Abdominal obesity and risk for esophageal cancer: A nationwide population-based cohort study of South Korea.

446 Background: The relationship between overall obesity, as measured by body mass index (BMI), and risk of esophageal squamous cell carcinoma (ESCC) has been reported, and it has a negative correlation. However, the relationship with abdominal obesity, as measured by waist circumference, may be different. We investigated the association between abdominal obesity and ESCC. Methods: Retrospective cohort study with 22,809,722 individuals who had undergone regular health check-ups provided by the National Health Insurance Corporation between 2009 and 2012 (median follow-up period was 6.4 years) in South Korea. Abdominal obesity was defined as a waist circumference over 90 cm for men and 85 cm for women. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) using Chi-squared test and Cox proportional hazard model adjusted for confounding factors. Primary outcome was newly developed esophageal cancer. Results: After adjusting for BMI, abdominal obesity increased the risk of ESCC (HR 1.29, 95% CI 1.23–1.36). Waist circumference is associated with increased risk of ESCC in a dose-dependent manner ( P for trend < 0.0001). We analyzed individuals divided into five categories of BMI. Among individuals with overweight (BMI 23–24.9 kg/m2) and obese I (BMI 25–29.9 kg/m2), abdominal obesity was a risk factor associated with developing ESCC (HR 1.22, 95% CI 1.11–1.34; HR 1.28, 95% CI 1.18–1.39, respectively). Conclusions: Abdominal obesity, not BMI itself, is associated with an increased risk for ESCC. Therefore, reducing abdominal obesity may affect decreasing the development of ESCC.

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Abdominal obesity increases risk for esophageal cancer: a nationwide population-based cohort study of South Korea

Journal of Gastroenterology ◽

10.1007/s00535-019-01648-9 ◽

2019 ◽

Vol 55 (3) ◽

pp. 307-316

Author(s):

Jae Ho Cho ◽

Cheol Min Shin ◽

Kyung-Do Han ◽

Hyuk Yoon ◽

Young Soo Park ◽

...

Keyword(s):

Esophageal Cancer ◽

Cohort Study ◽

South Korea ◽

Abdominal Obesity ◽

Population Based

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Mo1724 – Metabolic Syndrome is Associated with Increased Risk of Esophageal Cancer : A Nationwide Population-Based Cohort Study of South Korea

Gastroenterology ◽

10.1016/s0016-5085(19)39008-0 ◽

2019 ◽

Vol 156 (6) ◽

pp. S-821

Author(s):

Dong Ho Lee ◽

Dong Jin Song ◽

Cheol Min Shin ◽

Kyungdo Han ◽

Jae Ho Cho ◽

...

Keyword(s):

Metabolic Syndrome ◽

Esophageal Cancer ◽

Cohort Study ◽

South Korea ◽

Population Based ◽

Increased Risk

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The relationship between drinking alcohol and esophageal, gastric or colorectal cancer: A nationwide population-based cohort study of South Korea

PLoS ONE ◽

10.1371/journal.pone.0185778 ◽

2017 ◽

Vol 12 (10) ◽

pp. e0185778 ◽

Cited By ~ 31

Author(s):

Yoon Jin Choi ◽

Dong Ho Lee ◽

Kyung-Do Han ◽

Hyun Soo Kim ◽

Hyuk Yoon ◽

...

Keyword(s):

Colorectal Cancer ◽

Cohort Study ◽

South Korea ◽

Population Based ◽

Drinking Alcohol ◽

The Relationship

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Risk of Heart Disease after Cholecystectomy: A Nationwide Population-Based Cohort Study in South Korea

Journal of Clinical Medicine ◽

10.3390/jcm10153253 ◽

2021 ◽

Vol 10 (15) ◽

pp. 3253

Author(s):

Yoo Jin Kim ◽

Young Soo Park ◽

Cheol Min Shin ◽

Kyungdo Han ◽

Sang Hyun Park ◽

...

Keyword(s):

Cohort Study ◽

Heart Disease ◽

South Korea ◽

Heart Diseases ◽

Previous History ◽

Population Based ◽

Increased Risk ◽

Subgroup Analyses ◽

History Of ◽

Cox Proportional Hazard Regression

The aim of the study is to evaluate the risk of heart disease in individuals who underwent cholecystectomy. This was a retrospective cohort study using the National Health Insurance Service database of South Korea. A total of 146,928 patients who underwent cholecystectomy and 268,502 age- and sex-matched controls were compared. Multivariate Cox proportional hazard regression analysis was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for heart disease after cholecystectomy. In results, a previous history of cholecystectomy increased the risk of heart disease (congestive heart failure [CHF], myocardial infarction [MI], atrial fibrillation [AF]) (adjusted HR [aHR]: 1.40, 95% CI: [1.36–1.44]). The increased risk was particularly seen for CHF (1.22 [1.16–1.29]) but not for MI and AF (p > 0.05). In the subgroup analyses, cholecystectomy was associated with an increased risk of MI in patients aged <65 years (1.49 [1.16–1.92] and 1.18 [1.05–1.35] in patients aged 40–49 and 50–64 years, respectively), but not in those aged ≥ 65 years (0.932 [0.838–1.037]). Moreover, the risk of MI was increased in patients without diabetes mellitus (DM) (1.16 [1.06–1.27]); however, it was decreased in patients with DM (0.83 [0.72–0.97]). In contrast, cholecystectomy did not modify the risk of AF in the subgroup analyses (all p > 0.05). In conclusion, a history of cholecystectomy is associated with an increased risk of CHF. Cholecystectomy may increase the risk of MI in the younger population without DM. These findings suggest that the alteration of bile metabolism and homeostasis might be potentially associated with the development of some heart diseases.

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Correction: The relationship between drinking alcohol and esophageal, gastric or colorectal cancer: A nationwide population-based cohort study of South Korea

PLoS ONE ◽

10.1371/journal.pone.0197765 ◽

2018 ◽

Vol 13 (5) ◽

pp. e0197765

Author(s):

Yoon Jin Choi ◽

Dong Ho Lee ◽

Kyung-Do Han ◽

Hyun Soo Kim ◽

Hyuk Yoon ◽

...

Keyword(s):

Colorectal Cancer ◽

Cohort Study ◽

South Korea ◽

Population Based ◽

Drinking Alcohol ◽

The Relationship

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Oral health of high-cost patients and evaluation of oral health measures as predictors for high-cost patients in South Korea: a population-based cohort study

BMJ Open ◽

10.1136/bmjopen-2019-032446 ◽

2019 ◽

Vol 9 (9) ◽

pp. e032446 ◽

Cited By ~ 1

Author(s):

Yeonkook Joseph Kim

Keyword(s):

Cohort Study ◽

Oral Health ◽

South Korea ◽

National Health ◽

Health Behaviours ◽

Population Based ◽

Health Measures ◽

Patient Status ◽

Increased Risk ◽

Oral Health Behaviours

ObjectiveTo examine the oral health conditions and oral health behaviour of high-cost patients and evaluate oral health measures as predictors of future high-cost patients.DesignA retrospective, population-based cohort study using administrative healthcare records.SettingThe National Health Insurance Service (NHIS) medical check-up database (a.k.a. NHIS—national health screening cohort database) in South Korea.Participants131 549 individuals who received biennial health check-ups including dental check-ups in 2011 or 2012, aged 49–88.Primary outcome measuresCurrent and subsequent year high-cost patient status.ResultsHigh-cost patients, on average, incur higher dental costs, suffer more from periodontal disease, brush their teeth less and use secondary oral hygiene products less. Some of the self-reported oral health behaviours and oral symptom variables show statistically significant associations with subsequent year high-cost patient indicators, even after adjusting for demographic, socioeconomic, medical conditions, and prior healthcare cost and utilisation.ConclusionsWe demonstrate that oral health measures are associated with an increased risk of becoming a high-cost patient.

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Hydroxychloroquine reduces risk of incident diabetes mellitus in lupus patients in a dose-dependent manner: a population-based cohort study

Rheumatology ◽

10.1093/rheumatology/keu451 ◽

2015 ◽

Vol 54 (7) ◽

pp. 1244-1249 ◽

Cited By ~ 56

Author(s):

Yi-Ming Chen ◽

Ching-Heng Lin ◽

Tsuo-Hung Lan ◽

Hsin-Hua Chen ◽

Shih-Ni Chang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Cohort Study ◽

Cumulative Dose ◽

Population Based ◽

Incident Diabetes ◽

High Dose ◽

Dependent Manner ◽

Newly Diagnosed ◽

Increased Risk ◽

Dose Dependent

Abstract Objective. SLE is associated with increased risk of diabetes mellitus. Treatment for SLE requires high-dose glucocorticoids that may worsen glucose homoeostasis. HCQ can reduce diabetes risk in RA. This study aimed to investigate the association of HCQ use and diabetes mellitus risk in SLE patients. Methods. This nationwide, population-based cohort study was conducted using the Taiwan National Health Insurance Research Database. In the period 2001–10, 8628 newly diagnosed SLE patients were identified after excluding those with a previous diagnosis of RA, psoriasis or diabetes mellitus. Incidence of diabetes mellitus was identified as a new diagnostic code using a diabetes mellitus-specific medication. Results. Two hundred and twenty-one newly diagnosed diabetes mellitus patients were identified among SLE patients (6795 had taken HCQ and 1833 had never taken HCQ), with an average follow-up period of 5.6 years. Compared with patients without HCQ treatment, the hazard ratio (HR) of diabetes mellitus in patients taking HCQ at a cumulative dose ≥129 g was reduced [HR 0.26 (95% CI 0.18, 0.37), P < 0.001]. Daily glucocorticoid ≥10 mg prednisolone-equivalent dose was associated with increased risk of developing diabetes mellitus [HR 2.47 (95% CI 1.44, 4.23), P = 0.001], which was minimized by concomitant HCQ use at a cumulative dose ≥129 g. Conclusion. In SLE patients, the use of HCQ is associated with reduced risk of incident diabetes mellitus in a dose-dependent manner. High-dose glucocorticoids increase the risk of diabetes, which can be decreased by concomitant HCQ use.

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