scholarly journals Potential use of GAPDH m-RNA in estimating PMI in brain tissue of albino rats at different environmental conditions

Author(s):  
Hoda Abdelmagid Elghamry ◽  
Marwa Issak Mohamed ◽  
Fatma Mohamed Hassan ◽  
Dina Sabry Abdelfattah ◽  
Aly Gamaleldin Abdelaal
1963 ◽  
Vol 204 (5) ◽  
pp. 861-866 ◽  
Author(s):  
Walter Riss ◽  
Stephen D. Burstein ◽  
Robert W. Johnson

Lesions were produced in the brains of male and female albino rats at 1 week of age. It was found that bilateral hippocampal damage is associated with diminished gonadal and adrenal development when that development is estimated by morphologic and behavioral indices (running activity). Only those female rats with bilateral degeneration of the dorsal fornix failed to exhibit cyclic running. Both male and female rats with considerable bilateral hippocampal damage showed diminished running, smaller-sized gonads, and larger thymus bodies at 75–80 days of age. On the other hand, male and female rats with bilateral damage to the pyriform lobe developed a precocious spurt in running activity. A spurt is normally associated with puberty. The question of whether the hippocampus and pyriform lobe should be regarded only as "centers" for trophic stimulation or suppression or whether they should be regarded as important links in circuits mediating an endocrine response to environmental conditions is discussed.


2021 ◽  
Vol 21 ◽  
pp. 142-145
Author(s):  
J. S. Rabo ◽  
A. B. Wakil ◽  
H. C. C. Maduka

Ten Albino rats were each infected intraperitoneally with 0.5 million Trypanosoma strain 8/18 organisms. Cerebral lesions were absent in all rats and mice injected with brain tissue and choroid plexus homogenates from group A rats were aparasitaemic over anobservation period of 30 days. However, infected rats developed intermittent (parasitaemia, lost weight progressively and became anaemic with death intervening in one case. We conclude that T. bricci strain 8/18 infection in rats produces moderate to severe disease which may lead to death; but the organism is is not pushed across the blood-brainbarrier by berenil treatment in the acute stage.


2013 ◽  
Author(s):  
Javier Eduardo Becerra Becerra ◽  
Antônio Gilberto Costa

As rochas ornamentais experimentam processos de deterioração ocasionados pela poluição atmosférica epor sustâncias industriais usadas nos processos de instalação e manutenção, apresentando perda de brilho,alterações da cor original e redução da resistência mecânica. Os ensaios de alteração acelerada junto com osde caracterização tecnológica, realizados a partir de uma amostragem sistemática nos trabalhos de exploração permitem conhecer antecipadamente a resposta destas rochas face à ação do meio ambiente, podendo sepredizer problemas que podem afetar o uso potencial de determinada litologia como rocha ornamental esuas possibilidades de comercialização. Seis variedades de granitos brasileiros foram submetidas a ensaiosde lixiviação estática, lixiviação dinâmica, exposição a vapores de ácido sulfuroso e ensaio de cristalizaçãode sais. Todos estes ensaios simulam os principais agentes físicos e químicos que ocasionam deterioração em rochas aplicadas em revestimentos internos e externos. O grau de microfissuramento e a constituiçãomineralógica foram considerados os fatores petrográficos mais importantes na determinação da alterabilidade.Também foram observadas mudanças nos índices físicos dos granitos mais alteráveis.Palavras-chave: rochas ornamentais, alterabilidade, caracterização tecnológica. ABSTRACT: Dimension stone present deterioration caused by air pollution and some industrial substances used forapplication and maintenance causing loss of brilliance, alterations of original color and reduction of mechanicalresistance. The tests of rapid alteration and technological characterization, carried out on base of a systematicsampling during quarrying, permit to establish with anticipation the behavior of rocks against those reagentsof environmental conditions, predicting problems that may affect the potential use of determined lithologiesas dimension stones and consequently its commerce. Systematic testing of manufactured pieces will increasequality control considerably. Six types of Brazilian granites were submitted to the static lixiviation, expositionto vapors of sulphurous acid and salt crystallization, all of them accelerated alteration tests for simulation ofthe main chemical and physical agents of deterioration in rocks applied in external and internal revetment.The degree of microfracturing and the mineralogical constitution are the most important petrographic factorsof the alterability. A control of technological properties of the materials was also carried out, showing higheralterability of some types.Keywords: Dimension stones, alterability tests, technological characterization.


Author(s):  
Livia V. A. de Castilho ◽  
Ilson P. Pasqualino ◽  
Alan M. Duarte ◽  
Vinicius de A. Waldow ◽  
Maíra P. de Sousa ◽  
...  

The aim of this work was to compare the efficiency of a biosurfactant (BS) and a commercial surfactant under post-salt and pre-salt reservoirs conditions, to evaluate their potential use to EOR (Enhanced Oil Recovery). Rhamnolipids BS from Pseudomonas aeruginosa (INCQS 4046), were produced [1] and characterized [2], [3], and Ultrasperse II® was purchased. Calcite flotation test was conducted to access wettability reversal [4]. IFT analysis was performed [5] under controlled pressure, temperature and salinity to simulate post-salt and pre-salt environmental conditions. Central Composite Rotational Designs (CCRD) were analyzed [6]. According to results, it was demonstrated that both products can reverse wettability and are even more effective under post-salt and pre-salt reservoirs environmental conditions. However, rhamnolipids present better potential for use, since it was more effective when compared to the commercial surfactant, attaining lower interfacial tension values and higher reversal wettability percentages using lower concentrations of product.


2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Hoda Abdelmagid Elghamry ◽  
Fatma Mohamed Hassan ◽  
Marwa Issak Mohamed ◽  
Dina Sabry Abdelfattah ◽  
Aly Gamaleldin Abdelaal

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4937
Author(s):  
Sadia Rahman ◽  
Karlo Wittine ◽  
Mirela Sedić ◽  
Elitza P. Markova-Car

The circadian rhythms are an intrinsic timekeeping system that regulates numerous physiological, biochemical, and behavioral processes at intervals of approximately 24 h. By regulating such processes, the circadian rhythm allows organisms to anticipate and adapt to continuously changing environmental conditions. A growing body of evidence shows that disruptions to the circadian rhythm can lead to various disorders, including cancer. Recently, crucial knowledge has arisen regarding the essential features that underlie the overt circadian rhythm and its influence on physiological outputs. This knowledge suggests that specific small molecules can be utilized to control the circadian rhythm. It has been discovered that these small molecules can regulate circadian-clock-related disorders such as metabolic, cardiovascular, inflammatory, as well as cancer. This review examines the potential use of small molecules for developing new drugs, with emphasis placed on recent progress that has been made regarding the identification of small-molecule clock modulators and their potential use in treating cancer.


2013 ◽  
Vol 04 (03) ◽  
pp. 292-297 ◽  
Author(s):  
Gaafar M Ishaq ◽  
Yusuf Saidu ◽  
Lawal S Bilbis ◽  
Suleiman A Muhammad ◽  
Nasir Jinjir ◽  
...  

ABSTRACT Background: Traumatic brain injury (TBI) is accompanied by substantial accumulation of biomarkers of oxidative stress and depletion of antioxidants reserve which initiate chain reactions that damage brain cells. The present study investigated the role of ascorbic acid and α-tocopherol on the severity and management of TBI in rats. Materials and Methods: Wistar rats were subjected to closed head injury using an accelerated impact device. Rats were administered 45 mg/kg and 60 mg/kg body weight of ascorbic acid, α-tocopherol or a combination of the two vitamins for 2 weeks pre- and post injury. Blood and brain tissue homogenates were analyzed for vitamin C, vitamin E, malondialdehyde, superoxide dismutase, and creatine kinase activities. Results: The results indicated that TBI caused significant (P < 0.05) decreased in vitamins C and E levels in the blood and brain tissue of TBI-untreated rats. The activities of superoxide dismutase in TBI rats were markedly reduced when compared with non traumatized control and showed a tendency to increased following supplementation with vitamins C and E. Supplementation of the vitamins significantly (P < 0.05) reduced malondialdehyde in the treatment groups compared with the TBI-untreated group. Conclusion: The study indicated that pre and post treatment with ascorbic acid and α-tocopherol reduced oxidative stress induced by brain injury and effectively reduced mortality rate in rats.


2011 ◽  
Vol 68 (6) ◽  
pp. 1257-1269 ◽  
Author(s):  
Eider Andonegi ◽  
Jose Antonio Fernandes ◽  
Iñaki Quincoces ◽  
Xabier Irigoien ◽  
Andrés Uriarte ◽  
...  

Abstract Andonegi, E., Fernandes, J. A., Quincoces, I., Irigoien, X., Uriarte, A., Pérez, A., Howell, D., and Stefánsson, G. 2011. The potential use of a Gadget model to predict stock responses to climate change in combination with Bayesian networks: the case of Bay of Biscay anchovy. – ICES Journal of Marine Science, 68: 1257–1269. The European anchovy (Engraulis encrasicolus) is a short-lived pelagic species distributed in Atlantic European waters, with the Bay of Biscay being one of the main centres of abundance. Because it is a short-lived species, the state of the stock is determined largely by incoming recruitment. Recruitment is highly variable and depends on a variety of factors, such as the size of the spawning stock and environmental conditions in the area. The use of a coupled model that could serve to predict the evolution of the anchovy stock in the short, medium, and long term under several fishing-pressure scenarios and given climate scenarios is demonstrated. This coupled model consists of a Gadget (Globally Applicable Disaggregated General Ecosystem Toolbox) model that was used to analyse the status of the Bay of Biscay anchovy population and to simulate future scenarios based on the estimated recruitment levels, combined with a probabilistic Bayesian network model for recruitment estimation based on machine-learning methods and using climatic indices as potential forecasting factors. The results indicate that certain combinations of medium to high fishing pressure and adverse environmental conditions could force the stock outside its biological reference boundaries.


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