scholarly journals Informed consent and informed intervention: SARS-CoV-2 vaccinations not just call for disclosure of newly emerging safety data but also for hypothesis generation and testing

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Johannes C. Fischer ◽  
Albrecht G. Schmidt ◽  
Edwin Bölke ◽  
Verena Keitel ◽  
Torsten Feldt ◽  
...  

Abstract Background COVID-19 infection is a major threat to patients and health care providers around the world. One solution is the vaccination against SARS-CoV-2. Methods We performed a comprehensive query of the latest publications on the prevention of viral infections including the recent vaccination program and its side effects. Results The situation is evolving rapidly and there is no reasonable alternative to population-scale vaccination programs as currently enrolled. Conclusion Therefore, regulatory authorities should consider supplementing their conventional mandate of post-approval pharmacovigilance, which is based on the collection, assessment, and regulatory response to emerging safety findings.

Dental Update ◽  
2021 ◽  
Vol 48 (2) ◽  
pp. 157-160
Author(s):  
Lakshman Samaranayake ◽  
Sukumaran Anil

COVID-19 Vaccines are currently the talk of the world. The internet is full of memes on COVID-19 vaccines - myths more than truths. In this commentary we further review some of the issues related to the success and failure of COVID-19 vaccines, and the theoretical and practical elements on vaccinations and immunity that the dental health care providers have to be knowledgeable, so as to offer advice and guidance to their team, the patients, as well as the public.


Author(s):  
Md Jamal Hossain

Background: The world has been passing the most critical time of the century with the COVID-19 pandemic since late December 2019, and numerous people, including a significant portion of health care providers, got the infection and are still sacrificing their lives. Objective: The study was aimed systematically to assess the severity of the SARS-CoV-2 infection, especially in health care sectors, and to appraise the physical, psychological, and social effects of the COVID-19 epidemic among frontline fighters in Bangladesh. Methodology: The keywords: “COVID-19”, “SARS-CoV-2”, “health care system in Bangladesh”, “health care providers”, etc. were searched to collect the desired articles by utilizing various search engines like google, google scholar, pub med, and science direct journals. Data were extracted and finally, were summarized, discussed, analysed, and reported the study results. Result: Numerous specialist doctors, nurses, and all other healthcare workers are immolating their lives to save human entities amid the current coronavirus pandemic, 2019 (COVID-19). In Bangladesh, till August 9, 2020, 73 doctors, including some senior specialists, died of COVID-19 infection reported by various national newspapers. At the early phase of this epidemic in Bangladesh, around 10% of the total infection was found among health workers, alarmingly reported by the Bangladesh Medical Association (BMA). These frontline fighters are additionally confronting numerous challenges, including psychological sufferings, and furthermore, they are assaulted by the society. Conclusion: Since these fighters are relinquishing their beloved lives to protect us from this brutal virus, we are trying to show our profound gratitude, appreciation, thousands of salutes, and undying tribute to these health care fighters with this publication. Bangladesh Journal of Infectious Diseases, October 2020;7(suppl_2):S8-S15


2020 ◽  
Vol 13 (2) ◽  
Author(s):  
Rathor MY ◽  
Mohammad Fauzi AR ◽  
Omar AM

Fasting during the month of Ramadan is one of the five pillars of Islam, a recurring annual ritual, which is passionately practiced by most Muslims across the world. It is obligatory on every healthy Muslim; however, the Qur’an and Islamic teachings specifically exempt people with acute or chronic illnesses from this duty, especially if it might have harmful consequences. Muslims with diabetes are exempted from fasting, but many of them still fast during Ramadan, for their personal convictions as revealed by EPIDIAR study which showed that 43% of patients with type 1 diabetes and 79% with type 2 diabetes fasted during Ramadan. Muslims constitute about a quarter of the world’s population who are spread all over the globe. It is inevitable that health care issues peculiar to them will be encountered worldwide and health care providers will have to counsel them regarding medications and whether it is safe to undertake the fast. This paper is an update on the management of Ramadan fasting based on current evidence from published literature and expert opinions.


2011 ◽  
Vol 1 (2) ◽  
pp. 24-36 ◽  
Author(s):  
Nancy J. Beaudet ◽  
Garry C. Alcedo ◽  
Quan C. Nguyen ◽  
Dan Jacoby ◽  
Quynh Kieu ◽  
...  

Background. In rapidly developing regions of the world such as Southeast Asia, marked industrialization with insufficient regulation places children at increased risk for significant environmental exposures. Health care providers have a key role in identifying, treating and preventing environmentally-related illnesses. Objectives. The authors undertook a survey of pediatric health care providers in Vietnam in order to gain preliminary insight into environmental hazard knowledge, and attitudes and beliefs regarding the relative importance of environmental factors in child health that could guide future initiatives towards building up capacity for children's environmental health in the region. Methods. A formal written and self-administered survey instrument was adapted from the World Health Organization's Children's Environmental Health Survey and translated into Vietnamese. The survey was administered via convenience sampling after formal introduction to children's environmental health (CEH) was made through lectures or meetings with pediatric care providers affiliated with the major children's hospitals and pediatric departments in Vietnam. Results. One hundred forty-one pediatric care providers completed the survey. Most indicated environmental factors are considered to be very important in child health (84%); 98% felt the magnitude of the problem is increasing; and air pollution is seen as the top environmental health issue facing the country. The most commonly identified problems in their clinical experience included: food poisoning due to microbiological agents (85%); pesticide poisoning (77%); tobacco smoke exposure (75%); and inadequate sanitation (60%). Although most (80%) endorsed asking about children's environmental conditions in clinical practice, a little more than a third (39%) were confident taking an environmental exposure history. For most key topics, less than half had received specific training. A majority (63%) of survey respondents were very interested in more environmental health training. Conclusions. Pediatric health care providers in Vietnam believe that environmental hazards in child health is an important topic that is routinely encountered in their care of patients, but training, experience and self-efficacy in these topics are limited.


2021 ◽  
Vol 2 ◽  
Author(s):  
Emily Y. Chu ◽  
Janina Golob Deeb ◽  
Brian L. Foster ◽  
Evlambia Hajishengallis ◽  
Martha J. Somerman ◽  
...  

The goal of this perspective article is to use multiple idiopathic cervical root resorption (MICRR) as a model to demonstrate the need for transdisciplinary collaborations, from basic science to treatment planning, to improve the quality of health care for all. This is not a review of the literature on the current state of MICRR. Tooth root resorption is a normal physiological process required for resorption and exfoliation of primary teeth; however, root resorption of adult teeth is largely pathological. MICRR is an aggressive form of external root resorption, which occurs near the cemento-enamel junction (CEJ). The cause of MICRR remains elusive, however, it is mediated primarily by osteoclasts/odontoclasts. Accumulating case studies and experiments in animal models have provided insights into defining the etiologies and pathophysiological mechanisms for MICRR, which include: systemic conditions and syndromes, inherited genetic variants affecting osteoclast/odontoclast activity, altered periodontal structures, drug-induced root resorption and rebound effects after cessation of anti-resorptive treatment, chemotherapy, exposure to pets or viral infections, and other factors such as inflammatory conditions or trauma. To determine the causative factors for MICRR, as well as other oral-dental conditions, at minimum, a comprehensive health history should be collected for all patients by dental care providers, discussed with other health care providers and appropriate collaborations established. The examples highlighted in this perspective emphasize the need for transdisciplinary research collaborations coupled with integrated management strategies between medicine and dentistry in order to identify cause(s) early and improve clinical outcomes.


2020 ◽  
Vol 11 (SPL1) ◽  
pp. 430-432
Author(s):  
Vaishnavi C. Ghate ◽  
Swapnil Borage ◽  
Priyanka Shelotkar

Corona virus disease (COVID-19) is an emerging disease with rapid increases in cases. COVID-19 is a single-stranded RNA virus which can produce diseases in Humans and Animals also. As COVID-19 is a developing health issue in the World, Experts also remain unsure whether pregnant women are having a higher risk of COVID-19 or not. The emergency of acute health care, it is particularly deadly in large populations and communities in which health care providers are insufficiently prepared to manage the COVID-19 infection. And cases have increased in other countries around the world day by day. It has increased the possibility of vertical transmission of the virus from the mother to the fetus—the WHO the total confirmed cases as of 12th April as 1,836,041. Total death 113,233and pregnant women having positive corona cases is 38, as of 1st April 2020. Partial suppression of the immune system in pregnancy can increase the chances of a viral infection such as flu (influenza) in pregnant women. World Health Organization (WHO) suggests that there is no specific evidence exists that pregnant women are more prone to severe COVID-19 symptoms than other general people. Physiologic and immunologic changes in pregnant women have systemic effects which in an increased risk of respiratory infections, various other changes like cardiovascular system, Respiratory system, increased heart rate and decreased lung capacity. Pregnant women become infected with two pathogenic corona virus infections, one as a severe acute respiratory syndrome (SARS) and other one is Middle East respiratory syndrome (MERS).


2020 ◽  
Vol 163 (5) ◽  
pp. 931-933
Author(s):  
Taher S. Valika ◽  
Sarah E. Maurrasse ◽  
Lara Reichert

The outbreak of COVID-19 has affected the globe in previously unimaginable ways, with far-reaching economic and social implications. It has also led to an outpouring of daily, ever-changing information. To assess the amount of data that were emerging, a PubMed search related to COVID-19 was performed. Nearly 8000 articles have been published since the virus was defined 4 months ago. This number has grown exponentially every month, potentially hindering our ability to discern what is scientifically important. Unlike previous global pandemics, we exist in a world of instantaneous access. Information, accurate or otherwise, is flowing from one side of the world to the other via word of mouth, social media, news, and medical journals. Changes in practice guidelines should be based on high-quality, well-powered research. Our job as health care providers is to mitigate misinformation and provide reassurance to prevent a second pandemic of misinformation.


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