Stress biomarkers in advanced cancer patients experiencing the pain, fatigue, sleep disturbance symptom cluster.

2015 ◽  
Vol 33 (29_suppl) ◽  
pp. 5-5 ◽  
Author(s):  
Kristine L Kwekkeboom ◽  
Erin S. Costanzo ◽  
Toby Christopher Campbell
Keyword(s):  
Sleep Disturbance ◽  
Advanced Disease ◽  
Metastatic Cancer ◽  
Small Sample ◽  
Symptom Cluster ◽  
Alpha Amylase ◽  
Advanced Cancer Patients ◽  
Specific Symptom ◽  
Salivary Alpha Amylase ◽  
Stress Biomarkers

5 Background: Cancer symptom clusters such as co-occurring pain, fatigue, and sleep disturbance, are common and debilitating for patients with advanced disease. Stress-related neuorendocrine system alterations are thought to play a significant role in symptom co-occurrence. While studies have documented relationships between stress biomarkers and symptoms in persons with cancer, few have done so in the context of a specific symptom cluster or among persons receiving treatment for advanced disease. Objectives: This preliminary analysis describes biomarkers of neuroendocrine stress systems – salivary cortisol and salivary alpha amylase (sAA) – and their relationship with the pain, fatigue, sleep disturbance symptom cluster in cancer. Methods: We analyzed baseline data from 14 participants of a RCT of a cognitive-behavioral symptom cluster intervention. Participants were receiving chemotherapy for recurrent or metastatic cancer. The sample was largely female (93%), aged 50-74 years old (M=63.57), with lung (57%), breast (14%), GYN (22%) or prostate (7%) cancer. Participants reported symptom cluster severity and collected saliva over two days prior to a new chemotherapy cycle. Cortisol concentrations were determined by luminescence immunoassay and salivary alpha-amylase by enzyme kinetic reaction assay using standardized kits (Salimetrics, State College, PA). Results: Mean (SD) cortisol and sAA levels were within normal range and followed typical diurnal patterns (Table 1); although evening levels of cortisol appeared higher in this sample compared to those of healthy adults. Low to moderate observed correlations between symptom cluster severity and stress biomarkers (evening cortisol r = -.204; evening sAA r = .326) were not significant in this small sample. Conclusions: Elevated evening cortisol levels may suggest dysregulation of the stress response in this population. The ongoing study will further evaluate if alterations in neuroendocrine function contribute to the symptom cluster experience. Clinical trial information: NCT01954420. [Table: see text]

scholarly journals Evaluation of hormonal profile and some stress biomarkers in infertile couples in Abuja, Nigeria

2020 ◽  
Vol 8 (4) ◽  
pp. 1514
Author(s):  
Simon P. Abriba ◽  
Humphrey B. Osadolor
Keyword(s):  
Alpha Amylase ◽  
Serum Prolactin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Sperm Cells ◽  
Study Group ◽  
Salivary Alpha Amylase ◽  
Hormonal Profile ◽  
Stress Biomarkers ◽  
Infertile Couples

Background: Infertility is a growing gynaecological problem in couples of childbearing age having difficulties bearing children. Couples with infertility are known to present with high levels of stress and psychopathology A cross sectional case control study aimed at evaluating the hormonal profile, some stress biomarkers, sperm analysis in infertile couples was carried out to ascertain their contributions to infertility in couples of child bearing age.Methods: Serum Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Prolactin, Progesterone, Estrogen (E2), Testosterone, Salivary Cortisol and Salivary Alpha Amylase were evaluated using both competitive and non-competitive Enzyme Linked Immunosorbent Assay (ELISA) techniques; while sperm cells analysis were evaluated using conventional methods, in 164 infertile couples (study) and 100 fertile couples (control) attending fertility clinic in General Hospitals in Abuja, Nigeria.Results: The mean serum Prolactin and Salivary (S) Cortisol in the female were significantly higher (p<0.05) in the study group relative to the control group, while Salivary Alpha Amylase and LH show no significant difference (p>0.05) between the two groups. FSH, Progesterone and E2 in the female were significantly lower in the study group (p<0.05) compared with control group. Testosterone, FSH, Sperm cells count and Sperm activity (%) were significantly lower (p<0.05) in the male study group relative to the control group; while prolactin, S. cortisol and S. amylase were significantly higher (p<0.05) in the male study group relative to the control group. Conclusions: Abnormal hormones values and abnormal sperm quality and quantity are associated with elevated stress biomarkers in couples presenting with infertility. Strong positive correlations exist between hormones and stress biomarker in infertility conditions.

Combination of AST to ALT and neutrophils to lymphocytes ratios as predictors of locally advanced disease in patients with bladder cancer subjected to radical cystectomy: Results from a single-institutional series

2021 ◽  
pp. 039156032110351
Author(s):  
Alessandro Uleri ◽  
Rodolfo Hurle ◽  
Roberto Contieri ◽  
Pietro Diana ◽  
Nicolòmaria Buffi ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Advanced Disease ◽  
Independent Predictor ◽  
Small Sample Size ◽  
Statistical Significance ◽  
Locally Advanced ◽  
Small Sample ◽  
Locally Advanced Disease ◽  
Increased Risk

Background: Bladder cancer (BC) staging is challenging. There is an important need for available and affordable predictors to assess, in combination with imaging, the presence of locally-advanced disease. Objective: To determine the role of the De Ritis ratio (DRR) and neutrophils to lymphocytes ratio (NLR) in the prediction of locally-advanced disease defined as the presence of extravescical extension (pT ⩾ 3) and/or lymph node metastases (LNM) in patients with BC treated with radical cystectomy (RC). Methods: We retrospectively analyzed clinical and pathological data of 139 consecutive patients who underwent RC at our institution. Logistic regression models (LRMs) were fitted to test the above-mentioned outcomes. Results: A total of 139 consecutive patients underwent RC at our institution. Eighty-six (61.9%) patients had a locally-advanced disease. NLR (2.53 and 3.07; p = 0.005) and DRR (1 and 1.17; p = 0.01) were significantly higher in patients with locally-advanced disease as compared to organ-confined disease. In multivariable LRMs, an increasing DRR was an independent predictor of locally-advanced disease (OR = 3.91; 95% CI: 1.282–11.916; p = 0.017). Similarly, an increasing NLR was independently related to presence of locally-advanced disease (OR = 1.28; 95% CI: 1.027–1.591; p = 0.028). In univariate LRMs, patients with DRR > 1.21 had a higher risk of locally advanced disease (OR = 2.83; 95% CI: 1.312–6.128; p = 0.008). Similarly, in patients with NLR > 3.47 there was an increased risk of locally advanced disease (OR = 3.02; 95% CI: 1.374–6.651; p = 0.006). In multivariable LRMs, a DRR > 1.21 was an independent predictor of locally advanced disease (OR = 2.66; 95% CI: 1.12–6.35; p = 0.027). Similarly, an NLR > 3.47 was independently related to presence of locally advanced disease (OR = 2.24; 95% CI: 0.95–5.25; p = 0.065). No other covariates such as gender, BMI, neoadjuvant chemotherapy or diabetes reached statistical significance. The AUC of the multivariate LRM to assess the risk of locally advanced disease was 0.707 (95% CI: 0.623–0.795). Limitations include the retrospective nature of the study and the relatively small sample size.

Inhaled Salmeterol Induces Salivary Alpha Amylase Activity in Healthy Subjects

2015 ◽  
Vol 135 (2) ◽  
pp. AB4
Author(s):  
Andrea A. Pappalardo ◽  
Sherlyana Surja ◽  
Caitlin M. Campion ◽  
Sarah J. Aldrich ◽  
James N. Moy
Keyword(s):  
Healthy Subjects ◽  
Amylase Activity ◽  
Alpha Amylase ◽  
Salivary Alpha Amylase

scholarly journals Gender Differences in Salivary Alpha Amylase Responses to Exercise

2013 ◽  
Vol 28 (4) ◽  
pp. 451-455
Author(s):  
Kayoko SHIRAIWA ◽  
Izumi NAGATANI ◽  
Satoshi TANAKA
Keyword(s):  
Gender Differences ◽  
Alpha Amylase ◽  
Salivary Alpha Amylase

Salivary alpha‐amylase and hormones levels of young adults with different body composition

2019 ◽  
Vol 50 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Bárbara de Lima Lucas ◽  
Taís de Souza Barbosa ◽  
Paula Midori Castelo ◽  
Maria Beatriz Duarte Gavião
Keyword(s):  
Young Adults ◽  
Body Composition ◽  
Alpha Amylase ◽  
Salivary Alpha Amylase

scholarly journals SALIVARY ALPHA-AMYLASE AS A MEASURE OF ANXIETY BEFORE AND AFTER DENTAL TREATMENT FOR VISUALLY AND HEARING-IMPAIRED CHILDREN AND THEIR MOTHERS

2018 ◽  
Vol 9 ◽  
pp. 128
Author(s):  
Eka S Shofiyah ◽  
Margaretha Sovaria ◽  
Mochamad F Rizal ◽  
Sarworini B Budiardjo
Keyword(s):  
Dental Treatment ◽  
Post Treatment ◽  
Hearing Impaired ◽  
Alpha Amylase ◽  
Hearing Impairments ◽  
Waiting Room ◽  
Salivary Alpha Amylase ◽  
Before And After ◽  
Impaired Children ◽  
Hearing Impaired Children

Objective: Visual and hearing impairments are known to profoundly affect children’s psychological development, including their anxiety. However, strong emotional relationship with their mother found in these children may help them cope. Measuring salivary alpha-amylase (sAA) in saliva samples is widely used in clinical settings as a reliable, non-invasive biomarker of anxiety level.Methods: Our objective was to evaluate sAA levels in visually and hearing-impaired children and their mothers before and after dental treatment. This study included 60 children with visual and hearing impairments and their mothers. sAA level of both children and mothers was sampled while they were together in the waiting room before treatment. The children then underwent dental prophylaxis in a separate room, and their post-treatment sAA was measured immediately afterward. At that time, their mother’s post-treatment sAA was sampled in the waiting room. Data were analyzed using a Wilcoxon test.Results: sAA levels were found to differ significantly between pre- and post-dental treatment (p<0.05).Conclusion: This difference indicates that reducing maternal anxiety would be of great benefit in reducing anxiety in visually and hearing-impaired children. Practical implications: Appropriately managing anxiety in this group of children can be of great benefit to dentists in daily practice, helping them provide the care that these children need.

scholarly journals CORRELATION BETWEEN WONG-BAKER FACES PAIN SCALE AND SALIVARY ALPHA-AMYLASE LEVEL IN CHILDREN AGED 6–11 YEARS

2018 ◽  
Vol 9 ◽  
pp. 133
Author(s):  
Hastin Dian Anggraeni ◽  
Margaretha Suharsini ◽  
Ike Siti Indiarti ◽  
Faraghea Yumasdhika
Keyword(s):  
Pain Intensity ◽  
Local Anesthetic ◽  
Extraction Procedure ◽  
Pain Scale ◽  
Alpha Amylase ◽  
Primary Tooth ◽  
Amylase Level ◽  
Salivary Alpha Amylase ◽  
Local Anesthetic Injection ◽  
Spearman’S Correlation

Objective: Several studies have tried to objectively assess pain measurements. The Wong-Baker Faces Pain Scale (WBFPS) is an instrument that is commonly used to assess pain intensity in children. This study aimed to analyze the correlation between the WBFPS and salivary alpha-amylase (SAA) level during a tooth extraction procedure with a local anesthetic injection in children aged 6–11 years.Methods: Twenty-five children aged 6–11 years who were to undergo the extraction of a primary tooth at the Dental and Oral Educational Hospital, Faculty of Dentistry Universitas Indonesia, were enrolled in this study. From all children, saliva was collected using a disposable saliva strip shortly after local anesthetic injection, and the SAA activity was then determined using a portable Nipro Cocoro Meter device. The WBFPS was measured at the same time. The correlation between the WBFPS and the SAA level was analyzed using Spearman’s correlation test. The statistically significant level was set at p≤0.05.Results: There was a significant correlation between the WBFPS and SAA level (p=0.002, r=0.581).Conclusion: Our data suggest that the SAA level might be a good index for objective pain intensity assessment.

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