Intraocular retinoblastoma group V: an analysis of prognostic factors.

1985 ◽  
Vol 3 (5) ◽  
pp. 680-685 ◽  
Author(s):  
C M Rubin ◽  
L L Robison ◽  
J D Cameron ◽  
W G Woods ◽  
M E Nesbit ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prognostic Factors ◽  
Optic Nerve ◽  
Life Table ◽  
Tumor Size ◽  
Large Tumor ◽  
Group V ◽  
Large Tumor Size ◽  
Poor Risk ◽  
Undifferentiated Histology

A retrospective analysis of the University of Minnesota (Minneapolis) experience with retinoblastoma is presented. Seventy-five patients were diagnosed with retinoblastoma between 1958 and 1983, of which 53 (71%) had at least one Reese-Ellsworth group V eye. Nineteen group V patients and one group II patient developed extraocular disease recurrence. The cumulative actuarial rate of recurrence at 12 years was 36% for patients with group V disease. The median time from diagnosis to recurrence for unilateral patients was seven months and for bilateral patients 28 months (P = .001). Patients developing extraocular disease had a 10-year actuarial survival rate postrecurrence of 34%. The four long-term survivors of extraocular recurrences had had isolated orbital or local soft tissue recurrences only. Features of group V patients associated with extraocular recurrences were identified by univariate life table analyses. Clinical poor-risk factors included the nongenetic form of the disease (P = .03) and male sex (P = .02). Pathologic poor risk factors included rubeosis (P = .01), undifferentiated histology (P = .03), large tumor size (P = .05), and intraocular extension to the anterior segment (P = .02), retinal pigment epithelium (P = .03), choroid (P less than .001), and optic nerve beyond the lamina cribrosa (P = .02). Treatment-associated poor-risk factors included an optic nerve length of less than 5 mm removed at enucleation (P = .003). Multivariate life table analyses demonstrated the following parameters to be independent poor-prognostic factors: optic nerve length of less than 5 mm removed at enucleation (P = .001), optic nerve involvement (P = .004), and large tumor size (P = .01). These results will help to identify patients with retinoblastoma who are at greatest risk for extraocular recurrence.

Surgical Management and Prognostic Factors Based on 50 Tectal Plate Gliomas

2020 ◽  
Author(s):  
Jie Kang ◽  
Chuzhong Li ◽  
Peng Zhao ◽  
Chunhui Liu ◽  
Lei Cao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prognostic Factors ◽  
Tumor Size ◽  
Surgical Procedure ◽  
Preoperative Imaging ◽  
Low Grade ◽  
Large Tumor ◽  
Large Tumor Size ◽  
Cystic Changes ◽  
Tectal Glioma

Abstract BackgroundThe management and prognostic factors of tectal glioma (TG) remain ambiguous, because it is an extremely rare neoplasm that occurs predominantly in the pediatric population. The objective of this study was to evaluate the risk factors for progression-free survival (PFS) in TG patients after ETV operation, elucidate the radiological features of TG, and propose a treatment protocol.MethodsFrom 2002 to 2018, 50 patients that preoperative imaging manifestations were low-grade TGs were treated at our institute. Clinical features, treatments, radiologic findings, biopsies, and pertinent risk factors were evaluated.ResultsA total of 50 patients with a diagnosis of TG were identified. Twenty-six (52%) patients were males. The median age at diagnosis was 11.5 years (range 0.5–19 years). All patients had symptoms related to obstructive hydrocephalus and were treated with endoscopic third ventriculostomy (ETV). After a median follow-up duration of 59 months (range 11.0–208.0 months), progression occurred in six patients (12%), with a median PFS time of 18.0 months (range 4.0–56.0 months). Twelve patients (24%) underwent a biopsy, one patient (8.3%) was diagnosed with anaplastic oligodendroglioma, one patient (8.3%) was diagnosed with astrocytoma (WHO grade II-III), five patients (41.7%) were diagnosed with pilocytic astrocytoma, and the type of tumor could not be confirmed in five patients (41.7%) due to the small amount of tumor sample, thus, these patients were diagnosed with gliosis. PFS rates at 1 and 5 years were 91.2% ± 4.2% and 84.9% ± 5.9%, respectively. A multivariate model demonstrated that a large tumor size and cystic changes are risk factors for progression.ConclusionETV has been uniformly successful in the management of hydrocephalus caused by TG. A large tumor size and cystic changes are risk factors for progression. Under the condition of safety, a biopsy should be performed. For patients with low-grade TG, ETV is often the only surgical procedure that most patients require.HighlightsTectal gliomas are generally low-grade gliomas with a favorable prognosis.The only surgical procedure that most patients with tectal glioma require is ETV.Under the condition of safety, neuroendoscopy for a pathological diagnosis should be performed.A large tumor size and cystic changes are risk factors for progression.

scholarly journals Distant metastasis at diagnosis and large tumor size are significant prognostic factors of widely invasive follicular thyroid carcinoma

2013 ◽  
Vol 60 (6) ◽  
pp. 829-833 ◽  
Author(s):  
Yasuhiro Ito ◽  
Mitsuyoshi Hirokawa ◽  
Hiroo Masuoka ◽  
Tomonori Yabuta ◽  
Mitsuhiro Fukushima ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Thyroid Carcinoma ◽  
Distant Metastasis ◽  
Tumor Size ◽  
Follicular Thyroid Carcinoma ◽  
Large Tumor ◽  
Large Tumor Size ◽  
Widely Invasive

Risk Factors of Survival and Surgical Treatment for Advanced Gastric Cancer with Large Tumor Size

2009 ◽  
Vol 13 (5) ◽  
pp. 881-885 ◽  
Author(s):  
Chen Li ◽  
Sung Jin Oh ◽  
Sungsoo Kim ◽  
Woo Jin Hyung ◽  
Min Yan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Surgical Treatment ◽  
Advanced Gastric Cancer ◽  
Tumor Size ◽  
Large Tumor ◽  
Large Tumor Size

Impact of Large Tumor Size on Survival After Resection of Pathologically Node Negative (pN0) Non–Small Cell Lung Cancer

2005 ◽  
Vol 79 (4) ◽  
pp. 1142-1146 ◽  
Author(s):  
Shin-ichi Takeda ◽  
Shimao Fukai ◽  
Hikotaro Komatsu ◽  
Etsuo Nemoto ◽  
Kenji Nakamura ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumor Size ◽  
Small Cell ◽  
Small Cell Lung ◽  
Large Tumor ◽  
Node Negative ◽  
Large Tumor Size

scholarly journals Comparison of Lobectomy and Sublobar Resection for Stage IA Elderly NSCLC Patients (≥70 Years): A Population-Based Propensity Score Matching’s Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Bo Zhang ◽  
Renwang Liu ◽  
Dian Ren ◽  
Xiongfei Li ◽  
Yanye Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Propensity Score ◽  
Tumor Size ◽  
Cox Regression ◽  
Large Tumor ◽  
Cox Regression Analysis ◽  
Large Tumor Size ◽  
Significant Difference ◽  
Stage Ia ◽  
Nsclc Patients

BackgroundTo investigate the differences in survival between lobectomy and sub-lobar resection for elderly stage I non-small-cell lung cancer (NSCLC) patients using the Surveillance, Epidemiology, and End Results (SEER) registry.MethodThe data of stage IA elderly NSCLC patients (≥ 70 years) with tumors less than or equal to 3 cm in diameter were extracted. Propensity-matched analysis was used. Lung cancer-specific survival (LCSS) was compared among the patients after lobectomy and sub-lobar resection. The proportional hazards model was applied to identify multiple prognostic factors.ResultsA total of 3,504 patients met criteria after propensity score matching (PSM). Although the LCSS was better for lobectomy than for sub-lobar resection in patients with tumors ≤ 3 cm before PSM (p < 0.001), no significant difference in the LCSS was identified between the two treatment groups after PSM (p = 0.191). Multivariate Cox regression showed the elder age, male gender, squamous cell carcinoma (SQC) histology type, poor/undifferentiated grade and a large tumor size were associated with poor LCSS. The subgroup analysis of tumor sizes, histologic types and lymph nodes (LNs) dissection, there were also no significant difference for LCSS between lobectomy and sub-lobar resection. The sub-lobar resection was further divided into segmentectomy or wedge resection, and it demonstrated that no significant differences in LCSS were identified among the treatment subgroups either. Multivariate Cox regression analysis showed that the elder age, poor/undifferentiated grade and a large tumor size were a statistically significant independent factor associated with survival.ConclusionIn terms of LCSS, lobectomy has no significant advantage over sub-lobar resection in elderly patients with stage IA NSCLC if lymph node assessment is performed adequately. The present data may contribute to develop a more suitable surgical treatment strategy for the stage IA elderly NSCLC patients.

scholarly journals Large tumor size is a poor prognostic factor of gastric cancer with signet ring cell

Medicine ◽  
2019 ◽  
Vol 98 (40) ◽  
pp. e17367 ◽  
Author(s):  
Liyuan Zhou ◽  
Weihua Li ◽  
Shaoxin Cai ◽  
Changshun Yang ◽  
Yi Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factor ◽  
Tumor Size ◽  
Signet Ring Cell ◽  
Large Tumor ◽  
Poor Prognostic Factor ◽  
Large Tumor Size ◽  
Signet Ring ◽  
Ring Cell

The association between hyperfibrinogenemia and clinicopathological factors, and the survival analysis of gastric cancer.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e16547-e16547
Author(s):  
Yu Su ◽  
Xuecong Zhu ◽  
Jing Zuo ◽  
Fengling Liu ◽  
Yudong Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Size ◽  
Odds Ratio ◽  
Fibrinogen Level ◽  
Large Tumor ◽  
Large Tumor Size ◽  
Node Metastasis ◽  
Advanced Tumor

e16547 Background: It is reported that hyperfibrinogenemia is commonly seen in gastric cancer. This study aim to discuss the association between fibrinogen level and preoperative clinicopathological factors and to evaluate the value as a predictor of prognosis. Methods: Retrospectively reviewed the medical records and follow-up data of patients with gastric cancer who underwent curative resection from January 2011 to December 2014 at Surgery Department of the Fourth Hospital of Hebei Medical University. Fibrinogen was measured a week before the surgery. Results: A total of 248 cases were enrolled. The means±SD of fibrinogen was 3.28±1.06g/L. Fibrinogen level was higher in older adults(≥60y), advanced tumor, poorly differentiated, deep invasion, lymph node metastasis, large tumor size and in those with high CEA, platelet count, albumin, NLR and PLR,( P< 0.05). All the people were divided by the TNM staging system and found that the plasma fibrinogen was higher in stageⅡand Ⅲ (stageⅠvs. stageⅡ: 2.84±0.72g/L vs. 3.36±1.18g/L, P= 0.009;stageⅠvs. stage Ⅲ: 2.84±0.72g/L vs. 3.43±1.07g/L, P< 0.001), however, there was no difference between stageⅡand Ⅲ( P= 0.662)(our study did not enrolled stage IV patients).When patients were classified into 4 groups according to the T classification, the plasma fibrinogen level gradually increased with increasing depth of cancer invasion (one way ANOVA; P= 0.002). Yet, when the patients who have lymph nodes metastasis classified according to the N classification, the differences among them did not have statistically significance ( P= 0.333). Multivariate analysis revealed that hyperfibrinogenemia had an independent association with advanced cancer (odds ratio,2.686(1.012-7.125); P= 0.047), lymph node metastasis (odds ratio,2.012 (1.012-3.125); P= 0.035) and tumor size(odds ratio,1.949 (1.099-3.454); P= 0.022). Our study aslo suggested that the patients with hyperfibrinogenemia before surgery showed a significantly lower survival rate (Log-Rank test; P< 0.001), hyperfibrinogenemia was a independent predictor on the overall survival, which could predict worse clinical outcome. Conclusions: Hyperfibrinogenemia may be considered a useful biomarker to predict advanced tumor, lymph node metastasis and large tumor size and can be a good predictor of worse clinical outcome.

scholarly journals Platelet-to-Lymphocyte Ratio and Large Tumor Size Predict Microvascular Invasion after Resection for Hepatocellular Carcinoma

2018 ◽  
Vol 19 (12) ◽  
pp. 3435-3441 ◽  
Author(s):  
Narongsak Rungsakulkij ◽  
Somkit Mingphruedh ◽  
Wikran Suragul ◽  
Pongsatorn Tangtawee ◽  
Paramin Muangkaew ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Size ◽  
Microvascular Invasion ◽  
Platelet To Lymphocyte Ratio ◽  
Large Tumor ◽  
Large Tumor Size ◽  
Lymphocyte Ratio

scholarly journals Proportion of vulvar premalignant and malignant lesions in overall vulvar specimens in Thailand

2019 ◽  
Vol 12 (6) ◽  
pp. 281-286
Author(s):  
Ananya Trongpisutsak ◽  
Patou Tantbirojn ◽  
Ruangsak Lertkhachonsuk
Keyword(s):  
Tumor Size ◽  
Intraepithelial Neoplasia ◽  
Premalignant Lesions ◽  
Vulvar Intraepithelial Neoplasia ◽  
Large Tumor ◽  
Large Tumor Size ◽  
Malignancy Risk ◽  
Pathologic Features ◽  
Malignant Lesions ◽  
The Common

AbstractBackgroundVulvar lesion is one of the common gynecologic problems.ObjectiveTo assess the proportion of vulvar premalignant and malignant lesions in overall vulvar specimens and to evaluate the clinicopathologic features of each vulvar lesion in King Chulalongkorn Memorial Hospital (KCMH).MethodsPathological microscopic slides and medical records of the patients who underwent vulvar-related operations between January 1, 2002 and December 31, 2015 were reviewed. Patients’ clinical characteristics and pathologic features were evaluated and analyzed.ResultsA total number of 700 patients were included. The proportion of malignant and premalignant lesions in overall vulvar specimens were 16.3% and 8.4%, respectively. Squamous cell carcinoma was the most common malignant vulvar lesion (48.2%), whereas vulvar intraepithelial neoplasia 1 (VIN1) (33.9%) was the most common lesion in the premalignant group. On multivariate analysis, four clinical factors were significantly associated with malignancy risk: increased parity (odds ratio [OR] 1.19, P = 0.010), large tumor size (OR 2.00, P < 0.001), lesion at clitoris (OR 16.67, P = 0.002), and erythematous lesion (OR 2.41, P = 0.026).ConclusionsThe proportion of malignant and premalignant lesions in overall vulvar specimens was 24.7% in KCMH. Increased parity, large tumor size, clitoris-located lesion, and erythematous lesion were associated with increasing malignancy risk.

Sign in / Sign up

Export Citation Format

Share Document