Polygenic risk for schizophrenia, disordered eating behaviours and body mass index in adolescents

BackgroundRecent studies suggest psychotic and eating disorders can be comorbid and could have shared genetic liability. However, this comorbidity has been overlooked in the epidemiological literature.AimsTo test whether polygenic risk scores (PRS) for schizophrenia are associated with disordered eating behaviours and body mass index (BMI) in the general population.MethodUsing data from the Avon Longitudinal Study of Parents and Children and random-effects logistic and linear regression models, we investigated the association between PRS for schizophrenia and self-reported disordered eating behaviours (binge eating, purging, fasting and excessive exercise) and BMI at 14, 16 and 18 years.ResultsOf the 6920 children with available genetic data, 4473 (64.6%) and 5069 (73.3%) had at least one disordered eating and one BMI outcome measurement, respectively. An s.d. increase in PRS was associated with greater odds of having binge eating behaviours (odds ratio, 1.36; 95% CI 1.16–1.60) and lower BMI (coefficient, −0.03; 95% CI, −0.06 to −0.01).ConclusionsOur findings suggest the presence of shared genetic risk between schizophrenia and binge eating behaviours. Intermediate phenotypes such as impaired social cognition and irritability, previously shown to be positively correlated in this sample with schizophrenia PRS, could represent risk factors for both phenotypes. Shared genetic liability between binge eating and schizophrenia could also explain higher rates of metabolic syndrome in individuals with schizophrenia, as binge eating could be a mediator of this association in drug-naïve individuals. The finding of an association between greater PRS and lower BMI, although consistent with existing epidemiological and genetic literature, requires further investigation.Declaration of interestNone.

Download Full-text

Polygenic Score for Body Mass Index Is Associated with Disordered Eating in a General Population Cohort

Journal of Clinical Medicine ◽

10.3390/jcm9041187 ◽

2020 ◽

Vol 9 (4) ◽

pp. 1187 ◽

Cited By ~ 6

Author(s):

Mohamed Abdulkadir ◽

Moritz Herle ◽

Bianca L. De Stavola ◽

Christopher Hübel ◽

Diana L. Santos Ferreira ◽

...

Keyword(s):

Body Mass Index ◽

Binge Eating ◽

Body Dissatisfaction ◽

Disordered Eating ◽

Body Mass ◽

Genetic Variants ◽

Emotional Eating ◽

Mediation Analyses ◽

Parents And Children ◽

Polygenic Scores

Background: Disordered eating (DE) is common and is associated with body mass index (BMI). We investigated whether genetic variants for BMI were associated with DE. Methods: BMI polygenic scores (PGS) were calculated for participants of the Avon Longitudinal Study of Parents and Children (ALSPAC; N = 8654) and their association with DE tested. Data on DE behaviors (e.g., binge eating and compensatory behaviors) were collected at ages 14, 16, 18 years, and DE cognitions (e.g., body dissatisfaction) at 14 years. Mediation analyses determined whether BMI mediated the association between the BMI-PGS and DE. Results: The BMI-PGS was positively associated with fasting (OR = 1.42, 95% CI = 1.25, 1.61), binge eating (OR = 1.28, 95% CI = 1.12, 1.46), purging (OR = 1.20, 95% CI = 1.02, 1.42), body dissatisfaction (Beta = 0.99, 95% CI = 0.77, 1.22), restrained eating (Beta = 0.14, 95% CI = 0.10, 1.17), emotional eating (Beta = 0.21, 95% CI = 0.052, 0.38), and negatively associated with thin ideal internalization (Beta = −0.15, 95% CI = −0.23, −0.07) and external eating (Beta = −0.19, 95% CI = −0.30, −0.09). These associations were mainly mediated by BMI. Conclusions: Genetic variants associated with BMI are also associated with DE. This association was mediated through BMI suggesting that weight potentially sits on the pathway from genetic liability to DE.

Download Full-text

Disordered eating behaviours in an undergraduate sample: Associations among gender, body mass index, and difficulties in emotion regulation.

Canadian Journal of Behavioural Science/Revue canadienne des sciences du comportement ◽

10.1037/a0031123 ◽

2014 ◽

Vol 46 (3) ◽

pp. 320-326 ◽

Cited By ~ 20

Author(s):

Adele Lafrance Robinson ◽

Stacey Kosmerly ◽

Sarah Mansfield-Green ◽

Glenys Lafrance

Keyword(s):

Body Mass Index ◽

Emotion Regulation ◽

Disordered Eating ◽

Body Mass ◽

Eating Behaviours ◽

Difficulties In Emotion Regulation

Download Full-text

Body Image Disturbance, Weight Perception and Body Mass Index of Female College Students in Delhi having Normal and Disordered Eating Behaviours

The Indian Journal of Nutrition and Dietetics ◽

10.21048/ijnd.2019.56.2.22546 ◽

2019 ◽

Vol 56 (2) ◽

pp. 145

Author(s):

Shipra Gupta ◽

Deeksha Kapur

Keyword(s):

College Students ◽

Body Mass Index ◽

Body Image ◽

Disordered Eating ◽

Body Mass ◽

Eating Behaviour ◽

Body Image Disturbance ◽

Female College Students ◽

Eating Behaviours ◽

Female College

Body image and self-perception about weight, irrespective of their actual body mass index, may predispose young females to disordered eating behaviour. A study was conducted to determine body image disturbance, weight perception and body mass index among female college students in Delhi having normal and disordered eating behaviours. The study sample comprised 734 female under-graduate students between 18-21 years from women’s colleges of Delhi University. An interview-cum-questionnaire schedule was used to assess the general profile of subjects and perceptions about their body weight. Adapted Eating Attitudes Test (EAT)-26 and Body Shape Questionnaire (BSQ)-8c was used to determine disordered eating behaviour and body image disturbance among the subjects respectively. Body Mass Index of the subjects was also computed. Findings revealed a significant difference in self-perception about body weight among subjects showing normal and disordered eating behaviours. Higher percentage of subjects from disordered eating group perceived themselves to be either overweight or obese as compared to subjects from normal eating behaviour group.Significantly higher BSQ-8c scores and Body Mass Index were also observed among subjects having disordered eating behaviour. The study indicated that poor body image, self-perception about body weight being high as well as high body mass index played a significant role in occurrence of disordered eating behaviour among female college students in Delhi.The study depicted the urgent need to have appropriate health and nutrition education programmes for female college students to improve their perceptions about body shape and weight to further prevent the occurrence of disordered eating behaviour among them and make them less vulnerable to consequent nutritional problems.

Download Full-text

Polygenic score for body mass index is associated with disordered eating in a general population cohort

10.1101/2020.04.03.20051896 ◽

2020 ◽

Author(s):

Mohamed Abdulkadir ◽

Moritz Herle ◽

Bianca De Stavola ◽

Christopher Hübel ◽

Diana Santos Ferreira ◽

...

Keyword(s):

Body Mass Index ◽

Binge Eating ◽

Body Dissatisfaction ◽

Disordered Eating ◽

Body Mass ◽

Genetic Variants ◽

Emotional Eating ◽

Mediation Analyses ◽

Parents And Children ◽

Polygenic Scores

AbstractBackgroundDisordered eating (DE) is common and is associated with body mass index (BMI). We aimed to investigate if genetic variants for BMI were associated with DE.MethodsBMI polygenic scores (PGS) were calculated for participants of the Avon Longitudinal Study of Parents and Children (ALSPAC; N= 8,654) and their association with DE tested. Data on DE behaviors (e.g. binge eating, and compensatory behaviors) were collected at ages 14, 16, 18 years, and DE cognitions (e.g. body dissatisfaction) at 14 years. Mediation analyses determined whether BMI mediated the association between the BMI-PGS and DE.ResultsThe BMI-PGS was positively associated with fasting (OR= 1.42, 95% CI=1.25, 1.61), binge eating (OR=1.28, 95% CI= 1.12, 1.46), purging (OR= 1.20, 95% CI= 1.02, 1.42), body dissatisfaction (Beta= 0.99, 95% CI= 0.77, 1.22), restrained eating (Beta=0.14, 95% CI= 0.10, 1.17), emotional eating (Beta= 0.21, 95% CI= 0.052, 0.38), and negatively associated with thin ideal internalization (Beta= −0.15, 95% CI= −0.23, −0.07) and external eating (Beta= −0.19, 95% CI= −0.30, −0.09). These associations were mainly mediated by BMI.ConclusionsGenetic variants associated with BMI are also associated with DE. This association was mediated through BMI suggesting that weight potentially sits on the pathway from genetic liability to DE.

Download Full-text

BODY-ESTEEM, BODY MASS INDEX, AND RISK FOR DISORDERED EATING AMONG ADOLESCENTS IN SYNCHRONIZED SWIMMING

Perceptual and Motor Skills ◽

10.2466/pms.101.7.877-884 ◽

2005 ◽

Vol 101 (7) ◽

pp. 877 ◽

Cited By ~ 9

Author(s):

CLAUDE FERRAND

Keyword(s):

Body Mass Index ◽

Disordered Eating ◽

Body Mass ◽

Body Esteem ◽

Synchronized Swimming

Download Full-text

Lifestyle Changes and Body Mass Index during COVID-19 Pandemic Lockdown: An Italian Online-Survey

Nutrients ◽

10.3390/nu13041117 ◽

2021 ◽

Vol 13 (4) ◽

pp. 1117

Author(s):

Silvia Maffoni ◽

Silvia Brazzo ◽

Rachele De Giuseppe ◽

Ginevra Biino ◽

Ilaria Vietti ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Online Survey ◽

Negative Impact ◽

Phase 1 ◽

Adult Population ◽

Lifestyle Changes ◽

Eating Behaviours ◽

Public Health Services ◽

Activity Frequency

Background. COVID-19 pandemic has imposed a period of contingency measures, including total or partial lockdowns all over the world leading to several changes in lifestyle/eating behaviours. This retrospective cohort study aimed at investigating Italian adult population lifestyle changes during COVID-19 pandemic “Phase 1” lockdown (8 March–4 May 2020) and discriminate between positive and negative changes and BMI (body mass index) variations (ΔBMI). Methods. A multiple-choice web-form survey was used to collect retrospective data regarding lifestyle/eating behaviours during “Phase 1” in the Italian adult population. According to changes in lifestyle/eating behaviours, the sample was divided into three classes of changes: “negative change”, “no change”, “positive change”. For each class, correlations with ΔBMI were investigated. Results. Data were collected from 1304 subjects (973F/331M). Mean ΔBMI differed significantly (p < 0.001) between classes, and was significantly related to water intake, alcohol consumption, physical activity, frequency of “craving or snacking between meals”, dessert/sweets consumption at lunch. Conclusions. During “Phase 1”, many people faced several negative changes in lifestyle/eating behaviours with potential negative impact on health. These findings highlight that pandemic exacerbates nutritional issues and most efforts need to be done to provide nutrition counselling and public health services to support general population needs.

Download Full-text

Binge Eating and Addictive-Like Behaviours in Males and Females

Psychological Reports ◽

10.1177/0033294120971750 ◽

2020 ◽

pp. 003329412097175

Author(s):

Johanna Levallius ◽

Elin Monell ◽

Andreas Birgegård ◽

David Clinton ◽

Emma Forsén Mantilla

Keyword(s):

Gender Differences ◽

Binge Eating ◽

Disordered Eating ◽

Food Addiction ◽

Community Sample ◽

Eating Behaviours ◽

Compulsive Exercise ◽

Males And Females ◽

Common Behaviour ◽

The Relationship

Introduction Binge eating is a common behaviour that is strongly linked to both obesity and eating disorder. There is evidence that binge eating commonly co-occurs with other problematic and addictive-like behaviours; however, this has not been explored systematically. The present study aimed to examine the relationship between binge eating, body weight, disordered eating behaviours and associated addictive-like behaviours, with particular attention paid to gender differences. Method A community sample ( N = 500; 75% female, Mage = 32.5 years) reported disordered eating behaviours (i.e. binge eating, purging, restriction of eating, compulsive exercise), body mass index (BMI), food addiction, starvation addiction, exercise dependence, tobacco use and alcohol consumption. Results 42% of females and 21% of males reported binge eating during the past four weeks. Binge eating was significantly associated with all investigated behaviours in females, and with purging, compulsive exercise and overweight/obesity in males. Controlling for BMI, self-starvation predicted binge eating in males (OR = 1.07), while food addiction (OR = 1.73) and alcohol dependence (OR = 1.11) predicted binge eating in females. Conclusions The multiple associations between binge eating and addictive-like behaviors supports broad screening and generalized prevention efforts. Prevention efforts should reflect gender differences.

Download Full-text