Cyproheptadine in Anorexia Nervosa

1979 ◽  
Vol 134 (1) ◽  
pp. 67-70 ◽  
Author(s):  
Solomon C. Goldberg ◽  
Katherine A. Halmi ◽  
Elke D. Eckert ◽  
Regina C. Casper ◽  
John M. Davis
Keyword(s):  
Anorexia Nervosa ◽  
Weight Gain ◽  
Treatment Failure ◽  
Diagnostic Criteria ◽  
Outpatient Treatment ◽  
Severe Form ◽  
Behaviour Therapy ◽  
Delivery Complications ◽  
Female Patients ◽  
History Of

SummaryIn three hospitals 81 female patients satisfying rigorous diagnostic criteria for anorexia nervosa were randomly allocated to one of four treatment combinations of cyproheptadine and placebo with behaviour therapy and no behaviour therapy. Cyproheptadine was found to be effective in inducing weight gain in a subgroup of anorexia nervosa patients who (a) had a history of birth delivery complications, (b) had lost 41–52 per cent weight from norm and (c) had a history of prior outpatient treatment failure. This subgroup may represent a more severe form of anorexia nervosa.

Pretreatment Predictors of Outcome in Anorexia Nervosa

1979 ◽  
Vol 134 (1) ◽  
pp. 71-78 ◽  
Author(s):  
Katherine A. Halmi ◽  
Solomon C. Goldberg ◽  
Regina C. Casper ◽  
Elke D. Eckert ◽  
John M. Davis
Keyword(s):  
Anorexia Nervosa ◽  
Weight Gain ◽  
Prognostic Indicators ◽  
Predictors Of Outcome ◽  
Outcome Predictor ◽  
Delivery Complications ◽  
The Poor ◽  
History Of ◽  
Relationship Of ◽  
The Relationship

SummaryThe relationship of selected pretreatment characteristics to weight gain during treatment was examined in 81 anorexia nervosa patients. Good prognostic indicators correlating positively with weight gain were: no previous hospitalizations for anorexia nervosa, a great amount of overactivity before treatment, less denial of illness, less psychosexual immaturity and the admission to feeling hunger. A perinatal history of delivery complications was associated with the poor outcome predictor of prior hospitalizations.

Behaviour Therapy in Anorexia Nervosa

1979 ◽  
Vol 134 (1) ◽  
pp. 55-59 ◽  
Author(s):  
Elke D. Eckert ◽  
Solomon C. Goldberg ◽  
Katherine A. Halmi ◽  
Regina C. Casper ◽  
John M. Davis
Keyword(s):  
Anorexia Nervosa ◽  
Weight Gain ◽  
Behaviour Therapy ◽  
Behaviour Modification ◽  
Significant Difference

SummaryIn three collaborating hospitals, 81 anorexia nervosa patients were randomly assigned to behaviour modification or its absence and followed over 35 days. There was no overall significant difference in weight gain in the two groups except in a subset of patients: those with no prior out-patient treatments.

ENHANCED TESTOSTERONE IN FEMALE PATIENTS WITH ANOREXIA NERVOSA: ITS NORMALIZATION AFTER WEIGHT GAIN

1979 ◽  
Vol 90 (2) ◽  
pp. 328-335 ◽  
Author(s):  
B. Baranowska ◽  
S. Zgliczyński
Keyword(s):  
Body Weight ◽  
Anorexia Nervosa ◽  
Weight Gain ◽  
Serum Testosterone ◽  
Gonadal Hormones ◽  
High Serum ◽  
Control Group ◽  
Testosterone Concentration ◽  
Female Patients ◽  
Serum Lh

ABSTRACT In order to elucidate the mechanism of disturbances of gonadal hormones secretion in anorexia nervosa 14 female patients were investigated. A control group also consisted of 14 women of the same age. The serum LH, progesterone, oestrogens: oestrone + oestradiol (Oe1 + Oe2), oestriol (Oe3) and testosterone were determined by radioimmunological methods. In patients with anorexia nervosa the serum testosterone and Oe3 concentrations were dramatically elevated, whereas LH, progesterone and Oe1 + Oe2 were decreased as compared with the control group. Considerable weight gain induced by cyproheptadine treatment caused a normalization of the serum testosterone and Oe3 concentrations in all the patients. A negative correlation between the testosterone level and the deficit in body weight was observed. The mechanism causing the dramatically high serum testosterone concentration in the female patients with anorexia nervosa is discussed.

ANOREXIA SYNDROM AS A DETERMINING FACTOR FOR TIMELY PREVENTION OF SEVERE SOMATIC COMPLICATIONS OF EATING DISORDERS

2021 ◽  
Vol 5 (1) ◽  
pp. 1173-1183
Author(s):  
S. Shubina ◽  
◽  
O. Skugarevsky ◽  
S. Hunich ◽  
◽  
...  
Keyword(s):  
Eating Disorders ◽  
Anorexia Nervosa ◽  
Clinical Diagnosis ◽  
Eating Behavior ◽  
Clinical Pattern ◽  
Female Patients ◽  
History Of ◽  
Spectrum Disorders ◽  
Mental And Behavioral Disorders

The research objective was to identify the differences in neurocognitive functioning and social cognition (emotional processing) in the presence of anorexia nervosa and schizophrenia, which will eventually help in developing methodological approaches and improving differential and diagnostic parameters to assess anorexia syndrome associated with these disorders. Materials and methods. We studied neuropsychological and anthropometric characteristics of the respondents whose clinical pattern had evidence of anorexia syndrome (129 people): (1) female patients suffering from anorexia nervosa without changed clinical diagnosis (40 patients), (2) female patients suffering from anorexia nervosa whose clinical diagnosis was changed to bulimia nervosa within a 5-year follow-up (20 patients), (3) female patients with anorexia nervosa whose clinical diagnosis was changed to schizophrenic spectrum disorders within a 5-year follow-up (15 patients), (4) female patients suffering from a paranoid form of schizophrenia lasting for up to 5 years with a history of deviant eating behavior in the clinical pattern (23 patients), (5) girls and young women who did not have mental and behavioral disorders at the time of their participation in the study, but with preclinical signs of eating disorders (ED) (31 patients). The survey included a set of anamnestic, anthropometric, and psychometric methods, as well as psychometric techniques. The statistical processing of the obtained results was carried out with the help of the Statistica 10.0 and SPSS 22.0 software packs. Results. We established qualitative and quantitative differences in the parameters of neuropsychological and anthropometric profiles in the presence of concomitant ED symptoms in the clinical pattern. Moreover, great difficulties in the implementation of executive functioning were identified in patients with anorexia nervosa whose 5-year follow-up was changed to a diagnosis from the list of schizophrenic spectrum disorders, and in patients suffering from schizophrenia with a history of deviant eating behavior. Discriminant analysis based on the identified set of neuropsychological and anthropometric parameters enabledus to correctly classify the compared subgroups with an accuracy of 99.2%. Conclusion. Assessment of neurocognitive (in terms of executive functions) and anthropometric indicators enables determining the exact nosological affiliation of anorexia syndrome in the manifestation of mental and behavioral disorders, as well as establishing a correct clinical diagnosis, which will help to provide adequate treatment and rehabilitation in the future, along with timely prevention of severe complications of eating disorders. It is necessary to consider the fact that failures to diagnose the anorexia syndrome in such patients lead to difficulties in their treatment and worsen their social and medical prognosis.

Efficacy of galcanezumab in patients with episodic cluster headaches and a history of preventive treatment failure

2021 ◽  
Vol 4 ◽  
pp. 251581632110156
Author(s):  
Brian Plato ◽  
J Scott Andrews ◽  
Mallikarjuna Rettiganti ◽  
Antje Tockhorn-Heidenreich ◽  
Jennifer Bardos ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Treatment Failure ◽  
Preventive Treatment ◽  
Mean Difference ◽  
Least Square ◽  
Double Blind Study ◽  
Double Blind ◽  
Cluster Headache Attack ◽  
Episodic Cluster Headache ◽  
History Of

Objective: The efficacy of galcanezumab was evaluated in patients with episodic cluster headache and history of preventive treatment failure. Methods: In the randomized, 8-week, double-blind study (CGAL), patients with episodic cluster headache received once-monthly subcutaneous injections of galcanezumab 300 mg or placebo. Patients who completed CGAL and enrolled in an open-label study were queried for preventive treatment history. In a subset of patients with a known history of failure of verapamil or any other prior preventive treatment, a post hoc analysis of least square mean change from baseline in weekly cluster headache attack frequency across Weeks 1 to 3 was assessed. Results: Fifteen patients provided data for known history of prior preventive treatment failure (6 placebo, 9 galcanezumab), of whom 11 failed verapamil. The mean reduction in the weekly frequency of cluster headache attacks was greater with galcanezumab compared to placebo among patients with prior preventive treatment failure (8.2 versus 2.4); mean difference 5.8 (95% confidence interval [CI] 2.0, 13.6) and among patients with verapamil failure (10.1 versus 1.6); mean difference 8.5 (95% CI 0.4, 16.7). Conclusion: In this exploratory analysis of patients with a known history of prior preventive treatment failures, treatment with galcanezumab resulted in greater mean reductions in weekly cluster headache attacks compared with placebo. ClinicalTrials.gov: NCT02397473 (I5Q-MC-CGAL) NCT02797951 (I5Q-MC-CGAR)

scholarly journals Overcoming limitations of self-report: an assessment of fear of weight gain in anorexia nervosa and healthy controls using implicit association tests

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Tiana Borgers ◽  
Nathalie Krüger ◽  
Silja Vocks ◽  
Jennifer J. Thomas ◽  
Franziska Plessow ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Weight Gain ◽  
Normal Weight ◽  
Self Report ◽  
Healthy Controls ◽  
Drive For Thinness ◽  
Implicit Association ◽  
Association Tests ◽  
Implicit Assessment ◽  
Fear Of Weight Gain

Abstract Background Fear of weight gain is a characteristic feature of anorexia nervosa (AN), and reducing this fear is often a main target of treatment. However, research shows that 20% of individuals with AN do not report fear of weight gain. Studies are needed that evaluate the centrality of fear of weight gain for AN with a method less susceptible to deception than self-report. Methods We approximated implicit fear of weight gain by measuring implicit drive for thinness using implicit association tests (IATs). We asked 64 participants (35 AN, 29 healthy controls [HCs]) to categorize statements as pro-dieting vs. non-dieting and true vs. false in a questionnaire-based IAT, and pictures of underweight vs. normal-weight models and positive vs. negative words in a picture-based IAT using two response keys. We tested for associations between implicit drive for thinness and explicitly reported psychopathology within AN as well as group differences between AN and HC groups. Results Correlation analyses within the AN group showed that higher implicit drive for thinness was associated with more pronounced eating disorder-specific psychopathology. Furthermore, the AN group showed a stronger implicit drive for thinness than HCs in both IATs. Conclusion The results highlight the relevance of considering fear of weight gain as a continuous construct. Our implicit assessment captures various degrees of fear of weight gain in AN, which might allow for more individually tailored interventions in the future.

Dysfunctional Eating Behaviour and Leptin in Middle-Aged Women: Role of Menopause and a History of Anorexia Nervosa

2021 ◽  
Author(s):  
Suzana Stojiljkovic-Drobnjak ◽  
Susanne Fischer ◽  
Myrtha Arnold ◽  
Wolfgang Langhans ◽  
Ulrike Kuebler ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Eating Behaviour ◽  
Middle Aged ◽  
History Of

Pregnancy outcomes of women with and without a history of anorexia nervosa

2012 ◽  
Vol 42 (12) ◽  
pp. 2651-2660 ◽  
Author(s):  
J. M. Eagles ◽  
A. J. Lee ◽  
E. Amalraj Raja ◽  
H. R. Millar ◽  
S. Bhattacharya
Keyword(s):  
Anorexia Nervosa ◽  
Pregnancy Outcomes ◽  
Intrauterine Growth Restriction ◽  
Maternal Body Mass Index ◽  
Intrauterine Growth ◽  
North East ◽  
Increased Risk ◽  
History Of ◽  
Obstetric Services ◽  
Adverse Pregnancy

BackgroundWhen women have a history of anorexia nervosa (AN), the advice given about becoming pregnant, and about the management of pregnancies, has usually been cautious. This study compared the pregnancy outcomes of women with and without a history of AN.MethodWomen with a confirmed diagnosis of AN who had presented to psychiatric services in North East Scotland from 1965 to 2007 were identified. Those women with a pregnancy recorded in the Aberdeen Maternal and Neonatal Databank (AMND) were each matched by age, parity and year of delivery of their first baby with five women with no history of AN. Maternal and foetal outcomes were compared between these two groups of women. Comparisons were also made between the mothers with a history of AN and all other women in the AMND.ResultsA total of 134 women with a history of AN delivered 230 babies and the 670 matched women delivered 1144 babies. Mothers with AN delivered lighter babies but this difference did not persist after adjusting for maternal body mass index (BMI) in early pregnancy. Standardized birthweight (SBW) scores suggested that the AN mothers were more likely to produce babies with intrauterine growth restriction (IUGR) [relative risk (RR) 1.54, 95% confidence interval (CI) 1.11–2.13]. AN mothers were more likely to experience antepartum haemorrhage (RR 1.70, 95% CI 1.09–2.65).ConclusionsMothers with a history of AN are at increased risk of adverse pregnancy outcomes. The magnitude of these risks is relatively small and should be appraised holistically by psychiatric and obstetric services.

Sign in / Sign up

Export Citation Format

Share Document