Happy Families?

1984 ◽  
Vol 145 (2) ◽  
pp. 136-138 ◽  
Author(s):  
Judith Heron ◽  
Rachel Leheup

SummarySixteen consecutive patients with anorexia nervosa were studied and compared with a control group of other patients coming to an adolescent service, matched for sex and admission status. The anorexic group were not significantly different from the controls in social class and I.Q., and had a male-to-female ratio of one to four. However, they were significantly more likely to have perfectionistic personality traits and to profess to be happy with their families; these families had few external stresses, were very close, and had a high degree of exclusivity.

2002 ◽  
Vol 30 (4) ◽  
pp. 347-357 ◽  
Author(s):  
Erica B. FÄldt Ciccolo ◽  
Per Johnsson

The question of subgroups in eating disorders was addressed in this study. According to the Diagnostic and Statistical Manual of Mental Disorders, IV, the two subtypes for anorexia nervosa are restricting and binge-eating/purging. For bulimia nervosa, the subtypes are purging and nonpurging. An attempt was made here to examine alternative ways to create meaningful subgroups in the eating-disordered patient group. A cluster analysis was performed in a group of 52 female patients (AN=21, BN=31). Fifty-five undergraduate students served as a control group. Three self-report instruments were used: the Eating Disorder Inventory-2, Karolinska Scales of Personality, and Tennessee Self-Concept Scale. The results reveal three different groups of patients. Factors like poor interoceptive ability and high degree of somatization differentiate between the groups, and contribute to severity of pathology, as well as to lower levels of self-concept.The results reveal three different groups of patients. Factors like poor interoceptive ability and high degree of somatization differentiate between the groups, and contribute to severity of pathology, as well as to lower levels of self-concept.


1995 ◽  
Vol 35 (3) ◽  
pp. 207-212 ◽  
Author(s):  
Marie T Cassidy ◽  
Michael Curtis ◽  
Gillian Muir ◽  
John S Oliver

A survey of 62 drug deaths in Glasgow showed a wider age range than expected (16–49), a high male to female ratio (44:18) and, where mode of employment had been recorded, a high degree of unemployment (91%). The majority of deaths occurred near centres of known supply. Although a number occurred in the family home, a large proportion were not at the place of residence. In only two cases was morphine detected alone. The majority of the deaths were from combinations of drugs, primarily with benzodiazepines.


Author(s):  
Mohammed S Mustak ◽  
Chitta Chowdhury ◽  
Shahnawaz Khijmatgar ◽  
Mohammed S Mustak ◽  
Avidyuti Chowdhury ◽  
...  

Objective: To determine any genetic association of COL1A2 polymorphism and the occurrence of dental fluorosis within an Indian human dental fluorosis population. Material and Methods: Fifty-six (56) subjects from two groups i.e. cases with dental fluorosis from the Pavagada population (n=29) and a control group (n=27) without fluorosis, were explored. The ages ranged between 15 and 76 years (mean 50.8 years) were included, and the male to female ratio was 70:30. The severity of dental fluorosis was graded using WHO’s Thylstrup-Fejerskov index (TF), and the concentration of fluoride was determined by a fluoride ion selective electrode (ISE). Genomic DNA was extracted using the standard phenol-chloroform method. The rs412777 and rs414408 polymorphism in COL1A2 were genotyped using the Sanger sequence method. Results: Genotype distributions for rs412777 within each group were: AA 41%, AC 51%, and CC 7% for dental fluorosis participants, and AA 56%, AC 46%, and CC 0% for the control participants. Conclusions: The rs412777 and rs414408 polymorphisms in the COL1A2gene showed no significant association between COL1A2 and the occurrence of dental fluorosis amongst this Indian population.


2020 ◽  
Author(s):  
Mohammad Naghi Tahmasebi ◽  
Arash Sharafat Vaziri ◽  
Fardis Vosoughi ◽  
Mohamad Tahami ◽  
Majid Khalilizad ◽  
...  

Abstract Background: Utilizing intrawound vancomycin powder in TKA surgery has yielded rather contrasting results in the current literature. Furthermore, CDC criteria, although effective in general, are not specifically designed for post-TKA infections. Here, we present a 7-year experience of vancomycin use in primary TKA in a high-volume tertiary knee center in Iran. Also, new criteria are proposed to detect suspected superficial post-TKA infections. Methods: This is a retrospective analysis of primary total knee arthroplasties performed in a tertiary knee center, from March 2007 to December 2018, by a single senior knee surgeon. All patients with follow-up periods of less than one year were excluded from the study. Since March 2011, all patient received vancomycin (powder, 1gr) before water-tight closure of the joint capsule. Comparison was made between this group and historical control subjects (operated from March 2007 to March 2011). Results: Altogether, 2024 patients were included in the study. The vancomycin and the control group included 1710 and 314 cases respectively. Patients were mostly women (male to female ratio: 1 to 4), with a mean age of 65.20 (SD=10.83) years. In the vancomycin group, the rate of suspected SII (1.87%) and PJI (0.41%) was significantly lower than the control group (P= 0.002). Conclusions: Our experience shows that by utilizing intrawound vancomycin as a routine practice along with other measures, we were able to reach relatively low rates of deep post-TKA infections. Howbeit, randomized controlled trials are required to clarify the effect of intrawound vancomycin on post-TKA infection rate.


Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 4393-4393
Author(s):  
Dennis P. O'Malley ◽  
Christina Giudice ◽  
Averee S Chang ◽  
Dorothy Chang ◽  
Todd S Barry ◽  
...  

Abstract Abstract 4393 INTRODUCTION Chronic lymphocytic leukemia (CLL) is a commonly encountered hematologic neoplasm. Evaluation of prognosis in CLL is strongly based on genetic findings and the most commonly used studies are classical cytogenetics and targeted interphase fluorescence in situ hybridization (FISH). High resolution array comparative genomic hybridization (aCGH) is a relatively new and robust method of evaluating chromosomal alterations over the entire genome. We compared aCGH with routine cytogenetics and FISH in detecting genetic alterations in newly-diagnosed CLL cases. MATERIALS AND METHODS aCGH testing was performed on 55 cases of CLL in addition to a standard panel of FISH probes (ATM on 11q22, trisomy 12, 13q14, p53 on 17p13 using a standard cutoff for positivity of 10%). These results were compared to a control group of 100 CLL cases upon which routine cytogenetics and FISH were performed. The frequency of detecting abnormalities was compared between the groups and discordant results between methodologies were compared. RESULTS In the control group (n=100), the mean age was 71 (52-86) with a male to female ratio of 1.6:1. Genetic abnormalities were detected by classical cytogenetics in 19% (19/100) of cases as compared to FISH which detected abnormalities in 66% (66/100) of cases (Table 1). An additional group of 55 CLL cases [male to female ratio of 2.2:1 and a mean age of 71 (52-90)] was analyzed by both aCGH and FISH. This additional group of CLL cases showed a similar frequency of genetic abnormalities by FISH (60%; 27/45). In contrast to FISH, aCGH detected genetic abnormalities in 82% (45/55) of CLL cases (Table 1). aCGH identified genetic abnormalities not detected by FISH studies in 16% (7/45) of cases whereas FISH identified abnormalities not detected by aCGH in only 7% (3/45) of cases. Rare recurring genetic alterations were detected by aCGH, which would not have been detected by a standard FISH panel, and included losses in 6q, 8p, 10q, 14q32, and 18q, and gains in 10q. DISCUSSION Classical cytogenetics is often performed in cases of CLL, but is not particularly useful as CLL cells are often difficult to grow in culture and because of the low rate of detecting common genetic alterations. Our findings suggest that aCGH is an effective and robust technique for evaluating recurring genetic abnormalities in CLL and is better than classical cytogenetics and standard FISH in detecting common genetic abnormalities in CLL. Disclosures: No relevant conflicts of interest to declare.


2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Mohammad Naghi Tahmasebi ◽  
Arash Sharafat Vaziri ◽  
Fardis Vosoughi ◽  
Mohamad Tahami ◽  
Majid Khalilizad ◽  
...  

Abstract Background Utilizing intrawound vancomycin powder in TKA surgery has yielded rather contrasting results in the current literature. Furthermore, CDC criteria, although effective in general, are not specifically designed for post-TKA infections. Here, we present a 7-year experience of vancomycin use in primary TKA in a high-volume tertiary knee center in Iran. Also, new criteria are proposed to detect suspected superficial post-TKA infections. Methods This is a retrospective analysis of primary total knee arthroplasties performed in a tertiary knee center, from March 2007 to December 2018, by a single senior knee surgeon. All patients with follow-up periods of less than 1 year were excluded from the study. Since March 2011, all patients received vancomycin (powder, 1 g) before water-tight closure of the joint capsule. A comparison was made between this group and historical control subjects (operated from March 2007 to March 2011). Results Altogether, 2024 patients were included in the study. The vancomycin and the control groups included 1710 and 314 cases respectively. Patients were mostly women (male to female ratio, 1 to 4), with a mean age of 65.20 (SD = 10.83) years. In the vancomycin group, the rate of suspected SII (1.87%) and PJI (0.41%) was significantly lower than the control group (P = 0.002). Conclusions Our experience shows that application of local vancomycin during TKA surgery could be a reasonable infection prevention measure, although prospective randomized studies are required to evaluate its efficacy.


2013 ◽  
Vol 51 (1) ◽  
pp. 54-60
Author(s):  
A. Janovic ◽  
S. Antic ◽  
Z. Rakocevic ◽  
M. Djuric

Background: Developmental disturbances of the paranasal sinuses are proposed as the cause of osteoma. We examined whether such disturbances may result in the frequent presence of anatomical variations of the paranasal sinuses in patients with osteoma. Methodology/principal: The study was performed retrospectively on 2,820 patients subjected to CT examination during 2005 - 2011. Demographic and CT characteristics of osteoma, and associated pathological findings were evaluated for 104 patients with diagnosed osteoma. The presence of anatomical variations was assessed for 51 osteoma patients with a complete medical history, and for 1,233 patients from a control group. Results: The prevalence of osteomas was found to be 3.69%, with male to female ratio 1.08:1. The frontal sinus was most commonly affected. The presence of anatomical variations was more frequent in patients with osteoma than in controls, with significant differences confirmed for the sphenomaxillary plate, infraorbital cell, and crista galli pneumatization. Conclusions: The paranasal sinus osteoma is associated with higher prevalence of anatomical variations. This can be explained either by the stronger influence of genetic and/or environmental factors on the development of the paranasal sinuses in patients with osteoma, or by their higher susceptibility to above mentioned factors.


Author(s):  
Vivek Samor ◽  
Deepchand Sarowa ◽  
Pooja D. Nayak ◽  
Vaibhav Saini ◽  
Gagandeep Kaur ◽  
...  

<p class="abstract"><strong>Background:</strong> Aero-digestive foreign bodies are prevalent in our part of the country. Apart from the usual foreign body we encountered some unique foreign bodies, the diagnosis and management of which, is difficult due to varied and overlapping clinical presentation. Rare foreign bodies in the aero-digestive tract pose challenges in diagnosis and treatment.</p><p class="abstract"><strong>Methods:</strong> This was a retrospective observational study on thirty patients with aerodigestive foreign bodies who visited our hospital from July 2015 to October 2017.  </p><p class="abstract"><strong>Results:</strong> Maximum number of cases was seen in age group of 0-5 years. The male to female ratio was 2:1. Among various types of foreign bodies, majority were metallic (43.3%). The most common site was cricopharynx (53.3%) followed by bronchus (26.6%) and esophageal (16.6%). The most common procedure done was hypopharyngoscopy (53.3%).</p><p class="abstract"><strong>Conclusions:</strong> Aerodigestive tract foreign bodies are one of the emergencies that have considerable mortality and morbidity. High degree of skill and suspicion are required by surgeon for the management of foreign body.</p>


2021 ◽  
Author(s):  
Huachun Miao ◽  
Yuhui Ou ◽  
Longchi Chen ◽  
Ao Cao ◽  
Chenyang Ling ◽  
...  

Abstract Background: Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Its pathogenesis is complex and consists of different types of heart malformations. Whether for diagnosis or treatment, it is necessary to understand, in depth, the anatomical characteristics of this disease. With this, a full-colour model made by 3D printing technology is very suitable for helping users understand the complex configuration of organs and structures due to its high degree of simulation and homogeneity. The purpose of this study is to analyze the effect of 3D printing model on TOF teaching.Methods: TOF image data were obtained from the medical image centre of the hospital and inputted into a colour 3D printer after software processing to print the full-colour model of TOF. Among the senior students of majoring in clinical medicine at our college, 30 students with equal male-to-female ratio were randomly divided into two groups: the 3D printing model group (n=15) and the traditional teaching group (n=15). At the end of the teaching session, theoretical examinations and a teaching effect questionnaire were distributed to evaluate the teaching effect.Results: The overall score of the 3D model teaching group was higher than that of the traditional teaching group (P<0.05), with a higher number of students interested in the course compared to that of the control group. Additionally, the effect of the 3D printing model teaching group was better than that of the traditional teaching group (P<0.05), in terms of learning satisfaction.Conclusion: The introduction of a 3D printed heart model into teaching can compensate for the deficiencies of the traditional teaching mode, improve the efficiency and effect of teaching, and is worth popularising and applying in the field of medical education.


1980 ◽  
Vol 112 (2) ◽  
pp. 131-140 ◽  
Author(s):  
John H. Brower

AbstractOne-day-old P1 males of the almond moth, Ephestia cautella (Walker), were irradiated with 5, 10, 15, or 2 krad of gamma radiation and paired with untreated virgin females. Progeny were collected through three generations, and lines were established in theF1and F2 with all possible degrees of inbreeding and outbreeding. Radiation effects were assayed by determining mating success, sterility of pairs, average number of progeny/fertile pair, and sex ratio for pairs with males (U♂ × F1♀ U♂ × F2 ♀), females, or both sexes (F1♂ × F1♀, F2 ♂ × F2 ♀) from each dose. Results showed the greater the initial dose, the greater the reduction in the number of progeny and the greater the male to female ratio. Radiation effects on both F1 males and F1 females were greater than effects on the P1 males, though effects on F1 males were greater than effects on F1 females. Except for extinct lines, partial recovery occurred in the F2 generation though recovery was much greater in F2 females than in F2 males. In each generation males were more affected than females from the same breeding line when they were outcrossed with untreated moths. The greater the degree of inbreeding in irradiated lines, the greater the effect on both males and females. Although a high degree of population reduction occurred only in the F1 generation at a dose of 15 and 20 krad, population models showed inbreeding at the lower doses caused sufficient depression to greatly reduce abundance of a natural population for several generations after a single inundative release of substerilized males.


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