Preparation of injectable hydrogel with near-infrared light response and photo-controlled drug release

AbstractPhoto-controlled release hydrogel provides a new strategy for treating tumours. Under the stimulation of external light sources, the ability to release the entrapped drug on time and space on demand has outstanding advantages in improving drug utilisation, optimising treatment, and reducing toxicity and side effects. In this study, a photo-controlled drug delivery system for disulphide cross-linked polyaspartic acid (PASP-SS) hydrogels encapsulating proteinase K (ProK) adsorbed with platinum nanoparticles (PtNPs) was designed. The injectable cysteamine-modified polyaspartic acid (PASP-SH) sol and PtNPs adsorbed by ProK (ProK-PtNPs) as regulatory factors were prepared. Then, ProK-PtNPs and lentinan were dissolved in the sol, and the oxidant was added to the matrix to form the gel in situ quickly after injection. Finally, the degradation of PASP-SS hydrogel by ProK and the controllability of drug release under near-infrared (NIR) light irradiation were elucidated. In vitro degradation of hydrogels and drug release experiments showed that the degradation rate of PASP-SS hydrogel significantly increased and the drug release rate increased significantly under near-infrared radiation. The results of cytotoxicity test showed that PASP-SS, ProK-PtNPs, and lentinan all had more than 90% cell survival rate on NIH3T3, and the lentinan released from the carrier obviously inhibited the proliferation of MCF7. PASP hydrogel has the potential to respond to on-demand light control.

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Near-infrared light-triggered drug release from UV-responsive diblock copolymer-coated upconversion nanoparticles with high monodispersity

Journal of Materials Chemistry B ◽

10.1039/c8tb00651b ◽

2018 ◽

Vol 6 (21) ◽

pp. 3531-3540 ◽

Cited By ~ 23

Author(s):

Jun Xiang ◽

Xia Tong ◽

Feng Shi ◽

Qiang Yan ◽

Bing Yu ◽

...

Keyword(s):

Drug Release ◽

Diblock Copolymer ◽

Near Infrared ◽

Controlled Drug Release ◽

Infrared Light ◽

Upconversion Nanoparticles ◽

Near Infrared Light ◽

Nir Light ◽

Triggered Drug Release

The preparation of a new near-infrared (NIR) light-responsive nanocarrier for controlled drug release is demonstrated.

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Near-infrared light-responsive alginate hydrogels based on diselenide-containing cross-linkage for on demand degradation and drug release

Carbohydrate Polymers ◽

10.1016/j.carbpol.2019.115070 ◽

2019 ◽

Vol 223 ◽

pp. 115070 ◽

Cited By ~ 9

Author(s):

Daru Seto Bagus Anugrah ◽

Kaylan Ramesh ◽

Mingeun Kim ◽

Kyu Hyun ◽

Kwon Taek Lim

Keyword(s):

Drug Release ◽

Near Infrared ◽

Infrared Light ◽

Near Infrared Light ◽

On Demand ◽

Alginate Hydrogels ◽

Cross Linkage

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Microscale optoelectronic infrared-to-visible upconversion devices and their use as injectable light sources

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1802064115 ◽

2018 ◽

Vol 115 (26) ◽

pp. 6632-6637 ◽

Cited By ~ 31

Author(s):

He Ding ◽

Lihui Lu ◽

Zhao Shi ◽

Dan Wang ◽

Lizhu Li ◽

...

Keyword(s):

Near Infrared ◽

Biological Fluids ◽

Visible Spectral Range ◽

Infrared Light ◽

Light Sources ◽

Fully Integrated ◽

Broadband Absorption ◽

In Vivo Experiments

Optical upconversion that converts infrared light into visible light is of significant interest for broad applications in biomedicine, imaging, and displays. Conventional upconversion materials rely on nonlinear light-matter interactions, exhibit incidence-dependent efficiencies, and require high-power excitation. We report an infrared-to-visible upconversion strategy based on fully integrated microscale optoelectronic devices. These thin-film, ultraminiaturized devices realize near-infrared (∼810 nm) to visible [630 nm (red) or 590 nm (yellow)] upconversion that is linearly dependent on incoherent, low-power excitation, with a quantum yield of ∼1.5%. Additional features of this upconversion design include broadband absorption, wide-emission spectral tunability, and fast dynamics. Encapsulated, freestanding devices are transferred onto heterogeneous substrates and show desirable biocompatibilities within biological fluids and tissues. These microscale devices are implanted in behaving animals, with in vitro and in vivo experiments demonstrating their utility for optogenetic neuromodulation. This approach provides a versatile route to achieve upconversion throughout the entire visible spectral range at lower power and higher efficiency than has previously been possible.

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Near-Infrared Light-, Magneto-, and pH-Responsive GO–Fe3O4/Poly(N-isopropylacrylamide)/alginate Nanocomposite Hydrogel Microcapsules for Controlled Drug Release

Langmuir ◽

10.1021/acs.langmuir.1c00207 ◽

2021 ◽

Author(s):

Yuan Cao ◽

Yue Cheng ◽

Gang Zhao

Keyword(s):

Drug Release ◽

Near Infrared ◽

Controlled Drug Release ◽

Infrared Light ◽

Nanocomposite Hydrogel ◽

Ph Responsive ◽

Near Infrared Light

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Design and fabrication of cell-targeted, dual drug-loaded nanoparticles with pH-controlled drug release and near-infrared light-induced photothermal effects

Materials & Design ◽

10.1016/j.matdes.2020.109230 ◽

2021 ◽

Vol 197 ◽

pp. 109230

Author(s):

Chang-Ching Weng ◽

Tsu-An Yang ◽

Yaw-Kuen Li

Keyword(s):

Drug Release ◽

Near Infrared ◽

Controlled Drug Release ◽

Infrared Light ◽

Near Infrared Light ◽

Photothermal Effects ◽

Dual Drug ◽

Ph Controlled

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Near-Infrared Light-Responsive Shell-Crosslinked Micelles of Poly(d,l-lactide)-b-poly((furfuryl methacrylate)-co-(N-acryloylmorpholine)) Prepared by Diels–Alder Reaction for the Triggered Release of Doxorubicin

Materials ◽

10.3390/ma14247913 ◽

2021 ◽

Vol 14 (24) ◽

pp. 7913

Author(s):

Sonyabapu Yadav ◽

Kalyan Ramesh ◽

Parveen Kumar ◽

Sung-Han Jo ◽

Seong II Yoo ◽

...

Keyword(s):

Drug Release ◽

Near Infrared ◽

Click Reaction ◽

In Vitro Cytotoxicity ◽

Diels Alder ◽

Infrared Light ◽

Burst Release ◽

Crosslinking Reaction ◽

Triggered Release

In the present study, we developed near-infrared (NIR)-responsive shell-crosslinked (SCL) micelles using the Diels–Alder (DA) click reaction between an amphiphilic copolymer poly(d,l-lactide)20-b-poly((furfuryl methacrylate)10-co-(N-acryloylmorpholine)78) (PLA20-b-P(FMA10-co-NAM78)) and a diselenide-containing crosslinker, bis(maleimidoethyl) 3,3′-diselanediyldipropionoate (BMEDSeDP). The PLA20-b-P(FMA10-co-NAM78) copolymer was synthesized by RAFT polymerization of FMA and NAM using a PLA20-macro-chain transfer agent (PLA20-CTA). The DA reaction between BMEDSeDP and the furfuryl moieties in the copolymeric micelles in water resulted in the formation of SCL micelles. The SCL micelles were analyzed by 1H-NMR, FE-SEM, and DLS. An anticancer drug, doxorubicin (DOX), and an NIR sensitizer, indocyanine green (ICG), were effectively incorporated into the SCL micelles during the crosslinking reaction. The DOX/ICG-loaded SCL micelles showed pH- and NIR-responsive drug release, where burst release was observed under NIR laser irradiation. The in vitro cytotoxicity analysis demonstrated that the SCL was not cytotoxic against normal HFF-1 cells, while DOX/ICG-loaded SCL micelles exhibited significant antitumor activity toward HeLa cells. Thus, the SCL micelles of PLA20-b-P(FMA10-co-NAM78) can be used as a potential delivery vehicle for the controlled drug release in cancer therapy.

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Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug Release

Advances in Materials Science and Engineering ◽

10.1155/2014/169210 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 3

Author(s):

Ranran Zhang ◽

Risheng Yao ◽

Binbin Ding ◽

Yuxin Shen ◽

Shengwen Shui ◽

...

Keyword(s):

Drug Release ◽

Near Infrared ◽

Uv Light ◽

Nile Red ◽

Controlled Drug Release ◽

Hybrid Nanoparticles ◽

Infrared Light ◽

Nir Light ◽

Triggered Drug Release ◽

Model Drug

Low tissue penetration and harmful effects of (ultraviolet) UV or visible light on normal tissue limit exploiting nanocarriers for the application of light-controlled drug release. Two strategies may solve the problem: one is to improve the sensitivity of the nanocarriers to light to decrease the radiation time; the other one is using more friendly light as the trigger. In this work, we fabricated a core-shell hybrid nanoparticle with an upconverting nanoparticle (UCNP) as the core and thermo- and light-responsive block copolymers as the shell to combine the two strategies together. The results indicated that the sensitivity of the block copolymer to light could be enhanced by decreasing the photolabile moieties in the polymer, and the UCNP could transfer near-infrared (NIR) light, which is more friendly to tissue and cell, to UV light to trigger the phase conversion of the block polymersin situ. Using Nile Red (NR) as the model drug, the hybrid nanoparticles were further proved to be able to act as carriers with the character of NIR triggered drug release.

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Near-Infrared, Light-Triggered, On-Demand Anti-inflammatories and Antibiotics Release by Graphene Oxide/Elecrospun PCL Patch for Wound Healing

C – Journal of Carbon Research ◽

10.3390/c5040063 ◽

2019 ◽

Vol 5 (4) ◽

pp. 63 ◽

Cited By ~ 6

Author(s):

Mauro ◽

Cavallaro ◽

Giammona

Keyword(s):

Wound Healing ◽

Graphene Oxide ◽

Cell Adhesion ◽

Near Infrared ◽

Drug Loading ◽

Controlled Drug Release ◽

Infrared Light ◽

Adhesion Properties ◽

On Demand

Very recently, significant attention has been focused on the adsorption and cell adhesion properties of graphene oxide (GO), because it is expected to allow high drug loading and controlled drug release, as well as the promotion of cell adhesion and proliferation. This is particularly interesting in the promotion of wound healing, where antibiotics and anti-inflammatories should be locally released for a prolonged time to allow fibroblast proliferation. Here, we designed an implantable patch consisting of poly(caprolactone) electrospun covered with GO, henceforth named GO–PCL, endowed with high ibuprofen (5.85 mg cm−2), ketoprofen (0.86 mg cm−2), and vancomycin (0.95 mg cm−2) loading, used as anti-inflammatory and antibiotic models respectively, and capable of responding to near infrared (NIR)-light stimuli in order to promptly release the payload on-demand beyond three days. Furthermore, we demonstrated the GO is able to promote fibroblast adhesion, a key characteristic to potentially provide wound healing in vivo.

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