Systematic review of clinical evidence on postoperative delirium: literature search of original studies based on validated diagnostic scales

Abstract Background Postoperative delirium is a serious complication that can occur within the 5th postoperative day. In 2017, the European Society of Anesthesiologists delivered dedicated guidelines that reported the need for routine monitoring using validated scales. Objective Aim of this systematic review is to identify clinical studies related to postoperative delirium that included postoperative monitoring with validated scales. Design Systematic review Methods Searched keywords included the following terms: postoperative, postsurgical, post anesthesia, anesthesia recovery, delirium, and confusion. Two researchers independently screened retrieved studies using a data extraction form. Results Literature search led to retrieve 6475 hits; of these, 260 studies (5.6% of the retrieved), published between 1987 and 2021, included in their methods a diagnostic workup with the use of a postoperative delirium validated scale and monitored patients for more than 24 h, therefore are qualified to be included in the present systematic review. Conclusion In conclusion, available clinical literature on postoperative delirium relies on a limited number of studies, that included a validated diagnostic workup based on validated scales, extracted from a large series of studies that used inconsistent diagnostic criteria. In order to extract indications based on reliable evidence-based criteria, these are the studies that should be selectively considered. The analysis of these studies can also serve to design future projects and to test clinical hypothesis with a more standardized methodological approach.

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Impact of surgery timing for craniosynostosis on neurodevelopmental outcomes: a systematic review

Journal of Neurosurgery Pediatrics ◽

10.3171/2018.10.peds18536 ◽

2019 ◽

Vol 23 (4) ◽

pp. 442-454 ◽

Cited By ~ 6

Author(s):

Rachel Mandela ◽

Maggie Bellew ◽

Paul Chumas ◽

Hannah Nash

Keyword(s):

Systematic Review ◽

Beneficial Effect ◽

Data Extraction ◽

Sociodemographic Factors ◽

Future Research ◽

Neurodevelopmental Outcomes ◽

Age At Surgery ◽

Data Extraction Form ◽

Surgery Timing ◽

Anesthetic Exposure

OBJECTIVEThere are currently no guidelines for the optimum age for surgical treatment of craniosynostosis. This systematic review summarizes and assesses evidence on whether there is an optimal age for surgery in terms of neurodevelopmental outcomes.METHODSThe databases MEDLINE, PsycINFO, CINAHL, Embase + Embase Classic, and Web of Science were searched between October and November 2016 and searches were repeated in July 2017. According to PICO (participants, intervention, comparison, outcome) criteria, studies were included that focused on: children diagnosed with nonsyndromic craniosynostosis, aged ≤ 5 years at time of surgery; corrective surgery for nonsyndromic craniosynostosis; comparison of age-at-surgery groups; and tests of cognitive and neurodevelopmental postoperative outcomes. Studies that did not compare age-at-surgery groups (e.g., those employing a correlational design alone) were excluded. Data were double-extracted by 2 authors using a modified version of the Cochrane data extraction form.RESULTSTen studies met the specified criteria; 5 found a beneficial effect of earlier surgery, and 5 did not. No study found a beneficial effect of later surgery. No study collected data on length of anesthetic exposure and only 1 study collected data on sociodemographic factors.CONCLUSIONSIt was difficult to draw firm conclusions from the results due to multiple confounding factors. There is some inconclusive evidence that earlier surgery is beneficial for patients with sagittal synostosis. The picture is even more mixed for other subtypes. There is no evidence that later surgery is beneficial. The authors recommend that future research use agreed-upon parameters for: age-at-surgery cut-offs, follow-up times, and outcome measures.

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Private Rooms in Low Acuity Settings: A Systematic Review of the Literature

HERD Health Environments Research & Design Journal ◽

10.1177/1937586717702597 ◽

2017 ◽

Vol 11 (1) ◽

pp. 57-74 ◽

Cited By ~ 4

Author(s):

Jeffrey Voigt ◽

Michael Mosier ◽

Rabih Darouiche

Keyword(s):

Systematic Review ◽

Data Extraction ◽

Quality Data ◽

Review Of The Literature ◽

Single Patient ◽

Patient Falls ◽

Assessment Development ◽

High Acuity ◽

Data Extraction Form ◽

Quality Evidence

Objectives: Determine if the peer-reviewed evidence supports single-patient ward bedrooms in low-acuity care settings within a hospital. Background: New evidence exists since the 2006 Facility Guideline Institute guideline recommended single-bedded rooms (SBRs) in low-acuity care settings. Additionally, prior studies evaluated high-acuity care settings (e.g., critical care) in their recommendations on SBRs. There is a need to reevaluate the evidence. Methods: A systematic review of the literature was completed including electronic and hand searches of references. A data extraction form was utilized. Two reviewers evaluated the studies independently. Studies that were included examined the effect of single-patient rooms on medical surgical ward beds only. Each study was graded using accepted clinical evidence grading instruments. Results: Over 1,400 records were identified. After excluding studies, a total of 49 records were graded. The highest quality evidence identified (Center for Evidence-Based Medicine [CEBM]: 2a, 2b, and Grading of Recommendations, Assessment, Development, and Evaluation [GRADE] C) did not support the use of single-patient rooms for reducing infections, for minimizing patient falls, for reducing medication errors, or for patient satisfaction. Operational efficiencies were improved with SBRs but only addressed the maternity ward. The lowest quality evidence (CEBM: 4/5 and GRADE D) supported the use of single-patient rooms. Conclusions: Based on CEBM and GRADE assessments, there is a lack of high-quality data supporting the use of low-acuity SBRs throughout the entire hospital. Furthermore, it is recommended that more research be conducted on the effect of SBRs, so higher quality evidence is developed.

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The effect of including the Nordic Hamstring exercise on sprint and jump performance in athletes: protocol of a systematic review and meta-analyses

10.1101/2020.04.01.20048686 ◽

2020 ◽

Author(s):

Kasper Krommes ◽

Mathias F. Nielsen ◽

Laura Krohn ◽

Birk M. Grønfeldt ◽

Kristian Thorborg ◽

...

Keyword(s):

Systematic Review ◽

High Speed ◽

Data Extraction ◽

Force Production ◽

List Type ◽

Jump Performance ◽

Production Studies ◽

Hamstring Strain ◽

Data Extraction Form ◽

Meta Analyses

AbstractThe Nordic Hamstring exercise reduces hamstring strain injuries in football and other sports, but the exercise is not well adopted in practice. Barriers from practitioners include fear of performance decrements, due to lack of specificity of the exercise with high speed running. However, in theory, increased eccentric hamstring strength could transfer to faster sprinting due to higher horizontal force production. Studies on the effect of the Nordic Hamstring exercise on performance have been conflicting and no synthesis of the evidence exists. We therefore pose the following question: does including the Nordic Hamstring exercise hamper sprint or jump performance in athletes? We will answer this question by performing a systematic review of the literature, critically appraise relevant studies, and GRADE the evidence across key outcomes and perform meta-analyses, meta-regression and subgroup analyses. In this protocol we outline the planned methods and procedures.Progress reportBesides this protocol, our data extraction form and the process of data extraction has been piloted on 3 relevant studies, along with familiarization with the Risk of Bias 2.0 tool. We have also comprised a preliminary search strategy for PubMed.Supplementary filesData Extraction Form (.pdf)Populated PRISMA-P checklist (.pdf)

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Cancer services during the COVID-19 pandemic: systematic review of patients' and caregivers' experiences

10.1101/2021.03.19.21253949 ◽

2021 ◽

Author(s):

Symran Dhada ◽

Derek Stewart ◽

Ejaz Cheema ◽

Muhammed Abdul Hadi ◽

Vibhu Paudyal

Keyword(s):

Systematic Review ◽

Cancer Screening ◽

Cancer Patients ◽

English Language ◽

Resource Constraints ◽

Data Extraction ◽

Psychological Wellbeing ◽

Cancer Services ◽

Data Extraction Form ◽

The Impact

Background Cancer patients have faced intersecting crises in the face of COVID-19 pandemic. This review aimed to examine patients' and caregivers' experiences of accessing cancer services during the COVID-19 pandemic and perceived impact of the pandemic on their psychological wellbeing. Methods A protocol-led (CRD42020214906) systematic review was conducted by searching six databases including EMBASE, MEDLINE and CINAHL for articles published in English-language between 1/2020-12/2020. Data were extracted using a pilot-tested, structured data extraction form. Thematic synthesis of data was undertaken and reported as per the PRISMA guideline. Results A total of 1110 articles were screened of which 19 studies met the inclusion criteria. Studies originated from 10 different countries including the US, UK, India and China. Several themes were identified which were categorised into seven categories. Postponement and delays in cancer screening and treatment, drug shortages and inadequate nursing care were commonly experienced by patients. Hospital closures, resource constraints, national lockdowns and patient reluctance to use health services because of infection worries contributed to the delay. Financial and social distress, isolation; and spiritual distress due to the uncertainty of rites as well as fulfilment of last wishes were also commonly reported. Caregivers felt anxious about infecting cancer patients with COVID-19. Conclusions Patients and caregivers experienced extensive impact of COVID-19 on cancer screening, treatment and care, and their own psychological wellbeing. Patient and caregiver views and preferences should be incorporated in ensuring resilient cancer services that can minimise the impact of ongoing and future pandemic on cancer care and mitigate patient fears.

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Cancer Services During the COVID-19 Pandemic: Systematic Review of Patients’ and Caregivers’ Experiences

10.21203/rs.3.rs-294240/v1 ◽

2021 ◽

Author(s):

Symran Dhada ◽

Derek Stewart ◽

Ejaz Cheema ◽

Muhammed Abdul Hadi ◽

Vibhu Paudyal

Keyword(s):

Systematic Review ◽

Cancer Screening ◽

Cancer Patients ◽

English Language ◽

Resource Constraints ◽

Data Extraction ◽

Psychological Wellbeing ◽

Cancer Services ◽

Data Extraction Form ◽

The Impact

Abstract Background Cancer patients have faced intersecting crises in the face of COVID-19 pandemic. This review aimed to examine patients’ and caregivers’ experiences of accessing cancer services during the COVID-19 pandemic and perceived impact of the pandemic on their psychological wellbeing.Methods A protocol-led (CRD42020214906) systematic review was conducted by searching six databases including EMBASE, MEDLINE and CINAHL for articles published in English-language between 1/2020-12/2020. Data were extracted using a pilot-tested, structured data extraction form. Thematic synthesis of data was undertaken and reported as per the PRISMA guideline. Results A total of 1110 articles were screened of which 19 studies met the inclusion criteria. Studies originated from 10 different countries including the US, UK, India and China. Several themes were identified which were categorised into seven categories. Postponement and delays in cancer screening and treatment, drug shortages and inadequate nursing care were commonly experienced by patients. Hospital closures, resource constraints, national lockdowns and patient reluctance to use health services because of infection worries contributed to the delay. Financial and social distress, isolation; and spiritual distress due to the uncertainty of rites as well as fulfilment of last wishes were also commonly reported. Caregivers felt anxious about infecting cancer patients with COVID-19. Conclusions Patients and caregivers experienced extensive impact of COVID-19 on cancer screening, treatment and care, and their own psychological wellbeing. Patient and caregiver views and preferences should be incorporated in ensuring resilient cancer services that can minimise the impact of ongoing and future pandemic on cancer care and mitigate patient fears. Protocol Registration Published protocol registered with Centre for Review and Dissemination CRD42020214906 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=214906)

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Knowledge, attitudes and barriers pain management by nurses in Iran: A systematic review

Anaesthesia, Pain & Intensive Care ◽

10.35975/apic.v23i4.1168 ◽

2020 ◽

Author(s):

Ebrahim Khalighi ◽

Askar Soufinia ◽

Lale Solaimanizadeh ◽

Milad Borji ◽

Asma Tarjoman ◽

...

Keyword(s):

Systematic Review ◽

Pain Management ◽

Data Extraction ◽

Medical Personnel ◽

Educational Interventions ◽

Inclusion Criteria ◽

Negative Effects ◽

Knowledge Attitude And Practice ◽

Present Systematic Review ◽

Descriptive Method

Introduction: Pain is a phenomenon that may be experience d every human being. Pain is one of the symptoms of the disease that has negative effects on patients and causes challenges in medical personnel. The aim of the present systematic review was to determine the knowledge, attitude, and pain management status in Iranian nurses. Methodology: This is a systematic review carried out according to systematic review articles checklist (PRISMA). The search was conducted by two researchers separately. In case of inconsistency, the search was examined by a third researchers. In this study, articles that met the inclusion criteria and published between 2000 to June 2019, were included. The search process was carried out in Iranian and international databases. Data were reported in usinga descriptive method using Excel 2007 software. Result: According to result 180 articles were extracted in the initial search, of which 50 were excluded from the study, and finally 19 articles entered the data extraction phase. The extracted articles were classified into 4 dimensions of knowledge, attitude, and practice in pain management, nurses'understanding of pain management, nurses' problems in pain relief, and the extent of pain management implementation and assessment, which are described as follows. Conclusion: Nurses' knowledge, attitude, and managementregarding painmanagementis not in an excellent condition and many studies in Iran should include educational interventions for nurses to help improve their knowledge, attitude, and pain management. Citation: Khalighi E, Soufinia A, Solaimanizadeh L, Borji M, Tarjoman A, Soltany B, Hydaryian H. Knowledge, attitudes and barriers pain management by nurses in Iran: A systematic review. Anaesth pain & intensive care 2019;23(4):__ Received: 8 September 2019; Reviewed: 24, 30 September 2019; 6, 7 November 2019; Revised: 5 November 2019; Accepted: 12 November 2019

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Ascent of the Conus Medullaris in Human Foetuses: A Systematic Review and Meta-Analysis

10.21203/rs.3.rs-970944/v1 ◽

2021 ◽

Author(s):

Lucas Almeida ◽

Yasmin Juliany Figueiredo ◽

André Zylberman ◽

Diogo Garção

Keyword(s):

Systematic Review ◽

Evaluation Method ◽

Data Extraction ◽

Meta Analysis ◽

Conus Medullaris ◽

Normal Birth ◽

Morphological Studies ◽

Sample Characteristics ◽

Present Systematic Review ◽

Human Foetuses

Abstract The aim of the present systematic review and meta-analysis was to identify when the ascent of the conus medullaris occurs in human foetuses considering differences in evaluation methods and sample characteristics. Five databases were searched for relevant articles using different combinations of keywords. Article selection and data extraction were performed independently by two reviewers. Disagreements were resolved by a third reviewer. The variables were distributed into four groups according to the gestational age of the specimens: I (13 to 18 weeks); II (19 to 25 weeks); III (26 to 32 weeks); IV (33 weeks to the probable date of birth). Eighteen articles were included. The majority used imaging exams as the evaluation method. Cadaveric dissections were reported in the remaining articles. Only morphological studies were included in the meta-analysis. Significant ascent occurs between groups I and III as well as groups II and IV. Despite the considerable heterogeneity among the studies included in the present review, the findings enabled the determination that the conus medullaris reaches its normal birth level by the 26th week. Further analyses should be performed based on nationality and ethnicity to diminish the heterogeneity of the data.

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The Effectiveness of Nanoparticles on Gene Therapy for Glioblastoma Cells Apoptosis: A Systematic Review

Current Gene Therapy ◽

10.2174/1566523221666210224110454 ◽

2021 ◽

Vol 21 ◽

Author(s):

Firoozeh Alavian ◽

Sorayya Ghasemi

Keyword(s):

Systematic Review ◽

Gene Therapy ◽

Data Extraction ◽

Gene Therapies ◽

Gene Therapy Approach ◽

Therapy Studies ◽

Present Systematic Review

Background: Glioblastoma multiforme (GBM) is the most common and fatal type of glioma. Nanoparticles (NPs) are using new approaches for the delivery of gene therapy in the treatment of GBM. Introduction: This article was designed to review the efficacy of NPs as the targeted carriers in the gene therapy aimed at apoptosis in GBM. Method: The appropriate keywords such as nanoparticle, glioblastoma, gene therapy, apoptosis, and the related words were used to search from PubMed, ISI Web of Science, and Scopus for relevant publications up to September 4, 2020, with no language restrictions. The present systematic review was performed based on PRISMA protocol and reviewed the articles evaluating the effects of nanoparticles, carriers of various gene therapies essentials, on GBM cells apoptosis in vitro and in vivo. The selected articles were considered using specific scores on the quality of the articles. Data extraction and quality valuation were performed by two reviewers. Result: Of 101 articles retrieved, forty-two met the inclusion criteria and were, therefore, subjected to the final deduction. The most widely used NP in GBM gene therapy studies is polyamidoamine (PAMAM). The most common gene therapy approach for apoptosis in GBM is using siRNAs. Conclusions: In conclusion, these studies validated that NPs could be a practical choices to enhance the efficiency and specific delivery in gene therapies for GBM cell apoptosis. However, the choice of NP type and gene therapy mechanism affect the GBM cell apoptotic efficiency.

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Evaluating methodological quality of Prognostic models Including Patient-reported HeAlth outcomes iN oncologY (EPIPHANY): a systematic review protocol

BMJ Open ◽

10.1136/bmjopen-2018-025054 ◽

2018 ◽

Vol 8 (10) ◽

pp. e025054 ◽

Cited By ~ 2

Author(s):

Nina Deliu ◽

Francesco Cottone ◽

Gary S Collins ◽

Amélie Anota ◽

Fabio Efficace

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Methodological Quality ◽

Data Extraction ◽

Prognostic Models ◽

Published Data ◽

Evidence Based ◽

Patient Reported ◽

Data Extraction Form

IntroductionWhile there is mounting evidence of the independent prognostic value of patient-reported outcomes (PROs) for overall survival (OS) in patients with cancer, it is known that the conduct of these studies may hold a number of methodological challenges. The aim of this systematic review is to evaluate the quality of published studies in this research area, in order to identify methodological and statistical issues deserving special attention and to also possibly provide evidence-based recommendations.Methods and analysisAn electronic search strategy will be performed in PubMed to identify studies developing or validating a prognostic model which includes PROs as predictors. Two reviewers will independently be involved in data collection using a predefined and standardised data extraction form including information related to study characteristics, PROs measures used and multivariable prognostic models. Studies selection will be reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, with data extraction form using fields from the Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies (CHARMS) checklist for multivariable models. Methodological quality assessment will also be performed and will be based on prespecified domains of the CHARMS checklist. As a substantial heterogeneity of included studies is expected, a narrative evidence synthesis will also be provided.Ethics and disseminationGiven that this systematic review will use only published data, ethical permissions will not be required. Findings from this review will be published in peer-reviewed scientific journals and presented at major international conferences. We anticipate that this review will contribute to identify key areas of improvement for conducting and reporting prognostic factor analyses with PROs in oncology and will lay the groundwork for developing future evidence-based recommendations in this area of research.Prospero registration numberCRD42018099160.

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Non-adherence to immunosuppressants following renal transplantation: a protocol for a systematic review

BMJ Open ◽

10.1136/bmjopen-2016-015411 ◽

2017 ◽

Vol 7 (9) ◽

pp. e015411 ◽

Cited By ~ 6

Author(s):

Abigail Hucker ◽

Frances Bunn ◽

Lewis Carpenter ◽

Christopher Lawrence ◽

Ken Farrington ◽

...

Keyword(s):

Systematic Review ◽

Renal Transplant ◽

Data Extraction ◽

Meta Analysis ◽

Renal Transplant Recipients ◽

Transplant Recipients ◽

Data Extraction Form ◽

Registration Number ◽

Meta Analyses ◽

The Impact

IntroductionAdherence to immunosuppressant medication is essential for renal transplant recipients. This review aims to summarise what is known about non-adherence, with a view to providing comprehensive evidence to inform strategies aimed at advancing adherent behaviour.Methods and analysisA systematic review of quantitative studies that report adherence to immunosuppressants in adult (over 18 years) renal transplant recipients. The review will follow the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines; study quality will be assessed using the Downs and Black checklist. Systematic searches will be completed across relevant databases. Two reviewers will independently extract data using a predefined data extraction form. We will summarise the operationalisation of adherence across studies and use narrative synthesis to identify factors associated with non-adherence. A meta-analysis will be conducted if there is sufficient homogeneity, and available data, across studies to estimate the prevalence of non-adherence in renal transplant recipients. Heterogeneity will be assessed using the I2test. Survival analysis will be conducted to estimate hazard ratios to explore the impact of non-adherence on graft survival, graft failure and patient survival.Ethics and disseminationFindings will be published in a peer-reviewed journal and disseminated at conferences for professionals and researchers. Review outcomes will help support clinical practice by highlighting the extent of non-adherence among adults, and in doing so, signpost the need for suitable intervention.Trial registration numberPROSPERO registration number (CRD42016038751).

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