An international study of multitrial data investigating quality of life and symptoms as prognostic factors for survival in different cancer sites.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 6002-6002 ◽  
Author(s):  
Chantal Quinten ◽  
Efstathios Zikos ◽  
Miriam Sprangers ◽  
Eva Greimel ◽  
Francesca Martinelli ◽  
...  
Keyword(s):  
Prognostic Value ◽  
Assessment Tool ◽  
Self Report ◽  
World Health ◽  
Careful Examination ◽  
Cancer Site ◽  
Testis Cancer ◽  
Study Results ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

6002 Background: The prognostic value for survival of HRQOL data derived from self-report questionnaires, has been well documented in cancer research. The objective of this study was to examine the prognostic value of HRQOL parameters for different cancer sites using one standardized and validated patient self-assessment tool. Methods: A total of 11 different cancer sites, pooled from 30 European Organisation for Research and Treatment of Cancer (EORTC) Randomized Controlled Trials (RCTs), were selected for this study. For each cancer site, univariate and multivariate Cox proportional hazard modeling was used to assess the prognostic value (p<0.05) of 15 HRQOL parameters, assessed with the EORTC QLQ-C30 at baseline before randomization, for overall survival. Models were adjusted for the parameters age, gender, distant metastasis, World Health Organization performance status and stratified by clinical study. Results: A total of 7,417 patients completed the EORTC QLQ-C30 before randomization. For brain cancer cognitive functioning (CF) (hazard ratio (HR) =0.95; p<.0001) was prognostic. For breast cancer nausea and vomiting (NV) (HR=1.17; p=0.0011) was a prognostic indicator. For colorectal cancer physical functioning (PF) (HR=0.93; p<.0001), NV (HR=1.07; p<.0001), and appetite loss (AP) (HR=1.07; p<.0001) predicted survival. For esophageal cancer PF (HR=0.88; p=0.0072) and for head and neck cancer NV (HR=1.14; p=0.0097) were prognostic. For lung cancer PF (HR=0.94; p=0.0006) and pain (HR=1.08; p<0.0001), for melanoma dyspnea (HR=1.06; p<.0001), for ovarian cancer NV (HR=1.2; p<.0001), for pancreatic cancer global QOL (HR=0.83; p=0.0073), for prostate cancer role functioning (RF) (HR=0.96; p=0.006) and AP (HR=1.07; p<.0001), and for testis cancer RF (HR=0.81; p=0.0144) were predictors of survival. Conclusions: Our findings show that different HRQOL parameters provide prognostic information for survival for patients with different tumor sites and that no single HRQOL scale can predict survival in all cancer patients. Thus, each cancer site needs careful examination and no single QOL paramenter can predict survival in all cancer diseases.

Health-Related Quality of Life As a Survival Predictor for Patients With Localized Head and Neck Cancer Treated With Radiation Therapy

2009 ◽  
Vol 27 (18) ◽  
pp. 2970-2976 ◽  
Author(s):  
François Meyer ◽  
André Fortin ◽  
Michel Gélinas ◽  
Abdenour Nabid ◽  
François Brochet ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Radiation Therapy ◽  
Head And Neck ◽  
Prognostic Value ◽  
Health Related Quality ◽  
Related Quality ◽  
Eortc Qlq C30 ◽  
Health Related ◽  
Eortc Qlq

Purpose To assess the added prognostic value for overall survival (OS) of baseline health-related quality of life (HRQOL) and of early changes in HRQOL among patients with localized head and neck cancer (HNC) treated with radiation therapy. Patients and Methods All 540 patients with HNC who participated in a randomized trial completed two HRQOL instruments before radiation therapy: the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) and the Head and Neck Radiotherapy Questionnaire. Six months after the end of radiation therapy, 497 trial participants again completed the two HRQOL instruments. During the follow-up, 179 deaths were observed. Multivariate Cox proportional hazards models were used to test whether HRQOL variables, baseline and change, provided additional prognostic value beyond recognized prognostic factors. Results The baseline EORTC QLQ-C30 physical functioning (PF) score was an independent predictor of OS. The hazard ratio (HR) associated with a 10-point increment in baseline PF was 0.87 (95% CI, 0.81 to 0.94). In multivariate models, the change in HRQOL was significantly associated with OS for most HRQOL dimensions. Among these, PF change was the strongest predictor. The magnitude of the association between PF change and survival decreased over time. At 1 year, the HR associated with a positive PF change of 10 points was 0.75 (95% CI, 0.68 to 0.83). After PF is taken into account, no other HRQOL variable was associated with survival. Conclusion Our findings indicate that both baseline PF and PF change provide added prognostic value for OS beyond established predictors in patients with HNC. Assessing HRQOL could help better predict survival of cancer patients.

Assessing financial difficulty in patients with multiple myeloma: Preliminary results of ALLIANCE A231602CD.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 8031-8031
Author(s):  
Rena M. Conti ◽  
Shaylene McCue ◽  
Travis Dockter ◽  
Bruce D. Rapkin ◽  
Stacie Dusetzina ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Primary Objective ◽  
National Study ◽  
Financial Difficulty ◽  
The Past ◽  
Financial Difficulties ◽  
Study Results ◽  
Eortc Qlq C30 ◽  
Chart Abstraction ◽  
Eortc Qlq

8031 Background: New orally administered anticancer treatments have launched in recent years, promising gains in survival and quality of life, but with high prices.Financial difficulties encountered over the course of cancer diagnosis and treatment is a growing concern. These difficulties include inability to pay for basic necessities, presence of medical debt, and high out of pocket burdens relative to income. The primary objective of this study was to estimate the proportion of patients with multiple myeloma (MM) who experience financial difficulties in the past 12 months.Methods: Data collection entailed a comprehensive, theoretically grounded telephone survey and companion medical chart abstraction. Subjects included individuals with a current diagnosis of MM whose current or recent treatment included pharmaceutical-based care and who were not enrolled in a treatment-based trial. Practices eligible to recruit respondents included 44 NCORP affiliates of the Alliance. 14 geographically diverse NCORP affiliates participated between 11/2019 and 6/2020. The primary endpoint of the study was the proportion of subjects who reported financial difficulty in the past 12 months, as measured by the EORTC QLQ-C30 item #28. This proportion and 95% Wilson score confidence interval were estimated for all MM patients who responded to the financial difficulty question ((# reported financial difficulty)/(total # in that category who answered the question)). NCI Central IRB approved this study. Results: 393 subjects were recruited. 304 subjects completed the survey (77.4% response rate). Mean age was 67.5 years (SD 9.8), 143 (46.4%) were female, 24 (7.8%) self-reported race as ‘Black or African American’, 82 (26.6%) reported insured by government insurance Medicare only, 116 (38.2%) reported highest education as high school or below, and 94 (30.5%) reported high income. Mean time from diagnosis to survey enrollment was 3.6 years (SD 4.5). 292 (95.1%) were currently receiving treatment and 192 (62.5%) reported currently receiving a pre-defined ‘expensive’ oral pharmaceutical-based cancer treatment. 20.2% (95% CI:16.1%, 25.0%) reported financial difficulties. Conclusions: This is the first national study to systematically assess the prevalence of financial difficulties and its correlates among MM patients. Approximately 1 in 5 surveyed patients reported financial difficulties. Results of this study aim to inform efforts to improve financial navigation and resources for cancer patients.

Independent prognostic value of the EORTC QLQ-C30 summary score on all-cause mortality: Results from the population-based PROFILES registry.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 10070-10070 ◽  
Author(s):  
Olga Husson ◽  
Belle Hadewijch de Rooij ◽  
Jacobien M Kieffer ◽  
Simone Oerlemans ◽  
Floortje Mols ◽  
...  
Keyword(s):  
Prognostic Value ◽  
Population Based ◽  
Summary Score ◽  
All Cause Mortality ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

Understanding Distress Among Patients With Cancer Receiving Specialized, Supportive Care Services

2020 ◽  
Vol 37 (10) ◽  
pp. 830-836 ◽  
Author(s):  
Rachel Funk-Lawler ◽  
Katie Rider Mundey
Keyword(s):  
Supportive Care ◽  
Assessment Tool ◽  
Care Service ◽  
Self Report ◽  
Support Providers ◽  
Care Clinic ◽  
Patients With Cancer ◽  
Care Services ◽  
Study Results ◽  
Outpatient Supportive Care

Background: Cancer and its treatment can cause persistent psychosocial consequences for patients. Although distress among the general cancer population has been well studied, many patients who report high distress do not receive specialty, follow-up care. We know little about the distress needs of those who attend appointments with support services. Improved knowledge of this subpopulation of patients with cancer may improve supportive care service delivery. Methods: This is a descriptive chart review that examines results from a cancer distress tool in an outpatient supportive care clinic and explores factors associated with distress among patients who attend an appointment for support beyond usual oncologic care. All adult patients with a cancer diagnosis presenting to the supportive care clinic during a 120-day period for an initial intake completed a self-report needs assessment tool. A review of medical records was then conducted. Primarily descriptive statistics, mean comparison, and correlational analysis summarized the data. Results: Nearly 48% of individuals rated very severe distress in at least one area of functioning. Areas with the highest average distress ratings included pain, fatigue, sleep, and anxiety. No significant associations were found between total distress scores and demographic or illness-related variables. Anxiety and depression were higher among those scheduled to see a behavioral health specialist than a palliative provider. Conclusions: Patient and illness factors were not associated with needs among those who attended appointments with support providers. Study results suggest that a biopsychosocial approach from interdisciplinary providers is warranted to manage the needs of patients referred for additional supportive care.

scholarly journals Dysphagia, voice problems, and pain in head and neck cancer patients

2021 ◽  
Author(s):  
Veit Zebralla ◽  
Gunnar Wichmann ◽  
Markus Pirlich ◽  
Carola Hammermüller ◽  
Thomas Berger ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Assessment Tool ◽  
Emotional Quality ◽  
Eortc Qlq C30 ◽  
Important Symptom ◽  
The Mean ◽  
Eortc Qlq ◽  
The Impact

Abstract Purpose Head and neck cancer (HNC) and its treatment can leave devastating side effects with a relevant impact on physical and emotional quality of life (QoL) of HNC patients. The objectives were to examine the amount of dysphagia, voice problems, and pain in HNC patients, the impact of sociodemographic, behavioral, and clinical factors on these symptoms, the psychometric properties of the EAT-10, and the relationship between these symptoms and QoL variables. Methods HNC patients attending for regular follow-up from 07/2013 to 09/2019 completed questionnaires (Eating Assessment Tool-10 (EAT-10); questions from the EORTC QLQ-C30 and EORTC H&N35) on dysphagia, voice problems, pain, fatigue, and QoL collected with the software OncoFunction. Associations between prognostic factors and symptoms were tested with analyses of variance (ANOVAs). Associations between the symptom scales and QoL variables were expressed with Pearson correlations. Results Of 689 patients, 54.9% suffered from dysphagia, the EAT-10 proved to be a reliable measure. The mean voice score was 37.6 (± 33.9) [range 0–100], the mean pain score 1.98 (± 2.24) [range 0–10]. Trimodality treatment was associated with the highest dysphagia scores. Dysphagia, voice problems, and pain significantly correlated with each other, the highest association was found for dysphagia and pain (r = 0.51). QoL was strongly correlated with dysphagia and pain (r = − 0.39 and r = − 0.40, respectively), while the association with voice problems was weaker (r = − 0.28). Conclusion Dysphagia is an important symptom in HNC patients greatly affecting patients’ QoL and significantly correlating with voice problems and pain.

scholarly journals WHO ICF as an Assessment Tool For Evaluation of Selfcare Activities of the Child With Cerebral Palsy

2021 ◽  
Vol 3 (1) ◽  
pp. 49-65
Author(s):  
Mery Avetisyan
Keyword(s):  
Cerebral Palsy ◽  
Quantitative Methods ◽  
Assessment Tool ◽  
Numerical Models ◽  
World Health ◽  
International Classification Of Functioning ◽  
Study Results ◽  
Self Service ◽  
Objective Basis ◽  
Health Organization

The study was conducted in two stages. At the first stage, quantitative methods were chosen as methodologies, since the object that is studied by this method is a quantitative unit, which in the future allows to draw conclusions, based on the results, using certain numerical models to develop or confirm new hypotheses, or/and refute existing ones. At the second stage, a qualitative study was conducted on the basis of the results of the first stage, accordingly developing recommendations on ergotherapy for each code issue. According to the study results, in today's Armenia, it is possible to issue all the problems that children with Cerebral Palsy face in self-care and life by using certain assessing tools of occupational therapy. In this case, the study shows that the evaluation of the World Health Organization International Classification of Functioning and Disability, Children and Youth (2008) allows to observe and issue the existing problems of this sphere in a more accurate and comprehensive way․ It also provides an objective basis for identifying the problems in the field of children's self-service and life, which, in its turn, allows the occupational therapist to conduct a detailed assessment to find out which self-service actions are available to the child, to what extent the child’s actions and personal roles are compatible with the current state of the disease, and to what extent the actions correspond to their age.

scholarly journals Psychometric Properties of the Obsessive-compulsive Inventory: The Persian Child Version; a Preliminary Study

2021 ◽  
Vol 7 (4) ◽  
pp. 209-215
Author(s):  
Adele Isanazar ◽  
◽  
Mahnaz Fallahi-Khesht Masjedi ◽  
Robabeh Soleimani ◽  
Fatemeh Eslamdoust-Siahestalkhi ◽  
...  
Keyword(s):  
Psychometric Properties ◽  
Correlation Coefficient ◽  
Assessment Tool ◽  
Pearson Correlation ◽  
Self Report ◽  
Pearson Correlation Coefficient ◽  
Obsessive Compulsive ◽  
Cronbach Alpha ◽  
Compulsive Disorder ◽  
Study Results

Background: The Obsessive-Compulsive Inventory-Child Version (OCI-CV) is an approved self-report assessment tool that includes various domains of Obsessive-Compulsive Disorder (OCD). Objectives: This study was done to evaluate the psychometric properties of the OCI-CV in a sample of youth with OCD. Materials & Methods: This was a descriptive-analytic study. The subjects were 107 children and adolescents, 7 to 17 years old admitted to the Shafa hospital and Gill psychiatric center in the north of Iran in 2017-2018. The subjects with the diagnosis of OCD based on a diagnostic interview by a youth psychiatrist based on the DSM-5 were included in the study. They were assessed by the OCI-CV, Revised Children’s Manifest Anxiety Scale (RCMAS), and children depression inventory (CDI). Data were analyzed by SPSS v. 22, using Cronbach alpha, Pearson correlation coefficient, and exploratory factor analysis. Results: Youth with the Mean±SD age 11.18±3.1 years participated in the study. Results showed that 51% of the samples were girls. The internal consistency assessed by the Cronbach alpha for the total scale was 0.75, indicating good reliability. The Pearson correlation coefficient between OCI-CV and RCMAS was 0.584 (P=0.01), and between OCI-CV and CDI was 0.232 (P=0.05), showing an excellent concurrent validity. Construct validity showed that all subscales had a high correlation with the total score of the questionnaire and the correlation coefficient was significant (P<0.05). Conclusion: The Persian version of the OCI-CV has good psychometric characteristics in the clinical sample of youth with OCD.

Investigating Personality and Psychopathology in Patients With Psoriasis

2017 ◽  
Vol 38 (2) ◽  
pp. 87-107 ◽  
Author(s):  
Chiara Vari ◽  
Patrizia Velotti ◽  
Alessandro Crisi ◽  
Silvana Carlesimo ◽  
Antonio G. Richetta ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Clinical Importance ◽  
Self Report ◽  
Psychological Issues ◽  
Self Evaluation ◽  
Affective Quality ◽  
Millon Clinical Multiaxial Inventory ◽  
Study Results ◽  
Completion Test ◽  
Skin Conditions

Abstract. A broad range of literature reported higher rates of psychopathology and personality disorders among patients affected by skin conditions. Specifically, depression, anxiety, and suicidal ideations are more frequently reported by patients affected by skin diseases. This study aimed to examine psychopathology and personality in a group of patients affected by psoriasis by means of a self-report measure (Millon Clinical Multiaxial Inventory – MCMI-III) and a performance-based technique (Wartegg Drawing Completion Test [WDCT], CWS). Study results showed a higher rate of passive-aggressiveness and paranoia among psoriatic patients (MCMI-III). When assessing patients through the performance-based technique (WDCT, CWS), a higher rate of global rejection (GR) – linked by previous literature to suicidal ideation – and a lower affective quality of the drawings emerged. We discuss the clinical importance of detecting psychological issues in dermatology patients by means of a multimethod assessment that goes beyond patients’ self-evaluation of their symptoms and emotions.

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