Promoting psycho-social wellbeing for engaging inflammatory bowel disease patients in their care: an Italian consensus statement

Abstract Background Inflammatory bowel diseases (IBD) are remitting and relapsing diseases that mainly interest the gastrointestinal tract. IBD is associated with a condition of psycho-social discomfort that deeply compromises the quality of life and the competence of patient to be fully engaged in their self-management. As a consequence, effective care of IBD patients should include not only medical but also psychological support in order to improve patients' wellbeing. Although this, to date there is no standardized approach to promote psychological wellbeing of IBD patients in order to improve the perception of the quality of the care. To fill this gap, a consensus conference has been organized in order to define the psychosocial needs of IBD patients and to promote their engagement in daily clinical practice. This paper describes the process implemented and illustrates the recommendations deriving from it, which focus on the importance of a multidisciplinary approach in IBD management. Results The consensus conference has been organized in three phases: (1) literature review about life experiences, engagement, and psychosocial needs of IBD patients; (2) workshops with IBD experts and patients’ representatives; (3) drafting of statements and voting. Seventy-three participants were involved in the consensus conference, and sixteen statements have been voted and approved during the consensus process. Conclusions The main conclusion is the necessity of the early detection of – and, in case of need, intervention on- psycho-social needs of patients in order to achieve patient involvement in IBD care.

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Italian Consensus Statement for Promoting Psycho-Social Wellbeing and Engagement in the Care of Inflammatory Bowel Disease Patients

10.21203/rs.3.rs-587615/v1 ◽

2021 ◽

Author(s):

Guendalina Graffigna ◽

Caterina Bosio ◽

Francesco Pagnini ◽

Eleonora Volpato ◽

Enrica Previtali ◽

...

Keyword(s):

Quality Of Life ◽

Well Being ◽

Psychological Needs ◽

Consensus Conference ◽

Psychosocial Aspects ◽

Psychosocial Needs ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

Social Discomfort

Abstract Inflammatory bowel diseases (IBD) are remitting and relapsing diseases that mainly interest the gastrointestinal tract. This is associated with a condition of psycho-social discomfort that prevents the affected person from living normally and deeply compromises the quality of life in terms of personal, work, and interpersonal well-being. Management of IBD patients should include not only clinical but also psychosocial aspects not only clinical but also psychosocial aspects in order to improve patients' wellbeing and quality of life. The promotion of patient engagement is an effective strategy to achieve a better patient's quality of life. Although the undoubted role of patient involvement in the decision making process, to date there is no standardized approach to promote the engagement between physicians and patients and little attention is paid to social and psychological needs of subjects with IBD.To fill this gap, a consensus conference has been organized involving both gastroenterologists, healthcare professionals expert in IBD care and IBD patients in order to define the psychosocial needs of IBD patients and to promote their engagement in daily clinical practice.

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Systemic manifestations of inflammatory bowel diseases

Terapevticheskii arkhiv ◽

10.26442/00403660.2020.02.000535 ◽

2020 ◽

Vol 92 (2) ◽

pp. 4-11

Author(s):

A. I. Parfenov ◽

A. V. Kagramanova ◽

O. V. Knyazev

Keyword(s):

Inflammatory Bowel Diseases ◽

Multidisciplinary Approach ◽

Current Data ◽

Extraintestinal Manifestations ◽

Bowel Diseases ◽

Close Cooperation ◽

Inflammatory Bowel ◽

Systemic Manifestations ◽

Shared Genetic

The article is devoted to the current data regarding the pathogenesis, classification and frequency of extraintestinal manifestations (EIMs) in inflammatory bowel diseases. We discuss two distinct theories of EIMs pathogenesis. First, EIMs arise from an extension of antigen-specific immune responses from the intestine to non-intestinal sites. Second, EIMs are independent inflammatory events initiated or perpetuated by the presence of IBD or by shared genetic or environmental risk factors in the host. These mechanisms are not mutually exclusive and may contribute to varying degrees in different EIMs. Early diagnosis of EIMs contributes to prevention disability and enhancement of quality of life of IBD patients. It is concluded that treatment of extraintestinal manifestations should be carried out taking into account the course of the IBD and the multidisciplinary approach, which requires close cooperation of doctors of various specialties. Assessment of prognostic markers and predictors for EIM in IBD will be part of a future investigation.

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Does Infliximab Short Infusion have a Beneficial Impact on the Quality of Life in Patients with Inflammatory Bowel Diseases? A Single Centre Prospective Evaluation

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld.2014.1121.242.tezz ◽

2015 ◽

Vol 24 (2) ◽

pp. 165-170 ◽

Cited By ~ 8

Author(s):

Mariabeatrice Principi ◽

Giuseppe Losurdo ◽

Rosa Federica La Fortezza ◽

Pasquale Lopolito ◽

Rosa Lovero ◽

...

Keyword(s):

Quality Of Life ◽

Inflammatory Bowel Diseases ◽

Adverse Reactions ◽

Severe Disease ◽

Sexual Life ◽

Necrosis Factor Alpha ◽

Short Infusion ◽

Bowel Diseases ◽

Inflammatory Bowel

Background & Aims: Infliximab (IFX) is an anti-tumor necrosis factor alpha agent used in inflammatory bowel diseases (IBD) therapy. Usually, it is administered over a 2-hour intravenous infusion. However, shortening the infusion duration to 1 hour has proved to be feasible and safe. In the present study we evaluated whether shortening the IFX infusion could affect the patients' quality of life (QoL) compared to the standard protocol.Methods: Subjects affected by IBD receiving IFX were prospectively recruited. The main criterion to shorten the infusion was the absence of IFX-related adverse reactions during the previous three 2-h infusions. For each patient, demographic, clinical and anthropometric data were collected. A questionnaire investigating their overall/job/social/sexual QoL was administered. Ordinal regression was performed with odds ratios (OR) for significant independent variables.Results: Eighty-one patients were included (46 with ulcerative colitis - UC, 35 with Crohn's disease - CD). Sixteen received the 2-h infusion due to previous adverse reactions, and the remaining 65 underwent the 1-h schedule. Shortening the infusion to 1 hour determined a better QoL (OR=0.626). However, the QoL was negatively influenced by age (OR=1.023), female sex (OR=2.04) and severe disease activity (OR=7.242). One-hour IFX infusion induced a better outcome on work (OR=0.588) and social (OR=0.643) QoL. Long-standing disease was correlated with a slightly better sexual QoL (OR=0.93). Conversely, older age (OR=1.046), severe clinical score (OR=15.579), use of other immunomodulators (OR=3.693) and perianal CD (OR=3.265) were related to an unsatisfactory sexual life. The total number of infusions (OR=0.891), proctitis (OR=0.062) or pancolitis (OR=0.1) minimized the perception of infusion-related side effects.Conclusion: The 1-h short infusion improves overall, social and job QoL, so that, when indicated, it should be recommended.

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THE RELATIONSHIP OF QUALITY OF LIFE AND CLINICAL CHARACTERISTICS IN INFLAMMATORY BOWEL DISEASES IN CHILDREN

PEDIATRIA Journal named after G N SPERANSKY ◽

10.24110/0031-403x-2019-98-6-31-36 ◽

2019 ◽

Vol 98 (6) ◽

pp. 31-36 ◽

Cited By ~ 1

Author(s):

A.R. Tagirova ◽

◽

I.V. Sichinava ◽

Keyword(s):

Quality Of Life ◽

Inflammatory Bowel Diseases ◽

Clinical Characteristics ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

Relationship Of ◽

The Relationship

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The Effect of Joint Transition Visits on Quality of Life in Inflammatory Bowel Diseases (TRANS-IBD)

Case Medical Research ◽

10.31525/ct1-nct04290156 ◽

2020 ◽

Author(s):

Keyword(s):

Quality Of Life ◽

Inflammatory Bowel Diseases ◽

Bowel Diseases ◽

Inflammatory Bowel

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International Perspectives on Management of Inflammatory Bowel Disease: Opinion Differences and Similarities Between Patients and Physicians From the IBD GAPPS Survey

Inflammatory Bowel Diseases ◽

10.1093/ibd/izab006 ◽

2021 ◽

Author(s):

David T Rubin ◽

Charles Sninsky ◽

Britta Siegmund ◽

Miquel Sans ◽

Ailsa Hart ◽

...

Keyword(s):

Unmet Need ◽

Patient Survey ◽

Complex Disorders ◽

International Perspectives ◽

Bowel Diseases ◽

Life Impact ◽

Current Therapies ◽

Inflammatory Bowel ◽

Patient Advocacy Groups

Abstract Background Inflammatory bowel diseases (IBD), including Crohn disease (CD) and ulcerative colitis (UC), are complex disorders with multiple comorbidities. We conducted international patient and physician surveys to evaluate current experiences and perceptions of patients with CD or UC and physicians who treat IBD. Methods The IBD Global Assessment of Patient and Physician Unmet Need Surveys comprised a patient survey and a physician survey, fielded in North America and Europe between August 16, 2019, and November 10, 2019. Adults with CD or UC (targeted 1:1 ratio) were recruited from physicians, patient advocacy groups, and recruitment panels; physicians were recruited by recruitment agencies and panels. Results In total, 2398 patients with IBD (1368 CD, 1030 UC) and 654 physicians completed surveys. Anxiety and depression were the most common comorbidities among patients with IBD. Patients and physicians were generally aligned on treatment goals and patient-physician communication. Patients with IBD reported high quality-of-life impact by rectal urgency and need to use the toilet, which were rated as lower-impact by physicians. Patients defined remission based on symptoms; physicians defined remission based primarily on clinical tests. Patients expected current treatments to control their disease for a longer duration than did physicians. Patients expressed more concern about corticosteroid use compared with physicians; many physicians reported prescribing corticosteroids for more than 4 months per year in some patients. Conclusions Patients could benefit from education about disease remission and expectations for current therapies. High corticosteroid use is concerning to patients, and physicians should minimize the use of corticosteroids for extended periods of time.

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Antioxidant Therapy in Inflammatory Bowel Diseases

Antioxidants ◽

10.3390/antiox10030412 ◽

2021 ◽

Vol 10 (3) ◽

pp. 412

Author(s):

Katarzyna Dziąbowska-Grabias ◽

Małgorzata Sztanke ◽

Przemysław Zając ◽

Michał Celejewski ◽

Katarzyna Kurek ◽

...

Keyword(s):

Inflammatory Bowel Diseases ◽

Nitrosative Stress ◽

Treatment Options ◽

Chemical Compounds ◽

Continuous Increase ◽

Public Health Burden ◽

Bowel Diseases ◽

Significant Public Health ◽

Inflammatory Bowel

Inflammatory bowel diseases (IBD) are a group of chronic, incurable diseases of the digestive tract, the etiology of which remains unclear to this day. IBD result in significant repercussions on the quality of patients’ life. There is a continuous increase in the incidence and prevalence of IBD worldwide, and it is becoming a significant public health burden. Pharmaceuticals commonly used in IBD management, for example, mesalamine, sulfasalazine, corticosteroids, and others, expose patients to diverse, potentially detrimental side effects and frequently do not provide sufficient disease control. The chronic inflammation underlies the etiology of IBD and closely associates with oxidative/nitrosative stress and a vast generation of reactive oxygen/nitrogen species. Relative to this, several substances with antioxidant and anti-inflammatory properties are now intensively researched as possible adjunctive or independent treatment options in IBD. Representatives of several different groups, including natural and chemical compounds will be characterized in this dissertation.

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Cannabis and Canabidinoids on the Inflammatory Bowel Diseases: Going Beyond Misuse

International Journal of Molecular Sciences ◽

10.3390/ijms21082940 ◽

2020 ◽

Vol 21 (8) ◽

pp. 2940

Author(s):

Antonelly Cassio Alves de Carvalho ◽

Gabriela Achete de Souza ◽

Samylla Vaz de Marqui ◽

Élen Landgraf Guiguer ◽

Adriano Cressoni Araújo ◽

...

Keyword(s):

Quality Of Life ◽

Inflammatory Bowel Diseases ◽

Literature Search ◽

Cannabis Sativa ◽

Antioxidant Properties ◽

Number Of Patients ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

Anti Inflammatory

Inflammatory bowel diseases (IBD) are characterized by a chronic and recurrent gastrointestinal condition, including mainly ulcerative colitis (UC) and Crohn’s disease (CD). Cannabis sativa (CS) is widely used for medicinal, recreational, and religious purposes. The most studied compound of CS is tetrahydrocannabinol (THC) and cannabidiol (CBD). Besides many relevant therapeutic roles such as anti-inflammatory and antioxidant properties, there is still much controversy about the consumption of this plant since the misuse can lead to serious health problems. Because of these reasons, the aim of this review is to investigate the effects of CS on the treatment of UC and CD. The literature search was performed in PubMed/Medline, PMC, EMBASE, and Cochrane databases. The use of CS leads to the improvement of UC and CD scores and quality of life. The medical use of CS is on the rise. Although the literature shows relevant antioxidant and anti-inflammatory effects that could improve UC and CD scores, it is still not possible to establish a treatment criterion since the studies have no standardization regarding the variety and part of the plant that is used, route of administration and doses. Therefore, we suggest caution in the use of CS in the therapeutic approach of IBD until clinical trials with standardization and a relevant number of patients are performed.

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Disability in Patients with Inflammatory Bowel Disease: Correlations with Quality of Life and Patient’s Characteristics

Canadian Journal of Gastroenterology and Hepatology ◽

10.1155/2017/6138105 ◽

2017 ◽

Vol 2017 ◽

pp. 1-11 ◽

Cited By ~ 8

Author(s):

Konstantinos Argyriou ◽

Andreas Kapsoritakis ◽

Konstantinos Oikonomou ◽

Anastassios Manolakis ◽

Eirini Tsakiridou ◽

...

Keyword(s):

Quality Of Life ◽

Population Characteristics ◽

Life Domains ◽

Referral Centre ◽

Extensive Disease ◽

Bowel Diseases ◽

Significant Disability ◽

Inflammatory Bowel ◽

Lower Education

Background. Inflammatory bowel diseases may cause significant disability. However, little is known regarding the life domains where patients encounter most limitations. Objectives. To assess patients’ overall disability and determine the life domains where most restrictions were applied. Secondarily, we sought for possible relationships among disability, quality of life (HRQoL), and population characteristics. Method. The study lasted for two years (2013–2015) and included 200 patients [52% ulcerative colitis (UC)] from a referral centre. Disability was evaluated using the 36-item version of WHODAS 2.0 questionnaire. The influence of population characteristics on overall disability was assessed with linear regression. Results. Crohn’s disease (CD) patients showed greater overall disability compared to UC (19.22 versus 15.01, p=0.001), with higher scores in the domains of relationships, life activities, and participation. Disability was negatively associated with HRQoL (p<0.001). Long activity, extensive disease, rural residence, and employment independently influenced the overall disability in both groups. Additionally, significant influence was recorded for lower education in the UC and for operation and celibacy in the CD group. Conclusions. CD patients were facing more limitations compared to those with UC, especially in the domains of relationships, activities, and participation. Other than clinical factors, sociodemographic characteristics were also associated with increased disability.

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