scholarly journals Late chronotype predicts more depressive symptoms in bipolar disorder over a 5 year follow-up period

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Parisa Vidafar ◽  
Anastasia K. Yocum ◽  
Peisong Han ◽  
Melvin G. McInnis ◽  
Helen J. Burgess
Keyword(s):  
Bipolar Disorder ◽  
Depressive Symptoms ◽  
Depressive Mood ◽  
Self Report ◽  
Circadian Timing ◽  
Clinical Interviews ◽  
Circadian Phase ◽  
Patients At Risk ◽  
Larger Sample

Abstract Background There is increasing evidence that bipolar disorder is influenced by circadian timing, including the timing of sleep and waking activities. Previous studies in bipolar disorder have shown that people with later timed daily activities, also known as late chronotypes, are at higher risk for subsequent mood episodes over the following 12–18 months. However, these studies were limited to euthymic patients and smaller sample sizes. The aim of the current study was to further examine baseline chronotype as a potentially important predictor of mood-related outcomes in a larger sample of individuals with bipolar disorder and over the longest follow up period to date, of 5 years. Participants included 318 adults diagnosed with bipolar I and II (19–86 years) who were enrolled in the Prechter Longitudinal Study of Bipolar Disorder. Results Participants with a late chronotype were found to be more likely to have mild to more severe depressive symptoms (PHQ-9 ≥ 5) as captured with PHQ-9 assessments every 2 months over the 5 year follow up period. This higher risk for depressive symptoms remained even after adjusting for age, sex and mood at baseline. Additionally, late chronotypes reported fewer hypomania/mania episodes during the 5 year follow up, as derived from clinical interviews every two years. Conclusions These results highlight the potential clinical usefulness of a single self-report question, in identifying patients at risk for a more depressive mood course. The results also suggest that circadian phase advancing treatments, that can shift circadian timing earlier, should be explored as a means to reduce depressive symptoms in late chronotypes with bipolar disorder.

Latent Growth Curve Model of Perceived Family Relationship Quality and Depressive Symptoms During Middle Adolescence in Spain

2017 ◽  
Vol 39 (7) ◽  
pp. 2037-2060 ◽  
Author(s):  
Diego Gomez-Baya ◽  
Ramon Mendoza ◽  
Ines Camacho ◽  
Margarida Gaspar de Matos
Keyword(s):  
Gender Differences ◽  
Depressive Symptoms ◽  
Family Relationships ◽  
Family Relationship ◽  
Self Report ◽  
Adolescent Mother ◽  
Middle Adolescence ◽  
Adolescent Father

This study aimed to examine longitudinal associations between the perceived quality of family relationships and self-reported depressive symptoms during middle adolescence. A 2-year follow-up study, with three assessments at 1-year intervals, was conducted. A total of 525 Spanish adolescents completed paper-based self-report assessments, which included the 10-item Child Depression Inventory and a brief Likert-type scale to measure the quality of the relationships with their father and their mother separately. The results indicated that a decline in the quality of both adolescent–father and adolescent–mother relationships were related to an increase in depressive symptoms during middle adolescence. Furthermore, adolescent–father relationships were found to be worse for girls than for boys and were observed to be associated with gender differences in depressive symptoms after the follow-up. The results provide longitudinal evidence on the importance of parent–adolescent relationships and gender differences in depressive symptoms during adolescence.

scholarly journals A Prospective Investigation of the Impact of Distinct Posttraumatic (PTSD) Symptom Clusters on Suicidal Ideation

2017 ◽  
Vol 41 (4) ◽  
pp. 645-653 ◽  
Author(s):  
Maria Panagioti ◽  
Ioannis Angelakis ◽  
Nicholas Tarrier ◽  
Patricia Gooding
Keyword(s):  
Depressive Symptoms ◽  
Suicidal Ideation ◽  
Ptsd Symptom ◽  
Symptom Clusters ◽  
Self Report ◽  
Ptsd Symptoms ◽  
Cross Sectional ◽  
The Impact

AbstractInconsistent findings have been reported by previous cross-sectional studies regarding the association between specific posttraumatic stress disorder (PTSD) symptom clusters and suicidality. To advance the understanding of the role of specific PTSD symptoms in the development of suicidality, the primary aim of this study was to investigate the predictive effects of the three specific PTSD symptom clusters on suicidal ideation prospectively. Fifty-six individuals diagnosed with PTSD completed a two-stage research design, at baseline and 13–15 months follow-up. The clinician administered PTSD scale (CAPS) was used to assess the severity of the PTSD symptom clusters and validated self-report measures were used to assess suicidal ideation, severity of depressive symptoms and perceptions of defeat entrapment. The results showed that only the hyperarousal symptom cluster significantly predicted suicidal ideation at follow-up after controlling for baseline suicidal ideation, severity of depressive symptoms and perceptions of defeat and entrapment. These findings suggest that both disorder-specific and transdiagnostic factors are implicated in the development of suicidal ideation in PTSD. Important clinical implications are discussed in terms of predicting and treating suicidality in those with PTSD.

The Mental Health of Visitors of Web-Based Support Forums for Bereaved by Suicide

Crisis ◽  
2015 ◽  
Vol 36 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Jeannet Kramer ◽  
Brigitte Boon ◽  
Marijke Schotanus-Dijkstra ◽  
Wouter van Ballegooijen ◽  
Ad Kerkhof ◽  
...  
Keyword(s):  
Mental Health ◽  
Depressive Symptoms ◽  
Repeated Measures ◽  
Complicated Grief ◽  
Well Being ◽  
Self Report ◽  
Online Support ◽  
Mutual Support ◽  
Web Based

Background: Persons bereaved by suicide are reluctant to ask for social support when they experience feelings of guilt and blame. A web-based peer forum may provide a safe and anonymous place for mutual support. Aims: This study examined the mental health changes of visitors of two online support forums for persons bereaved by suicide and their experiences with the forum over 1 year. Method: Visitors of two forums completed self-report measures at baseline and at 6 and 12 months' follow-up. Repeated measures analyses were used to study changes in well-being, depressive symptoms, and complicated grief. Additionally, participants were interviewed about their experiences with the forum. Results: The 270 participants were mostly female, low in well-being, with high levels of depressive symptoms and complicated grief. Suicidal risk was high for 5.9%. At 12 months, there were small to medium-sized significant improvements in well-being and depressive symptoms (p < .001) and nearly as much for grief (p = .08). About two thirds reported benefit from visiting the forum. Because of the pre–post design we cannot determine whether a causal relationship exists between the form and changes in mental health. Conclusion: After 1 year some positive changes but a large group was still struggling with their mental health. Interviews indicate that the forum was valued for finding recognition.

Efficacy of an online intervention for treatment of depressive disorders: a three-arm randomized controlled trial comparing guided and unguided self-help with waitlist control (Preprint)

2021 ◽  
Author(s):  
Krämer Rico
Keyword(s):  
Depressive Symptoms ◽  
Depressive Disorders ◽  
Depressive Symptomatology ◽  
Controlled Trial ◽  
Intervention Group ◽  
Online Intervention ◽  
Self Report ◽  
Secondary Outcome ◽  
Control Group

BACKGROUND Digital health applications are efficacious treatment options for mild-to-moderate depressive disorders. However, the extent to which psychological guidance increases the efficacy of these applications is controversial. OBJECTIVE We evaluated the efficacy of the online intervention “Selfapy” for unipolar depression. We also investigated differences between a psychotherapist-guided vs. unguided version compared with those from a control group. METHODS A cohort of 401 participants with mild-to-severe depressive disorders were assigned randomly to either participate in a guided version of Selfapy (involving weekly telephone calls of 25-min duration), an unguided version of Selfapy, or to the waiting list (control group). Selfapy is a cognitive behavioral therapy-based intervention for depressive disorders of duration 12 weeks. Symptom assessment was undertaken at T1 (before study entrance), T2 (after 6 weeks), T3 (post-treatment, after 12 weeks), and T4 (follow-up, after 6 months). The main outcome was reduction in depressive symptoms in the Beck Depression Inventory (BDI-II) from T1 to T3. Secondary-outcome parameters were the Quick Inventory of Depressive Symptomatology – Self Report (QIDS-SR 16) and Beck Anxiety Inventory (BAI). RESULTS A total of 297 out of 401 participants (74.06%) completed the post-measurement at T3. In the primary analysis, both intervention groups showed a significantly higher reduction in depressive symptoms (BDI-II) from T1 to T3 compared with that in the control group, with high within-effect sizes (guided: d = 1.46; unguided d = 1.36). No significant differences were found for guided vs. unguided treatment groups. The response rate (BDI-II) for intention-to-treat data in the guided version was 46.4%, 40.0% for the unguided version, and 2.0% in the control group. After 6 months (T4), treatment effects could been maintained for both intervention groups (BDI-II) without differences between either intervention group. CONCLUSIONS Conclusions: Selfapy can help to reduce depressive symptoms in guided or unguided version. Follow-up data suggest that these effects could be maintained. The guided version was not superior to the unguided version. CLINICALTRIAL Trial Registration: Current Controlled Trial DRKS00017191 Date of registration: 14 May 2019 INTERNATIONAL REGISTERED REPORT RR2-https://doi.org/10.1186/s13063-021-05218-4

The Quick Inventory of Depressive Symptomatology (Clinician and Self-Report Versions) in Patients With Bipolar Disorder

CNS Spectrums ◽  
2010 ◽  
Vol 15 (6) ◽  
pp. 367-373 ◽  
Author(s):  
Ira H. Bernstein ◽  
A. John Rush ◽  
Trisha Suppes ◽  
Yakasushi Kyotoku ◽  
Diane Warden
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Depressive Symptoms ◽  
Depressive Disorder ◽  
Depressive Symptomatology ◽  
Self Report ◽  
General Interest ◽  
Major Depressive ◽  
Sad Mood ◽  
Illness Phase

ABSTRACTIntroduction: The clinical and self-report versions of the Quick Inventory of Depressive Symptomatology (QIDS-C16 and QIDS-SR16) have been well studied in patients with major depressive disorder and in one recent study using patients with bipolar disorder. This article examines these measures in a second sample of 141 outpatients with bipolar disorder in different phases of the illness.Methods: At baseline, 61 patients were depressed and 30 were euthymic; at exit, 50 were depressed and 52 were euthymic. The remaining patients (at baseline or exit) were in either a manic or mixed phase and were pooled for statistical reasons.Results: Similar results were found for the QIDS-C16 and QIDS-SR16. Scores were reasonably reliable to the extent that variability within groups permitted. As expected, euthymic patients showed less depressive symptomatology than depressed patients. Sad mood and general interest were tne most discriminating symptoms between depressed and euthymic phases. Changes in illness phase (baseline to exit) were associated with substantial changes in scores. The relation of individual depressive symptoms to the overall level of depression was consistent across phases.Conclusion: Both the QIDS-SR16 and QIDS-C16 are suitable measures of depressive symptoms in patients with bipolar disorder.

scholarly journals The moderating role of psychosocial working conditions on the long-term relationship between depressive symptoms and work ability among employees from the Baby Boom generation

2020 ◽  
Author(s):  
Jeannette Weber ◽  
Hans Martin Hasselhorn ◽  
Daniela Borchart ◽  
Peter Angerer ◽  
Andreas Müller
Keyword(s):  
Depressive Symptoms ◽  
Working Conditions ◽  
Work Ability ◽  
Baby Boom ◽  
Time Lag ◽  
Self Report ◽  
Baby Boom Generation ◽  
Psychosocial Working Conditions ◽  
Leadership Quality

Abstract Objective Mental disorders have been identified as a leading cause for reduced work ability in industrialized countries. Identification of workplace factors that can increase the work ability of employees with depressive symptoms from the Baby Boom generation is, therefore, highly relevant. This study thus aims to investigate whether changes in psychosocial working conditions can moderate the negative association between depressive symptoms and work ability. Methods Two waves with a 3-year time lag of the German lidA cohort study with 3609 participants born in 1959 and 1965 (aged 46 and 52 years at first wave) were analyzed. Self-report data about depressive symptoms at baseline and changes of working conditions from baseline to follow-up were used to calculate main and interaction effects on perceived work ability at follow-up. These analyses were controlled for baseline work ability and working conditions. Results Depressive symptoms were predictive for an unfavorable course of work ability from baseline to follow-up (B = − 0.173, 95% CI = − 0.219 to − 0.128). However, no interaction effect between depressive symptoms and psychosocial working conditions was found. Instead, independent from the level of depressive symptoms, a decrease in quantitative demands (B = − 0.279, 95% CI = − 0.326 to − 0.232) and increases in leadership quality (B = 0.242, 95% CI = 0.192–0.292) and development opportunities (B = 0.177, 95% CI = 0.127–0.277) were related to a more favorable course of work ability. Only small effects were found for social support (B = 0.057, 95% CI = 0.008–0.106) and job control (B = 0.043, 95% CI = − 0.005–0.091). Conclusions The results indicate that the lagged and negative effect of depressive symptoms on work ability was not moderated by changes in psychosocial working conditions. However, the promotion of favorable working conditions may contribute to a positive development of work ability among employees from the Baby Boom generation independently from the level of depressive symptoms.

scholarly journals Stressful life events moderate the effect of neural reward responsiveness in childhood on depressive symptoms in adolescence

2019 ◽  
Vol 50 (9) ◽  
pp. 1548-1555 ◽  
Author(s):  
Brandon L. Goldstein ◽  
Ellen M. Kessel ◽  
Autumn Kujawa ◽  
Megan C. Finsaas ◽  
Joanne Davila ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Life Events ◽  
Stressful Life Events ◽  
Community Sample ◽  
Reward Processing ◽  
Event Related Potential ◽  
Self Report ◽  
Stressful Life ◽  
Depression Symptoms

AbstractBackgroundReward processing deficits have been implicated in the etiology of depression. A blunted reward positivity (RewP), an event-related potential elicited by feedback to monetary gain relative to loss, predicts new onsets and increases in depression symptoms. Etiological models of depression also highlight stressful life events. However, no studies have examined whether stressful life events moderate the effect of the RewP on subsequent depression symptoms. We examined this question during the key developmental transition from childhood to adolescence.MethodsA community sample of 369 children (mean age of 9) completed a self-report measure of depression symptoms. The RewP to winning v. losing was elicited using a monetary reward task. Three years later, we assessed stressful life events occurring in the year prior to the follow-up. Youth depressive symptoms were rated by the children and their parents at baseline and follow-up.ResultsStressful life events moderated the effect of the RewP on depression symptoms at follow-up such that a blunted RewP predicted higher depression symptoms in individuals with higher levels of stressful life events. This effect was also evident when events that were independent of the youth's behavior were examined separately.ConclusionsThese results suggest that the RewP reflects a vulnerability for depression that is activated by stress.

Resolution of Depressive Symptoms in Medical Inpatients after Discharge

1992 ◽  
Vol 22 (3) ◽  
pp. 281-289 ◽  
Author(s):  
Andrew S. Pomerantz ◽  
Alexander De Nesnera ◽  
Alan N. West
Keyword(s):  
Depressive Symptoms ◽  
Self Report ◽  
Medical Illness ◽  
Medical Patients ◽  
Persistent Symptoms ◽  
Number Of Patients ◽  
Threshold Score ◽  
Medical Inpatients ◽  
The One

Objective: Most studies to date demonstrate a high prevalence of depressive symptoms and depressive disorders in general medical inpatients. In order to determine whether these symptoms represent a self limited epiphenomenon of medical illness or evidence of psychiatric comorbidity, assessment of the natural history of such symptoms in this population is necessary. In this study we focused on resolution versus persistence of depressive symptoms in hospitalized medical patients following medical, but not psychiatric, treatment. Method: Every second admission to the acute care medical ward of a VA teaching hospital was assessed for inclusion in the study. Fifty-seven were screened, fifty participated initially, forty-two remained in the study for the one-week post-discharge follow-up, and thirty-three remained at the one-month follow-up. Depressive symptomatology was measured with the Beck Depression Inventory at each time point. Subjects whose scores at follow-ups were above threshold were considered to have persistent symptoms and those whose scores fell below threshold were considered to have resolved. No patients were treated with antidepressants prior to or during the study. Results: With a conventionally accepted threshold score (14) on the BDI as representing clinically significant depression, roughly half of those patients identified as depressed at the time of admission were nondepressed at both follow-ups. The BDI predicted persistence of depression with a sensitivity of .64 and specificity of .74 at one week and .71 and .73 at one month. Raising the threshold score to 20 raised the sensitivity to 1.00 and the specificity to .95 at one week and 1.00 and .93 at one month. Conclusions: Depressive symptoms seen in acutely-ill medical patients can be expected to resolve without potentially-hazardous antidepressant treatment in a significant number of patients. Persistence of depressive symptoms may be better predicted by raising the threshold on commonly used self-report scales.

Predictive Validity of the HCR-20V3 With Incarcerated Males in Mexico City

2021 ◽  
pp. 009385482199752
Author(s):  
Alicia Nijdam-Jones ◽  
Eric García-López ◽  
Libertad Merchan-Rojas ◽  
Aura Ruiz Guarneros ◽  
Barry Rosenfeld
Keyword(s):  
Mexico City ◽  
Predictive Validity ◽  
Area Under The Curve ◽  
Self Report ◽  
Clinical Interviews ◽  
Institutional Violence ◽  
Medium Security ◽  
Document Review ◽  
Incarcerated Males

This prospective study investigated the predictive validity of the Historical-Clinical-Risk Management–20, Version 3 (HCR-20V3) in a sample of incarcerated males in a Mexico City prison. Data were collected from 114 male adults incarcerated in a medium-security prison in Mexico City. Participants were an average of 36.86 years old ( SD = 9.93 years) and were all born in Mexico. Data collection for HCR-20V3 ratings involved clinical interviews and a review of institutional documents. Aggressive incidents for a 3-month period following each completed risk assessment were collected through document review, self-report follow-up interviews, and guard reports. Participants who engaged in institutional violence during the 3-month follow-up period were given significantly higher summary risk ratings and had higher HCR-20 total scores than the participants who did not engage in violence (area under the curve [AUC] ranged from .71 to .77). The study demonstrated support for the cross-cultural utility of the HCR-20V3 for institutional violence in a Mexican prison.

scholarly journals Effect of medication therapy combined with transcranial direct current stimulation on depression and response inhibition of patients with bipolar disorder type I: a clinical trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Parnaz Mardani ◽  
Ahmad Zolghadriha ◽  
Mohsen Dadashi ◽  
Hossein Javdani ◽  
Seyedeh Elnaz Mousavi
Keyword(s):  
Clinical Trial ◽  
Bipolar Disorder ◽  
Depressive Symptoms ◽  
Direct Current ◽  
Response Inhibition ◽  
Transcranial Direct Current Stimulation ◽  
Combined Therapy ◽  
Direct Current Stimulation ◽  
Medication Therapy

Abstract Objective Bipolar Disorder (BD) is one of the most common mental disorders associated with depressive symptoms and impairment in executive functions such as response inhibition. This study aimed to investigate the effectiveness of medication therapy combined with Transcranial Direct Current Stimulation (tDCS) on depression and response inhibition of patients with BD. Method This is a double-blinded randomized clinical trial with pretest, posttest, and follow-up design. Participants were 30 patients with BD randomly assigned to two groups of Medication+tDCS (n = 15, receiving medications plus tDCS with 2 mA intensity over dorsolateral prefrontal cortex for 10 days, two sessions per day each for 20 min) and Medication (n = 15, receiving mood stabilizers including 2–5 tables of 300 mg (mg) lithium, 200 mg sodium valproate, and 200 mg carbamazepine two times per day). Pretest, posttest and 3-month follow-up assessments were the 21-item Hamilton Depression Rating Scale (HDRS) and a Go/No-Go test. Collected data were analyzed in SPSS v.20 software. Results The mean HDRS score in both groups was reduced after both interventional techniques, where the group received combined therapy showed more reduction (P < 0.01), although their effects were not maintained after 3 months. In examining response inhibition variable, only the combined therapy could reduce the commission error of patients under a go/no-go task (p < 0.05), but its effect was not maintained after 3 months. There was no significant difference in the group received medication therapy alone. Conclusion Medication in combination with tDCS can reduce the depressive symptoms and improve the response inhibition ability of people with BD. Trial registration This study was registred by Iranian Registry of Clinical Trials (Parallel, ID: IRCT20191229045931N1, Registration date: 24/08/2020).

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