scholarly journals Blood purification could tackle COVID-19?

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Hiroyuki Yamada ◽  
Shigeru Ohtsuru
Keyword(s):  
Effective Treatment ◽  
Plasma Exchange ◽  
Inflammatory Cytokines ◽  
Clinical Studies ◽  
Clinical Effect ◽  
Polymyxin B ◽  
Blood Purification ◽  
Considerable Potential ◽  
Positive Clinical Effect ◽  
Polymyxin B Hemoperfusion

AbstractCoronavirus disease 2019 (COVID-19) threatened human lives worldwide since first reported. The current challenge for global intensivists is to establish an effective treatment for severe COVID-19. Blood purification has been applied to the treatment of various critical illnesses. Theoretically, its technique also has an enormous possibility of treating severe COVID-19 in managing inflammatory cytokines and coagulopathy. Recent clinical studies have revealed the positive clinical effect of therapeutic plasma exchange. Other studies have also indicated the considerable potential of other blood purification techniques, such as Cytosorb, AN69 surface-treated membrane, and polymyxin b hemoperfusion. Further research is needed to elucidate the actual effects of these applications.

EFFICIENCY OF NEW HEMOSORBENT IN ACUTE AMITRIPTYLINE AND CYCLODOL POISONING

2020 ◽  
pp. 14-18
Author(s):  
A. M. Fomin
Keyword(s):  
Clinical Effect ◽  
High Efficiency ◽  
Initial Level ◽  
Synthetic Polymer ◽  
Complex Treatment ◽  
Direct Hemoperfusion ◽  
Selective Sorption ◽  
Positive Clinical Effect ◽  
Before And After

A complex treatment of a patient with acute amitriptyline and cyclodol poisoning using enterosorption, intestinal lavage and hemosorption on a new column with a synthetic sorbent is presented. A two-layer synthetic polymer column developed for the selective sorption of cytokines by direct hemoperfusion was used for hemosorption. Quantitative determinations of amitriptyline and cyclodol levels before and after the column, as well as before and after hemosorption have showed high efficiency of the sorbent to remove the toxicant from the blood. The use of 6-hour hemosorption allowed to reduce the level of amitriptyline from the initial level by more than 4 times and the level of cyclodol - by more than 3 times to therapeutic levels and to obtain a pronounced positive clinical effect in the complex treatment of a patient with severe poisoning.

scholarly journals Effects of Polymyxin B Hemoperfusion on Septic Shock Patients Requiring Noradrenaline: Analysis of a Nationwide Administrative Database in Japan

2021 ◽  
pp. 1-6
Author(s):  
Kenji Fujimori ◽  
Kunio Tarasawa ◽  
Kiyohide Fushimi
Keyword(s):  
Septic Shock ◽  
Propensity Score ◽  
Propensity Score Matching ◽  
Polymyxin B ◽  
Administrative Database ◽  
Control Group ◽  
Continuous Hemodiafiltration ◽  
Significant Survival ◽  
Maximum Daily Dose ◽  
Polymyxin B Hemoperfusion

<b><i>Introduction:</i></b> Polymyxin B hemoperfusion (PMX) reduces endotoxin in septic shock patients’ blood and can improve hemodynamics and organ functions. However, its effects on the reduction of septic shock mortality are controversial. <b><i>Methods:</i></b> Using the Japanese diagnosis procedure combination database from April 2016 to March 2019, we identified adult septic shock patients treated with noradrenaline. This study used propensity score matching to compare the outcome between PMX-treated and non-treated patients. The primary endpoint was 28-day mortality, counting from the day of noradrenaline initiation. The secondary endpoints were noradrenaline-, ventilator-, and continuous hemodiafiltration (CHDF)-free days at day 28. <b><i>Results:</i></b> Of 30,731 eligible patients, 4,766 received PMX. Propensity score matching produced a matched cohort of 4,141 pairs with well-balanced patient backgrounds. The 28-day survival rate was 77.9% in the PMX group and 71.1% in the control group (<i>p</i> &#x3c; 0.0001). Median days of noradrenalin-, CHDF-, and ventilator-free days were 2 days (<i>p</i> &#x3c; 0.0001), 2 days (<i>p</i> &#x3c; 0.0001), and 6 days (<i>p</i> &#x3c; 0.0001) longer in the PMX group than in the control group, respectively. When stratified with the maximum daily dose of noradrenaline, the PMX group showed a statistically significant survival benefit in the groups with noradrenaline dose &#x3c;20 mg/day but not in the noradrenaline group dose ≥20 mg/day. <b><i>Conclusion:</i></b> Analysis of large Japanese databases showed that septic shock patients who received noradrenaline might benefit from PMX treatment.

scholarly journals EFFICACY AND SAFETY OF NASAL SPRAY PREVALIN IN THE TREATMENT OF ALLERGIC RHINITIS PATIENTS

2012 ◽  
Vol 9 (5) ◽  
pp. 55-59
Author(s):  
A A Tsyvkina ◽  
L V Luss ◽  
S V Tsarev ◽  
N V Shartanova
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Cavity ◽  
Nasal Spray ◽  
Clinical Effect ◽  
Clinical Symptoms ◽  
Efficacy And Safety ◽  
Nasal Breathing ◽  
Results Of Treatment ◽  
Functional Methods ◽  
Positive Clinical Effect

Background. To study of efficacy, tolerability and safety of nasal spray Prevalin in the treatment of allergic rhinitis patients. Methods. 30 patients with allergic rhinitis in the age of18 till 45 years were observed. Prevalin was given as one insufflation into each nasal cavity 3 times a day for 21 days. Results of treatment were assessed by the dynamics of clinical symptoms and the results of functional methods . Results. The positive clinical effect was observed in 22 patients (73,3%), using Prevalin. Clinical effect was characterized by the restoration of nasal breathing, reduce swelling of the nasal mucosa. We did not establish a good result of treatment in 8 patients. Conclusion. The study demonstrated clinical efficacy and safety of spray Prevalin.

scholarly journals LABORATORY AND CLINICAL STUDIES OF POLYMYXIN B AND E 12

1949 ◽  
Vol 28 (5 Pt 1) ◽  
pp. 1028-1031 ◽  
Author(s):  
Edwin J. Pulaski ◽  
Hinton J. Baker ◽  
Milton L. Rosenberg ◽  
James F. Connell
Keyword(s):  
Clinical Studies ◽  
Polymyxin B

scholarly journals Efficiency Of Intra-Articular Administration In Early Osteoarthrosis

2020 ◽  
Vol 02 (11) ◽  
pp. 22-27
Author(s):  
Islamova K. A . ◽  
◽  
Khasanov F. Sh ◽  
Toirov E. S. ◽  
◽  
...  
Keyword(s):  
Visual Analogue Scale ◽  
Knee Joint ◽  
Treatment Outcomes ◽  
Analogue Scale ◽  
Clinical Effect ◽  
Early Stage ◽  
Knee Joints ◽  
Joint Function ◽  
Early Osteoarthritis ◽  
Positive Clinical Effect

The purpose of this study was to investigate the function of knee joints in patients with early osteoarthritis (OA, according to the criteria of the American rheumatology Association 2010) stage I-III using visual analogue scale (VAS) for pain intensity and treatment outcomes, Lequesne index, expert indicators, samples of 4 meter walk to assess the effectiveness of intra-articular injection Hyaluronic Chondro. 80 patients aged 28 to 55 years were examined. The treatment regimen included recommendations from the European rheumatology League (EULAR, 2016) and Russia (Nasonov E. L., 2017). The results of therapy were evaluated in two groups. The first group included 43 patients who received Hyaluronic Chondro in the form of intra-articular injections, the second-37 patients who received chondroprotectors inside or in the form of intramuscular injections. Conclusion. Intra-articular administration of the drug Chondrogard has a positive clinical effect in early stage II-III OA with moderate impairment of knee joint function. The course of treatment should last at least 2 months

scholarly journals Effect of plasma exchange plus hemofiltration on inflammatory cytokines in patients with liver failure

2015 ◽  
Vol 23 (2) ◽  
pp. 281
Author(s):  
Xue-Hua Zhang ◽  
Ming Li ◽  
Chuan-Wu Zhu ◽  
Xing-Hua Shen ◽  
Xiao-Yan Zhu
Keyword(s):  
Liver Failure ◽  
Plasma Exchange ◽  
Inflammatory Cytokines

scholarly journals More effective use of polymyxin-B hemoperfusion for nonoperation cases

Critical Care ◽  
2014 ◽  
Vol 18 (S2) ◽  
Author(s):  
M Yahata ◽  
Y Sakamoto ◽  
S Inoue ◽  
T Iwamura ◽  
R Fujita ◽  
...  
Keyword(s):  
Polymyxin B ◽  
Effective Use ◽  
Polymyxin B Hemoperfusion
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