scholarly journals Soft Tissue and Uterine Leiomyosarcoma

2018 ◽  
Vol 36 (2) ◽  
pp. 144-150 ◽  
Author(s):  
Suzanne George ◽  
César Serrano ◽  
Martee L. Hensley ◽  
Isabelle Ray-Coquard
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Treatment Options ◽  
Uterine Sarcoma ◽  
The Body ◽  
Current Understanding ◽  
Uterine Leiomyosarcoma ◽  
Shed Light

Leiomyosarcoma (LMS) is one of the most common subtypes of soft tissue sarcoma in adults and can occur in almost any part of the body. Uterine leiomyosarcoma is the most common subtype of uterine sarcoma. Increased awareness of this unique histology has allowed for the development of drugs that are specific to LMS and has begun to shed light on the similarities and possible unique aspects of soft tissue and uterine LMS. In this review, we summarize the current understanding of the epidemiology, diagnosis, genomics, and treatment options for LMS.

scholarly journals Clinicopathological study of soft tissue sarcoma-retrospective study of tertiary cancer institute in eastern India

2020 ◽  
Vol 8 (11) ◽  
pp. 4075
Author(s):  
Kunhi Mohammed K. P. ◽  
Snehasis Pradhan ◽  
Supratim Bhattacharyya ◽  
Prafulla Kumar Das ◽  
Muhammed Navas N. K.
Keyword(s):  
Retrospective Study ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Malignant Tumors ◽  
Soft Tissue Sarcomas ◽  
The Body ◽  
Female Ratio ◽  
Pleomorphic Sarcoma ◽  
Frequent Variety ◽  
Male To Female

Background: Soft tissue sarcomas are a rare and heterogeneous group of malignant tumors of mesenchymal origin that comprise less than 1 percent of all adult malignancies. Although they occur anywhere in the body, they involve most commonly in extremities, trunk, retroperitoneum and head and neck. The aim of the study was to analyze clinical and histopathological features of various soft tissue sarcomas.Methods: This was a retrospective study, conducted in tertiary cancer centre in Odisha during the period 2015 to 2018. We collected clinical parameters like age, sex, site of swelling, any associated pain and biopsy reports and these variables were correlated with final histopathology reports.Results: A total of 107 patients were included in the study, with male to female ratio of 2:1(71 and 36) and average age of 43.45 years. All of them presented with a swelling. The lower extremities were the most common sites i.e. 44.62%. Pleomorphic sarcoma was the most frequent histologic variety comprising 43% and less frequent variety were angiosarcoma, and myxoid sarcoma.Conclusions: Soft tissue sarcoma are predominant in males and middle aged population are frequently affected. Most common affected site is lower extremity and pleomorphic sarcoma is the prominent histologic type.

Primary Salivary Rhabdomyosarcoma in Childhood: A Rare Presentation

2021 ◽  
Author(s):  
Imane Mbarki
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Parotid Gland ◽  
Head And Neck ◽  
The Body ◽  
Rare Presentation

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood. It is originated from embryonic mesenchyma and can arise anywhere in the body. Head and neck location accounts for 35% of all RMC locations. The parotid gland is very rarely affected. Because of this infrequent occurrence and the multiplicity of therapeutic means of management, we report a case a 5-year-old child which was diagnosed as parotid RMS.

Listening to the Musicking Body

2018 ◽  
pp. 417-436
Author(s):  
Youn Kim
Keyword(s):  
Human Body ◽  
Auditory Perception ◽  
The Body ◽  
Current Understanding ◽  
Historical Changes ◽  
The Past ◽  
Late Nineteenth ◽  
Shed Light

Listening is generally discussed in connection with auditory perception, with the ear as the primary perceptual organ. Recently, however, more comprehensive approaches are being emphasized along with the need to understand listening in the context of cultural and historical changes. This chapter investigates the plasticity of the idea of listening, both across disciplines and across historical contexts. By engaging with various discourses on seeing, hearing, and kinesthetics in the late nineteenth and early twentieth centuries, the present chapter examines how a holistic conceptualization of listening that goes beyond the ear and functions in the context of the whole human body emerged and argues how understanding the past can shed light on the current understanding of music and the body.

scholarly journals Advanced soft-tissue sarcoma and treatment options: critical appraisal of trabectedin

2016 ◽  
Vol Volume 8 ◽  
pp. 95-104 ◽  
Author(s):  
Winette van der Graaf ◽  
Ingrid Desar ◽  
Anastasia Constantinidou ◽  
Suzanne Kaal ◽  
Robin Jones
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Critical Appraisal ◽  
Treatment Options ◽  
Advanced Soft Tissue Sarcoma

scholarly journals Reconstruction and Financial Remuneration Following Soft Tissue Sarcoma Surgery

2013 ◽  
Vol 95 (5) ◽  
pp. 160-162 ◽  
Author(s):  
S Hassan ◽  
J Gale ◽  
AGB Perks ◽  
A Raurell ◽  
RU Ashford
Keyword(s):  
Soft Tissue ◽  
Treatment Options ◽  
Soft Tissue Sarcomas ◽  
Clinical History ◽  
The Body ◽  
Complex Nature ◽  
Triple Assessment ◽  
Diagnostic Biopsy ◽  
Long Term Follow Up ◽  
The Uk

Soft tissue sarcomas are relatively uncommon, with approximately 3,200 new cases per year in the UK, accounting for 1% of all malignancies. They are a heterogeneous group of malignancies that occur anywhere in the body, and arise from the mesenchyme inclusive of muscle, endothelial cells, cartilage and supporting elements. Diagnosis is based on triple assessment with clinical history, imaging and diagnostic biopsy. Histological stage and grade is based on the Trojani classification. Owing to their complex nature, a specialist sarcoma multidisciplinary team (MDT) manages patients. Treatment options include one or more of surgery with wide or planned marginal excision, isolated limb perfusion, chemotherapy or radiotherapy. Long-term follow-up to rule out recurrence of disease is mandatory.

scholarly journals Study of soft tissue sarcomas over a period of 3 years

2017 ◽  
Vol 5 (6) ◽  
pp. 2678 ◽  
Author(s):  
Jenna Prabhakar ◽  
J. Sushma ◽  
B. V. S. Kartheek ◽  
A. Bhagya Lakshmi ◽  
Chapara Vaibhav
Keyword(s):  
Soft Tissue ◽  
Health Education ◽  
Soft Tissue Sarcoma ◽  
Treatment Options ◽  
Survival Rates ◽  
Soft Tissue Sarcomas ◽  
Mesenchymal Cell ◽  
Histological Type ◽  
Treatment Modalities ◽  
Site Distribution

Background: Soft tissue malignancies constituted a heterogeneous group of rare solid tumors of mesenchymal cell origin with distinct clinical and pathological features. The aim of the study was to know the prevalence of soft tissue sarcoma, sex, age and site distribution, histopathology and various treatment options adopted with follow up.Methods: A total of 26 cases of soft tissue sarcoma were analyzed for a three-year period. Clinical presentation, age and sex distribution, histological type and treatment modalities adopted were recorded and analyzed.Results: Out of 26 cases 44% of cases were between 30-50 years and 44% of tumors were situated in lower extremity. The commonest histological type was liposarcomas and fibrosarcoma. Lymph node metastasis was seen in 4% of cases. Distant metastasis was present in 3 cases, 2 with lung metastasis and l with lung and liver metastasis. Surgery was the main modality of the treatment. 12% of the cases presented with recurrent tumor, the duration between surgery and recurrence was 6 months. Only 38% turned for follow up, 2 patients succumbed to death because of multiple pulmonary secondaries and chest infections.Conclusion: In the present study, all the cases of soft tissue sarcoma presented in late stage of the disease due to illiteracy and lack of health education. Recurrence was seen in 12% of cases. The overall survival rates and quality of life of the patients can be improved by frequent health camps at primary health centers for early detection of the disease, providing adequate health education, diagnostic and management facilities.

Surgical Management of Extremity and Truncal Sarcoma

2017 ◽  
Author(s):  
Christina L Roland ◽  
Janice N Cormier
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Treatment Approach ◽  
Multidisciplinary Treatment ◽  
Survival Rates ◽  
Soft Tissue Sarcomas ◽  
The Body ◽  
Wide Resection ◽  
Staging Surgery

Soft tissue sarcomas are a heterogeneous group of neoplasms that arise throughout the body, but most commonly in the extremity and trunk. A multidisciplinary treatment approach has resulted in local control rates exceeding 90% and 5-year survival rates exceeding 70%. For patients with localized soft tissue sarcoma, limb-sparing surgical resection is the mainstay of therapy, with radiation therapy and chemotherapy used as adjuncts to reduce local and distant recurrences. Amputation is reserved for patients with primary or recurrent tumors that cannot be grossly resected with a limb-sparing procedure and preservation of function, which should occur in less than 5% of patients. Most patients who die of soft tissue sarcoma die of metastatic disease, which becomes evident within 2 to 3 years of initial diagnosis in 80% of cases, highlighting the need for improved systemic therapy options and optimal treatment at the time of diagnosis. This review contains 13 figures, 4 tables and 53 references Key words: amputation, multimodality, radiation therapy, soft tissue sarcoma, staging, surgery, treatment, wide resection  

Efficacy of temozolomide in pretreated patients with metastatic sarcoma.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e23550-e23550
Author(s):  
Nail Paksoy ◽  
Izzet Dogan ◽  
Meltem Ekenel ◽  
Mert Basaran
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Metastatic Disease ◽  
De Novo ◽  
Treatment Options ◽  
Palliative Radiotherapy ◽  
Progression Free Survival ◽  
Primary Treatment Modality ◽  
Heavily Pretreated ◽  
Metastatic Sarcoma

e23550 Background: Sarcoma is a rare heterogeneous group malignancy and most commonly arises from soft tissue. The primary treatment modality is surgery. However, in metastatic disease, treatment options are limited. Cytotoxic chemotherapy is preferred for palliative treatment. This study aimed to assess the efficacy of temozolomide in heavily pretreated soft tissue sarcoma. Methods: We evaluated the patients with a metastatic various types of soft tissue sarcoma retrospectively. The patients with gastrointestinal stromal tumors and bone sarcomas were excluded from the study. We recorded the clinical, pathological, and treatment data of the patients. SPSS 25v was used for statistical analysis. Survival analysis was performed with the Kaplan-Meier method. Results: Sixteen patients were included in this study. The median age was 48 (range, 21-73) years. Six (37.5%) patients were de-novo metastatic. Tumor localizations were intra-abdominal (43.8%), extremity (31.2%), intrathoracic (12.5%), and head-and-neck (12.5%). The most common metastatic sites were lung (75%), bone (31.8%), liver (18.8%), respectively. For metastatic disease, the patients received at least two different chemotherapy regimens (75%), pazopanib (50%) and palliative radiotherapy (31.3%). Metastasectomy was also performed on five (31.3%) patients. Median progression-free survival was 3.5 (95% CI, 2.6-4.3) months. Partial response was observed in one (6.3%) patients, stable disease in four (25 %) patients. Eleven (68.8%) patients had progressive disease. Grade 1-2 adverse events were observed in nine (56.3%) patients, grade 3-4 in one (6.3%) patients. Conclusions: We showed that temozolomide was well-tolerated but had a limited efficacy for the treatment of patients with metastatic sarcoma. Treatment options for metastatic sarcomas are limited. Temozolomide may be considered a treatment option in patients with heavily pretreated soft tissue sarcoma.

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