scholarly journals Cardiovascular system and coronavirus disease-2019 (COVID-19): mutual injuries and unexpected outcomes

2021 ◽  
Vol 73 (1) ◽  
Author(s):  
Eman Sobh ◽  
Muhammad Saad Reihan ◽  
Tamer M. S. Hifnawy ◽  
Khloud Gamal Abdelsalam ◽  
Sohaila Sabry Awad ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Poor Prognosis ◽  
Clinical Decision ◽  
Cardiovascular Complications ◽  
Main Body ◽  
Negative Consequences ◽  
Coronary Syndrome ◽  
System A ◽  
High Index Of Suspicion ◽  
Unexpected Outcomes

Abstract Background Cardiovascular system involvement in coronavirus disease-2019 (COVID-19) has gained great interest in the scientific community. Main body Several studies reported increased morbidity and mortality among COVID-19 patients who had comorbidities, especially cardiovascular diseases like hypertension and acute coronary syndrome (ACS). COVID-19 may be associated with cardiovascular complications as arrhythmia, myocarditis, and thromboembolic events. We aimed to illustrate the interactions of COVID-19 disease and the cardiovascular system and the consequences on clinical decision as well as public health. Conclusions COVID-19 has negative consequences on the cardiovascular system. A high index of suspicion should be present to avoid poor prognosis of those presenting with unusual presentation.

scholarly journals Exercise Training and Cardiac Rehabilitation in COVID-19 Patients with Cardiovascular Complications: State of Art

Life ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 259
Author(s):  
Mariaconsiglia Calabrese ◽  
Marina Garofano ◽  
Roberta Palumbo ◽  
Paola Di Pietro ◽  
Carmine Izzo ◽  
...  
Keyword(s):  
Exercise Training ◽  
Cardiac Rehabilitation ◽  
Cardiovascular System ◽  
Patient Monitoring ◽  
Scientific Evidence ◽  
Cardiovascular Complications ◽  
Angiotensin Converting Enzyme 2 ◽  
Coronary Syndrome ◽  
Cardiovascular Damage ◽  
Include Heart Failure

Recent scientific literature has investigated the cardiovascular implications of COVID-19. The mechanisms of cardiovascular damage seem to involve the protein angiotensin-converting enzyme 2 (ACE2), to which severe acute respiratory syndrome (SARS) coronavirus-2 (CoV-2) binds to penetrate cells and other mechanisms, most of which are still under study. Cardiovascular sequelae of COVID-19 include heart failure, cardiomyopathy, acute coronary syndrome, arrhythmias, and venous thromboembolism. This article aims to collect scientific evidence by exploiting PubMed, Scopus, and Pedro databases to highlight the cardiovascular complications of COVID-19 and to define the physiotherapy treatment recommended for these patients. Exercise training (ET), an important part of cardiac rehabilitation, is a powerful tool in physiotherapy, capable of inducing significant changes in the cardiovascular system and functional in the recovery of endothelial dysfunction and for the containment of thromboembolic complications. In conclusion, due to the wide variety of possible exercise programs that can be obtained by combining intensity, duration, and speed in various ways, and by adjusting the program based on continuous patient monitoring, exercise training is well suited to the treatment of post-COVID patients with an impaired cardiovascular system of various degrees.

scholarly journals Cardiovascular System and SARS-CoV-2: Etiology, Physiopathology and Clinical Presentation: A Systematic Review

2021 ◽  
Author(s):  
Jucier Gonçalves Júnior ◽  
Estelita Lima Cândido ◽  
Gislene Farias de Oliveira ◽  
Modesto Leite Rolim Neto
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Cardiovascular System ◽  
Clinical Presentation ◽  
Meta Analysis ◽  
Cardiovascular Complications ◽  
Review Of The Literature ◽  
Governmental Organizations ◽  
System A ◽  
The Impact

During SARS-CoV-1 and Middle East Respiratory Distress Syndrome (MERS) outbreaks it was observed a particularly elevated incidence of cardiovascular disease among patients. With COVID-19, this correlation becomes evident again. However, the cardiovascular impacts by COVID-19 pandemic are not yet well established although publications about its potential deleterious effects are constant. Thus, aimed to carry a systematic review of the literature with meta-analysis, the following question was used as a guide: what practical contributions does the scientific literature produced in the period of 2019-2020 has to offer about the impact of the COVID-19 on cardiovascular system? A systematic review of the literature using the Virtual Health Library (VHL) and PubMed with the following descriptors: #1 “cardiovascular disease” [MeSH] AND #2 “COVID-19” [keyword], as well as their equivalents in the Portuguese and Spanish language, during the period from December 2019 to March 2020 was performed. One hundred articles were found in Pubmed and twenty-seven were selected. In VHL there are 59 articles and four were selected totaling thirty-one papers. The findings were then divided into three subcategories: Etiology, Physiopathology and Risk factors of SARS-CoV-2 in Cardiovascular System; Clinical presentation, laboratory markers and imagenological aspects of SARS-CoV-2 in cardiovascular system; and Anti-Hypertensive Drugs, Cardiovascular System and SARS-CoV-2. When it comes to the cardiovascular system, these issues are aggravated and urge as a joint commitment from researchers, medical and governmental organizations to carry out more robust studies with bold methodologies aimed at mapping prognostic factors and assertive therapeutic approaches in the management of cardiovascular complications of COVID- 19.

scholarly journals Post COVID-19 Conditions and the Cardiovascular System

2021 ◽  
Author(s):  
Iana Simova ◽  
Denislava Hristova ◽  
Hristina Tzanovska ◽  
Denis Nikolov ◽  
Diliana Iakova ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Personal Experience ◽  
Signs And Symptoms ◽  
Limb Ischemia ◽  
Cardiovascular Complications ◽  
Medical Attention ◽  
Acute Limb Ischemia ◽  
Coronary Syndrome ◽  
Campaign Life ◽  
Rhythm Disorder

One out of four patients affected by COVID-19 will experience persistent (>3-4 weeks) signs and symptoms (Post COVID-19 conditions or Post-Acute Sequelae of SARS-CoV-2 – PASC) and this fact will have a major significance for the healthcare and economic systems in the upcoming years. The cardiovascular system is one of the key targets for the Post COVID-19 syndrome, given the pathogenesis of the virus and prevalence of ACE-2 receptors. According to our initial personal experience via the campaign “Life after COVID” of the Bulgarian Cardiac Institute, a substantial proportion of patients having suffered from COVID-19 develop long-term cardiovascular consequences. They could range from rhythm disorder and blood pressure variation, through impairment of myocardial mechanics and heart failure, and to acute vascular manifestations of Post COVID-19 conditions, such as acute coronary syndrome, acute pulmonary embolism, and acute limb ischemia. These cardiovascular complications require special and dedicated medical attention, and we could share our personal experience on the matter.

scholarly journals Stabilizing interventional instruments in the cardiovascular system: A classification of mechanisms

2021 ◽  
Vol 89 ◽  
pp. 22-32
Author(s):  
Awaz Ali ◽  
Dimitra Dodou ◽  
Gerwin Smit ◽  
Ruben Rink ◽  
Paul Breedveld
Keyword(s):  
Cardiovascular System ◽  
System A

scholarly journals Ovarian tissue freezing and activation after thawing: an update

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Li-fan Peng
Keyword(s):  
Granulosa Cells ◽  
Clinical Decision Making ◽  
Ovarian Function ◽  
Ovarian Tissue ◽  
Clinical Decision ◽  
The Body ◽  
Endocrine Function ◽  
Ovarian Tissue Cryopreservation ◽  
Main Body ◽  
Tissue Cryopreservation

Abstract Background With the growth of women’s age, ovarian failure can be caused by various factors. For the women who need chemotherapy because of cancer factors, the preservation of fertility is more urgent. The treatment of cancer is also a process in which all tissues and organs of the body are severely damaged, especially in the reproductive system. Main body As a new fertility preservation technology, autologous ovarian tissue cryopreservation and transplantation is developing rapidly and showing great potentiality in preserving ovarian endocrine function of young cervical cancer patients. Vitrification and slow freezing are two common techniques applied for ovarian tissue cryopreservation. Thus, cryopreserved/thawed ovarian tissue and transplantation act as an important method to preserve ovarian function during radiotherapy and chemotherapy, and ovarian cryopreservation by vitrification is a very effective and extensively used method to cryopreserve ovaries. The morphology of oocytes and granulosa cells and the structure of organelles were observed under the microscope of histology; the hormone content in the stratified culture medium of granulosa cells with the diameter of follicle was used to evaluate the development potential of ovarian tissue, and finally the ovarian tissue stimulation was determined by the technique of ovarian tissue transplantation. Conclusions Although there are some limitations, the team members still carry out this review to provide some references and suggestions for clinical decision-making and further clinical research.

scholarly journals Management of constipation in patients with schizophrenia—a case study and review of literature

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Ashish Sarangi ◽  
Sabiha Armin ◽  
Aurelio Vargas ◽  
Victoria M. Chu ◽  
Kristen Fain ◽  
...  
Keyword(s):  
Side Effect ◽  
Negative Symptoms ◽  
Early Recognition ◽  
Cardiovascular Complications ◽  
Cochrane Library ◽  
Main Body ◽  
Complication Rates ◽  
Anticholinergic Effects ◽  
Routine Surveillance ◽  
Delayed Recognition

Abstract Background Schizophrenia is a disorder that affects about 1% of the US population, with an extensive impact on patients’ health and their risk of later developing comorbidities from treatment. While literature on the side effect profile of antipsychotics is abundant, there are few studies on identification of anticholinergic effects on gut motility and prophylaxis development. The aim of this review is to consider antipsychotic-associated constipation in patients with schizophrenia and to discuss management of antipsychotic-induced constipation as documented in the literature. Main body We present a case of antipsychotic-induced constipation and conducted a literature review assessing the prevalence of this issue in this population. The search was done on Embase, MEDLINE, Cochrane Library, and PubMed databases. Key word searches included constipation with concurrent antipsychotic use, antipsychotics and anticholinergic effects, factors causing constipation in schizophrenia, social disparities involved with constipation, and colorectal cancer screenings. Main findings included high complication rates that may be explained by clozapine-specific side effects, negative health habits, disease, and treatment-related metabolic disorders. Co-existing negative symptoms could also be associated with health outcomes and was found to have adverse consequences on schizophrenia progression. Comorbidities of diabetes and cardiovascular complications contributed to gut hypomotility. Caregiver burden was a factor in delayed recognition of constipation as a side effect. Routine surveillance for symptoms and optimization of medications facilitates early recognition of constipation. Conclusion Overall, there is insufficient trial-based evidence to compare the effectiveness and safety of common pharmacological interventions for constipation, such as lactulose, polyethylene glycol, stool softeners, and lubricant laxatives.

scholarly journals Chest pain in general practice: a systematic review of prediction rules

BMJ Open ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. e027081 ◽  
Author(s):  
Ralf E Harskamp ◽  
Simone C Laeven ◽  
Jelle CL Himmelreich ◽  
Wim A M Lucassen ◽  
Henk C P M van Weert
Keyword(s):  
Systematic Review ◽  
General Practice ◽  
Chest Pain ◽  
Coronary Disease ◽  
Clinical Decision ◽  
Clinical Judgement ◽  
Predictive Values ◽  
Heart Score ◽  
Coronary Syndrome ◽  
Rule Out

ObjectiveTo identify and assess the performance of clinical decision rules (CDR) for chest pain in general practice.DesignSystematic review of diagnostic studies.Data sourcesMedline/Pubmed, Embase/Ovid, CINAHL/EBSCO and Google Scholar up to October 2018.Study selectionStudies that assessed CDRs for intermittent-type chest pain and for rule out of acute coronary syndrome (ACS) applicable in general practice, thus not relying on advanced laboratory, computer or diagnostic testing.Review methodsReviewers identified studies, extracted data and assessed the quality of the evidence (using Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2)), independently and in duplicate.ResultsEight studies comprising five CDRs met the inclusion criteria. Three CDRs are designed for rule out of coronary disease in intermittent-type chest pain (Gencer rule, Marburg Heart Score, INTERCHEST), and two for rule out of ACS (Grijseels rule, Bruins Slot rule). Studies that examined the Marburg Heart Score had the highest methodological quality with consistent sensitivity (86%–91%), specificity (61%–81%) and positive (23%–35%) and negative (97%–98%) predictive values (PPV and NPV). The diagnostic performance of Gencer (PPV: 20%–34%, NPV: 95%–99%) and INTERCHEST (PPV: 35%–43%, NPV: 96%–98%) appear comparable, but requires further validation. The Marburg Heart Score was more sensitive in detecting coronary disease than the clinical judgement of the general practitioner. The performance of CDRs that focused on rule out of ACS were: Grijseels rule (sensitivity: 91%, specificity: 37%, PPV: 57%, NPV: 82%) and Bruins Slot (sensitivity: 97%, specificity: 10%, PPV: 23%, NPV: 92%). Compared with clinical judgement, the Bruins Slot rule appeared to be safer than clinical judgement alone, but the study was limited in sample size.ConclusionsIn general practice, there is currently no clinical decision aid that can safely rule out ACS. For intermittent chest pain, several rules exist, of which the Marburg Heart Score has been most extensively tested and appears to outperform clinical judgement alone.

OPTIMIZATION OF THE INVASIVE STRATEGY FOR ACUTE CORONARY SYNDROME IN PATIENTS OF THE OLDER AGE GROUP

2020 ◽  
pp. 87-91
Author(s):  
А. С. Петров ◽  
В. В. Яковлев ◽  
К. Л. Козлов ◽  
В. А. Яковлев ◽  
А. В. Барсуков ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Unfractionated Heparin ◽  
Postoperative Period ◽  
Cardiovascular Complications ◽  
Older Age ◽  
Percutaneous Coronary Interventions ◽  
Age Group ◽  
Invasive Strategy ◽  
Coronary Syndrome ◽  
Percutaneous Coronary

Представлено исследование по изучению эффективности и безопасности различных антикоагулянтов, используемых у больных старшей возрастной группы с острым коронарным синдром при чрескожных коронарных вмешательствах. Показана высокая эффективность бивалирудина по сравнению с нефракционированным гепарином и Монафрамом в отношении числа кровотечений, возникающих в послеоперационном периоде, и неблагоприятных сердечно-сосудистых осложнений . A study is presented on the effectiveness and safety of various anticoagulants used in patients of an older age group with acute coronary syndrome during percutaneous coronary interventions. Bivalirudin was shown to be highly effective in comparison with unfractionated heparin and monafram in relation to the amount of bleeding that occurs in the postoperative period and adverse cardiovascular complications.

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