T2DM.

scholarly journals The Prevalence of Giardia Intestinalis in Dyspeptic and Diabetic Patients

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Gözde Derviş Hakim ◽  
Şafak Kızıltaş ◽  
Hilmi Çiftçi ◽  
Şafak Göktaş ◽  
İlyas Tuncer
Keyword(s):  
Diabetes Mellitus ◽  
Giardia Intestinalis ◽  
Diabetic Patients ◽  
Elisa Method ◽  
Number Of Patients ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
Stool Specimens ◽  
Positive Results ◽  
Healthy Persons

Background and Aims. We aimed to investigate the prevalence of Giardiasis in patients with dyspepsia and patients with diabetes mellitus. Methods. 400 patients and 100 healthy persons were included in this clinical prospective study. The number of patients in each group was equal, 200 dyspeptic and 200 diabetic, respectively. The antigen of G. lntestinalis was determined in the stool specimens by ELISA method. Results. The frequency of Giardiasis was 7% in dyspeptic and 15% in diabetic patients. There was no positive results in any of the healthy persons. There was a significant difference in prevalence rate of Giardiasis between patients with dyspepsia and diabetes mellitus (P<0.05). Conclusions. These results revealed that the prevalence of Giardiasis in dyspepsia and with diabetes mellitus was high in our country. This is the first study investigating the prevalence of Giardiasis in diabetic patients. To investigate Giardiasis in diabetic patients, who have dyspepsia or not, may be a good approach for public health.

scholarly journals Association betweenTCF7L2Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Martin Javorský ◽  
Eva Babjaková ◽  
Lucia Klimčáková ◽  
Zbynek Schroner ◽  
Jozef Židzik ◽  
...  
Keyword(s):  
Genetic Model ◽  
Melting Curve ◽  
Specific Effect ◽  
Melting Curve Analysis ◽  
Diabetic Patients ◽  
Genotype Group ◽  
Site Group ◽  
Significant Difference ◽  
Group 2 ◽  
A Site

Previous studies showed associations between variants inTCF7L2gene and the therapeutic response to sulfonylureas. All sulfonylureas stimulate insulin secretion by the closure of ATP-sensitive potassium (KATP) channel. The aim of the present study was to compareTCF7L2genotype specific effect of gliclazide binding toKATPchannel A-site (Group 1) with sulfonylureas binding to AB-site (Group 2). A total of 101 patients were treated with sulfonylureas for 6 months as an add-on therapy to the previous metformin treatment.TCF7L2rs7903146 C/T genotype was identified by real-time PCR with subsequent melting curve analysis. Analyses using the dominant genetic model showed significantly higher effect of gliclazide in the CC genotype group in comparison with combined CT + TT genotype group (1.32±0.15% versus0.73±0.11%,Padj=0.005). No significant difference in ΔHbA1c between the patients with CC genotype and the T-allele carriers was observed in Group 2. In the multivariate analysis, only theTCF7L2genotype (P=0.006) and the baseline HbA1c (P<0.001) were significant predictors of ΔHbA1c. After introducing an interaction term between theTCF7L2genotype and the sulfonylurea type into multivariate model, the interaction became a significant predictor (P=0.023) of ΔHbA1c. The results indicate significantly higher difference in ΔHbA1c among theTCF7L2genotypes in patients treated with gliclazide than in patients treated with glimepiride, glibenclamide, or glipizide.

Foot Function in Diabetic Patients after Partial Amputation

1996 ◽  
Vol 17 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Juan Carlos Garbalosa ◽  
Peter R. Cavanagh ◽  
Ge Wu ◽  
Jan S. Ulbrecht ◽  
Mary B. Becker ◽  
...  
Keyword(s):  
Range Of Motion ◽  
Plantar Pressure ◽  
Three Dimensional ◽  
Diabetic Patients ◽  
Plantar Pressures ◽  
Plantar Pressure Distribution ◽  
Patients With Diabetes ◽  
Peak Plantar Pressure ◽  
Partial Amputation ◽  
Foot Function

The function of partially amputated feet in 10 patients with diabetes mellitus was studied. First-step bilateral barefoot plantar pressure distribution and three-dimensional kinematic data were collected using a Novel EMED platform and three video cameras. Analysis of the plantar pressure data revealed a significantly greater mean peak plantar pressure in the feet with transmetatarsal amputation (TMA) than in the intact feet of the same patients. The heels of the amputated feet had significantly lower mean peak plantar pressures than all the forefoot regions. A significantly greater maximum dynamic dorsiflexion range of motion was seen in the intact compared with the TMA feet. However, no difference was noted in the static dorsiflexion range of motion between the two feet and there was, therefore, a trend for the TMA feet to use less of the available range of motion. Given the altered kinematics and elevated plantar pressures noted in this study, careful postsurgical footwear management of feet with TMA would appear to be essential if ulceration is to be prevented.

scholarly journals COVID-19 Severity and Comorbidities in Diabetic Patients

2021 ◽  
Vol 10 (3) ◽  
pp. 91-98
Author(s):  
Hamid Reza Samimagham ◽  
Mehdi Hassani Azad ◽  
Mohsen Arabi ◽  
Dariush Hooshyar ◽  
Abbas Sheikhtaheri ◽  
...  
Keyword(s):  
Disease Severity ◽  
Demographic Factors ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Severity Of Disease ◽  
Significant Difference ◽  
Laboratory Results ◽  
Patients With Diabetes ◽  
Severe Group

Background: This study aimed to investigate the demographic factors, comorbidities, and laboratory results of diabetic patients with coronavirus disease 2019 (COVID-19) severity. Materials and Methods: This cross-sectional study enrolled 171 diabetic patients with COVID-19 admitted based on chest CT scan findings to the COVID-19 ward of Shahid Mohammadi Hospital in Hormozgan, Iran from 1 March to 1 June, 2020. Reverse-transcriptase polymerase chain reaction (RT-PCR) test was performed, and the patients were divided into three groups (mild, moderate, and severe) based on the severity of disease. Then we investigated the demographic factors, comorbidities, and laboratory results of diabetic patients with severe COVID-19 severity. Results: Regarding comorbidities, there was no significant difference between the three groups. Moreover, there was a significantly lower lymphocyte count in the severe group compared to moderate and mild groups (P = 0.001). We showed the increase in blood urea nitrogen (BUN) and creatinine to be significantly associated with increased disease severity (P = 0.001 and P = 0.009, respectively). We also showed a significant difference in aspartate aminotransferase (AST) levels between different groups of patients (P = 0.002) with a higher level of AST in the severe group (P = 0.020). Lactate dehydrogenase (LDH) and troponin were also significantly associated with an increase in COVID-19 severity in patients with diabetes (P = 0.013 and P = 0.002, respectively). Conclusion: There was a significant association between disease severity and BUN, creatinine, AST, LDH, and troponin levels in diabetic patients with COVID-19. There was no significant association between different groups regarding severity of disease and comorbidities.

scholarly journals MEAL INDUCED OXIDATIVE STRESS LEVELS IN CONTROLLED AND POORLY CONTROLLED DIABETES

2017 ◽  
Vol 10 (6) ◽  
pp. 105
Author(s):  
Sulekha Sinha ◽  
Poornima A Manjrekar ◽  
Anupama Hegde ◽  
Rukmini Ms
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Thiobarbituric Acid ◽  
T Test ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Significant Difference ◽  
Stress Levels ◽  
Group 2

Objective:  The postprandial metabolic derangements are accentuated in type-2 diabetes and are important risk factors for cardiovascular disease since they induce oxidative stress and endothelial dysfunction. Aim of the study was to analyse meal induced oxidative stress levels in controlled and poorly controlled diabetes.Methods: Total 60 type 2 diabetic patients on oral hypoglycemics of duration 5-15 years were divided into two groups based on HbA1c values (£7.5% for controlled /Group-1 and ³7.6% for poorly controlled/ Group-2). They were assayed for serum/plasma glucose, thiobarbituric acid reacting substances (TBARS) and oxidised LDL (ox-LDL) parameters both in fasting and 2 hrs post meal in both the groups. Statistical analysis was done using independent t test between the groups and paired t test within each group.Results: The Postprandial TBARS was found significantly higher in both the groups, whereas no significant difference between the two groups. The ox-LDL levels were found similar at two points of time in both the groups.Conclusion: An exaggerated postprandial oxidative stress levels are associated with diabetes and its complications including endothelial dysfunction.  

scholarly journals Measures of Foot Pain, Foot Function, and General Foot Health

2020 ◽  
Vol 72 (S10) ◽  
pp. 294-320
Author(s):  
Glen A. Whittaker ◽  
Shannon E. Munteanu ◽  
Edward Roddy ◽  
Hylton B. Menz
Keyword(s):  
Foot Pain ◽  
Foot Health ◽  
Foot Function

Sleep Quality of Diabetic Patients with Metabolic Syndrome, Is There A Difference?

2020 ◽  
Author(s):  
Savas Karatas ◽  
Aysun Işıklar
Keyword(s):  
Metabolic Syndrome ◽  
Sleep Quality ◽  
Diabetic Patients ◽  
Poor Sleep ◽  
Type 2 Diabetic Patients ◽  
Subjective Sleep Quality ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
Type 2 Diabetic

Poor sleep quality is a prevalent health problem among patients with diabetes. Metabolic syndrome (MetS) is common in type 2 diabetic patients and associated with morbidity and mortality. We aimed to investigate sleep quality among type 2 diabetes patients according to their metabolic syndrome status. This was an analysis of data collected from 189 adult type 2 diabetic patients. The patients divided into two groups (metabolic and non-metabolic) based on the presence of MetS. Anthropometric measurements, blood pressure, and serum glucose, lipid levels were collected. The Pittsburgh Sleep Quality Index (PSQI) calculated for all patients. There was no significant difference in subjective sleep quality scores between the two groups (p > 0.05). However, there was a significant difference in sleep latency scores between the two groups; the scores of patients with MetS were lower than those of patients without MetS (p = 0.010, p < 0.05).Sleep quality was low in 57.1% (n = 108) of patients with diabetes. Poor sleep is common among diabetic patients, but in this study, metabolic syndrome existence not associated with sleep quality in type 2 diabetic patients.

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