Sleep disorders and gout in Australian adults

Abstract Background The aims of our study were two-fold. Firstly, to determine if there is an association between gout and OSA in a representative Australian adult population. Secondly, to explore associations between gout and patient reported sleep outcomes. Methods A cross-sectional national online survey of a representative sample of Australian adults > 18 years assessed self-reported doctor-diagnosed OSA, insomnia and patient reported sleep outcomes. Possible undiagnosed OSA was estimated using self-reported frequent loud snoring and witnessed apnoeas. Participants self-reported physician-diagnosed gout and other health conditions. Multivariable logistic regression analyses were performed for both objectives. Odds ratios with 95% confidence intervals were reported. Results There were 1948 participants of whom 126 (6.5%) had gout and 124 (6.4%) had diagnosed sleep apnoea. After adjusting for age, body mass index (BMI), sex, alcohol intake and the presence of arthritis, those with obstructive sleep apnoea diagnosed on polysomnography were twice as likely to report having gout compared to those without. (OR = 2.6, 95% CI 1.5–4.6). Additionally, participants with symptoms suggestive of sleep apnoea were also twice as likely to have gout compared to those without (OR = 2.8, 95%CI 1.6–5.1). There was also a higher likelihood of restless legs syndrome, insomnia and worry about sleep in patients with gout. Conclusion Diagnosed and suspected OSA are associated with higher likelihood of gout. Participants with gout are also more likely to report suffering from restless legs syndrome, insomnia and worry about their sleep. Given the morbidity associated with sleep problems, we should be vigilant regarding sleep health in our patients with gout.

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Sleep Disorders and Gout in Australian Adults

10.21203/rs.3.rs-144965/v1 ◽

2021 ◽

Author(s):

Julia New-Tolley ◽

Amy Reynolds ◽

Sarah Appleton ◽

Tiffany Gill ◽

Susan Lester ◽

...

Keyword(s):

Restless Legs Syndrome ◽

Online Survey ◽

Sleep Problems ◽

Adult Population ◽

Sleep Apnoea ◽

Sleep Health ◽

Cross Sectional ◽

Restless Legs ◽

Obstructive Sleep ◽

Patient Reported

Abstract BACKGROUND: The aims of our study were two-fold. Firstly, to determine if there is an association between gout and OSA in a representative Australian adult population. Secondly, to explore associations between gout and patient reported sleep outcomes. METHODS: A cross-sectional national online survey of a representative sample of Australian adults > 18 years assessed self-reported doctor-diagnosed OSA, insomnia and patient reported sleep outcomes. Possible undiagnosed OSA was estimated using self-reported frequent loud snoring and witnessed apnoeas. Participants self-reported physician-diagnosed gout and other health conditions. Multivariable logistic regression analyses were performed for both objectives. Odds ratios with 95% confidence intervals were reported.RESULTS: There were 1948 participants of whom 126 (6.5%) had gout and 124 (6.4%) had diagnosed sleep apnoea. After adjusting for age, body mass index (BMI), sex, alcohol intake and the presence of arthritis, those with obstructive sleep apnoea diagnosed on polysomnography were twice as likely to report having gout compared to those without. (OR=2.6, 95% CI 1.5 - 4.6). Additionally, participants with symptoms suggestive of sleep apnoea were also twice as likely to have gout compared to those without (OR=2.8, 95%CI 1.6 - 5.1). There was also a higher likelihood of restless legs syndrome, insomnia and worry about sleep in patients with gout. CONCLUSION: Diagnosed and suspected OSA are associated with higher likelihood of gout. Participants with gout are also more likely to report suffering from restless legs syndrome, insomnia and worry about their sleep. Given the morbidity associated with sleep problems, we should be vigilant regarding sleep health in our patients with gout.

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Examining relationships between sleep posture, waking spinal symptoms and quality of sleep: A cross sectional study

PLoS ONE ◽

10.1371/journal.pone.0260582 ◽

2021 ◽

Vol 16 (11) ◽

pp. e0260582

Author(s):

Doug Cary ◽

Angela Jacques ◽

Kathy Briffa

Keyword(s):

Sleep Quality ◽

Online Survey ◽

General Information ◽

Control Group ◽

Quality Of Sleep ◽

Cross Sectional ◽

Obstructive Sleep ◽

Patient Reported ◽

Sleep Posture

Introduction Research with a focus on sleep posture has been conducted in association with sleep pathologies such as insomnia and positional obstructive sleep apnoea. Research examining the potential role sleep posture may have on waking spinal symptoms and quality of sleep is however limited. The aims of this research were to compare sleep posture and sleep quality in participants with and without waking spinal symptoms. Methods Fifty-three participants (36 female) were, based on symptoms, allocated to one of three groups; Control (n = 20, 16 female), Cervical (n = 13, 10 female) and Lumbar (n = 20, 10 female). Participants completed an online survey to collect general information and patient reported outcomes and were videoed over two consecutive nights to determine sleep posture using a validated classification system including intermediate sleep postures. Results Participants in the symptomatic groups also reported a lower sleep quality than the Control group. Compared to Control group participants, those in the Cervical group had more frequent posture changes (mean (SD); 18.3(6.5) versus 23.6(6.6)), spent more time in undesirable/provocative sleep postures (median IQR; 83.8(16.4,105.2) versus 185.1(118.0,251.8)) minutes and had more long periods of immobility in a provocative posture, (median IQR: 0.5(0.0,1.5) versus 2.0 (1.5,4.0)). There were no significant differences between the Control and Lumbar groups in the number of posture changes (18.3(6.5) versus 22.9(9.1)) or the time spent in provocative sleep postures (0.5(0.0,1.5) versus 1.5(1.5,3.4)) minutes. Discussion This is the first study using a validated objective measure of sleep posture to compare symptomatic and Control group participants sleeping in their home environment. In general, participants with waking spinal symptoms spent more time in provocative sleep postures, and experienced poorer sleep quality.

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Gender differences in obstructive sleep apnoea, insomnia and restless legs syndrome in adults – What do we know? A clinical update

Sleep Medicine Reviews ◽

10.1016/j.smrv.2017.03.003 ◽

2018 ◽

Vol 38 ◽

pp. 28-38 ◽

Cited By ~ 31

Author(s):

Jenny Theorell-Haglöw ◽

Christopher B. Miller ◽

Delwyn J. Bartlett ◽

Brendon J. Yee ◽

Hannah D. Openshaw ◽

...

Keyword(s):

Gender Differences ◽

Obstructive Sleep Apnoea ◽

Restless Legs Syndrome ◽

Sleep Apnoea ◽

Restless Legs ◽

Obstructive Sleep

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Restless legs syndrome and its correlation with other sleep problems in the general adult population of Japan

Sleep and Biological Rhythms ◽

10.1111/j.1479-8425.2006.00220.x ◽

2006 ◽

Vol 4 (2) ◽

pp. 153-159 ◽

Cited By ~ 8

Author(s):

Minori ENOMOTO ◽

Lan LI ◽

Sayaka ARITAKE ◽

Yukihiro NAGASE ◽

Tatsuhiko KAJI ◽

...

Keyword(s):

Restless Legs Syndrome ◽

Sleep Problems ◽

Adult Population ◽

Restless Legs ◽

General Adult Population

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Sleep pattern, sleep problems and comorbidities among resident doctors at a tertiary care institution in India: a cross sectional study

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20175165 ◽

2017 ◽

Vol 4 (12) ◽

pp. 4477 ◽

Cited By ~ 1

Author(s):

Siddalingaiah H.S. ◽

Chandrakala D. ◽

Amarjeet Singh

Keyword(s):

Sleep Problems ◽

Tertiary Care ◽

Sleep Time ◽

Cross Sectional Study ◽

Sleep Apnoea ◽

Sleep Pattern ◽

Sectional Study ◽

Cross Sectional ◽

Obstructive Sleep ◽

Study Results

Background: Sleep problems are a major concern in population working under stress such as resident doctors. Sleep has many health benefits; sleep problems are linked with short and long term adverse health outcomes. Aim was to study sleep pattern, problems and comorbidities among resident doctors. Methods: A cross-sectional study design with a pre-validated sleep assessment proforma was used to collect information on socio-demographics, sleep pattern, sleep problems and comorbidities from 428 resident doctors found eligible for the study. Results: 350 subjects returned the filled proforma (82% response rate). Mean daily sleep hours were 6.21 (SD, 1.39) and work hours 12.77 (SD, 3.63). Sleep time was night in 64.6%, day in 12%, and both in 23.4%. Monthly average of 5.8 night shifts and 2.03 duty offs were found. Visual analogue scale (0-10) mean scores for sleepiness and tiredness were 4.41 (SD, 2.55; 95% CI, 4.14-4.68; P<0.01) and 4.73 (SD, 2.62; 95% CI, 4.45-5.00; P<0.01) respectively. Presence of different symptoms related to sleep problems ranged from 7 to 26% and various problems interfering with sleep ranged from 10 to 25%. Comorbidities such as allergy (29.4%), jerky legs (24.3%), sinus infections (22.8%), restless leg syndrome (16.3%), snoring (8.3%), asthma/lung diseases (5.8%), chronic diseases (3.4%), severe snoring disturbing others (1.8%), and obstructive sleep apnoea (0.9%) were present. Conclusions: Sleep problems were highly prevalent among resident doctors. The resident doctors were sleep-deprived, overworked, tired, excessively sleepy, and had significant presence of factors affecting circadian rhythm and sleep fragmentation. Various comorbidities were also present with varying prevalence.

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Treating restless legs syndrome in the context of sleep disordered breathing comorbidity

European Respiratory Review ◽

10.1183/16000617.0061-2019 ◽

2019 ◽

Vol 28 (153) ◽

pp. 190061 ◽

Cited By ~ 2

Author(s):

Sofía Romero-Peralta ◽

Irene Cano-Pumarega ◽

Celia Garcia-Malo ◽

Lina Agudelo Ramos ◽

Diego García-Borreguero

Keyword(s):

Restless Legs Syndrome ◽

Sleep Disordered Breathing ◽

Current Knowledge ◽

Treatment Options ◽

Sleep Apnoea ◽

Clinical Implications ◽

Adequate Treatment ◽

Restless Legs ◽

Obstructive Sleep ◽

Disordered Breathing

Obstructive sleep apnoea (OSA) and restless legs syndrome (RLS) are two of the most prevalent sleep disorders and can coexist within the same patient. Nonetheless, the recognition of RLS among OSA patients has important clinical implications, since RLS can disrupt sleep despite adequate treatment of sleep disordered breathing and should be treated accordingly. Furthermore, the presence of OSA can also increase the severity of RLS. Therefore, it is important to be able to correctly identify both disorders and treat them effectively. The present article reviews our current knowledge on this comorbidity and discusses potential treatment options for RLS in the context of OSA.

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Investigation on emotion and behavior of children aged 1-11 during the pandemic of COVID-19: A Cross-sectional study in Guizhou, China (Preprint)

10.2196/preprints.24454 ◽

2020 ◽

Author(s):

Yushi Mo ◽

Yan Luo ◽

Hong Li ◽

Dewei Xiao ◽

Shuqing Liu ◽

...

Keyword(s):

Behavioral Problems ◽

Prevention And Control ◽

Online Survey ◽

Sleep Problems ◽

Emotional Problems ◽

Control Measures ◽

Emotional And Behavioral Problems ◽

Guizhou Province ◽

Cross Sectional ◽

And Control

BACKGROUND In face of the sudden epidemic of COVID-19, strict prevention and control measures had been urgently carried out all over China. Because of the long-term home quarantine, all kinds of people were affected by it. OBJECTIVE In order to understand the mental health of children during the pandemic of COVID-19, this study investigated the prevalence and characteristics of emotional and behavioral problems of children aged 1-11 in Guizhou. METHODS Based on the online survey platform, the survey link was pushed through Wechat in April 2020. Electronic questionnaires were used to investigate children's demographic characteristics, emotional or behavioral problems. RESULTS A total of 3505 valid questionnaires were received from 9 prefectures and cities in Guizhou Province. 39.67% of the children in the 1-2-year-old group had emotional problems. 17.63% of the children agd 3-5 years had behavioral or emotional problems. And 23.57% of the children agd 6-11 years havd behavioral problems. CONCLUSIONS During the home quarantine period of prevention and control of COVID-19, even young children were adversely affected. The prevalence of emotional and behavioral problems in children was high, which was mainly manifested as anxiety, difficulty in concentration and sleep problems.

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BASAN index (Body mass index, Age, Sex, Arterial hypertension and Neck circumference) predicts severe apnoea in adults living at high altitude

BMJ Open ◽

10.1136/bmjopen-2020-044228 ◽

2021 ◽

Vol 11 (6) ◽

pp. e044228

Author(s):

Henry Oliveros ◽

Rafael Lobelo ◽

Luis Fernando Giraldo-Cadavid ◽

Alirio Bastidas ◽

Constanza Ballesteros ◽

...

Keyword(s):

Body Mass Index ◽

Arterial Hypertension ◽

High Altitude ◽

Body Mass ◽

Sleep Apnoea ◽

Neck Circumference ◽

Binary Logistic Regression Model ◽

Cross Sectional ◽

Derivation Cohort ◽

Obstructive Sleep

ObjectivesObstructive sleep apnoea (OSA)/hypopnoea syndrome is associated with serious and major multiorgan morbidities, particularly in its most severe forms. However, no severe OSA screening instruments are available for high altitude residents that enable adequate identification and clinical prioritisation of such patients. We aimed at developing a severe OSA prediction tool based on the clinical characteristics and anthropometric measurements of a clinical referral cohort living at 2640 m.a.s.l.DesignCohort-nested cross-sectional study.SettingSleep laboratory for standard polysomnography (PSG) in Colombia.ParticipantsA predictive model was generated from 8718 participants referred to the PSG laboratory. Results were subsequently validated in a second cohort of 1898 participants.Primary outcomeTo identify clinical and anthropometric variables associated with severe OSA (>30 events/hour) and to include them in a binary logistic regression model.ResultsThe significant variables that were retained with the presence of severe OSA included Body mass index (BMI), Age, Sex, Arterial hypertension and Neck circumference (BASAN). The area under the receiver operating characteristic curvefor the BASAN index was 0.69 (95% CI: 0.68 to 0.70) in the derivation cohort and 0.67 (95% CI: 0.65 to 0.69) in the validation cohort, whereby a BASAN index ≥2 had a sensitivity of 95% and a specificity of 17% to detect severe OSA.ConclusionAn objectively based approach to screen for the presence of severe OSA, the BASAN index, exhibits favourable sensitivity characteristics that should enable its operational use as a screening tool in a Hispanic population with a clinical suspicion of OSA and living at high altitude.

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Young adults’ coping strategies against loneliness during the COVID-19-related quarantine in Greece

Health Promotion International ◽

10.1093/heapro/daab053 ◽

2021 ◽

Author(s):

Adrianos Golemis ◽

Panteleimon Voitsidis ◽

Eleni Parlapani ◽

Vasiliki A Nikopoulou ◽

Virginia Tsipropoulou ◽

...

Keyword(s):

Social Media ◽

Young Adults ◽

Social Responsibility ◽

Coping Strategies ◽

Online Survey ◽

Adult Population ◽

Psychological Impact ◽

Well Being ◽

Daily Routine ◽

Cross Sectional

Summary COVID-19 and the related quarantine disrupted young adults’ academic and professional life, daily routine and socio-emotional well-being. This cross-sectional study focused on the emotional and behavioural responses of a young adult population during the COVID-19-related quarantine in April 2020, in Greece. The study was conducted through an online survey. A total of 1559 young adults, aged 18−30 years, completed Steele’s Social Responsibility Motivation Scale and the De Jong Gierveld Loneliness Scale, and answered questions about compliance with instructions, quarantine-related behaviours and coping strategies. According to the results, participants displayed a relatively high sense of social responsibility (M = 16.09, SD = 2.13) and a trend towards moderate feeling of loneliness (M = 2.65, SD = 1.62); young women reported significantly higher levels of loneliness than men. The majority complied with instructions often (46.4%) or always (44.8%). Significantly more women created a new social media account and used the social media longer than 5 h/day, compared with men. Resorting to religion, practicing sports and sharing thoughts and feelings about COVID-19 with others predicted higher levels of social responsibility; humour, practicing sports and sharing thoughts and feelings about COVID-19 with others predicted lower levels of loneliness. Conclusively, COVID-19 is expected to have a significant psychological impact on young adults. Currently, Greece is going through the second quarantine period. This study raises awareness about loneliness in young adults during the COVID-19-related quarantine and highlights the importance of developing online programmes, attractive to younger people, to nurture adaptive coping strategies against loneliness.

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614 The Development and Psychometrics of an Assessment of Children’s Sleep Environments

SLEEP ◽

10.1093/sleep/zsab072.612 ◽

2021 ◽

Vol 44 (Supplement_2) ◽

pp. A241-A242

Author(s):

Jack Peltz ◽

Ronald Rogge ◽

Joseph Buckhalt ◽

Lori Elmore-Staton

Keyword(s):

Online Survey ◽

Sleep Problems ◽

Clinical Work ◽

Sleep Health ◽

Insufficient Sleep ◽

Hygiene Behavior ◽

Sleep Environment ◽

Healthy Functioning ◽

Total Scale Score ◽

Children’S Sleep

Abstract Introduction Approximately half of school-aged children (ages 5–18) get either insufficient sleep during school nights or barely meet the required amount of sleep expected for healthy functioning (National Sleep Foundation, 2014).This percentage increases as children develop into adolescents (National Sleep Foundation, 2006). Accordingly, sleep problems and insufficient sleep are so pervasive that they could be considered an epidemic due to their adverse impact on children’s mental and physical health (Owens, 2015; Shochat et al., 2014). Fundamental to children’s sleep health is their sleep environment (Billings et al., 2019; Spilsbury et al., 2005). Despite its importance, however, there remains a noticeable absence of valid and reliable assessments of this construct. The current study sought to develop a measure of children’s sleep environments to support research and clinical work on youth’s sleep health. Methods A total of 813 parents (Mage = 40.6, SD = 8.6; 72% female) completed an online survey regarding their child’s (Mage = 10.5, SD = 3.8; 45% female) sleep environment and sleep-related behavior. The majority of families identified as Caucasian (approximately 80%). Parents reported fairly high annual incomes (Median = $75,000), but 28.2% of families reported incomes less than $50,000. A total of 18 items (total scale score; alpha = .74) were selected from a pool of 38 items developed from previous research that examined aspects of the sleep environment and were entered into an exploratory factor analysis from which 4 factors emerged: general sleep environment (10 items, alpha = .91), sleeping alone vs. with siblings (2 items, alpha = .78), presence of electronic screens (4 items, alpha = .75), and emotional environment (2 items, alpha = .80). Results The subscales demonstrated distinct patterns of correlations with related constructs, and unique predictive variance in explaining children’s daytime sleepiness even after controlling for children’s sleep hygiene, behavior problems, and sleep problems. Conclusion The current study is one of the first to demonstrate a valid/reliable assessment of children’s sleep environments. Not only will this measure provide researchers with an assessment of a fundamental influence on children’s sleep, but it will also enable clinicians to better measure this construct and support effective sleep health recommendations. Support (if any):

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