Evaluation of maxillary first molar rotation during direct miniscrew-supported maxillary canine retraction: a before-and-after study

Abstract Background Extraction of the first premolar followed by canine retraction into the extraction space is a common treatment in orthodontics. Molar rotation occurs when they are used as anchorage units for the canine distalization. The aim of this single-arm clinical trial was to evaluate the maxillary first molar rotation during maxillary canine retraction with elastic power chains and direct miniscrew anchorage. Results The mean difference between pre-retraction and post-retraction molar rotation was 1.89° ± 0.6 which was statistically insignificant. Conclusion The use of miniscrews for direct anchorage can eliminate unwanted rotation of the maxillary first molars during canine retraction. Trial registration ClinicalTrials.gov, NCT04887974. Registered on May 6, 2021- Retrospectively registered https://clinicaltrials.gov/ct2/show/NCT04887974?id=NCT04887974&draw=2&rank=1.

Download Full-text

Impact of a theory-informed and user-centered stroke information campaign on the public’s behaviors, attitudes, and knowledge when facing acute stroke: a controlled before-and-after study

BMC Public Health ◽

10.1186/s12889-020-09795-y ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Julie Haesebaert ◽

Caroline Laude ◽

Anne Termoz ◽

Estelle Bravant ◽

Nathalie Perreton ◽

...

Keyword(s):

Public Awareness ◽

Warning Signs ◽

Trial Registration ◽

Information Campaign ◽

Link Type ◽

Significant Difference ◽

Before And After ◽

Attitudes And Knowledge ◽

Before And After Study ◽

User Centered

Abstract Background Public awareness of stroke symptoms is a key factor to ensure access to reperfusion strategies in due time. We designed and launched a regional theory-informed and user-centered information campaign and assessed its impact on emergency medical services (EMS) calls for stroke suspicion, time-to-call, and public attitudes and awareness concerning stroke. Methods A controlled before-and-after study was conducted during 3 sequential time-periods in 2 separate counties. Key messages of the campaign were underpinned by stroke representations and the theory of planned behavior, and focused on recognition of stroke warning signs and the need to call EMS urgently. The campaign included posters, leaflets, adverts and films displayed in bus and subway stations, internet, social networks, and local radio. Outcome measures on behavior, attitudes, and knowledge were assessed before the launch of the campaign, at 3 months, and 12 months. Results The number of EMS calls for stroke suspicion increased by 21% at 12 months in the intervention county and this change was significantly different to that observed in the control county (p = 0.02). No significant changes were observed regarding self-reported attitudes in case of stroke. An 8% significant increase in recognizing at least 2 stroke warning signs was observed in the intervention county (p = 0.04) at 3 months, while it did not change significantly in the control county (p = 0.6). However, there was no significant difference in warning sign recognition between both counties (p = 0.16). Conclusion The campaign significantly improved public’s behavior of calling EMS, although stroke knowledge was not improved as much as expected. Repeating these campaigns over time might further help improve timeliness and access to reperfusion strategies. Trial registration Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT02846363.

Download Full-text

Effectiveness of Laceback Ligatures on Maxillary Canine Retraction

The Angle Orthodontist ◽

10.2319/100605-351 ◽

2006 ◽

Vol 76 (6) ◽

pp. 1010-1014 ◽

Cited By ~ 13

Author(s):

Melih Y. Sueri ◽

Tamer Turk

Keyword(s):

Orthodontic Treatment ◽

Contralateral Side ◽

Wilcoxon Test ◽

Maxillary Canine ◽

Mean Values ◽

Canine Retraction ◽

Skeletal Changes ◽

The Mean ◽

Mean Differences ◽

Canine Distalization

Abstract Objective: To evaluate the effects of laceback ligatures on canine distalization during the leveling and aligning stage and to compare the effectiveness of laceback ligatures with that of superelastic NiTi closed coil springs. Materials and Methods: Fifteen subjects were included in this study. Fixed orthodontic treatment was planned with the extraction of first premolars to solve crowding in upper and/or lower arches. Stainless steel direct-bonding Roth brackets (0.022-inch) were used. For canine distalization superelastic NiTi closed coil springs generating 150 g of force were used on one side. Lacebacks made from 0.010-inch ligature wire were applied on the contralateral side. Dental and skeletal changes were evaluated from predistalization and postdistalization lateral cephalometric and submento vertical radiographs. A Wilcoxon test was applied to determine the differences between predistalization and postdistalization mean values and to determine the mean differences between the groups. Results: Upper incisor crowns moved posteriorly. Distal movement and tipping of the canines were significant for both groups. Likewise, mesial movement and tipping of the first molars were significant for both groups. Furthermore, distopalatinal rotation of the canines was significant in the coil group. Canine and molar movements were greater for the coil group than for the laceback group, and the differences were significant. These differences may be attributed to force characterization, as well as to arch wire size and material. Conclusion: The laceback ligatures proved to be effective for canine distalization. Less canine and molar movement was found for the laceback group, but more controlled movements were obtained for the sagittal, vertical, and transverse planes.

Download Full-text

MEBO versus topical Diltiazem versus a combination of both ointments in the treatment of acute anal fissure: a randomized clinical trial protocol

BMC Complementary Medicine and Therapies ◽

10.1186/s12906-021-03227-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Mohamad Hadi El Charif ◽

Samer Doughan ◽

Rawya Kredly ◽

Sara Kassas ◽

Rayan Azab ◽

...

Keyword(s):

Clinical Trial ◽

Wound Healing ◽

Anal Fissure ◽

Topical Therapy ◽

Trial Registration ◽

Clinical Trial Registration ◽

Anal Fissures ◽

Link Type ◽

Anorectal Region ◽

Registration Date

Abstract Background Anal fissure is a common complication of the anorectal region and one of the most reported causes of anal pain. Acute anal fissure can be cured by surgery or medical treatment. There is an increase in the use of topical therapy for the treatment of anal fissures. A common topical drug used is Diltiazem (DTZ), a calcium-channel blocker, which relaxes the anal sphincter and thus promotes healing of the anal fissure. Moist exposed burn ointment (MEBO) is an ointment that is effective for the treatment of burns and wound healing and is becoming popular in the treatment of anal fissures. Methods This is a 1:1:1 randomized, controlled, parallel design, with endpoint measures of change in pain score, wound healing, defecation strain score and patient’s global impression of improvement. The study will be conducted at AUBMC over a 10-week period. Patients will be randomized to three treatment arms: MEBO, Diltiazem, and a combination of MEBO and Diltiazem ointments. Discussion The results of this study will allow physicians to assess the efficacy and safety of MEBO in the treatment of acute anal fissure, and also in comparison to Diltiazem. This trial will generate evidence-based conclusions regarding the use of a herbal/natural-based product (MEBO ointment) for the treatment of anal fissures. Trial registration ClinicalTrials.gov Identifier NCT04153032. Clinical Trial Registration Date: 06-NOVEMBER-2019.

Download Full-text

Effects of mechanical vibrations on maxillary canine retraction and perceived pain: a pilot, single-center, randomized-controlled clinical trial

Odontology ◽

10.1007/s10266-019-00480-0 ◽

2020 ◽

Vol 108 (2) ◽

pp. 321-330 ◽

Cited By ~ 6

Author(s):

Khaled Taha ◽

R. Scott Conley ◽

Praveen Arany ◽

Stephen Warunek ◽

Thikriat Al-Jewair

Keyword(s):

Clinical Trial ◽

Controlled Clinical Trial ◽

Randomized Controlled Clinical Trial ◽

Single Center ◽

Mechanical Vibrations ◽

Maxillary Canine ◽

Canine Retraction ◽

Randomized Controlled ◽

Perceived Pain

Download Full-text

A timed activity protocol to address sleep-wake disorders in home dwelling persons living with dementia: the healthy patterns clinical trial

BMC Geriatrics ◽

10.1186/s12877-021-02397-2 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Nancy A. Hodgson ◽

Nalaka Gooneratne ◽

Adriana Perez ◽

Sonia Talwar ◽

Liming Huang

Keyword(s):

Quality Of Life ◽

Clinical Trial ◽

Trial Registration ◽

Phase Iii ◽

Poor Sleep ◽

Sleep Wake Disorders ◽

Clinical Trial Registration ◽

Link Type ◽

Home Based

Abstract Background Sleep-wake disorders occur in most persons living with dementia and include late afternoon or evening agitation, irregular sleep-wake rhythms such as daytime hypersomnia, frequent night awakenings, and poor sleep efficiency. Sleep-wake disorders pose a great burden to family caregivers, and are the principal causes of distress, poor quality of life, and institutionalization. Regulating the sleep-wake cycle through the use of light and activity has been shown to alter core clock processes and suggests that a combination of cognitive, physical, and sensory-based activities, delivered at strategic times, may be an effective mechanism through which to reduce sleep-wake disorders. Methods A definitive Phase III efficacy trial of the Healthy Patterns intervention, a home-based activity intervention designed to improve sleep-wake disorders and quality of life, is being conducted using a randomized two-group parallel design of 200 people living with dementia and their caregivers (dyads). Specific components of this one-month, home-based intervention involve 4 in-home visits and includes: 1) assessing individuals’ functional status and interests; 2) educating caregivers on environmental cues to promote activity and sleep; and 3) training caregivers in using timed morning, afternoon, and evening activities based on circadian needs across the day. The patient focused outcomes of interest are quality of life, measures of sleep assessed by objective and subjective indicators including actigraphy, subjective sleep quality, and the presence of neuropsychiatric symptoms. Caregiver outcomes of interest are quality of life, burden, confidence using activities, and sleep disruption. Salivary measures of cortisol and melatonin are collected to assess potential intervention mechanisms. Discussion The results from the ongoing study will provide fundamental new knowledge regarding the effects of timing activity participation based on diurnal needs and the mechanisms underlying timed interventions which can lead to a structured, replicable treatment protocol for use with this growing population of persons living with dementia. Clinical trial registration Clinicaltrials.gov # NCT03682185 at https://clinicaltrials.gov/; Date of clinical trial registration: 24 September 2018.

Download Full-text

Comparing the Efficacy of Topical Metformin and Placebo in the Treatment of Melasma: A Randomized, Double-blind, Clinical Trial

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2019/v30i430276 ◽

2019 ◽

pp. 1-8

Author(s):

Mohammad Ali Mapar ◽

Ali Asghar Hemmati ◽

Ghazal Namdari

Keyword(s):

Clinical Trial ◽

Placebo Group ◽

Double Blind ◽

Laboratory Findings ◽

Double Blind Clinical Trial ◽

Metformin Group ◽

Significant Difference ◽

Before And After ◽

P 16 ◽

The Mean

Introduction: Generally affecting women, melasma is the acquired disorder of hyperpigmentation, and researches are still ongoing to find an effective, fast, and low-side-effect drug treating this disease. The present study is aimed at comparing the efficacy of topical metformin and placebo in the treatment of melasma. Methods: Sixty patients with melasma were treated in placebo and topical metformin recipient groups in a double-blind clinical trial. In addition to the demographic and laboratory findings of patients before and after the intervention, the MASI Score of patients in weeks 0, 4, 8, and 12 of the study and then one month after the study were analyzed using SPSS version 20 software. Results: The mean age of the studied patients was 35.25 ± 7.11 years. No significant difference was observed between the phenotypes (P= .49) and the type of melasma (P= .63) in the two groups. The mean MASI score of patients at the time of being included in the study in the placebo group was 10.47 ± 3.08; and in the metformin group, it was 11.93 ± 4.64 (P = .16). Compared to the beginning of the study, the MASI scores were significantly decreased in both groups of placebo (P = .00) and metformin (P = .00) one month after the end of the study; nevertheless, no statistically significant difference was observed between the MASI Scores of two groups in any of the study periods (P > .05). Conclusion: The results of the present study showed that metformin cream significantly declines the patients’ MASI score and does not have any effect on patients’ laboratory markers. Of course, no significant difference was observed between the MASI scores of the patients receiving metformin and the placebo group; however, the MASI score decrease trend continued until the 12th week; while in the placebo group, no significant decrease was seen after eight weeks.

Download Full-text

N-Acetylcystein has Potential Effect to Reduce Haematological Abnormalities in HIV/AIDS Patients Undergoing ARV Treatment

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v10i4-s.4319 ◽

2020 ◽

Vol 10 (4-s) ◽

pp. 197-200

Author(s):

Filia Yuniza ◽

Eddy Mart Salim ◽

Nova Kurniati ◽

Harun Hudari ◽

Erial Bahar ◽

...

Keyword(s):

Clinical Trial ◽

Placebo Group ◽

Potential Effect ◽

Aids Patients ◽

Exclusion Criteria ◽

Double Blind ◽

Before And After ◽

The Mean ◽

Hematological Abnormalities ◽

Hiv Aids

Aims: to determine the effect of NAC administration on hematological abnormalities in HIV/AIDS patients who are undergoing ARV treatment. Method: This was a pilot study using a double blind randomized clinical trial. A total of 32 subjects who met the inclusion and exclusion criteria were divided into 2 groups, namely placebo and NAC. Subjects in the NAC group were given NAC at a dose of 3x200 mg/day, while the placebo group was given lactose at a dose of 3x200 mg/day. Each group was given treatment for 12 weeks. Before and after treatment, subjects were examined for hematologic parameters. Results: Most of subjects had normal hematological features. NAC administration did not have a significant effect on the mean levels of Hb, Ht, number of erythrocytes, leukocytes and platelets (p> 0.05). However, NAC administration can reduce the degree of anemia and improve the condition of thrombocytopenia, leukopenia and lymphopenia. Conclusion: NAC administration can reduce hematological abnormalities HIV/AIDS patients undergoing ARV treatment. Keywords: ARV, Hematological abnormalities, HIV/AIDS, NAC.

Download Full-text

Limited effects of long-term daily cranberry consumption on the gut microbiome in a placebo-controlled study of women with recurrent urinary tract infections

BMC Microbiology ◽

10.1186/s12866-021-02106-4 ◽

2021 ◽

Vol 21 (1) ◽

Cited By ~ 1

Author(s):

Timothy J. Straub ◽

Wen-Chi Chou ◽

Abigail L. Manson ◽

Henry L. Schreiber ◽

Bruce J. Walker ◽

...

Keyword(s):

Clinical Trial ◽

Urinary Tract ◽

Urinary Tract Infections ◽

The United States ◽

Trial Registration ◽

Controlled Study ◽

Metagenomic Sequencing ◽

Recurrent Uti ◽

Link Type ◽

Tract Infections

Abstract Background Urinary tract infections (UTIs) affect 15 million women each year in the United States, with > 20% experiencing frequent recurrent UTIs. A recent placebo-controlled clinical trial found a 39% reduction in UTI symptoms among recurrent UTI sufferers who consumed a daily cranberry beverage for 24 weeks. Using metagenomic sequencing of stool from a subset of these trial participants, we assessed the impact of cranberry consumption on the gut microbiota, a reservoir for UTI-causing pathogens such as Escherichia coli, which causes > 80% of UTIs. Results The overall taxonomic composition, community diversity, carriage of functional pathways and gene families, and relative abundances of the vast majority of observed bacterial taxa, including E. coli, were not changed significantly by cranberry consumption. However, one unnamed Flavonifractor species (OTU41), which represented ≤1% of the overall metagenome, was significantly less abundant in cranberry consumers compared to placebo at trial completion. Given Flavonifractor’s association with negative human health effects, we sought to determine OTU41 characteristic genes that may explain its differential abundance and/or relationship to key host functions. Using comparative genomic and metagenomic techniques, we identified genes in OTU41 related to transport and metabolism of various compounds, including tryptophan and cobalamin, which have been shown to play roles in host-microbe interactions. Conclusion While our results indicated that cranberry juice consumption had little impact on global measures of the microbiome, we found one unnamed Flavonifractor species differed significantly between study arms. This suggests further studies are needed to assess the role of cranberry consumption and Flavonifractor in health and wellbeing in the context of recurrent UTI. Trial registration Clinical trial registration number: ClinicalTrials.govNCT01776021.

Download Full-text

Analisis Kadar Kreatinin Serum Sebelum dan Setelah Terapi Tenovofir pada Penyandang HIV di RS Dr. M. Djamil Padang Periode 2012-2013

Jurnal Kesehatan Andalas ◽

10.25077/jka.v3i2.93 ◽

2014 ◽

Vol 3 (2) ◽

Author(s):

Regina Ivanovna ◽

Efrida Efrida ◽

Roza Kurniati

Keyword(s):

Serum Creatinine ◽

Serum Creatinine Level ◽

Creatinine Level ◽

Mean Difference ◽

Tubular Dysfunction ◽

Research Subjects ◽

Hiv Patients ◽

Before And After ◽

The Mean ◽

Related Mortality

AbstrakPenyakit ginjal merupakan penyebab kematian nonAIDS paling tinggi pada penyandang HIV. Penggunaan regimen anti- retroviral diselidiki memiliki kontribusi terhadap kejadian penyakit ginjal. Disfungsi tubulus ditemukan pada penyandang HIV dengan terapi tenofovir. Pemeriksaan kreatinin digunakan untuk skrining kerusakan ginjal. Tujuan penelitian ini adalah untuk mengetahui perbedaan kadar kreatinin sebelum dan setelah terapi tenofovir. Telah dilakukan penelitian secara kohort retrospektif terhadap penyandang HIV dengan terapi tenofovir di RS dr. M. Djamil Padang periode 2012-2013. Dilakukan pemeriksaan kreatinin serum sebelum dan setelah terapi tenofovir dengan metode Jaffe. Data kadar kreatinin serum didapatkan melalui rekam medik. Hasil perbedaan rata-rata kadar kreatinin serum sebelum dan setelah terapi tenofovir dianalisis menggunakan uji T berpasangan. Sebanyak 18 subyek penelitian dipilih dari jumlah total 652 penyandang HIV rawat inap dan rawat jalan. Sebanyak 196 penyandang HIV memakai terapi tenofovir (30%). Rentang lama pemberian terapi tenofovir adalah 2-57 minggu. Pada hasil penelitian, didapatkan perbedaan rata-rata kadar kreatinin serum yang bermakna sebelum dan setelah terapi tenofovir sebesar 0,7± 0,2 mg/dLdan 0,9 ± 0,5 mg/dL (P<0,05). Dapat disimpulkan bahwa terdapat peningkatan kreatinin serum setelah terapi tenofovir pada penyandang HIV.Kata kunci: HIV, tenofovir, kreatinin serumAbstractKidney disease is the highest nonAIDS related mortality among HIV patients. The use of antiretroviral therapy is investigated to contribute in kidney disease. Tubular dysfunction is found in HIV patients with tenofovir therapy. Creatinine test is used to screen kidney dysfunction. The aim of this study was to determine the mean difference of serum creatinine level before and after tenofovir administration.A cohort retrospective research was carried out in DR..M. Djamil Hospital upon HIV patients with tenofovir within 2012-2013. Serum creatinine test was conducted before and after administration of tenofovir with automatic machine and Jaffe reaction. The result of mean difference of serum creatinine before and after administration of tenofovir is analised by paired T test.Eighteen research subjects is determined from total amount of in and out patient. A total of 196 patients were administered with tenofovir (30%). The range of tenofovir administration was between 2-57 weeks. From the research, obtained a significant mean difference before (0,7± 0,2 mg/dL) and after (0,9 ± 0,5 mg/dL) administration of tenofovir (P<0,05).The conclusion of this study is there is increasing of serum creatinine level before and after administration of tenofovir.Keywords: HIV, tenofovir, serum creatinine

Download Full-text